Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_file Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID transcript_name strand transcript_status amino_acid_change ucsc_cons normal_depth normal_vaf tumor_depth tumor_vaf rna_depth rna_vaf polyphen sift condel domain ARID1A 8289 genome.wustl.edu 37 1 27100183 27100183 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_006015.4 +1 reviewed p.Q1327* 0.981 41 0% 54 22.2% 2 50% - - - NULL HEATR8 374977 genome.wustl.edu 37 1 55166892 55166892 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001039464.2 +1 validated p.A1061V 0.971 38 0% 48 31.2% 3 33.3% probably_damaging(0.979) tolerated(0.35) neutral(0.443) superfamily_ARM repeat ZNF687 57592 genome.wustl.edu 37 1 151259082 151259082 + Silent SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_020832.1 +1 provisional p.D105 0.257 14 0% 65 29.2% 3 66.6% - - - NULL DCAF8 50717 genome.wustl.edu 37 1 160209896 160209907 + In_Frame_Del DEL TCCTCTTCCTCT TCCTCTTCCTCT - novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 TCCTCTTCCTCT TCCTCTTCCTCT Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_015726.3 -1 reviewed p.EEEE105in_frame_del 0.989:0.991:0.929:0.997:0.995:0.087:0.948:0.957:0.464:1.000:1.000:1.000 - - - - - - - - - superfamily_WD40 repeat-like TDRD5 163589 genome.wustl.edu 37 1 179621302 179621302 + Silent SNP A A G novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_173533.2 +1 provisional p.P710 0.067 99 0% 78 25.6% 5 40% - - - NULL CFHR5 81494 genome.wustl.edu 37 1 196973890 196973890 + Missense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_030787.3 +1 reviewed p.R477H 0.001 65 0% 70 18.6% 0 - probably_damaging(0.997) tolerated(0.17) deleterious(0.525) HMMPfam_Sushi,HMMSmart_CCP,superfamily_Complement_control_module OR2M4 26245 genome.wustl.edu 37 1 248403030 248403030 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_017504.1 +1 provisional p.T267M 0.000 43 0% 40 12.5% 0 - probably_damaging(0.963) deleterious(0) deleterious(0.850) HMMPfam_7tm_1,superfamily_SSF81321 ZFP36L2 678 genome.wustl.edu 37 2 43452639 43452640 + Frame_Shift_Ins INS - - A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_006887.4 -1 reviewed p.K101fs 0.879:0.797 - - - - - - - - - HMMPfam_Tis11B_N LOC388946 388946 genome.wustl.edu 37 2 46707884 46707884 + Missense_Mutation SNP A A G novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001145051.1 +1 validated p.Q153R 0.238 12 0% 13 30.8% 0 - benign(0) tolerated(0.57) neutral(0.006) NULL NCKAP5 344148 genome.wustl.edu 37 2 133543153 133543153 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_207363.2 -1 validated p.R411* 1.000 83 0% 93 23.7% 0 - - - - NULL GALNT13 114805 genome.wustl.edu 37 2 155295135 155295135 + Missense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_052917.2 +1 validated p.R476Q 1.000 127 0% 99 19.2% 1 0% probably_damaging(0.996) tolerated(0.08) deleterious(0.762) HMMPfam_Ricin_B_lectin,HMMSmart_SM00458,superfamily_Ricin B-like lectins EFHB 151651 genome.wustl.edu 37 3 19929950 19929950 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_144715.3 -1 validated p.R640K 0.806 49 0% 57 29.8% 4 50% benign(0.005) tolerated(0.41) neutral(0.015) superfamily_EF-hand TTC21A 199223 genome.wustl.edu 37 3 39167772 39167772 + Frame_Shift_Del DEL C C - novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001105513.2 +1 validated p.I479fs 0.636 - - - - - - - - - NULL GAP43 2596 genome.wustl.edu 37 3 115439666 115439666 + Missense_Mutation SNP G G T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001130064.1 +1 reviewed p.K254N 1.000 82 0% 106 20.8% 0 - possibly_damaging(0.913) tolerated(0.17) neutral(0.423) HMMPfam_Neuromodulin GPR149 344758 genome.wustl.edu 37 3 154146490 154146490 + Silent SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001038705.1 -1 provisional p.S305 0.333 9 0.000 37 0.189 0 - - - - NULL IL1RAP 3556 genome.wustl.edu 37 3 190326902 190326976 + Frame_Shift_Del DEL AGGATCACTTGTCCAAATGTAGATGGATATTTTCCTTCCAGTGTCAAACCGACTATCACTTGGTATATGGTAAGG AGGATCACTTGTCCAAATGTAGATGGATATTTTCCTTCCAGTGTCAAACCGACTATCACTTGGTATATGGTAAGG - novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 AGGATCACTTGTCCAAATGTAGATGGATATTTTCCTTCCAGTGTCAAACCGACTATCACTTGGTATATGGTAAGG AGGATCACTTGTCCAAATGTAGATGGATATTTTCCTTCCAGTGTCAAACCGACTATCACTTGGTATATGGTAAGG Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_002182.3 +1 reviewed p.R157fs 0.125:0.007:0.008:0.752:0.974:0.977:0.967:0.966:0.951:0.999:1.000:1.000:1.000:1.000:0.998:0.989:0.991:0.958:0.953:0.991:0.989:1.000:1.000:0.997:1.000:1.000:0.999:1.000:0.989:0.987:1.000:1.000:1.000:1.000:1.000:0.969:0.522:0.527:0.362:0.342:0.014:0.036:0.255:0.559:0.557:0.731:0.915:0.929:0.983:0.976:0.025:0.001:0.000:0.000:0.000:0.979:0.999:1.000:1.000:0.999:1.000:1.000:1.000:1.000:1.000:1.000:1.000:0.999:1.000 - - - - - - - - - HMMSmart_SM00409,superfamily_Immunoglobulin PCGF3 10336 genome.wustl.edu 37 4 728731 728731 + Missense_Mutation SNP T T A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_006315.4 +1 reviewed p.C41S 1.000 25 0% 46 41.3% 19 26.3% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00184,PatternScan_ZF_RING_1,HMMPfam_zf-C3HC4,superfamily_RING/U-box DCUN1D4 23142 genome.wustl.edu 37 4 52777240 52777240 + Missense_Mutation SNP A A T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001040402.1 +1 validated p.K207M 1.000 90 0% 83 22.9% 1 100% probably_damaging(0.986) deleterious(0.01) deleterious(0.840) HMMPfam_DUF298 UGT2B10 7365 genome.wustl.edu 37 4 69682456 69682456 + Splice_Site SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001075.4 +1 validated e1+1 1.000 118 0% 43 23.3% 0 - - - - - ADH4 127 genome.wustl.edu 37 4 100062725 100062725 + Frame_Shift_Del DEL T T - novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_000670.3 -1 reviewed p.S77fs 1.000 - - - - - - - - - PatternScan_ADH_ZINC,superfamily_GroES-like,HMMPfam_ADH_N FBXW7 55294 genome.wustl.edu 37 4 153249384 153249384 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_033632.2 -1 reviewed p.R465H 1.000 72 0% 53 22.6% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00320,superfamily_WD40 repeat-like,HMMPfam_WD40 CTNND2 1501 genome.wustl.edu 37 5 11199624 11199624 + Silent SNP G G T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001332.2 -1 validated p.G637 0.999 70 0% 133 27.8% 1 0% - - - HMMPfam_Arm,HMMSmart_SM00185,superfamily_ARM repeat AFF4 27125 genome.wustl.edu 37 5 132219164 132219164 + Missense_Mutation SNP C C A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_014423.3 -1 validated p.A1078S 1.000 42 0% 61 21.3% 0 - benign(0.055) tolerated(0.43) neutral(0.017) HMMPfam_AF-4 PCDHB16 57717 genome.wustl.edu 37 5 140563352 140563352 + Silent SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_020957.1 +1 reviewed p.E406 0.000 45 0% 109 23.9% 0 - - - - HMMPfam_Cadherin,HMMSmart_CA,superfamily_Cadherin PCDHGB3 56102 genome.wustl.edu 37 5 140751455 140751455 + Silent SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_018924.2 +1 reviewed p.P498 0.000 8 0.000 23 0.261 0 - - - - HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like PCDHGA7 56108 genome.wustl.edu 37 5 140764219 140764219 + Missense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_018920.2 +1 reviewed p.G585S 1.000 28 0% 83 26.5% 0 - possibly_damaging(0.949) deleterious(0.02) deleterious(0.776) HMMPfam_Cadherin,superfamily_Cadherin-like GRIA1 2890 genome.wustl.edu 37 5 153054149 153054149 + Silent SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_000827.3 +1 reviewed p.P263 0.206 49 0% 44 22.7% 0 - - - - HMMPfam_ANF_receptor,superfamily_Periplasmic binding protein-like I MLIP 90523 genome.wustl.edu 37 6 54025357 54025357 + Missense_Mutation SNP G G T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_138569.2 +1 validated p.C265F 1.000 31 0% 22 22.7% 0 - probably_damaging(0.976) tolerated(0.2) neutral(0.467) NULL EYS 346007 genome.wustl.edu 37 6 66005779 66005779 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001142800.1 -1 reviewed p.R667H 0.049 58 0% 107 15% 0 - unknown(0) - - HMMSmart_SM00181,superfamily_EGF/Laminin ANKRD6 22881 genome.wustl.edu 37 6 90340473 90340473 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_014942.3 +1 validated p.P640L 0.731 23 0% 61 24.6% 2 50% benign(0.001) tolerated(0.1) neutral(0.286) NULL SGK1 6446 genome.wustl.edu 37 6 134491990 134491992 + In_Frame_Del DEL TCT TCT - novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 TCT TCT Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001143676.1 -1 reviewed p.K462in_frame_del 1.000:1.000:1.000 - - - - - - - - - HMMSmart_S_TK_X,superfamily_Kinase_like DNAH11 8701 genome.wustl.edu 37 7 21747335 21747335 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_003777.3 +1 reviewed p.R2196* 0.875 61 0% 90 22.2% 0 - - - - HMMSmart_SM00382,HMMPfam_AAA_5,superfamily_P-loop containing nucleoside triphosphate hydrolases CHN2 1124 genome.wustl.edu 37 7 29539630 29539630 + Missense_Mutation SNP T T A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_004067.2 +1 reviewed p.I296K 0.999 41 0% 36 22.2% 1 100% benign(0.045) tolerated(1) neutral(0.003) HMMPfam_RhoGAP,HMMSmart_SM00324,superfamily_GTPase activation domain GAP KCND2 3751 genome.wustl.edu 37 7 119915274 119915274 + Silent SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_012281.2 +1 reviewed p.A196 0.992 30 0% 87 25.3% 0 - - - - superfamily_Voltage-gated potassium channels LRRC4 64101 genome.wustl.edu 37 7 127669748 127669748 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_022143.4 -1 validated p.R316* 0.994 24 0% 26 26.9% 5 0% - - - HMMSmart_SM00082,superfamily_L domain-like DEFB136 613210 genome.wustl.edu 37 8 11831628 11831628 + Splice_Site SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001033018.2 -1 provisional e2-1 0.694 41 0% 43 23.3% 0 - - - - - UBXN2B 137886 genome.wustl.edu 37 8 59359975 59359975 + Silent SNP A A G novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001077619.1 +1 validated p.V287 0.385 93 0% 101 24.8% 4 100% - - - HMMPfam_UBX,HMMSmart_UBX,superfamily_SSF54236 TSTA3 7264 genome.wustl.edu 37 8 144696827 144696827 + Missense_Mutation SNP G G C novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_003313.3 -1 reviewed p.S144W 1.000 26 0% 138 28.3% 144 45.8% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Epimerase,superfamily_NAD(P)-binding Rossmann-fold domains TLE1 7088 genome.wustl.edu 37 9 84202635 84202635 + Silent SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_005077.3 -1 provisional p.R646 0.011 22 0% 41 29.3% 37 29.7% - - - superfamily_WD40 repeat-like DAPK1 1612 genome.wustl.edu 37 9 90114038 90114038 + Missense_Mutation SNP G G C novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_004938.2 +1 reviewed p.G16R 1.000 52 0% 166 22.9% 0 - benign(0.001) tolerated(0.49) neutral(0.011) HMMSmart_S_TKc,superfamily_Kinase_like,HMMPfam_Pkinase NOL8 55035 genome.wustl.edu 37 9 95086320 95086320 + Missense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_017948.5 -1 validated p.R42W 0.987 53 0% 173 23.7% 1 100% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMSmart_SM00360,superfamily_RNA-binding domain RBD TMEM245 23731 genome.wustl.edu 37 9 111798567 111798567 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_032012.3 -1 validated p.G773E 1.000 56 0% 68 20.6% 4 50% possibly_damaging(0.907) tolerated(0.11) deleterious(0.632) NULL TTC16 158248 genome.wustl.edu 37 9 130485414 130485414 + Missense_Mutation SNP G G A rs184426971 by1000genomes TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_144965.1 +1 provisional p.R225Q 0.428 6 0.000 22 0.273 2 100% benign(0.077) tolerated(0.56) neutral(0.012) HMMPfam_TPR_1,HMMSmart_TPR,superfamily_SSF48452 ANAPC2 29882 genome.wustl.edu 37 9 140075360 140075360 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_013366.3 -1 reviewed p.R497H 1.000 17 0% 55 34.5% 35 42.8% probably_damaging(0.973) deleterious(0) deleterious(0.859) HMMPfam_Cullin,superfamily_Cullin homology domain MPP7 143098 genome.wustl.edu 37 10 28347423 28347423 + Splice_Site SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_173496.3 -1 validated e14+1 1.000 173 0% 106 20.8% 0 - - - - - ZWINT 11130 genome.wustl.edu 37 10 58119788 58119788 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_007057.3 -1 reviewed p.D83N 0.999 10 0% 34 20.6% 23 47.8% possibly_damaging(0.748) deleterious(0) deleterious(0.719) NULL CTNNA3 29119 genome.wustl.edu 37 10 67829178 67829178 + Missense_Mutation SNP C C A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001127384.1 -1 validated p.V683L 1.000 94 0% 96 18.8% 0 - possibly_damaging(0.792) tolerated(0.31) neutral(0.324) HMMPfam_Vinculin,superfamily_alpha-catenin/vinculin PTEN 5728 genome.wustl.edu 37 10 89690809 89690810 + Frame_Shift_Ins INS - - GAAA novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c ENST00000371953 +1 known p.H74fs 1.000:1.000 - - - - - - - - - HMMSmart_SM00404,superfamily_(Phosphotyrosine protein) phosphatases II PTEN 5728 genome.wustl.edu 37 10 89692794 89692794 + Missense_Mutation SNP A A G rs121909238 TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c ENST00000371953 +1 known p.H93R 1.000 147 0% 138 21% 11 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00404,superfamily_(Phosphotyrosine protein) phosphatases II MUC15 143662 genome.wustl.edu 37 11 26584699 26584699 + Missense_Mutation SNP A A T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001135091.1 -1 validated p.S297T 1.000 49 0% 46 54.3% 0 - unknown(0) deleterious(0) - NULL OR5T2 219464 genome.wustl.edu 37 11 56000492 56000492 + Missense_Mutation SNP G G T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001004746.1 -1 provisional p.T57K 0.000 32 0% 26 30.8% 0 - probably_damaging(0.994) deleterious(0.01) deleterious(0.858) superfamily_SSF81321 CTNND1 1500 genome.wustl.edu 37 11 57573395 57573395 + Nonsense_Mutation SNP T T A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001085458.1 +1 validated p.Y588* 0.872 74 0% 84 21.4% 5 0% - - - HMMSmart_SM00185,superfamily_ARM repeat DTX4 23220 genome.wustl.edu 37 11 58949532 58949532 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_015177.1 +1 validated p.P178S 0.993 21 0% 20 45% 0 - benign(0.004) tolerated(0.86) neutral(0.001) NULL RAD9A 5883 genome.wustl.edu 37 11 67163619 67163620 + Frame_Shift_Del DEL TT TT - novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 TT TT Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_004584.2 +1 reviewed p.L236fs 0.990:0.927 - - - - - - - - - HMMPfam_Rad9 CHD4 1108 genome.wustl.edu 37 12 6701638 6701638 + Missense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001273.2 -1 reviewed p.R957W 1.000 37 0% 69 29% 2 50% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_SNF2_N LPAR5 57121 genome.wustl.edu 37 12 6730193 6730193 + Silent SNP C C A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001142961.1 -1 reviewed p.S74 0.801 12 0% 51 21.6% 1 0% - - - HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like SLC38A1 81539 genome.wustl.edu 37 12 46592424 46592424 + Missense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001077484.1 -1 validated p.P369L 1.000 29 0% 24 29.2% 0 - probably_damaging(1) tolerated(0.1) deleterious(0.786) HMMPfam_Aa_trans MARS 4141 genome.wustl.edu 37 12 57884398 57884398 + Missense_Mutation SNP G G T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_004990.2 +1 reviewed p.L247F 0.300 52 0% 165 14.5% 6 16.6% benign(0.027) tolerated(0.5) neutral(0.011) NULL NAV3 89795 genome.wustl.edu 37 12 78515775 78515775 + Missense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_014903.4 +1 validated p.V1269M 1.000 23 0% 21 23.8% 0 - benign(0.001) tolerated(0.78) neutral(0.001) NULL TRPV4 59341 genome.wustl.edu 37 12 110238516 110238516 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_021625.4 -1 reviewed p.V254M 1.000 12 0% 43 32.6% 1 100% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Ank,HMMSmart_SM00248,superfamily_Ankyrin repeat PCDH9 5101 genome.wustl.edu 37 13 67802004 67802004 + Missense_Mutation SNP A A T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_203487.2 -1 reviewed p.L190Q 1.000 70 0% 176 12.5% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like PTPN21 11099 genome.wustl.edu 37 14 88945618 88945618 + Silent SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_007039.3 -1 reviewed p.F719 0.000 10 0% 40 17.5% 0 - - - - NULL MTMR10 54893 genome.wustl.edu 37 15 31266607 31266607 + Missense_Mutation SNP T T A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_017762.2 -1 validated p.K128N 1.000 109 0% 194 19.6% 0 - probably_damaging(0.996) deleterious(0.02) deleterious(0.845) superfamily_PH domain-like TPSD1 23430 genome.wustl.edu 37 16 1306560 1306560 + Frame_Shift_Del DEL G G - rs145614905 byCluster;by1000genomes TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_012217.2 +1 reviewed p.E43fs 0.030 - - - - - - - - - HMMPfam_Trypsin,HMMSmart_SM00020,superfamily_Trypsin-like serine proteases GNAO1 2775 genome.wustl.edu 37 16 56370656 56370656 + Missense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_020988.2 +1 validated p.G203R 1.000 15 0% 40 37.5% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_G-alpha,HMMSmart_SM00275,superfamily_P-loop containing nucleoside triphosphate hydrolases GLG1 2734 genome.wustl.edu 37 16 74487171 74487171 + Missense_Mutation SNP T T C novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_012201.5 -1 validated p.N1145S 1.000 73 0% 92 26.1% 68 48.5% benign(0.019) tolerated(0.1) neutral(0.287) NULL ABR 29 genome.wustl.edu 37 17 913998 913998 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_021962.2 -1 reviewed p.R736Q 0.998 23 0% 73 30.1% 5 0% probably_damaging(0.995) tolerated(0.72) neutral(0.459) HMMPfam_RhoGAP,HMMSmart_SM00324,superfamily_GTPase activation domain GAP SLC13A5 284111 genome.wustl.edu 37 17 6594140 6594140 + Silent SNP G G A rs150722760 by1000genomes TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_177550.3 -1 validated p.N465 0.789 35 0% 78 29.5% 1 0% - - - HMMPfam_Na_sulph_symp KDM6B 23135 genome.wustl.edu 37 17 7751859 7751864 + In_Frame_Del DEL CACCAC CACCAC - novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 CACCAC CACCAC Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001080424.1 +1 provisional p.TT755in_frame_del 0.000:0.006:0.963:0.964:0.935:0.971 - - - - - - - - - NULL GLP2R 9340 genome.wustl.edu 37 17 9763365 9763365 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_004246.1 +1 reviewed p.P291L 0.794 63 0% 70 30% 0 - possibly_damaging(0.923) tolerated(1) neutral(0.372) HMMPfam_7tm_2 TRPV2 51393 genome.wustl.edu 37 17 16329465 16329465 + Missense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_016113.3 +1 reviewed p.R326Q 1.000 27 0% 108 20.4% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_ANK RHBDF2 79651 genome.wustl.edu 37 17 74467762 74467762 + Missense_Mutation SNP T T G novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_024599.3 -1 validated p.T842P 1.000 25 0% 34 14.7% 33 3% probably_damaging(1) deleterious(0) deleterious(0.945) NULL LAMA1 284217 genome.wustl.edu 37 18 6999455 6999455 + Missense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_005559.2 -1 validated p.T1551I 0.001 28 0% 27 25.9% 0 - benign(0.018) tolerated(0.22) neutral(0.043) HMMPfam_Laminin_EGF,HMMSmart_SM00180,superfamily_Concanavalin A-like lectins/glucanases,superfamily_EGF/Laminin MBD1 4152 genome.wustl.edu 37 18 47806298 47806298 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_015846.3 -1 reviewed p.R22H 1.000 20 0% 52 25% 2 50% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_MBD,HMMSmart_SM00391,superfamily_DNA-binding domain TCF4 6925 genome.wustl.edu 37 18 53254345 53254345 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001083962.1 -1 reviewed p.M1I 1.000 46 0% 221 24% 0 - benign(0.004) deleterious(0) neutral(0.445) NULL INSR 3643 genome.wustl.edu 37 19 7132244 7132244 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_000208.2 -1 reviewed p.V923M 0.999 29 0% 26 23.1% 3 66.6% probably_damaging(0.996) deleterious(0.02) deleterious(0.845) HMMPfam_fn3,HMMSmart_SM00060,superfamily_Fibronectin type III ZNF486 90649 genome.wustl.edu 37 19 20308415 20308415 + Missense_Mutation SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_052852.2 +1 provisional p.C299Y 1.000 92 0% 87 25.3% 1 0% benign(0.251) deleterious(0.01) neutral(0.431) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 PPP1R13L 10848 genome.wustl.edu 37 19 45895165 45895165 + Missense_Mutation SNP G G T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001142502.1 -1 validated p.S596R 1.000 23 0% 42 28.6% 12 58.3% unknown(0) tolerated(0.3) - superfamily_Ankyrin repeat ZNF525 170958 genome.wustl.edu 37 19 53884295 53884295 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c ENST00000474037 +1 known p.Q155* 0.055 68 0% 139 23% 0 - - - - NULL NLRP4 147945 genome.wustl.edu 37 19 56382340 56382340 + Silent SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_134444.4 +1 validated p.P834 0.002 33 0% 30 26.7% 0 - - - - superfamily_RNI-like ZIK1 284307 genome.wustl.edu 37 19 58101761 58101761 + Silent SNP C C A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001010879.2 +1 provisional p.P194 0.000 36 0% 75 32% 1 0% - - - superfamily_Multiheme cytochromes JAG1 182 genome.wustl.edu 37 20 10644615 10644615 + Frame_Shift_Del DEL G G - novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_000214.2 -1 reviewed p.V146fs 0.144 - - - - - - - - - NULL SERINC3 10955 genome.wustl.edu 37 20 43128987 43128987 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_006811.2 -1 validated p.V458I 0.010 22 0% 16 43.8% 30 33.3% benign(0.042) tolerated(0.93) neutral(0.003) HMMPfam_Serinc PKNOX1 5316 genome.wustl.edu 37 21 44427698 44427698 + Missense_Mutation SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_004571.3 +1 validated p.P50L 0.977 62 0% 85 14.1% 2 50% benign(0.008) tolerated(0.2) neutral(0.049) NULL TUBA8 51807 genome.wustl.edu 37 22 18604311 18604311 + Silent SNP C C T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_018943.1 +1 provisional p.L23 1.000 25 0% 39 15.4% 0 - unknown(0) - - HMMPfam_Tubulin,superfamily_Tubulin nucleotide-binding domain-like RIMBP3 85376 genome.wustl.edu 37 22 20458310 20458310 + Missense_Mutation SNP G G T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_015672.1 -1 validated p.Q998K 0.224 58 0% 185 11.4% 0 - benign(0.075) deleterious(0.03) neutral(0.369) superfamily_Fibronectin type III TNRC6B 23112 genome.wustl.edu 37 22 40662003 40662006 + Frame_Shift_Del DEL GTCG GTCG - novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 GTCG GTCG Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_015088.2 +1 validated p.S592fs 1.000:1.000:1.000:1.000 - - - - - - - - - NULL TUBGCP6 85378 genome.wustl.edu 37 22 50659925 50659925 + Missense_Mutation SNP T T C novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_020461.3 -1 reviewed p.T955A 0.471 12 0% 12 33.3% 5 20% possibly_damaging(0.452) deleterious(0) deleterious(0.593) HMMPfam_Spc97_Spc98 SHROOM2 357 genome.wustl.edu 37 X 9912854 9912854 + Silent SNP G G A novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_001649.2 +1 reviewed p.L1495 1.000 27 0% 51 25.5% 0 - - - - HMMPfam_ASD2 FAM120C 54954 genome.wustl.edu 37 X 54107765 54107765 + Missense_Mutation SNP G G C novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_017848.4 -1 validated p.P990A 1.000 34 0% 46 19.6% 0 - benign(0.138) tolerated(0.16) neutral(0.071) NULL AR 367 genome.wustl.edu 37 X 66905913 66905913 + Missense_Mutation SNP A A T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_000044.2 +1 reviewed p.K610N 1.000 93 0% 65 20% 0 - possibly_damaging(0.45) deleterious(0) deleterious(0.592) HMMPfam_zf-C4,HMMSmart_SM00399,superfamily_Glucocorticoid receptor-like (DNA-binding domain) IRS4 8471 genome.wustl.edu 37 X 107977987 107977987 + Silent SNP G G T novel TCGA-A5-A0R8-01A-11D-A10B-09 TCGA-A5-A0R8-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 54bbae9a-8226-41cf-949a-8f019e4b5e23 7bb8c7b0-0255-4530-8e82-6eff93f3035c NM_003604.2 -1 reviewed p.R530 0.962 63 0% 202 26.2% 0 - - - - NULL