Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_file Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID transcript_name strand transcript_status amino_acid_change ucsc_cons normal_depth normal_vaf tumor_depth tumor_vaf rna_depth rna_vaf polyphen sift condel domain KLHL17 339451 genome.wustl.edu 37 1 898231 898231 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198317.1 +1 provisional p.V326I 1.000 24 0% 11 54.5% 11 45.4% benign(0.011) tolerated(0.2) neutral(0.050) superfamily_Gal_oxid_central TAS1R3 83756 genome.wustl.edu 37 1 1269651 1269651 + Missense_Mutation SNP T T A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152228.1 +1 provisional p.L789H 0.004 20 0% 14 28.6% 3 66.6% possibly_damaging(0.845) tolerated(0.39) neutral(0.340) HMMPfam_7tm_3 DVL1 1855 genome.wustl.edu 37 1 1277148 1277148 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004421.2 -1 reviewed p.R168 0.999 25 0% 13 53.8% 32 31.2% - - - HMMPfam_Dishevelled MMEL1 79258 genome.wustl.edu 37 1 2537012 2537012 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033467.3 -1 reviewed p.G258 0.000 82 0% 32 31.2% 0 - - - - "HMMPfam_Peptidase_M13_N,superfamily_Metalloproteases (""zincins"") catalytic domain" PRDM16 63976 genome.wustl.edu 37 1 3322095 3322095 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022114.3 +1 reviewed p.R357C 1.000 28 0% 18 72.2% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers ARHGEF16 27237 genome.wustl.edu 37 1 3379773 3379773 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014448.3 +1 reviewed p.P42L 0.056 32 0% 13 30.8% 5 20% benign(0) tolerated(1) - NULL LRRC47 57470 genome.wustl.edu 37 1 3703574 3703574 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020710.2 -1 validated p.R306W 0.123 81 0% 63 49.2% 33 45.4% probably_damaging(0.982) deleterious(0.02) deleterious(0.809) NULL AJAP1 55966 genome.wustl.edu 37 1 4772564 4772564 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001042478.1 +1 validated p.R212W 0.996 66 0% 29 37.9% 0 - probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL NPHP4 261734 genome.wustl.edu 37 1 5967251 5967251 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015102.2 -1 reviewed p.R512Q 0.000 44 0% 29 48.3% 3 66.6% benign(0) tolerated(0.48) neutral(0.011) NULL KCNAB2 8514 genome.wustl.edu 37 1 6155645 6155645 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003636.2 +1 reviewed p.Y255 0.923 100 0% 65 50.8% 2 0% - - - HMMPfam_Aldo_ket_red,superfamily_NAD(P)-linked oxidoreductase CHD5 26038 genome.wustl.edu 37 1 6202296 6202296 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015557.1 -1 provisional p.Y776 0.937 102 0% 64 40.6% 0 - - - - HMMPfam_SNF2_N,HMMSmart_DEXDc,superfamily_SSF52540 RNF207 388591 genome.wustl.edu 37 1 6270962 6270962 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_207396.2 +1 validated p.T325 0.835 38 0% 16 62.5% 4 75% - - - NULL GPR153 387509 genome.wustl.edu 37 1 6314184 6314184 + Missense_Mutation SNP G G A rs148779940 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_207370.2 -1 validated p.A127V 1.000 77 0% 35 31.4% 2 50% probably_damaging(1) tolerated(0.2) deleterious(0.549) HMMPfam_7tm_1,superfamily_SSF81321 TAS1R1 80835 genome.wustl.edu 37 1 6639530 6639530 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138697.3 +1 reviewed p.F804 0.998 144 0.7% 61 49.2% 1 0% - - - HMMPfam_7tm_3 KLHL21 9903 genome.wustl.edu 37 1 6653515 6653515 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014851.2 -1 provisional p.S568 0.000 36 0% 20 20% 3 33.3% - - - NULL CA6 765 genome.wustl.edu 37 1 9030987 9030987 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001215.2 +1 reviewed p.R264H 0.992 132 0% 105 37.1% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Carb_anhydrase,superfamily_Euk_COanhd KIF1B 23095 genome.wustl.edu 37 1 10435430 10435430 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000355249 +1 known p.R1803* 1.000 131 0% 118 39% 4 50% - - - NULL CLCN6 1185 genome.wustl.edu 37 1 11896106 11896106 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001286.2 +1 reviewed p.R626C 1.000 115 0% 82 43.9% 2 100% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_CBS,HMMSmart_SM00116,superfamily_CBS-domain TNFRSF1B 7133 genome.wustl.edu 37 1 12252977 12252977 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001066.2 +1 reviewed p.T203 0.010 124 0% 81 46.9% 15 26.6% - - - NULL PRAMEF2 65122 genome.wustl.edu 37 1 12919751 12919751 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_023014.1 +1 provisional p.L164P 0.000 149 0% 193 15% 0 - probably_damaging(0.997) deleterious(0.02) deleterious(0.849) superfamily_SSF52047 PRDM2 7799 genome.wustl.edu 37 1 14105517 14105517 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012231.4 +1 reviewed p.E409 1.000 59 0% 48 39.6% 4 50% - - - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers CELA2B 51032 genome.wustl.edu 37 1 15809871 15809871 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015849.2 +1 reviewed p.V157I 0.992 206 0% 132 47% 0 - benign(0.126) tolerated(1) neutral(0.011) HMMPfam_Trypsin,HMMSmart_Tryp_SPc,superfamily_Pept_Ser_Cys DDI2 84301 genome.wustl.edu 37 1 15953248 15953248 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032341.3 +1 provisional p.R75* 1.000 163 0% 126 50% 2 50% - - - HMMPfam_ubiquitin,superfamily_Ubiquitin-like ZBTB17 7709 genome.wustl.edu 37 1 16273450 16273450 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003443.2 -1 validated p.A125V 0.000 77 0% 20 35% 12 25% benign(0.006) tolerated(0.41) neutral(0.015) NULL TMCO4 255104 genome.wustl.edu 37 1 20107148 20107148 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_181719.4 -1 validated p.T35I 0.054 50 0% 26 19.2% 9 0% benign(0.04) deleterious(0.02) neutral(0.386) NULL UBXN10 127733 genome.wustl.edu 37 1 20517120 20517120 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152376.3 +1 provisional p.V22 0.016 26 0% 31 38.7% 17 29.4% - - - NULL MUL1 79594 genome.wustl.edu 37 1 20827484 20827484 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024544.2 -1 validated p.A253V 1.000 62 0% 30 36.7% 16 56.2% benign(0.04) tolerated(1) neutral(0.003) NULL EIF4G3 8672 genome.wustl.edu 37 1 21180089 21180089 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003760.3 -1 validated p.T1116M 0.880 245 0% 188 29.3% 17 23.5% possibly_damaging(0.765) tolerated(0.22) neutral(0.326) NULL ECE1 1889 genome.wustl.edu 37 1 21551880 21551880 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001397.2 -1 reviewed p.V635M 0.993 142 0% 60 40% 82 42.6% possibly_damaging(0.95) deleterious(0) deleterious(0.838) "HMMPfam_Peptidase_M13,superfamily_Metalloproteases (""zincins"") catalytic domain" ECE1 1889 genome.wustl.edu 37 1 21554507 21554507 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000436918 -1 known p.R26C 0.980 132 0% 82 28% 80 25% - - - "HMMPfam_Peptidase_M13,superfamily_Metalloproteases (""zincins"") catalytic domain" HSPG2 3339 genome.wustl.edu 37 1 22183650 22183650 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005529.5 -1 reviewed p.R1791W 0.996 170 0% 74 36.5% 17 29.4% - - - NULL HSPG2 3339 genome.wustl.edu 37 1 22186165 22186165 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005529.5 -1 reviewed p.R1709* 0.031 90 0% 37 35.1% 11 36.3% - - - NULL EPHB2 2048 genome.wustl.edu 37 1 23111494 23111494 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004442.6 +1 reviewed p.E246K 1.000 36 0% 16 56.2% 8 62.5% probably_damaging(0.987) deleterious(0.05) deleterious(0.782) PatternScan_RECEPTOR_TYR_KIN_V_2 LUZP1 7798 genome.wustl.edu 37 1 23418352 23418352 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001142546.1 -1 reviewed p.S801 0.003 187 0% 145 29% 2 0% - - - NULL HMGCL 3155 genome.wustl.edu 37 1 24130962 24130962 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000235958 -1 known p.T125M 1.000 59 0% 23 30.4% 64 39% - - - PatternScan_HMG_COA_LYASE,HMMPfam_HMGL-like,superfamily_Aldolase GRHL3 57822 genome.wustl.edu 37 1 24657930 24657930 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021180.2 +1 reviewed p.R16Q 0.996 124 0% 94 40.4% 3 66.6% possibly_damaging(0.864) deleterious(0.03) deleterious(0.699) NULL MAN1C1 57134 genome.wustl.edu 37 1 26109095 26109095 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020379.2 +1 validated p.R557Q 1.000 182 0% 107 29% 34 44.1% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Glyco_hydro_47,superfamily_Glyco_hydro_47 ARID1A 8289 genome.wustl.edu 37 1 27105870 27105870 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006015.4 +1 reviewed p.C1827 1.000 60 0% 46 50% 57 50.8% - - - NULL C1orf172 126695 genome.wustl.edu 37 1 27278168 27278168 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000374109 -1 known p.R196* 0.991 38 0% 16 50% 33 45.4% - - - NULL SLC9A1 6548 genome.wustl.edu 37 1 27426972 27426972 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003047.3 -1 validated p.D758 0.122 165 0% 68 36.8% 87 44.8% - - - NULL GPR3 2827 genome.wustl.edu 37 1 27720955 27720955 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005281.2 +1 provisional p.R218H 1.000 183 0% 105 13.3% 0 - probably_damaging(0.997) tolerated(0.06) deleterious(0.788) HMMPfam_7tm_1,superfamily_SSF81321 RNU11 26824 genome.wustl.edu 37 1 28975245 28975280 + RNA DEL TTCTTTACTGTTATATGTTAGGCGAAATATTACGCG TTCTTTACTGTTATATGTTAGGCGAAATATTACGCG - novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 TTCTTTACTGTTATATGTTAGGCGAAATATTACGCG TTCTTTACTGTTATATGTTAGGCGAAATATTACGCG Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NR_004407.1 +1 provisional NULL 0.000:0.001 - - - - - - - - - - OPRD1 4985 genome.wustl.edu 37 1 29189552 29189552 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000911.3 +1 validated p.R292 1.000 35 0% 17 58.8% 0 - - - - HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like EPB41 2035 genome.wustl.edu 37 1 29385119 29385119 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_203342.2 +1 reviewed p.E413K 1.000 145 0% 235 38.7% 8 50% possibly_damaging(0.69) tolerated(0.12) deleterious(0.508) NULL SPOCD1 90853 genome.wustl.edu 37 1 32279675 32279675 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_144569.4 -1 provisional p.K420 0.001 68 0% 61 29.5% 0 - - - - NULL TXLNA 200081 genome.wustl.edu 37 1 32647120 32647120 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_175852.3 +1 validated p.D149 0.676 47 0% 39 46.2% 15 26.6% - - - NULL ADC 113451 genome.wustl.edu 37 1 33562394 33562394 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_052998.2 +1 validated p.Y280 0.431 181 0% 130 39.2% 3 33.3% - - - HMMPfam_Orn_Arg_deC_N,superfamily_Alanine racemase C-terminal domain-like,superfamily_PLP-binding barrel C1orf94 84970 genome.wustl.edu 37 1 34666479 34666479 + Silent SNP C C T rs149791275 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001134734.1 +1 validated p.D372 0.972 79 0% 41 26.8% 0 - - - - NULL MAP7D1 55700 genome.wustl.edu 37 1 36643787 36643787 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018067.3 +1 provisional p.A565T 0.000 8 0.000 9 0.444 32 28.1% probably_damaging(0.965) tolerated(0.84) neutral(0.407) NULL THRAP3 9967 genome.wustl.edu 37 1 36748232 36748232 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005119.3 +1 validated p.R23H 1.000 139 0% 145 29% 23 30.4% unknown(0) deleterious(0) - NULL GRIK3 2899 genome.wustl.edu 37 1 37325450 37325450 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000831.3 -1 reviewed p.M319V 1.000 97 1% 63 31.7% 1 0% possibly_damaging(0.588) tolerated(0.65) neutral(0.206) HMMPfam_ANF_receptor,superfamily_SSF53822 GRIK3 2899 genome.wustl.edu 37 1 37325576 37325576 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000831.3 -1 reviewed p.V277M 0.999 110 0% 79 39.2% 2 0% probably_damaging(0.996) deleterious(0.01) deleterious(0.867) HMMPfam_ANF_receptor,superfamily_SSF53822 MTF1 4520 genome.wustl.edu 37 1 38289411 38289411 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005955.2 -1 reviewed p.T381M 0.020 195 0% 218 45% 2 100% possibly_damaging(0.83) deleterious(0.01) deleterious(0.721) NULL HPCAL4 51440 genome.wustl.edu 37 1 40148355 40148355 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016257.2 -1 reviewed p.D143 0.988 95 1.1% 67 44.8% 0 - - - - superfamily_EF-hand PPIE 10450 genome.wustl.edu 37 1 40214583 40214583 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006112.2 +1 reviewed p.R173C 1.000 65 0% 50 20% 19 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Pro_isomerase,superfamily_Cyclophilin-like PPCS 79717 genome.wustl.edu 37 1 42925433 42925433 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024664.2 +1 validated p.N258D 1.000 120 0% 158 13.9% 71 4.2% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_DFP,superfamily_DNA/pantothenate-metab_flavo_C YBX1 4904 genome.wustl.edu 37 1 43166469 43166469 + Missense_Mutation SNP G G C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004559.3 +1 validated p.R253T 1.000 61 0% 36 38.9% 933 41.2% possibly_damaging(0.864) deleterious(0.01) deleterious(0.740) NULL SZT2 23334 genome.wustl.edu 37 1 43905375 43905375 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015284.2 +1 predicted p.R1427Q 0.952 116 0% 88 45.5% 3 66.6% benign(0) tolerated(0.38) neutral(0.018) NULL ATP6V0B 533 genome.wustl.edu 37 1 44442793 44442793 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004047.3 +1 reviewed p.D166N 1.000 92 0% 67 50.7% 504 44% probably_damaging(1) tolerated(0.24) deleterious(0.537) HMMPfam_ATP-synt_C,superfamily_F1F0 ATP synthase subunit C KLF17 128209 genome.wustl.edu 37 1 44595230 44595230 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_173484.3 +1 validated p.R96H 0.000 73 0% 34 47.1% 0 - benign(0.004) tolerated(1) - NULL HECTD3 79654 genome.wustl.edu 37 1 45471685 45471685 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024602.5 -1 validated p.R610Q 1.000 71 0% 37 32.4% 18 44.4% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_HECT,HMMSmart_SM00119,superfamily_Hect E3 ligase catalytic domain TOE1 114034 genome.wustl.edu 37 1 45808875 45808875 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_025077.3 +1 validated p.R345Q 0.834 65 0% 42 28.6% 11 36.3% probably_damaging(0.988) tolerated(0.08) deleterious(0.738) HMMPfam_CAF1 TESK2 10420 genome.wustl.edu 37 1 45810774 45810774 + Missense_Mutation SNP C C T rs186592461 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007170.2 -1 reviewed p.R485H 0.990 146 0% 77 41.6% 7 28.5% probably_damaging(0.991) deleterious(0) deleterious(0.889) NULL RAD54L 8438 genome.wustl.edu 37 1 46740259 46740259 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001142548.1 +1 reviewed p.L580P 1.000 131 0% 88 40.9% 16 75% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Helicase_C,HMMSmart_HELICc,superfamily_SSF52540 ATPAF1-AS1 374973 genome.wustl.edu 37 1 47138872 47138872 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001145474.1 +1 predicted p.A122V 0.001 99 0% 63 30.2% 1 0% - - - NULL BEND5 79656 genome.wustl.edu 37 1 49208350 49208350 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024603.2 -1 validated p.S280F 1.000 133 0% 107 24.3% 14 28.5% benign(0.28) deleterious(0.01) deleterious(0.492) NULL PODN 127435 genome.wustl.edu 37 1 53544326 53544326 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153703.3 +1 validated p.V430M 1.000 40 0% 13 53.8% 0 - probably_damaging(0.991) deleterious(0.03) deleterious(0.808) superfamily_SSF52047 SLC1A7 6512 genome.wustl.edu 37 1 53569136 53569136 + Silent SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006671.4 -1 validated p.S193 0.010 91 0% 34 20.6% 0 - - - - HMMPfam_SDF SSBP3 23648 genome.wustl.edu 37 1 54723815 54723815 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145716.2 -1 validated p.P125L 1.000 68 0% 26 30.8% 5 0% probably_damaging(0.999) deleterious(0.04) deleterious(0.839) HMMPfam_SSDP PCSK9 255738 genome.wustl.edu 37 1 55509595 55509595 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_174936.2 +1 reviewed p.R96H 0.943 55 0% 37 27% 0 - benign(0.016) tolerated(0.15) neutral(0.241) superfamily_Protease propeptides/inhibitors,HMMPfam_Inhibitor_I9 USP24 23358 genome.wustl.edu 37 1 55625357 55625357 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015306.2 -1 validated p.P220H 1.000 132 0% 214 40.2% 4 25% probably_damaging(0.992) tolerated(0.09) deleterious(0.744) NULL WDR78 79819 genome.wustl.edu 37 1 67293571 67293571 + Missense_Mutation SNP C C A rs78356162 TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024763.4 -1 validated p.G679V 1.000 110 0% 225 42.2% 0 - probably_damaging(1) deleterious(0.01) deleterious(0.905) superfamily_WD40 repeat-like SLC35D1 23169 genome.wustl.edu 37 1 67507947 67507947 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015139.2 -1 reviewed p.I234T 1.000 231 0% 332 38% 1 100% benign(0.005) tolerated(0.17) neutral(0.059) NULL FUBP1 8880 genome.wustl.edu 37 1 78425870 78425870 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003902.3 -1 reviewed p.P525 1.000 55 0% 67 34.3% 54 16.6% - - - NULL GTF2B 2959 genome.wustl.edu 37 1 89318985 89318985 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001514.5 -1 reviewed p.S288P 1.000 200 0% 237 34.2% 51 45% probably_damaging(0.973) deleterious(0.01) deleterious(0.821) HMMSmart_SM00385,superfamily_Cyclin-like GBP4 115361 genome.wustl.edu 37 1 89658703 89658703 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_052941.4 -1 validated p.A185V 0.968 169 0% 218 41.3% 0 - benign(0) tolerated(1) - HMMPfam_GBP,superfamily_SSF52540 BARHL2 343472 genome.wustl.edu 37 1 91182656 91182656 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020063.1 -1 validated p.R33C 1.000 95 0% 76 44.7% 0 - unknown(0) deleterious(0) - NULL RWDD3 25950 genome.wustl.edu 37 1 95710013 95710013 + Missense_Mutation SNP T T G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015485.4 +1 validated p.L111R 0.996 164 0% 164 36% 12 50% probably_damaging(0.994) deleterious(0.01) deleterious(0.858) HMMPfam_RWD,HMMSmart_SM00591,superfamily_UBC-like PTBP2 58155 genome.wustl.edu 37 1 97272008 97272008 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021190.2 +1 reviewed p.G360S 1.000 375 0% 686 37.9% 3 66.6% probably_damaging(0.974) tolerated(0.07) deleterious(0.735) HMMPfam_RRM_1,HMMSmart_SM00360,superfamily_RNA-binding domain RBD LPPR4 9890 genome.wustl.edu 37 1 99771647 99771647 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014839.4 +1 reviewed p.R458Q 0.997 49 0% 21 52.4% 0 - probably_damaging(0.985) deleterious(0.01) deleterious(0.838) NULL HIAT1 64645 genome.wustl.edu 37 1 100535201 100535201 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033055.2 +1 validated p.A284V 1.000 246 0.4% 471 44.2% 11 63.6% benign(0.001) tolerated(1) - HMMPfam_MFS_1,superfamily_MFS_gen_substrate_transporter HENMT1 113802 genome.wustl.edu 37 1 109191481 109191481 + Missense_Mutation SNP G G A rs140991391 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001102592.1 -1 validated p.R297W 0.000 119 1.7% 112 40.2% 19 52.6% benign(0) deleterious(0.01) neutral(0.406) NULL PRPF38B 55119 genome.wustl.edu 37 1 109242529 109242529 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018061.2 +1 validated p.R510* 1.000 38 0% 65 44.6% 53 58.4% - - - NULL AKNAD1 254268 genome.wustl.edu 37 1 109394366 109394366 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152763.3 -1 validated p.P307 0.015 367 0% 564 40.6% 0 - - - - NULL FAM40A 85369 genome.wustl.edu 37 1 110596531 110596531 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033088.2 +1 validated p.Q837H 1.000 73 1.4% 54 29.6% 30 60% probably_damaging(0.983) deleterious(0) deleterious(0.873) NULL ADORA3 140 genome.wustl.edu 37 1 112043018 112043018 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000677.3 -1 reviewed p.V171I 0.998 92 0% 81 37% 1 0% probably_damaging(0.987) deleterious(0.01) deleterious(0.842) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like CTTNBP2NL 55917 genome.wustl.edu 37 1 112999002 112999002 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018704.2 +1 validated p.V296 0.003 72 0% 87 37.9% 7 28.5% - - - HMMPfam_CortBP2 RSBN1 54665 genome.wustl.edu 37 1 114340623 114340623 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018364.3 -1 validated p.D247N 1.000 100 0% 153 17.6% 6 33.3% probably_damaging(0.979) deleterious(0.01) deleterious(0.828) NULL SYCP1 6847 genome.wustl.edu 37 1 115469149 115469149 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003176.2 +1 validated p.A631T 1.000 112 0% 313 35.5% 0 - probably_damaging(0.999) tolerated(0.18) deleterious(0.546) HMMPfam_SCP-1 TSPAN2 10100 genome.wustl.edu 37 1 115596000 115596000 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005725.4 -1 reviewed p.T200 1.000 134 0% 214 40.7% 1 0% - - - HMMPfam_Tetraspannin CD2 914 genome.wustl.edu 37 1 117307211 117307212 + Frame_Shift_Del DEL AG AG - novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 AG AG Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001767.3 +1 validated p.R241fs 0.080:0.107 - - - - - - - - - NULL PTGFRN 5738 genome.wustl.edu 37 1 117484366 117484366 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020440.2 +1 provisional p.P27T 0.965 26 0% 17 47.1% 19 26.3% probably_damaging(0.978) tolerated(0.17) deleterious(0.479) HMMPfam_V-set,superfamily_Immunoglobulin CD101 9398 genome.wustl.edu 37 1 117560898 117560898 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004258.3 +1 validated p.T578M 0.003 123 0% 104 16.3% 1 0% benign(0.142) deleterious(0.02) neutral(0.395) HMMSmart_IG,HMMPfam_ig,superfamily_SSF48726 TRIM45 80263 genome.wustl.edu 37 1 117661072 117661072 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_025188.3 -1 reviewed p.R269Q 0.433 90 0% 59 33.9% 10 30% benign(0.008) tolerated(0.18) neutral(0.056) HMMSmart_SM00502 BCL9 607 genome.wustl.edu 37 1 147086382 147086382 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004326.2 +1 reviewed p.V176A 1.000 183 0% 200 10.5% 8 37.5% possibly_damaging(0.792) deleterious(0.04) deleterious(0.646) NULL LOC729086 729086 genome.wustl.edu 37 1 148193828 148193828 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_001129280.3 +1 model p.P164L 0.994 100 0% 55 27.3% 12 0% - - - NULL VPS45 11311 genome.wustl.edu 37 1 150054802 150054802 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007259.3 +1 reviewed p.A313 0.984 236 0% 273 44.7% 25 44% - - - HMMPfam_Sec1,superfamily_Sec1/munc18-like (SM) proteins ARNT 405 genome.wustl.edu 37 1 150802422 150802422 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001668.2 -1 reviewed p.G330 1.000 90 0% 77 39% 6 50% - - - NULL TNFAIP8L2 79626 genome.wustl.edu 37 1 151131654 151131654 + Frame_Shift_Del DEL G G - novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024575.3 +1 validated p.P162fs 0.939 - - - - - - - - - HMMPfam_DUF758 OAZ3 51686 genome.wustl.edu 37 1 151739334 151739334 + Missense_Mutation SNP G G A rs141059076 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016178.2 +1 reviewed p.R46Q 1.000 143 0% 154 41.6% 1 100% possibly_damaging(0.867) deleterious(0) deleterious(0.781) NULL RORC 6097 genome.wustl.edu 37 1 151787154 151787154 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005060.3 -1 reviewed p.V277I 0.994 55 0% 34 44.1% 2 0% benign(0.004) tolerated(1) - superfamily_Nuclear receptor ligand-binding domain FLG2 388698 genome.wustl.edu 37 1 152329231 152329231 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001014342.2 -1 provisional p.N344S 0.010 185 0.5% 197 32% 0 - unknown(0) tolerated(0.84) - NULL PGLYRP3 114771 genome.wustl.edu 37 1 153276340 153276340 + Silent SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_052891.1 -1 provisional p.P174 0.262 187 0% 145 26.9% 0 - - - - NULL ATP8B2 57198 genome.wustl.edu 37 1 154300597 154300597 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020452.3 +1 reviewed p.A27T 1.000 156 0% 132 30.3% 0 - unknown(0) - - NULL GBA 2629 genome.wustl.edu 37 1 155204997 155204997 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000157.3 -1 reviewed p.V498 0.997 143 0% 83 42.2% 38 26.3% - - - HMMPfam_Glyco_hydro_30,superfamily_Glycosyl hydrolase domain ASH1L 55870 genome.wustl.edu 37 1 155313213 155313213 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018489.2 -1 reviewed p.R2729C 1.000 223 0% 251 45% 3 66.6% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_BAH,HMMSmart_SM00439 ASH1L 55870 genome.wustl.edu 37 1 155448204 155448204 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018489.2 -1 reviewed p.R1486H 1.000 222 0.5% 206 44.2% 1 100% probably_damaging(0.989) tolerated(0.72) neutral(0.441) NULL ARHGEF2 9181 genome.wustl.edu 37 1 155932911 155932911 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004723.3 -1 validated p.T235M 0.997 97 0% 47 10.6% 24 0% probably_damaging(0.998) deleterious(0.01) deleterious(0.880) HMMPfam_RhoGEF,HMMSmart_SM00325,superfamily_DBL homology domain (DH-domain) UBQLN4 56893 genome.wustl.edu 37 1 156011374 156011374 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020131.3 -1 provisional p.A519T 0.778 140 0% 75 41.3% 4 50% benign(0.007) tolerated(0.93) - NULL UBQLN4 56893 genome.wustl.edu 37 1 156020972 156020972 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020131.3 -1 provisional p.R136Q 1.000 69 0% 25 24% 7 42.8% unknown(0) tolerated(0.36) - NULL C1orf85 112770 genome.wustl.edu 37 1 156262860 156262860 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_144580.1 -1 provisional p.Y399C 0.268 54 0% 33 12.1% 34 5.8% benign(0.001) tolerated(0.18) neutral(0.056) NULL ISG20L2 81875 genome.wustl.edu 37 1 156697248 156697248 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_030980.1 -1 provisional p.T66M 0.000 58 0% 47 40.4% 16 37.5% benign(0.004) tolerated(0.1) neutral(0.286) NULL INSRR 3645 genome.wustl.edu 37 1 156814409 156814409 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014215.1 -1 validated p.T861I 1.000 77 0% 30 43.3% 0 - benign(0.124) tolerated(0.19) neutral(0.060) HMMPfam_fn3,HMMSmart_FN3,superfamily_FN_III-like CD5L 922 genome.wustl.edu 37 1 157804401 157804401 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005894.2 -1 validated p.A172T 0.968 98 0% 53 32.1% 0 - possibly_damaging(0.907) deleterious(0) deleterious(0.805) HMMPfam_SRCR,HMMSmart_SM00202,superfamily_SRCR-like OR6P1 128366 genome.wustl.edu 37 1 158533230 158533230 + Silent SNP A A T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000334632 -1 known p.L55 0.988 54 0% 44 31.8% 0 - - - - HMMPfam_7tm_1,superfamily_SSF81321 FCER1A 2205 genome.wustl.edu 37 1 159272661 159272661 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002001.2 +1 reviewed p.A25T 0.039 424 0% 491 39.3% 1 0% benign(0.017) tolerated(0.23) neutral(0.042) superfamily_SSF48726 CRP 1401 genome.wustl.edu 37 1 159683707 159683707 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000567.2 -1 reviewed p.V95M 0.436 190 0% 232 37.5% 0 - probably_damaging(0.998) deleterious(0.01) deleterious(0.880) HMMPfam_Pentaxin,HMMSmart_SM00159,superfamily_Concanavalin A-like lectins/glucanases ATP1A2 477 genome.wustl.edu 37 1 160099971 160099971 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000702.3 +1 reviewed p.R514Q 1.000 42 0% 35 11.4% 12 0% probably_damaging(0.979) tolerated(0.05) deleterious(0.767) HMMPfam_Hydrolase,superfamily_SSF56784,superfamily_SSF81660,superfamily_SSF81665 ATP1A4 480 genome.wustl.edu 37 1 160145951 160145951 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_144699.3 +1 reviewed p.T794M 0.993 209 0% 150 36% 3 66.6% probably_damaging(0.997) deleterious(0.02) deleterious(0.849) superfamily_Calcium ATPase transmembrane domain M COPA 1314 genome.wustl.edu 37 1 160283780 160283780 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001098398.1 -1 reviewed p.R281Q 1.000 45 0% 62 50% 13 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_WD40,superfamily_WD40_like ARHGAP30 257106 genome.wustl.edu 37 1 161018208 161018208 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001025598.1 -1 validated p.A868V 0.004 166 0% 108 35.2% 10 0% benign(0) deleterious(0) neutral(0.445) NULL NDUFS2 4720 genome.wustl.edu 37 1 161180394 161180394 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004550.4 +1 reviewed p.R294W 0.998 138 0% 101 40.6% 84 39.2% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Complex1_49kDa,superfamily_SSF56762 NR1I3 9970 genome.wustl.edu 37 1 161205693 161205693 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001077482.1 -1 reviewed p.R61H 1.000 146 0% 126 42.1% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_zf-C4,HMMSmart_ZnF_C4,superfamily_SSF57716 OLFML2B 25903 genome.wustl.edu 37 1 161969985 161969985 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015441.1 -1 provisional p.P289 0.072 46 0% 47 51.1% 2 0% - - - NULL POU2F1 5451 genome.wustl.edu 37 1 167358897 167358897 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002697.2 +1 provisional p.R273* 1.000 426 0% 348 12.6% 3 0% - - - NULL CD247 919 genome.wustl.edu 37 1 167487689 167487689 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198053.2 -1 reviewed p.A5V 0.000 112 0% 55 41.8% 1 0% benign(0) tolerated(0.95) - NULL F5 2153 genome.wustl.edu 37 1 169521963 169521963 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000130.4 -1 reviewed p.R376 0.991 171 0% 313 39.9% 0 - - - - superfamily_Cupredoxins PAPPA2 60676 genome.wustl.edu 37 1 176668317 176668317 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020318.2 +1 validated p.T943M 1.000 78 0% 53 41.5% 0 - probably_damaging(1) deleterious(0.02) deleterious(0.883) HMMPfam_Peptidase_M43 ABL2 27 genome.wustl.edu 37 1 179079565 179079565 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007314.3 -1 reviewed p.A559 0.011 182 0% 176 33% 2 0% - - - superfamily_Protein kinase-like (PK-like) TOR1AIP1 26092 genome.wustl.edu 37 1 179887078 179887078 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015602.2 +1 validated p.A486T 0.962 98 0% 91 39.6% 26 53.8% - - - HMMPfam_LAP1C CEP350 9857 genome.wustl.edu 37 1 179965742 179965742 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014810.4 +1 reviewed p.H150 0.000 86 0% 127 30.7% 0 - - - - NULL RGSL1 353299 genome.wustl.edu 37 1 182491223 182491223 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001137669.1 +1 validated p.R637M 0.288 99 0% 174 42.5% 0 - - - - superfamily_Regulator of G-protein signaling RGS RNASEL 6041 genome.wustl.edu 37 1 182550480 182550480 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021133.2 -1 reviewed p.T595 0.637 230 0% 376 46.8% 1 100% - - - HMMPfam_Ribonuc_2-5A FAM5C 339479 genome.wustl.edu 37 1 190130013 190130013 + Missense_Mutation SNP G G C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_199051.1 -1 provisional p.F323L 1.000 104 0% 147 40.8% 0 - possibly_damaging(0.94) deleterious(0.02) deleterious(0.768) NULL ASPM 259266 genome.wustl.edu 37 1 197073483 197073483 + Missense_Mutation SNP C C T rs181624297 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018136.4 -1 reviewed p.R1633H 0.189 100 0% 126 42.1% 1 0% probably_damaging(1) tolerated(0.19) deleterious(0.549) HMMPfam_IQ,HMMSmart_SM00015,superfamily_P-loop containing nucleoside triphosphate hydrolases ZBTB41 360023 genome.wustl.edu 37 1 197168600 197168600 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_194314.2 -1 validated p.P335H 0.144 176 0% 256 38.3% 1 100% benign(0.072) tolerated(0.23) neutral(0.046) NULL CAMSAP2 23271 genome.wustl.edu 37 1 200818158 200818158 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_203459.1 +1 validated p.R754M 1.000 67 0% 90 31.1% 4 75% possibly_damaging(0.846) deleterious(0.05) deleterious(0.670) NULL TNNI1 7135 genome.wustl.edu 37 1 201380578 201380578 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003281.3 -1 reviewed p.D121 0.941 143 0% 87 50.6% 1 0% - - - HMMPfam_Troponin NAV1 89796 genome.wustl.edu 37 1 201687682 201687682 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020443.4 +1 reviewed p.T342M 0.938 25 0% 17 41.2% 0 - possibly_damaging(0.945) deleterious(0.02) deleterious(0.772) NULL NAV1 89796 genome.wustl.edu 37 1 201778306 201778306 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020443.4 +1 reviewed p.D1405Y 1.000 119 0% 83 44.6% 6 33.3% possibly_damaging(0.951) deleterious(0) deleterious(0.839) NULL LMOD1 25802 genome.wustl.edu 37 1 201868736 201868736 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012134.2 -1 reviewed p.R469C 1.000 154 0% 93 36.6% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Tropomodulin,superfamily_SSF52047 KDM5B 10765 genome.wustl.edu 37 1 202718080 202718080 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006618.3 -1 validated p.R670H 0.584 62 0% 81 39.5% 18 66.6% possibly_damaging(0.812) deleterious(0.04) deleterious(0.654) NULL DSTYK 25778 genome.wustl.edu 37 1 205119906 205119906 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015375.2 -1 reviewed p.R790H 1.000 83 0% 51 25.5% 2 50% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase SRGAP2 23380 genome.wustl.edu 37 1 206566199 206566199 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000414359 +1 known p.R137C 1.000 345 0% 321 14.3% 18 11.1% probably_damaging(0.994) deleterious(0) deleterious(0.897) NULL SRGAP2 23380 genome.wustl.edu 37 1 206631980 206631980 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000367123 +1 known p.R158H 1.000 61 0% 30 30% 3 0% possibly_damaging(0.935) deleterious(0.02) deleterious(0.764) NULL PLXNA2 5362 genome.wustl.edu 37 1 208225778 208225778 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_025179.3 -1 reviewed p.R963* 1.000 93 0% 74 29.7% 4 0% - - - HMMPfam_TIG,HMMSmart_SM00429,superfamily_E set domains NEK2 4751 genome.wustl.edu 37 1 211836779 211836779 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002497.2 -1 validated p.G443C 1.000 69 0% 52 50% 15 73.3% probably_damaging(1) deleterious(0) deleterious(0.945) NULL PTPN14 5784 genome.wustl.edu 37 1 214638115 214638115 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005401.4 -1 reviewed p.R11Q 1.000 80 0% 26 42.3% 1 0% probably_damaging(1) deleterious(0.01) deleterious(0.905) NULL KCTD3 51133 genome.wustl.edu 37 1 215781387 215781387 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000452413 +1 known p.V78M 0.338 110 0% 138 39.1% 19 42.1% - - - NULL USH2A 7399 genome.wustl.edu 37 1 215822097 215822097 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_206933.2 -1 reviewed p.G4785 0.420 91 0% 47 21.3% 0 - - - - HMMPfam_fn3,HMMSmart_SM00060,superfamily_Fibronectin type III USH2A 7399 genome.wustl.edu 37 1 216108126 216108126 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_206933.2 -1 reviewed p.Y2378H 1.000 87 0% 136 11% 0 - probably_damaging(0.992) tolerated(0.23) deleterious(0.489) HMMSmart_SM00060,superfamily_Fibronectin type III HHIPL2 79802 genome.wustl.edu 37 1 222696957 222696957 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024746.3 -1 validated p.A629T 0.835 194 0% 113 39.8% 0 - benign(0.005) tolerated(0.1) neutral(0.286) NULL WDR26 80232 genome.wustl.edu 37 1 224581563 224581563 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_025160.6 -1 reviewed p.P496S 1.000 108 0% 93 38.7% 50 40% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) NULL DNAH14 127602 genome.wustl.edu 37 1 225195127 225195127 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001373.1 +1 validated p.R330* 0.997 85 0% 191 35.6% 0 - - - - NULL ACBD3 64746 genome.wustl.edu 37 1 226349289 226349289 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022735.3 -1 reviewed p.R224Q 0.998 363 0% 557 36.3% 17 52.9% unknown(0) tolerated(0.29) - NULL OBSCN 84033 genome.wustl.edu 37 1 228460993 228460993 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000359599 +1 known p.K514E 1.000 49 0% 25 28% 0 - probably_damaging(0.959) tolerated(0.51) neutral(0.412) HMMPfam_I-set,superfamily_Immunoglobulin OBSCN 84033 genome.wustl.edu 37 1 228466411 228466411 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001098623.1 +1 reviewed p.R2294H 1.000 57 0% 20 25% 1 0% probably_damaging(0.999) - - HMMPfam_I-set,superfamily_Immunoglobulin OBSCN 84033 genome.wustl.edu 37 1 228504534 228504534 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001098623.1 +1 reviewed p.G4470 0.000 13 0.000 9 0.444 0 - - - - HMMSmart_SM00409,HMMPfam_I-set,superfamily_Immunoglobulin RAB4A 5867 genome.wustl.edu 37 1 229438687 229438687 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004578.2 +1 provisional p.R207H 0.984 65 0% 56 41.1% 140 40.7% possibly_damaging(0.643) tolerated(0.07) deleterious(0.544) HMMSmart_SM00176,superfamily_P-loop containing nucleoside triphosphate hydrolases NUP133 55746 genome.wustl.edu 37 1 229636604 229636604 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018230.2 -1 reviewed p.V138I 0.969 50 0% 72 41.7% 6 50% benign(0.002) tolerated(0.7) neutral(0.002) HMMPfam_Nup133_N TAF5L 27097 genome.wustl.edu 37 1 229730560 229730560 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014409.3 -1 reviewed p.P418 0.003 64 0% 35 37.1% 12 50% - - - HMMSmart_SM00320,superfamily_WD40 repeat-like,HMMPfam_WD40 URB2 9816 genome.wustl.edu 37 1 229783376 229783376 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014777.2 +1 provisional p.H1342 0.784 89 0% 48 35.4% 9 44.4% - - - HMMPfam_Urb2 NTPCR 84284 genome.wustl.edu 37 1 233105748 233105748 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032324.1 +1 provisional p.R130C 0.999 121 0% 108 46.3% 76 32.8% benign(0.18) tolerated(0.05) neutral(0.362) HMMSmart_SM00382,HMMPfam_DUF265,superfamily_P-loop containing nucleoside triphosphate hydrolases HEATR1 55127 genome.wustl.edu 37 1 236719517 236719517 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018072.4 -1 validated p.A1799 0.993 189 0% 233 51.5% 5 40% - - - superfamily_ARM-type_fold ZP4 57829 genome.wustl.edu 37 1 238053787 238053787 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021186.2 -1 reviewed p.T50M 0.000 42 0% 39 48.7% 0 - probably_damaging(0.99) tolerated(0.08) deleterious(0.742) NULL KIF26B 55083 genome.wustl.edu 37 1 245775171 245775171 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018012.3 +1 provisional p.R664H 0.999 47 0% 35 40% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Kinesin,HMMSmart_SM00129,superfamily_P-loop containing nucleoside triphosphate hydrolases ZNF496 84838 genome.wustl.edu 37 1 247463934 247463934 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032752.1 -1 provisional p.R551W 0.236 72 0% 31 67.7% 43 48.8% probably_damaging(0.998) deleterious(0) deleterious(0.919) superfamily_SSF57667 ZNF496 84838 genome.wustl.edu 37 1 247464265 247464265 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032752.1 -1 provisional p.C440 1.000 61 0% 27 37% 18 44.4% - - - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 OR2C3 81472 genome.wustl.edu 37 1 247695447 247695447 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198074.4 -1 validated p.R123C 1.000 129 0% 68 42.6% 0 - probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_7tm_1,PatternScan_G_PROTEIN_RECEP_F1_1,superfamily_SSF81321 OR2M3 127062 genome.wustl.edu 37 1 248367069 248367069 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001004689.1 +1 provisional p.R234C 0.001 299 0% 323 41.2% 0 - benign(0.003) deleterious(0.02) neutral(0.383) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like SNTG2 54221 genome.wustl.edu 37 2 1093882 1093882 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018968.3 +1 reviewed p.R71C 1.000 240 0% 358 44.1% 0 - possibly_damaging(0.847) deleterious(0.01) deleterious(0.731) superfamily_PDZ domain-like PXDN 7837 genome.wustl.edu 37 2 1665927 1665927 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012293.1 -1 validated p.D533N 1.000 92 0% 39 20.5% 0 - probably_damaging(1) tolerated(0.76) deleterious(0.501) HMMSmart_SM00409,HMMPfam_I-set,superfamily_Immunoglobulin SOX11 6664 genome.wustl.edu 37 2 5834011 5834011 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003108.3 +1 reviewed p.A386 0.998 14 0% 13 38.5% 0 - - - - NULL ID2 3398 genome.wustl.edu 37 2 8822498 8822498 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002166.4 +1 reviewed p.V68A 1.000 58 0% 36 38.9% 241 39.4% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_HLH,HMMSmart_SM00353,superfamily_HLH helix-loop-helix DNA-binding domain ADAM17 6868 genome.wustl.edu 37 2 9630422 9630424 + In_Frame_Del DEL TGC TGC - novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 TGC TGC Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003183.4 -1 reviewed p.S786in_frame_del 0.996:1.000:1.000 - - - - - - - - - NULL PDIA6 10130 genome.wustl.edu 37 2 10927485 10927485 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005742.2 -1 validated p.A360V 1.000 153 0% 147 42.2% 786 47.2% benign(0) tolerated(1) - superfamily_Thioredoxin-like ROCK2 9475 genome.wustl.edu 37 2 11337653 11337653 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004850.3 -1 reviewed p.A1093V 1.000 183 0% 342 21.3% 12 0% probably_damaging(0.998) tolerated(0.19) deleterious(0.524) NULL GEN1 348654 genome.wustl.edu 37 2 17953927 17953927 + Nonsense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001130009.1 +1 validated p.G277* 1.000 97 0% 118 42.4% 7 42.8% - - - superfamily_5' to 3' exonuclease C-terminal subdomain MSGN1 343930 genome.wustl.edu 37 2 17997998 17997998 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001105569.1 +1 provisional p.H71 0.001 48 0% 25 40% 0 - - - - NULL LAPTM4A 9741 genome.wustl.edu 37 2 20234736 20234736 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014713.4 -1 reviewed p.I174V 1.000 127 0% 153 35.9% 443 39.7% benign(0.001) tolerated(0.6) neutral(0.004) HMMPfam_Mtp NCOA1 8648 genome.wustl.edu 37 2 24888781 24888781 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003743.4 +1 reviewed p.Q85* 1.000 77 0% 140 41.4% 5 40% - - - HMMSmart_SM00353,superfamily_HLH helix-loop-helix DNA-binding domain DTNB 1838 genome.wustl.edu 37 2 25851164 25851164 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021907.3 -1 reviewed p.R80C 1.000 155 0% 152 28.3% 44 34% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_efhand_1,superfamily_EF-hand GPR113 165082 genome.wustl.edu 37 2 26532963 26532963 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001145168.1 -1 validated p.A1030V 0.990 104 0% 55 41.8% 2 0% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) NULL EPT1 85465 genome.wustl.edu 37 2 26569133 26569133 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000407686 +1 known p.Q11 1.000 99 0% 55 47.3% 4 75% - - - NULL KHK 3795 genome.wustl.edu 37 2 27320508 27320508 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000221.2 +1 reviewed p.Y185 0.295 60 0% 26 50% 0 - - - - superfamily_Ribokinase-like CAD 790 genome.wustl.edu 37 2 27458472 27458472 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004341.3 +1 reviewed p.L1346 1.000 71 0% 55 38.2% 7 28.5% - - - HMMPfam_MGS,superfamily_SSF52335 IFT172 26160 genome.wustl.edu 37 2 27706492 27706492 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015662.1 -1 validated p.S146Y 1.000 224 0% 345 40.3% 2 0% benign(0.027) tolerated(0.44) neutral(0.014) HMMSmart_SM00320,superfamily_WD40 repeat-like CLIP4 79745 genome.wustl.edu 37 2 29404678 29404678 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024692.4 +1 validated p.P679 0.001 90 0% 76 35.5% 0 - - - - HMMPfam_CAP_GLY,superfamily_Cap-Gly domain SULT6B1 391365 genome.wustl.edu 37 2 37398608 37398608 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001032377.1 -1 provisional p.H212 0.961 137 0% 160 40.6% 0 - - - - HMMPfam_Sulfotransfer_1,superfamily_P-loop containing nucleoside triphosphate hydrolases THADA 63892 genome.wustl.edu 37 2 43519311 43519311 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001083953.1 -1 validated p.T1623 0.000 104 0% 95 47.4% 10 30% - - - NULL ABCG8 64241 genome.wustl.edu 37 2 44104732 44104732 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022437.2 +1 reviewed p.R597W 1.000 94 0% 79 36.7% 0 - probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_ABC2_membrane PRKCE 5581 genome.wustl.edu 37 2 46237546 46237546 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005400.2 +1 reviewed p.V443I 1.000 116 0% 139 46.8% 11 36.3% probably_damaging(0.992) tolerated(0.11) deleterious(0.719) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase MSH6 2956 genome.wustl.edu 37 2 48026126 48026127 + Frame_Shift_Del DEL AT AT - novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 AT AT Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000179.2 +1 reviewed p.T336fs 0.594:0.635 - - - - - - - - - NULL FOXN2 3344 genome.wustl.edu 37 2 48602499 48602499 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002158.3 +1 reviewed p.L405F 1.000 78 0% 77 42.9% 4 25% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL PSME4 23198 genome.wustl.edu 37 2 54154580 54154580 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014614.2 -1 validated p.P515H 1.000 143 0% 294 14.3% 11 18.1% probably_damaging(1) deleterious(0) deleterious(0.945) NULL SPTBN1 6711 genome.wustl.edu 37 2 54852045 54852045 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003128.2 +1 reviewed p.R429 1.000 67 0% 64 29.7% 13 30.7% - - - HMMPfam_Spectrin,HMMSmart_SM00150,superfamily_Spectrin repeat SPTBN1 6711 genome.wustl.edu 37 2 54858560 54858560 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003128.2 +1 reviewed p.E1126K 1.000 113 0% 55 10.9% 20 0% benign(0.029) deleterious(0.02) neutral(0.385) HMMPfam_Spectrin,HMMSmart_SM00150,superfamily_Spectrin repeat RPS27A 6233 genome.wustl.edu 37 2 55461327 55461327 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001135592.2 +1 reviewed p.Y59C 1.000 130 0% 192 33.9% 864 39.4% probably_damaging(0.995) deleterious(0) deleterious(0.902) HMMPfam_ubiquitin,HMMSmart_SM00213,superfamily_Ubiquitin-like USP34 9736 genome.wustl.edu 37 2 61492625 61492625 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014709.3 -1 validated p.G1895 1.000 99 0% 123 30.9% 4 0% - - - HMMPfam_UCH,PatternScan_UCH_2_1,superfamily_Cysteine proteinases XPO1 7514 genome.wustl.edu 37 2 61719259 61719259 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003400.3 -1 reviewed p.V600I 1.000 155 0% 223 40.8% 83 45.7% benign(0.019) deleterious(0.04) neutral(0.350) superfamily_ARM-type_fold XPO1 7514 genome.wustl.edu 37 2 61719526 61719526 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003400.3 -1 reviewed p.R553C 0.998 111 0% 194 34% 78 39.7% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_ARM-type_fold WDPCP 51057 genome.wustl.edu 37 2 63712088 63712088 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015910.4 -1 validated p.R96H 1.000 234 0% 393 37.7% 1 100% probably_damaging(1) deleterious(0.01) deleterious(0.905) NULL SPRED2 200734 genome.wustl.edu 37 2 65659119 65659119 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_181784.2 -1 validated p.M1I 1.000 134 0% 121 32.2% 1 100% probably_damaging(0.983) deleterious(0) deleterious(0.873) NULL CNRIP1 25927 genome.wustl.edu 37 2 68544362 68544362 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015463.2 -1 reviewed p.T86M 0.888 154 0% 145 42.8% 3 0% probably_damaging(0.987) deleterious(0.03) deleterious(0.801) NULL ANXA4 307 genome.wustl.edu 37 2 70035084 70035084 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001153.3 +1 reviewed p.R118Q 0.561 50 0% 34 44.1% 160 47.5% probably_damaging(1) deleterious(0.03) deleterious(0.865) superfamily_Annexin,PatternScan_ANNEXIN,HMMPfam_Annexin,HMMSmart_ANX ANXA4 307 genome.wustl.edu 37 2 70046463 70046463 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001153.3 +1 reviewed p.S259L 1.000 241 0% 414 37.9% 139 48.2% probably_damaging(0.998) deleterious(0) deleterious(0.919) superfamily_Annexin,HMMPfam_Annexin EXOC6B 23233 genome.wustl.edu 37 2 72945427 72945427 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015189.1 -1 validated p.P158 0.996 139 0.7% 110 43.6% 2 0% - - - NULL PRADC1 84279 genome.wustl.edu 37 2 73455925 73455925 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032319.1 -1 provisional p.D148 1.000 35 0% 19 42.1% 53 62.2% - - - HMMPfam_PA,superfamily_Transferrin receptor ectodomain apical domain AUP1 550 genome.wustl.edu 37 2 74755981 74755981 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_181575.3 -1 reviewed p.S141P 1.000 57 0% 34 32.4% 134 44% probably_damaging(0.977) tolerated(0.14) deleterious(0.668) HMMSmart_PlsC SEMA4F 10505 genome.wustl.edu 37 2 74902718 74902718 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004263.3 +1 provisional p.L480S 0.995 172 0% 129 45% 1 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_Sema,HMMSmart_SM00630,superfamily_Sema domain FAM176A 84141 genome.wustl.edu 37 2 75720644 75720644 + Missense_Mutation SNP G G C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001135032.1 -1 validated p.C59W 1.000 37 0% 25 52% 1 0% benign(0.049) deleterious(0.03) neutral(0.367) NULL LRRTM1 347730 genome.wustl.edu 37 2 80530635 80530635 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178839.4 -1 validated p.V104M 1.000 143 0% 84 27.4% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_LRR_1,superfamily_SSF52058 KCMF1 56888 genome.wustl.edu 37 2 85255017 85255017 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020122.4 +1 validated p.S8G 1.000 118 0% 217 42.9% 18 38.8% possibly_damaging(0.559) deleterious(0.01) deleterious(0.596) HMMPfam_ZZ,HMMSmart_ZnF_ZZ TEKT4 150483 genome.wustl.edu 37 2 95541339 95541339 + Missense_Mutation SNP C C T rs193072346 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_144705.2 +1 provisional p.R315W 1.000 300 0% 245 40.4% 1 0% probably_damaging(0.979) deleterious(0.01) deleterious(0.828) HMMPfam_Tektin MRPS5 64969 genome.wustl.edu 37 2 95753290 95753290 + Frame_Shift_Del DEL G G - novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031902.3 -1 reviewed p.H369fs 0.998 - - - - - - - - - NULL KCNIP3 30818 genome.wustl.edu 37 2 96040619 96040619 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013434.4 +1 reviewed p.D110 0.938 61 0% 42 50% 0 - - - - superfamily_EF-hand CIAO1 9391 genome.wustl.edu 37 2 96934237 96934237 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004804.2 +1 validated p.R178W 1.000 152 0% 114 31.6% 24 33.3% probably_damaging(0.957) tolerated(0.05) deleterious(0.746) HMMSmart_WD40,superfamily_WD40_like,HMMPfam_WD40 FER1L5 90342 genome.wustl.edu 37 2 97368124 97368124 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001113382.1 +1 provisional p.D1783 1.000 57 0% 33 39.4% 0 - - - - HMMSmart_SM00239,superfamily_C2 domain (Calcium/lipid-binding domain CaLB) TMEM131 23505 genome.wustl.edu 37 2 98435150 98435150 + Missense_Mutation SNP G G A rs187747732 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015348.1 -1 validated p.T370M 1.000 282 0% 508 38.6% 5 40% probably_damaging(1) tolerated(0.15) deleterious(0.741) NULL AFF3 3899 genome.wustl.edu 37 2 100170917 100170917 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001025108.1 -1 reviewed p.A1164T 0.000 130 0% 62 48.4% 2 50% benign(0) tolerated(0.2) neutral(0.049) HMMPfam_AF-4 TBC1D8 11138 genome.wustl.edu 37 2 101624479 101624479 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001102426.1 -1 validated p.A1076V 0.000 87 0% 92 41.3% 72 33.3% benign(0) tolerated(0.5) neutral(0.010) NULL TMEM87B 84910 genome.wustl.edu 37 2 112856184 112856184 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032824.2 +1 validated p.R429C 1.000 523 0% 690 42.2% 14 57.1% possibly_damaging(0.888) deleterious(0) deleterious(0.792) HMMPfam_Lung_7-TM_R RGPD8 727851 genome.wustl.edu 37 2 113127769 113127769 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000302558 -1 known p.R1762C 1.000 207 0% 375 13.3% 2 0% unknown(0) deleterious(0) - NULL MARCO 8685 genome.wustl.edu 37 2 119752091 119752091 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006770.3 +1 reviewed p.V520I 0.006 116 0% 54 44.4% 2 0% benign(0.05) - - NULL STEAP3 55240 genome.wustl.edu 37 2 120020847 120020847 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_182915.2 +1 validated p.R477M 0.733 68 0% 23 47.8% 53 18.8% benign(0.257) deleterious(0.01) neutral(0.432) NULL CNTNAP5 129684 genome.wustl.edu 37 2 124999868 124999868 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_130773.2 +1 reviewed p.T93 0.441 94 0% 92 38% 0 - - - - HMMPfam_F5_F8_type_C,HMMSmart_FA58C,superfamily_Gal_bind_like CNTNAP5 129684 genome.wustl.edu 37 2 125521376 125521376 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_130773.2 +1 reviewed p.R787* 1.000 123 0% 176 40.9% 0 - - - - superfamily_ConA_like_lec_gl MYO7B 4648 genome.wustl.edu 37 2 128393413 128393413 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080527.1 +1 provisional p.V1953 0.744 73 0% 35 22.9% 1 0% - - - HMMPfam_FERM_M,superfamily_Second domain of FERM,HMMSmart_SM00295 ARHGEF4 50649 genome.wustl.edu 37 2 131797621 131797621 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015320.2 +1 reviewed p.D260 0.020 25 0% 18 50% 0 - - - - superfamily_SH3-domain POTEE 445582 genome.wustl.edu 37 2 132021143 132021143 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001083538.1 +1 validated p.T705 1.000 177 0% 253 16.6% 0 - - - - HMMPfam_Actin,HMMSmart_SM00268,superfamily_Actin-like ATPase domain LOC100127989 100127989 genome.wustl.edu 37 2 132294518 132294518 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_001724172.1 -1 model p.V45 1.000 90 1.1% 45 20% 0 - - - - NULL NEB 4703 genome.wustl.edu 37 2 152384042 152384042 + Silent SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004543.4 -1 reviewed p.R5564 0.998 136 0% 115 53.9% 0 - - - - HMMPfam_Nebulin,HMMSmart_SM00227 NEB 4703 genome.wustl.edu 37 2 152410411 152410411 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004543.4 -1 reviewed p.H4818 0.991 157 0% 123 12.2% 1 0% - - - HMMSmart_SM00227 NEB 4703 genome.wustl.edu 37 2 152435934 152435934 + Missense_Mutation SNP C C T rs182029307 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000413693 -1 known p.R271H 1.000 650 0% 489 26.6% 0 - probably_damaging(0.995) - - HMMSmart_SM00227 NEB 4703 genome.wustl.edu 37 2 152534188 152534188 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004543.4 -1 reviewed p.A1222V 1.000 253 0% 273 37% 0 - possibly_damaging(0.696) tolerated(0.35) neutral(0.270) HMMSmart_SM00227 LY75 4065 genome.wustl.edu 37 2 160731975 160731975 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002349.2 -1 validated p.A652T 0.069 97 0% 140 12.9% 4 0% benign(0) tolerated(0.43) neutral(0.013) HMMSmart_SM00034,superfamily_C-type lectin-like KLHL23 151230 genome.wustl.edu 37 2 170592350 170592350 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_144711.4 +1 validated p.Y276H 1.000 77 0% 76 42.1% 6 50% probably_damaging(0.981) deleterious(0.01) deleterious(0.831) HMMPfam_Kelch_1,HMMSmart_Kelch,superfamily_Gal_oxid_central WIPF1 7456 genome.wustl.edu 37 2 175436684 175436684 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001077269.1 -1 reviewed p.P283 0.000 77 0% 46 52.2% 10 40% - - - NULL TTN 7273 genome.wustl.edu 37 2 179400726 179400726 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000356127 -1 known p.A31013V 1.000 102 0% 118 44.1% 0 - benign(0.1) - - HMMSmart_SM00409,HMMPfam_I-set TTN 7273 genome.wustl.edu 37 2 179401719 179401719 + Missense_Mutation SNP C C T rs55880786 TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000356127 -1 known p.G30803S 1.000 94 0% 104 13.5% 1 0% probably_damaging(0.996) - - HMMPfam_fn3,HMMSmart_SM00060 TTN 7273 genome.wustl.edu 37 2 179419345 179419345 + Missense_Mutation SNP T T G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000356127 -1 known p.S27007R 1.000 158 0% 114 49.1% 0 - probably_damaging(0.997) - - HMMPfam_fn3,HMMSmart_SM00060 TTN 7273 genome.wustl.edu 37 2 179419672 179419672 + Missense_Mutation SNP C C T rs143193258 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000356127 -1 known p.R26935H 1.000 135 0% 124 43.5% 0 - probably_damaging(0.999) - - HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_I-set TTN 7273 genome.wustl.edu 37 2 179436729 179436729 + Missense_Mutation SNP T T G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000356127 -1 known p.K22140N 1.000 112 0.9% 82 37.8% 0 - possibly_damaging(0.845) - - NULL TTN 7273 genome.wustl.edu 37 2 179453923 179453923 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_133378.4 -1 reviewed p.*18275W 0.238 91 1.1% 92 31.5% 0 - - - - NULL TTN 7273 genome.wustl.edu 37 2 179473629 179473629 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000356127 -1 known p.P14802L 1.000 173 0% 259 25.5% 0 - benign(0.049) - - HMMPfam_fn3,HMMSmart_SM00060 TTN 7273 genome.wustl.edu 37 2 179597401 179597401 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000356127 -1 known p.P4219S 1.000 174 0% 160 40.6% 0 - unknown(0) - - HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_I-set SESTD1 91404 genome.wustl.edu 37 2 180008405 180008405 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178123.4 -1 validated p.R255* 1.000 229 0% 307 36.8% 13 23% - - - NULL NEUROD1 4760 genome.wustl.edu 37 2 182543214 182543214 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002500.2 -1 reviewed p.R125H 1.000 138 0% 104 44.2% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_HLH,HMMSmart_SM00353,superfamily_HLH helix-loop-helix DNA-binding domain COL3A1 1281 genome.wustl.edu 37 2 189854839 189854839 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000090.3 +1 reviewed p.P236 0.000 130 0% 174 42.5% 13 0% - - - HMMPfam_Collagen ANKAR 150709 genome.wustl.edu 37 2 190584478 190584478 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_144708.3 +1 validated p.R731H 1.000 180 0% 198 39.4% 1 0% probably_damaging(1) deleterious(0.02) deleterious(0.883) HMMPfam_Arm,HMMSmart_SM00185,superfamily_ARM repeat MSTN 2660 genome.wustl.edu 37 2 190927105 190927105 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005259.2 -1 reviewed p.S73N 1.000 264 0% 360 29.2% 0 - probably_damaging(0.988) deleterious(0) deleterious(0.882) HMMPfam_TGFb_propeptide MFSD6 54842 genome.wustl.edu 37 2 191301949 191301949 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017694.3 +1 validated p.N398 0.000 113 0% 70 38.6% 21 42.8% - - - superfamily_MFS_gen_substrate_transporter SLC39A10 57181 genome.wustl.edu 37 2 196548468 196548468 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001127257.1 +1 validated p.N352D 0.999 137 0% 263 44.5% 3 0% benign(0.002) tolerated(0.9) - NULL MARS2 92935 genome.wustl.edu 37 2 198571078 198571078 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138395.2 +1 validated p.A317T 1.000 90 0% 61 36.1% 2 100% probably_damaging(1) deleterious(0.05) deleterious(0.845) HMMPfam_tRNA-synt_1g,superfamily_SSF52374 PLCL1 5334 genome.wustl.edu 37 2 198950305 198950305 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006226.3 +1 validated p.N590 0.848 35 0% 37 40.5% 0 - - - - HMMPfam_PI-PLC-Y,HMMSmart_PLCYc,superfamily_PLC-like_Pdiesterase_TIM-brl SATB2 23314 genome.wustl.edu 37 2 200173524 200173524 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015265.3 -1 reviewed p.R567C 1.000 86 0% 39 38.5% 0 - benign(0.274) deleterious(0) deleterious(0.474) NULL TRAK2 66008 genome.wustl.edu 37 2 202251189 202251189 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015049.2 -1 validated p.H572R 0.997 108 0% 132 37.1% 8 37.5% possibly_damaging(0.449) deleterious(0.04) deleterious(0.496) NULL MAP2 4133 genome.wustl.edu 37 2 210570332 210570332 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002374.3 +1 reviewed p.R1538H 1.000 96 0% 117 33.3% 4 50% probably_damaging(1) deleterious(0) deleterious(0.945) NULL UNC80 285175 genome.wustl.edu 37 2 210683747 210683747 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032504.1 +1 validated p.A575V 1.000 121 0% 110 41.8% 0 - probably_damaging(0.997) deleterious(0) deleterious(0.911) NULL UNC80 285175 genome.wustl.edu 37 2 210761101 210761101 + Silent SNP G G A rs143838455 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032504.1 +1 validated p.A1449 0.047 206 0% 162 13% 0 - - - - NULL UNC80 285175 genome.wustl.edu 37 2 210791672 210791672 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032504.1 +1 validated p.L1857P 0.998 186 0% 130 40.8% 0 - probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL ATIC 471 genome.wustl.edu 37 2 216191614 216191614 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004044.6 +1 reviewed p.V201I 0.011 113 0% 91 35.2% 30 43.3% benign(0) tolerated(0.25) neutral(0.037) HMMPfam_AICARFT_IMPCHas,HMMSmart_AICARFT_IMPCHas,superfamily_AICARFT_IMPCHas_formly FN1 2335 genome.wustl.edu 37 2 216230227 216230227 + Splice_Site SNP C C T rs112323657 byCluster TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_212482.1 -1 reviewed e43+1 1.000 222 0% 254 43.7% 1 100% - - - - FN1 2335 genome.wustl.edu 37 2 216256432 216256432 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_212482.1 -1 reviewed p.R1392H 0.998 135 0% 142 12% 7 0% probably_damaging(1) deleterious(0.03) deleterious(0.865) HMMPfam_fn3,HMMSmart_SM00060,superfamily_Fibronectin type III CXCR2 3579 genome.wustl.edu 37 2 219000146 219000146 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001557.3 +1 reviewed p.R208W 0.983 149 0.7% 89 27% 0 - probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like CRYBA2 1412 genome.wustl.edu 37 2 219857805 219857805 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005209.1 -1 reviewed p.D32N 1.000 26 0% 10 70% 0 - possibly_damaging(0.494) deleterious(0.02) deleterious(0.547) HMMPfam_Crystall,HMMSmart_SM00247,superfamily_gamma-Crystallin-like CCDC108 255101 genome.wustl.edu 37 2 219896006 219896006 + Silent SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_194302.2 -1 provisional p.T279 0.854 38 0% 17 41.2% 0 - - - - superfamily_PapD-like SPEG 10290 genome.wustl.edu 37 2 220309647 220309647 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000451076 +1 known p.G44S 1.000 29 0% 10 70% 0 - - - - NULL STK11IP 114790 genome.wustl.edu 37 2 220471828 220471828 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000456909 +1 known p.P396 0.892 101 0% 82 31.7% 15 40% - - - NULL EPHA4 2043 genome.wustl.edu 37 2 222301253 222301253 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004438.3 -1 reviewed p.S738P 1.000 107 0% 72 41.7% 9 33.3% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Pkinase_Tyr,HMMSmart_TyrKc,superfamily_Kinase_like EPHA4 2043 genome.wustl.edu 37 2 222428681 222428681 + Missense_Mutation SNP C C T rs184759178 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004438.3 -1 reviewed p.R198H 1.000 466 0% 383 42.8% 4 0% benign(0.2) tolerated(0.08) neutral(0.319) HMMPfam_Ephrin_lbd,HMMSmart_EPH_lbd,PatternScan_RECEPTOR_TYR_KIN_V_1,superfamily_Gal_bind_like CCL20 6364 genome.wustl.edu 37 2 228681053 228681053 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004591.2 +1 validated p.C74 0.985 151 0% 233 37.8% 174 33.9% - - - PatternScan_SMALL_CYTOKINES_CC,HMMPfam_IL8,HMMSmart_SM00199,superfamily_Interleukin 8-like chemokines ENSG00000252333 0 genome.wustl.edu 37 2 230802537 230802537 + RNA SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000516524 -1 novel NULL 0.353 11 0% 41 41.5% 0 - - - - - SP110 3431 genome.wustl.edu 37 2 231033860 231033860 + Missense_Mutation SNP C C T rs181058279 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080424.2 -1 reviewed p.G708S 0.000 99 0% 150 16.7% 1 100% benign(0) tolerated(0.93) - NULL SP100 6672 genome.wustl.edu 37 2 231333811 231333811 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000341950 +1 known p.Q449* 0.705 124 0% 283 42.8% 77 57.1% - - - NULL NCL 4691 genome.wustl.edu 37 2 232320272 232320272 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005381.2 -1 reviewed p.D632 1.000 191 0.5% 179 36.3% 643 44.4% - - - HMMPfam_RRM_1,HMMSmart_RRM,superfamily_SSF54928 SAG 6295 genome.wustl.edu 37 2 234250956 234250956 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000541.4 +1 reviewed p.P362 0.563 316 0% 340 15.6% 0 - - - - HMMPfam_Arrestin_C,superfamily_Ig_E-set UGT1A4 54657 genome.wustl.edu 37 2 234681014 234681014 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007120.2 +1 reviewed p.A472T 1.000 103 0% 67 38.8% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_UDPGT TRPM8 79054 genome.wustl.edu 37 2 234891731 234891731 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024080.4 +1 validated p.A875V 0.995 104 0% 66 42.4% 0 - probably_damaging(0.981) tolerated(0.52) neutral(0.434) HMMPfam_Ion_trans COL6A3 1293 genome.wustl.edu 37 2 238277696 238277696 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004369.3 -1 reviewed p.P1470 0.569 87 0% 75 38.7% 2 0% - - - HMMPfam_VWA,HMMSmart_SM00327,superfamily_vWA-like ESPNL 339768 genome.wustl.edu 37 2 239039024 239039024 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_194312.2 +1 validated p.R557W 0.974 20 0% 11 63.6% 0 - probably_damaging(0.983) deleterious(0) deleterious(0.873) NULL TRAF3IP1 26146 genome.wustl.edu 37 2 239237705 239237705 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015650.3 +1 validated p.R213G 0.017 126 0% 148 29.1% 8 25% benign(0.343) tolerated(0.21) neutral(0.152) HMMPfam_MIP-T3 ANKMY1 51281 genome.wustl.edu 37 2 241468562 241468562 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016552.2 -1 validated p.R193H 0.000 215 0% 242 11.6% 3 0% benign(0.004) tolerated(0.43) neutral(0.013) NULL AQP12B 653437 genome.wustl.edu 37 2 241619821 241619821 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001102467.1 -1 validated p.S224 0.897 306 0% 166 21.1% 0 - - - - superfamily_MIP ATG4B 23192 genome.wustl.edu 37 2 242590686 242590686 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000344376 +1 known p.T38M 0.486 231 0% 288 42.4% 28 39.2% - - - HMMPfam_Peptidase_C54 ATG4B 23192 genome.wustl.edu 37 2 242606118 242606118 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013325.4 +1 reviewed p.S199 0.000 38 0% 32 43.8% 67 49.2% - - - HMMPfam_Peptidase_C54 CNTN4 152330 genome.wustl.edu 37 3 3097812 3097812 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_175607.1 +1 reviewed p.A997T 1.000 173 0% 180 42.8% 0 - benign(0.023) deleterious(0.01) neutral(0.407) NULL ITPR1 3708 genome.wustl.edu 37 3 4836840 4836840 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001099952.2 +1 reviewed p.A2252 0.342 257 0% 256 38.7% 8 62.5% - - - NULL ARL8B 55207 genome.wustl.edu 37 3 5220419 5220419 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000419534 +1 known p.Q148R 0.062 166 0% 334 41% 44 43.1% unknown(0) deleterious(0) - HMMPfam_Arf TATDN2 9797 genome.wustl.edu 37 3 10290981 10290981 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014760.3 +1 validated p.A33T 1.000 22 0% 12 41.7% 5 60% probably_damaging(0.97) deleterious(0) deleterious(0.857) NULL TAMM41 132001 genome.wustl.edu 37 3 11850997 11850997 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138807.2 -1 provisional p.R290* 0.768 200 0% 256 39.5% 11 27.2% - - - HMMPfam_Mmp37 PPARG 5468 genome.wustl.edu 37 3 12475421 12475421 + Missense_Mutation SNP A A C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015869.4 +1 reviewed p.K432T 1.000 96 0% 64 14.1% 6 0% possibly_damaging(0.865) tolerated(0.06) deleterious(0.657) HMMPfam_Hormone_recep,HMMSmart_SM00430,superfamily_Nuclear receptor ligand-binding domain FBLN2 2199 genome.wustl.edu 37 3 13659594 13659594 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001004019.1 +1 reviewed p.A583V 0.000 60 0% 22 31.8% 1 100% benign(0.122) deleterious(0.04) neutral(0.359) NULL FGD5 152273 genome.wustl.edu 37 3 14861998 14861998 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152536.3 +1 validated p.D474N 1.000 49 0% 27 33.3% 3 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL FGD5 152273 genome.wustl.edu 37 3 14964027 14964027 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152536.3 +1 validated p.R1260Q 0.976 60 0% 18 38.9% 6 33.3% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_FYVE,HMMSmart_SM00064,superfamily_FYVE/PHD zinc finger,PatternScan_C_TYPE_LECTIN_1 KAT2B 8850 genome.wustl.edu 37 3 20193899 20193899 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003884.4 +1 reviewed p.R794Q 1.000 145 0% 244 41.8% 9 55.5% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_Bromodomain,HMMSmart_BROMO,superfamily_Bromodomain,PatternScan_BROMODOMAIN_1 RBMS3 27303 genome.wustl.edu 37 3 29938905 29938905 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001003793.2 +1 reviewed p.R276H 1.000 328 0% 344 42.2% 2 100% probably_damaging(1) tolerated(0.21) deleterious(0.544) NULL TRIM71 131405 genome.wustl.edu 37 3 32932570 32932570 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001039111.1 +1 provisional p.R625H 1.000 40 0% 17 35.3% 0 - probably_damaging(1) tolerated(0.17) deleterious(0.559) HMMPfam_NHL,superfamily_SSF101898 GORASP1 64689 genome.wustl.edu 37 3 39142260 39142260 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031899.2 -1 reviewed p.A182T 1.000 44 0% 39 46.2% 27 25.9% benign(0.003) tolerated(0.6) neutral(0.004) superfamily_PDZ domain-like,HMMPfam_GRASP55_65 CTNNB1 1499 genome.wustl.edu 37 3 41268792 41268792 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001098209.1 +1 reviewed p.L344 0.989 116 0% 156 12.8% 112 1.7% - - - HMMSmart_SM00185,superfamily_ARM repeat NKTR 4820 genome.wustl.edu 37 3 42680746 42680746 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005385.3 +1 reviewed p.E1184K 0.265 129 0% 105 41.9% 41 51.2% unknown(0) tolerated(0.16) - NULL ZBTB47 92999 genome.wustl.edu 37 3 42705822 42705822 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145166.3 +1 validated p.P283L 1.000 35 0% 19 36.8% 15 53.3% probably_damaging(0.994) deleterious(0.01) deleterious(0.858) superfamily_SSF57667 KBTBD5 131377 genome.wustl.edu 37 3 42727748 42727748 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152393.2 +1 validated p.R213H 1.000 25 0% 14 42.9% 0 - possibly_damaging(0.843) deleterious(0.04) deleterious(0.672) HMMPfam_BACK CCDC13 152206 genome.wustl.edu 37 3 42754747 42754747 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_144719.3 -1 validated p.R594C 0.095 85 0% 45 40% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL C3orf39 84892 genome.wustl.edu 37 3 43121788 43121788 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032806.4 -1 provisional p.T379M 0.999 102 0% 30 16.7% 27 3.7% probably_damaging(1) deleterious(0) deleterious(0.945) NULL ZNF445 353274 genome.wustl.edu 37 3 44491048 44491048 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_181489.5 -1 validated p.M296I 0.001 133 0% 96 41.7% 7 42.8% benign(0) tolerated(0.27) neutral(0.034) NULL TMEM42 131616 genome.wustl.edu 37 3 44906624 44906624 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_144638.1 +1 provisional p.H144 1.000 214 0% 132 37.9% 9 11.1% - - - NULL LTF 4057 genome.wustl.edu 37 3 46501253 46501253 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002343.2 -1 reviewed p.E34K 0.316 190 0% 121 33.1% 26 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Transferrin,HMMSmart_TR_FER,superfamily_SSF53850 ALS2CL 259173 genome.wustl.edu 37 3 46717820 46717820 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_147129.2 -1 validated p.A701T 0.001 74 1.4% 45 46.7% 1 0% benign(0.022) tolerated(0.19) neutral(0.051) superfamily_VPS9 domain (Pfam 02204) ALS2CL 259173 genome.wustl.edu 37 3 46718473 46718473 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_147129.2 -1 validated p.W599* 1.000 49 0% 23 39.1% 1 100% - - - NULL PRSS50 29122 genome.wustl.edu 37 3 46759022 46759022 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013270.4 -1 validated p.R71H 0.000 177 0% 104 42.3% 0 - probably_damaging(1) deleterious(0.01) deleterious(0.905) NULL SETD2 29072 genome.wustl.edu 37 3 47127764 47127764 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014159.6 -1 reviewed p.R1773H 1.000 151 0.7% 181 48.1% 12 41.6% benign(0.169) tolerated(0.05) neutral(0.361) NULL SCAP 22937 genome.wustl.edu 37 3 47455809 47455809 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012235.2 -1 reviewed p.R1152Q 1.000 92 0% 43 14% 101 22.7% possibly_damaging(0.949) tolerated(0.34) neutral(0.416) HMMSmart_SM00320,superfamily_WD40 repeat-like,HMMPfam_WD40 PFKFB4 5210 genome.wustl.edu 37 3 48560975 48560975 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004567.2 -1 provisional p.A427V 1.000 112 0% 72 44.4% 15 60% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_SSF53254 COL7A1 1294 genome.wustl.edu 37 3 48602350 48602350 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000094.3 -1 reviewed p.R2895Q 0.973 86 0% 45 42.2% 15 33.3% unknown(0) deleterious(0.01) - HMMPfam_Kunitz_BPTI,superfamily_BPTI-like COL7A1 1294 genome.wustl.edu 37 3 48612947 48612947 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000094.3 -1 reviewed p.R2002H 0.913 24 0% 17 29.4% 3 0% probably_damaging(1) deleterious(0.03) deleterious(0.865) HMMPfam_Collagen CELSR3 1951 genome.wustl.edu 37 3 48696363 48696363 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001407.2 -1 reviewed p.D1235 1.000 80 0% 46 37% 0 - - - - HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like NCKIPSD 51517 genome.wustl.edu 37 3 48712084 48712084 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016453.2 -1 reviewed p.R688* 1.000 224 0% 123 48.8% 33 57.5% - - - NULL ARIH2 10425 genome.wustl.edu 37 3 49011156 49011156 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006321.2 +1 provisional p.H265 1.000 118 0% 171 45.6% 37 32.4% - - - HMMPfam_IBR,HMMSmart_SM00647 DAG1 1605 genome.wustl.edu 37 3 49570345 49570345 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004393.4 +1 reviewed p.A801T 1.000 35 0% 26 19.2% 71 22.5% possibly_damaging(0.792) tolerated(0.1) deleterious(0.583) HMMPfam_DAG1 BSN 8927 genome.wustl.edu 37 3 49689307 49689307 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003458.3 +1 reviewed p.S773F 1.000 40 0% 32 46.9% 0 - probably_damaging(0.999) - - NULL AMIGO3 386724 genome.wustl.edu 37 3 49756366 49756366 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198722.2 -1 validated p.H178R 1.000 28 0% 15 46.7% 8 25% benign(0.009) tolerated(0.76) neutral(0.002) superfamily_SSF52058 TRAIP 10293 genome.wustl.edu 37 3 49879919 49879919 + Missense_Mutation SNP C C T rs143366962 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005879.2 -1 reviewed p.R157H 0.992 276 0% 202 11.9% 7 0% benign(0.007) tolerated(0.09) neutral(0.296) superfamily_Prefoldin MST1R 4486 genome.wustl.edu 37 3 49936519 49936519 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002447.2 -1 validated p.R470C 1.000 135 0% 48 47.9% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Sema,HMMSmart_SM00630,superfamily_Sema domain RBM6 10180 genome.wustl.edu 37 3 50091792 50091792 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005777.2 +1 validated p.R553* 0.785 243 0% 265 45.7% 26 38.4% - - - NULL CACNA2D2 9254 genome.wustl.edu 37 3 50405581 50405581 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001005505.1 -1 reviewed p.D711N 1.000 126 0% 121 38% 1 0% benign(0.01) tolerated(0.7) neutral(0.003) NULL DOCK3 1795 genome.wustl.edu 37 3 51198039 51198039 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004947.3 +1 validated p.R315* 1.000 93 0% 105 36.2% 0 - - - - NULL VPRBP 9730 genome.wustl.edu 37 3 51464927 51464927 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014703.2 -1 validated p.A528 0.001 64 0% 99 39.4% 1 100% - - - superfamily_ARM repeat RAD54L2 23132 genome.wustl.edu 37 3 51671198 51671198 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015106.2 +1 validated p.R454H 1.000 65 0% 60 46.7% 2 50% probably_damaging(0.997) deleterious(0.03) deleterious(0.831) HMMPfam_SNF2_N,HMMSmart_SM00487,superfamily_P-loop containing nucleoside triphosphate hydrolases RAD54L2 23132 genome.wustl.edu 37 3 51673506 51673506 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000432863 +1 known p.R473C 0.953 125 0% 101 38.6% 1 0% - - - NULL GRM2 2912 genome.wustl.edu 37 3 51749289 51749289 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000839.3 +1 reviewed p.C500 1.000 62 0% 28 46.4% 0 - - - - HMMPfam_NCD3G,superfamily_Periplasmic binding protein-like I IQCF2 389123 genome.wustl.edu 37 3 51897096 51897096 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_203424.1 +1 validated p.R69G 0.158 90 0% 32 40.6% 0 - benign(0.192) tolerated(0.22) neutral(0.060) HMMSmart_IQ,superfamily_SSF52540 RRP9 9136 genome.wustl.edu 37 3 51969223 51969223 + Missense_Mutation SNP C C T rs144222078 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004704.3 -1 provisional p.A342T 0.983 39 0% 42 45.2% 36 38.8% benign(0.013) tolerated(0.12) neutral(0.261) HMMSmart_SM00320,superfamily_WD40 repeat-like,HMMPfam_WD40 NISCH 11188 genome.wustl.edu 37 3 52505888 52505888 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007184.3 +1 validated p.A156 0.404 30 0% 28 53.6% 13 38.4% - - - NULL NT5DC2 64943 genome.wustl.edu 37 3 52563227 52563227 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000498608 -1 known p.Q63* 0.998 312 0% 166 23.5% 44 25% benign(0.045) tolerated(0.15) neutral(0.243) NULL DNAH12 201625 genome.wustl.edu 37 3 57431106 57431106 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178504.4 -1 validated p.A1384V 1.000 66 0% 98 16.3% 0 - probably_damaging(0.998) deleterious(0.04) deleterious(0.823) HMMSmart_SM00382,superfamily_P-loop containing nucleoside triphosphate hydrolases FLNB 2317 genome.wustl.edu 37 3 58084617 58084617 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001457.3 +1 reviewed p.V443I 0.000 138 0% 95 42.1% 8 12.5% benign(0) tolerated(0.19) neutral(0.050) HMMSmart_IG_FLMN,superfamily_Ig_E-set,HMMPfam_Filamin ABHD6 57406 genome.wustl.edu 37 3 58256757 58256757 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020676.5 +1 validated p.S163 0.000 179 0% 127 33.1% 1 0% - - - HMMPfam_Abhydrolase_1,superfamily_SSF53474 PTPRG 5793 genome.wustl.edu 37 3 62248538 62248538 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002841.3 +1 reviewed p.K875 1.000 195 0% 250 16.8% 8 25% - - - HMMPfam_Y_phosphatase,HMMSmart_SM00194,superfamily_(Phosphotyrosine protein) phosphatases II ADAMTS9 56999 genome.wustl.edu 37 3 64527528 64527528 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_182920.1 -1 reviewed p.R1728L 0.894 322 0% 359 40.7% 15 53.3% benign(0.161) tolerated(0.3) neutral(0.043) HMMPfam_TSP_1,HMMSmart_SM00209 MAGI1 9223 genome.wustl.edu 37 3 65464317 65464317 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001033057.1 -1 reviewed p.A236V 0.825 158 0% 158 46.8% 5 60% benign(0.025) deleterious(0.02) neutral(0.384) HMMSmart_SM00072 LRIG1 26018 genome.wustl.edu 37 3 66436501 66436501 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015541.2 -1 validated p.R565C 1.000 148 0% 80 42.5% 403 49.6% probably_damaging(0.998) tolerated(0.18) deleterious(0.530) HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_I-set,superfamily_Immunoglobulin ROBO1 6091 genome.wustl.edu 37 3 78655919 78655919 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002941.3 -1 reviewed p.R1570* 1.000 405 0% 398 36.2% 7 57.1% - - - NULL ROBO1 6091 genome.wustl.edu 37 3 78795967 78795967 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002941.3 -1 reviewed p.R195* 0.798 124 0% 117 42.7% 1 0% - - - HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_I-set,superfamily_Immunoglobulin CLDND1 56650 genome.wustl.edu 37 3 98235916 98235916 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001040182.1 -1 validated p.G197D 1.000 160 0.6% 176 10.2% 33 0% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_PMP22_Claudin GPR15 2838 genome.wustl.edu 37 3 98251268 98251268 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005290.1 +1 provisional p.R131C 1.000 85 0% 59 28.8% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_7tm_1,PatternScan_G_PROTEIN_RECEP_F1_1,superfamily_Family A G protein-coupled receptor-like DCBLD2 131566 genome.wustl.edu 37 3 98600507 98600507 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080927.3 -1 validated p.R104C 1.000 138 0% 185 49.2% 1 100% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_CUB,HMMSmart_SM00042,superfamily_Spermadhesin CUB domain LNP1 348801 genome.wustl.edu 37 3 100170795 100170795 + Splice_Site SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001085451.1 +1 validated e2+2 1.000 84 0% 120 20.8% 0 - - - - - ABI3BP 25890 genome.wustl.edu 37 3 100566512 100566512 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015429.3 -1 validated p.T486A 0.999 431 0% 816 12.6% 0 - possibly_damaging(0.63) deleterious(0) deleterious(0.664) NULL PVRL3 25945 genome.wustl.edu 37 3 110830909 110830909 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015480.1 +1 provisional p.H65Y 0.995 31 0% 32 31.2% 0 - benign(0) deleterious(0.04) neutral(0.349) HMMSmart_SM00409,HMMPfam_V-set,superfamily_Immunoglobulin C3orf17 25871 genome.wustl.edu 37 3 112727168 112727168 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015412.3 -1 validated p.R362Q 0.954 169 0% 257 11.3% 15 6.6% probably_damaging(1) tolerated(0.26) deleterious(0.534) NULL WDR52 55779 genome.wustl.edu 37 3 113082086 113082086 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018338.3 -1 validated p.R947Q 0.000 167 0% 372 40.3% 5 20% benign(0.006) tolerated(0.58) neutral(0.005) NULL POGLUT1 56983 genome.wustl.edu 37 3 119205693 119205693 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152305.2 +1 validated p.R218* 1.000 139 0% 160 39.4% 3 0% - - - HMMSmart_SM00672,HMMPfam_DUF821 NR1I2 8856 genome.wustl.edu 37 3 119530522 119530522 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022002.2 +1 reviewed p.D195 0.004 142 0% 101 46.5% 0 - - - - superfamily_Str_ncl_receptor SLC15A2 6565 genome.wustl.edu 37 3 121643217 121643217 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021082.3 +1 validated p.P341Q 1.000 299 0% 356 30.9% 36 55.5% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_PTR2,superfamily_MFS_gen_substrate_transporter KALRN 8997 genome.wustl.edu 37 3 124132413 124132413 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001024660.3 +1 reviewed p.R813C 1.000 107 0% 37 18.9% 3 33.3% possibly_damaging(0.911) tolerated(0.17) neutral(0.422) NULL PLXNA1 5361 genome.wustl.edu 37 3 126710338 126710338 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032242.3 +1 validated p.A413T 0.998 20 0% 12 58.3% 2 0% benign(0.406) deleterious(0) deleterious(0.575) HMMPfam_Sema,HMMSmart_SM00630,superfamily_Sema domain PODXL2 50512 genome.wustl.edu 37 3 127379259 127379259 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015720.2 +1 validated p.I130V 0.000 112 0% 123 38.2% 17 35.2% unknown(0) tolerated(0.56) - NULL COPG1 22820 genome.wustl.edu 37 3 128984505 128984505 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016128.3 +1 validated p.C446 0.367 105 0% 58 48.3% 161 47.2% - - - HMMPfam_Adaptin_N,superfamily_ARM repeat NPHP3 27031 genome.wustl.edu 37 3 132407950 132407950 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153240.3 -1 reviewed p.R951* 1.000 98 0% 90 32.2% 4 25% - - - HMMSmart_SM00028,superfamily_TPR-like TOPBP1 11073 genome.wustl.edu 37 3 133363195 133363195 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007027.3 -1 reviewed p.T506M 0.000 43 0% 60 48.3% 5 40% benign(0.004) tolerated(0.23) neutral(0.042) NULL RAB6B 51560 genome.wustl.edu 37 3 133560458 133560458 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016577.3 -1 validated p.R60H 1.000 175 0% 130 34.6% 2 50% possibly_damaging(0.875) deleterious(0.01) deleterious(0.746) HMMSmart_SM00176,HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases PCCB 5096 genome.wustl.edu 37 3 135975424 135975424 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000532.4 +1 reviewed p.R111* 1.000 248 0% 447 43.6% 17 5.8% - - - HMMPfam_Carboxyl_trans,superfamily_SSF52096 ZBTB38 253461 genome.wustl.edu 37 3 141161551 141161551 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080412.2 +1 validated p.L107 0.087 73 0% 96 39.6% 8 50% - - - HMMSmart_BTB,superfamily_BTB/POZ_fold,HMMPfam_BTB TFDP2 7029 genome.wustl.edu 37 3 141671839 141671839 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006286.4 -1 reviewed p.S297 0.032 133 0% 160 31.2% 24 33.3% - - - HMMPfam_DP GK5 256356 genome.wustl.edu 37 3 141889263 141889263 + Missense_Mutation SNP G G C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001039547.2 -1 validated p.Q449E 1.000 108 0% 107 15% 5 20% possibly_damaging(0.719) tolerated(0.06) deleterious(0.583) HMMPfam_FGGY_C,superfamily_Actin-like ATPase domain ATR 545 genome.wustl.edu 37 3 142204114 142204114 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001184.3 -1 reviewed p.A2030V 0.001 180 0% 197 38.1% 7 57.1% benign(0) tolerated(0.27) neutral(0.034) HMMPfam_FAT,superfamily_ARM repeat FAM194A 131831 genome.wustl.edu 37 3 150421333 150421333 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152394.3 -1 validated p.S118N 0.000 81 0% 48 29.2% 3 0% possibly_damaging(0.767) tolerated(0.32) neutral(0.308) NULL AADAC 13 genome.wustl.edu 37 3 151535364 151535364 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001086.2 +1 reviewed p.V117M 0.000 254 0.4% 208 38% 0 - benign(0) deleterious(0.02) neutral(0.383) HMMPfam_Abhydrolase_3,superfamily_alpha/beta-Hydrolases MBNL1 4154 genome.wustl.edu 37 3 152164521 152164521 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_207293.1 +1 validated p.R279Q 1.000 168 0.6% 174 48.3% 7 57.1% possibly_damaging(0.928) tolerated(0.53) neutral(0.383) NULL PLCH1 23007 genome.wustl.edu 37 3 155203410 155203410 + Silent SNP T T A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001130960.1 -1 validated p.R911 0.748 181 0% 160 45.6% 3 66.6% - - - NULL PLCH1 23007 genome.wustl.edu 37 3 155314063 155314063 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001130960.1 -1 validated p.R50C 1.000 129 0% 145 51% 0 - benign(0.007) tolerated(0.44) neutral(0.013) HMMPfam_PH,HMMSmart_SM00233,superfamily_PH domain-like KCNAB1 7881 genome.wustl.edu 37 3 155861000 155861000 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003471.3 +1 reviewed p.I11 1.000 104 0% 104 41.3% 0 - - - - NULL IFT80 57560 genome.wustl.edu 37 3 160025521 160025521 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020800.1 -1 validated p.R336G 0.998 134 0% 170 34.1% 4 50% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_Cyt_cd1_haem_C SLITRK3 22865 genome.wustl.edu 37 3 164906984 164906984 + Silent SNP A A C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014926.2 -1 validated p.A545 0.916 77 0% 54 40.7% 0 - - - - superfamily_SSF52058 SLITRK3 22865 genome.wustl.edu 37 3 164908117 164908117 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014926.2 -1 validated p.A168T 1.000 75 0% 110 48.2% 0 - possibly_damaging(0.86) deleterious(0.03) deleterious(0.697) superfamily_SSF52058 MECOM 2122 genome.wustl.edu 37 3 168818709 168818709 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000494292 -1 known p.R929Q 1.000 150 0% 209 11% 62 22.5% probably_damaging(1) tolerated(0.06) deleterious(0.823) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers PHC3 80012 genome.wustl.edu 37 3 169820380 169820380 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024947.3 -1 validated p.R907Q 0.953 82 0% 67 31.3% 9 44.4% probably_damaging(0.994) tolerated(0.58) neutral(0.457) NULL TBL1XR1 79718 genome.wustl.edu 37 3 176767841 176767841 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024665.4 -1 reviewed p.R216* 1.000 208 0.5% 226 44.7% 6 0% - - - HMMSmart_WD40 PIK3CA 5290 genome.wustl.edu 37 3 178916876 178916876 + Missense_Mutation SNP G G A rs121913287 TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006218.2 +1 reviewed p.R88Q 1.000 83 0% 137 40.1% 1 0% probably_damaging(1) deleterious(0.04) deleterious(0.849) HMMPfam_PI3K_p85B,HMMSmart_PI3K_p85B PIK3CA 5290 genome.wustl.edu 37 3 178936083 178936083 + Missense_Mutation SNP A A T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006218.2 +1 reviewed p.E542V 1.000 103 0% 205 49.8% 5 20% probably_damaging(0.998) deleterious(0.01) deleterious(0.880) HMMPfam_PI3Ka,HMMSmart_PI3Ka,superfamily_ARM-type_fold KCNMB3 27094 genome.wustl.edu 37 3 178984447 178984447 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_171828.1 -1 reviewed p.R18C 0.997 78 0% 38 21.1% 0 - probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL AP2M1 1173 genome.wustl.edu 37 3 183897998 183897998 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004068.3 +1 reviewed p.A128T 0.999 82 0% 61 27.9% 313 49.5% benign(0) tolerated(0.6) neutral(0.004) superfamily_SNARE-like CHRD 8646 genome.wustl.edu 37 3 184105204 184105204 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003741.2 +1 reviewed p.T797M 1.000 55 0% 23 39.1% 4 0% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_VWC,HMMSmart_SM00214 EPHB3 2049 genome.wustl.edu 37 3 184290765 184290765 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004443.3 +1 reviewed p.F219 0.974 43 0% 31 35.5% 2 0% - - - NULL EPHB3 2049 genome.wustl.edu 37 3 184295580 184295580 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004443.3 +1 reviewed p.A538 0.136 80 0% 26 46.2% 2 100% - - - superfamily_FN_III-like EPHB3 2049 genome.wustl.edu 37 3 184298262 184298262 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004443.3 +1 reviewed p.L749M 1.000 137 0% 75 40% 7 28.5% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_Pkinase_Tyr,HMMSmart_TyrKc,superfamily_Kinase_like TRA2B 6434 genome.wustl.edu 37 3 185635510 185635510 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004593.2 -1 validated p.R287H 1.000 135 0% 220 39.1% 160 46.2% unknown(0) deleterious(0) - NULL AHSG 197 genome.wustl.edu 37 3 186338558 186338558 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001622.2 +1 reviewed p.D315N 0.945 61 0% 30 50% 0 - possibly_damaging(0.939) tolerated(0.34) neutral(0.408) NULL TP63 8626 genome.wustl.edu 37 3 189526258 189526258 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003722.4 +1 reviewed p.P174 0.701 203 0% 96 53.1% 3 0% - - - superfamily_p53-like transcription factors,HMMPfam_P53 CLDN1 9076 genome.wustl.edu 37 3 190026071 190026071 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021101.4 -1 validated p.V211M 1.000 402 0.5% 532 39.7% 7 14.2% unknown(0) deleterious(0) - NULL LOC647309 647309 genome.wustl.edu 37 3 190573184 190573184 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002342387.1 -1 model p.H62R 1.000 114 0% 97 28.9% 2 50% probably_damaging(0.978) tolerated(0.12) deleterious(0.681) NULL MUC4 4585 genome.wustl.edu 37 3 195508188 195508188 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018406.5 -1 reviewed p.H3293 0.000 225 0% 166 25.3% 4 0% - - - NULL TNK2 10188 genome.wustl.edu 37 3 195605956 195605956 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000438207 -1 known p.T251M 0.976 75 0% 43 32.6% 15 20% - - - HMMPfam_Pkinase_Tyr,HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like) TM4SF19 116211 genome.wustl.edu 37 3 196053826 196053826 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138461.2 -1 validated p.S93 0.000 66 0% 40 45% 0 - - - - HMMPfam_L6_membrane KIAA0226 9711 genome.wustl.edu 37 3 197431563 197431563 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001145642.2 -1 validated p.V45M 0.988 67 0% 30 26.7% 4 25% benign(0.03) tolerated(0.2) neutral(0.051) NULL PDE6B 5158 genome.wustl.edu 37 4 649789 649789 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000283.3 +1 reviewed p.S351 1.000 116 0% 49 36.7% 0 - - - - HMMPfam_GAF,HMMSmart_SM00065,superfamily_GAF domain-like MYL5 4636 genome.wustl.edu 37 4 672842 672842 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000513662 +1 known p.T69 0.000 56 0% 43 44.2% 3 66.6% - - - NULL GAK 2580 genome.wustl.edu 37 4 882752 882752 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005255.2 -1 validated p.A363V 0.447 44 0% 23 39.1% 14 28.5% benign(0) tolerated(0.58) neutral(0.005) NULL IDUA 3425 genome.wustl.edu 37 4 998057 998057 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000203.3 +1 reviewed p.A613V 0.000 53 0% 36 11.1% 62 3.2% benign(0) tolerated(0.33) neutral(0.024) NULL KIAA1530 57654 genome.wustl.edu 37 4 1360177 1360177 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020894.2 +1 validated p.G416W 1.000 141 0% 76 44.7% 2 100% probably_damaging(1) deleterious(0) deleterious(0.945) NULL MFSD10 10227 genome.wustl.edu 37 4 2934097 2934097 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001120.4 -1 reviewed p.T225M 1.000 35 0% 10 70% 144 38.8% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_MFS_1,superfamily_MFS_gen_substrate_transporter OTOP1 133060 genome.wustl.edu 37 4 4199619 4199619 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_177998.1 -1 provisional p.G314 0.960 83 0% 40 32.5% 0 - - - - HMMPfam_DUF270 PPP2R2C 5522 genome.wustl.edu 37 4 6380162 6380162 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020416.3 -1 reviewed p.N102 0.987 169 0% 82 30.5% 11 36.3% - - - HMMSmart_SM00320,superfamily_WD40 repeat-like,HMMPfam_PP2A_B_N TADA2B 93624 genome.wustl.edu 37 4 7055935 7055935 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152293.2 +1 validated p.S139 0.992 30 0% 17 29.4% 13 46.1% - - - NULL SH3TC1 54436 genome.wustl.edu 37 4 8233724 8233724 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018986.3 +1 validated p.R991Q 0.000 47 0% 16 31.2% 8 12.5% benign(0.272) tolerated(0.47) neutral(0.040) NULL FAM184B 27146 genome.wustl.edu 37 4 17710912 17710912 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015688.1 -1 validated p.T166M 0.000 31 0% 14 50% 0 - possibly_damaging(0.861) deleterious(0.02) deleterious(0.716) NULL STIM2 57620 genome.wustl.edu 37 4 27019384 27019384 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020860.3 +1 reviewed p.R601H 1.000 152 0% 90 36.7% 43 39.5% probably_damaging(0.999) tolerated(0.21) deleterious(0.534) NULL KLF3 51274 genome.wustl.edu 37 4 38690342 38690342 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016531.5 +1 validated p.T65M 0.999 63 0% 39 48.7% 30 40% probably_damaging(0.994) deleterious(0) deleterious(0.897) NULL TLR10 81793 genome.wustl.edu 37 4 38776976 38776976 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001017388.1 -1 reviewed p.L79P 0.827 106 0% 163 46% 1 0% probably_damaging(0.996) deleterious(0) deleterious(0.906) superfamily_SSF52058 WDR19 57728 genome.wustl.edu 37 4 39187361 39187361 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_025132.3 +1 reviewed p.L8 0.005 139 0% 204 36.3% 3 33.3% - - - HMMSmart_SM00320 CHRNA9 55584 genome.wustl.edu 37 4 40356292 40356292 + Missense_Mutation SNP C C T rs55962300 byCluster;byFrequency TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017581.2 +1 reviewed p.R399C 0.026 99 0% 84 40.5% 0 - benign(0.003) tolerated(0.19) neutral(0.050) HMMPfam_Neur_chan_memb,superfamily_Neurotransmitter-gated ion-channel transmembrane pore UCHL1 7345 genome.wustl.edu 37 4 41263939 41263939 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004181.4 +1 reviewed p.R153Q 1.000 142 0% 158 28.5% 5 60% probably_damaging(0.998) tolerated(0.27) deleterious(0.508) HMMPfam_Peptidase_C12,superfamily_SSF54001 LIMCH1 22998 genome.wustl.edu 37 4 41682098 41682098 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014988.2 +1 validated p.R815C 1.000 157 0% 184 38% 8 37.5% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL SLAIN2 57606 genome.wustl.edu 37 4 48422195 48422195 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020846.1 +1 validated p.R472W 1.000 198 0% 162 42% 29 34.4% probably_damaging(1) deleterious(0) deleterious(0.945) NULL LPHN3 23284 genome.wustl.edu 37 4 62758502 62758502 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015236.4 +1 reviewed p.T469A 1.000 141 0% 104 25% 7 0% benign(0) tolerated(0.22) neutral(0.042) NULL TECRL 253017 genome.wustl.edu 37 4 65275041 65275041 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001010874.4 -1 validated p.S10L 0.999 136 0% 168 33.9% 0 - benign(0.071) deleterious(0) neutral(0.450) NULL UGT2A1 10941 genome.wustl.edu 37 4 70505247 70505247 + Splice_Site SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000457664 -1 known e2-1 1.000 111 0% 111 34.2% 0 - - - - - FRAS1 80144 genome.wustl.edu 37 4 79436967 79436967 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_025074.6 +1 reviewed p.D3396N 1.000 224 0% 125 37.6% 5 40% benign(0.001) tolerated(0.37) neutral(0.019) NULL BMP2K 55589 genome.wustl.edu 37 4 79832642 79832642 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198892.1 +1 reviewed p.R981C 1.000 56 0% 49 49% 3 66.6% unknown(0) deleterious(0) - NULL FGF5 2250 genome.wustl.edu 37 4 81188108 81188108 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004464.3 +1 reviewed p.S44P 0.088 39 0% 19 36.8% 0 - unknown(0) deleterious(0) - NULL LIN54 132660 genome.wustl.edu 37 4 83859581 83859581 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_194282.2 -1 validated p.R506Q 1.000 151 0% 234 38% 8 37.5% probably_damaging(0.998) deleterious(0.02) deleterious(0.857) NULL WDFY3 23001 genome.wustl.edu 37 4 85605097 85605097 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014991.4 -1 reviewed p.R3242Q 1.000 89 0% 88 48.9% 17 64.7% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMSmart_SM00320,superfamily_WD40 repeat-like,HMMPfam_WD40 WDFY3 23001 genome.wustl.edu 37 4 85654761 85654761 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014991.4 -1 reviewed p.R2332H 1.000 73 0% 54 38.9% 7 42.8% benign(0.034) tolerated(0.41) neutral(0.017) NULL MAPK10 5602 genome.wustl.edu 37 4 86989090 86989090 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138982.2 -1 reviewed p.K274R 1.000 198 0% 241 34.4% 1 0% benign(0.374) tolerated(0.36) neutral(0.139) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase HSD17B13 345275 genome.wustl.edu 37 4 88235097 88235097 + Silent SNP G G A rs143404524 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178135.3 -1 validated p.A191 1.000 212 0% 257 44.4% 0 - - - - HMMPfam_adh_short,superfamily_NAD(P)-binding Rossmann-fold domains GRID2 2895 genome.wustl.edu 37 4 94547529 94547529 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001510.2 +1 validated p.R768Q 1.000 250 0% 491 28.1% 0 - probably_damaging(0.973) deleterious(0) deleterious(0.859) HMMPfam_Lig_chan,HMMSmart_PBPe,superfamily_SSF53850 UNC5C 8633 genome.wustl.edu 37 4 96124015 96124015 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003728.2 -1 reviewed p.A668V 1.000 188 0.5% 91 25.3% 3 0% benign(0.273) tolerated(0.3) neutral(0.058) NULL UNC5C 8633 genome.wustl.edu 37 4 96140196 96140196 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003728.2 -1 reviewed p.A523 0.029 138 0% 117 35% 4 100% - - - NULL RAP1GDS1 5910 genome.wustl.edu 37 4 99363197 99363197 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001100426.1 +1 validated p.R586C 1.000 86 0% 115 49.6% 31 45.1% probably_damaging(0.978) tolerated(0.07) deleterious(0.740) superfamily_ARM repeat MTTP 4547 genome.wustl.edu 37 4 100503173 100503173 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000253.2 +1 reviewed p.R58H 0.925 117 0% 132 43.2% 0 - possibly_damaging(0.944) deleterious(0.02) deleterious(0.772) HMMPfam_Vitellogenin_N,HMMSmart_LPD_N,superfamily_Lipid_transp_b-sht_shell SLC9B2 133308 genome.wustl.edu 37 4 103947590 103947590 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000503103 -1 known p.A415T 0.970 189 0% 204 44.6% 1 0% unknown(0) - - NULL SLC9B2 133308 genome.wustl.edu 37 4 103966100 103966100 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178833.4 -1 validated p.A315T 0.973 209 0% 267 43.8% 0 - benign(0.005) tolerated(0.1) neutral(0.286) HMMPfam_Na_H_Exchanger TET2 54790 genome.wustl.edu 37 4 106156729 106156729 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001127208.1 +1 validated p.R544* 0.000 70 0% 74 43.2% 2 0% - - - NULL NPNT 255743 genome.wustl.edu 37 4 106859498 106859498 + Silent SNP T T C rs79192003 TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000514837 +1 known p.*119R 0.999 111 0% 75 42.7% 19 42.1% - - - HMMSmart_SM00181,superfamily_Growth factor receptor domain PITX2 5308 genome.wustl.edu 37 4 111539443 111539443 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000325.5 -1 reviewed p.Y271 0.925 80 0% 49 20.4% 2 0% - - - NULL ALPK1 80216 genome.wustl.edu 37 4 113353047 113353047 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001102406.1 +1 validated p.P782S 0.000 31 0% 21 57.1% 5 20% benign(0) tolerated(0.73) neutral(0.002) NULL LARP7 51574 genome.wustl.edu 37 4 113568387 113568387 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015454.1 +1 validated p.R227* 0.030 157 0% 239 33.1% 13 23% - - - NULL ANK2 287 genome.wustl.edu 37 4 114277096 114277096 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001148.4 +1 reviewed p.P2441H 1.000 77 0% 86 33.7% 0 - probably_damaging(1) - - NULL NDST3 9348 genome.wustl.edu 37 4 119064745 119064745 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004784.2 +1 reviewed p.H482R 1.000 97 0% 184 35.3% 0 - probably_damaging(0.99) deleterious(0.01) deleterious(0.847) NULL EXOSC9 5393 genome.wustl.edu 37 4 122731151 122731151 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001034194.1 +1 validated p.R212Q 1.000 155 0% 195 36.4% 48 45.8% possibly_damaging(0.591) tolerated(0.37) neutral(0.223) HMMPfam_RNase_PH_C,superfamily_3_ExoRNase TRPC3 7222 genome.wustl.edu 37 4 122853893 122853893 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001130698.1 -1 validated p.R174C 1.000 41 0% 17 58.8% 0 - probably_damaging(0.983) deleterious(0.01) deleterious(0.835) HMMSmart_ANK,superfamily_ANK KIAA1109 84162 genome.wustl.edu 37 4 123192397 123192397 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015312.3 +1 reviewed p.R2573H 1.000 109 0% 98 38.8% 3 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL KIAA1109 84162 genome.wustl.edu 37 4 123236649 123236649 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015312.3 +1 reviewed p.V3449I 1.000 153 0% 183 11.5% 8 0% benign(0.095) tolerated(0.21) neutral(0.051) NULL SETD7 80854 genome.wustl.edu 37 4 140432959 140432959 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_030648.2 -1 validated p.R320H 1.000 48 0% 34 47.1% 2 100% probably_damaging(1) deleterious(0.04) deleterious(0.849) HMMPfam_SET,HMMSmart_SM00317,superfamily_SET domain MAML3 55534 genome.wustl.edu 37 4 140811420 140811420 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018717.4 -1 validated p.T390 0.583 172 0% 128 36.7% 1 0% - - - NULL POU4F2 5458 genome.wustl.edu 37 4 147561226 147561226 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004575.2 +1 validated p.A166T 0.998 138 0% 77 42.9% 0 - benign(0.002) tolerated(0.09) neutral(0.296) NULL POU4F2 5458 genome.wustl.edu 37 4 147561860 147561860 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004575.2 +1 validated p.A377V 1.000 45 0% 31 29% 0 - possibly_damaging(0.804) deleterious(0.02) deleterious(0.685) HMMPfam_Homeobox,HMMSmart_SM00389,superfamily_Homeodomain-like ARHGAP10 79658 genome.wustl.edu 37 4 148867828 148867828 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024605.3 +1 validated p.I455T 1.000 205 0% 267 18% 1 0% benign(0.297) deleterious(0) deleterious(0.536) HMMPfam_RhoGAP,HMMSmart_RhoGAP,superfamily_Rho_GAP FBXW7 55294 genome.wustl.edu 37 4 153332916 153332916 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033632.2 -1 reviewed p.R14* 1.000 161 0.6% 124 46% 3 66.6% - - - NULL GLRA3 8001 genome.wustl.edu 37 4 175598272 175598272 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006529.2 -1 validated p.T295M 1.000 130 0% 95 44.2% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Neur_chan_memb,superfamily_Neurotransmitter-gated ion-channel transmembrane pore WWC2 80014 genome.wustl.edu 37 4 184190138 184190138 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024949.5 +1 validated p.A741V 0.996 204 0% 191 30.4% 5 80% benign(0.024) tolerated(0.24) neutral(0.038) HMMPfam_C2,superfamily_C2 domain (Calcium/lipid-binding domain CaLB) MTNR1A 4543 genome.wustl.edu 37 4 187455422 187455422 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005958.3 -1 reviewed p.A158 0.000 130 0% 59 42.4% 0 - - - - HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like FAT1 2195 genome.wustl.edu 37 4 187541997 187541997 + Missense_Mutation SNP T T A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005245.3 -1 reviewed p.I1915F 0.083 151 0% 161 41.6% 9 77.7% benign(0) tolerated(0.72) neutral(0.002) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Concanavalin A-like lectins/glucanases,superfamily_Cadherin-like FAT1 2195 genome.wustl.edu 37 4 187630461 187630461 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005245.3 -1 reviewed p.T174M 1.000 213 0% 215 38.6% 3 66.6% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like TRIML1 339976 genome.wustl.edu 37 4 189063617 189063617 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178556.3 +1 provisional p.S239L 0.000 100 0% 84 35.7% 0 - benign(0.001) tolerated(0.28) neutral(0.032) NULL CCDC127 133957 genome.wustl.edu 37 5 205859 205859 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145265.2 -1 provisional p.K112N 0.997 177 0% 215 38.1% 16 50% possibly_damaging(0.844) deleterious(0.02) deleterious(0.707) NULL EXOC3 11336 genome.wustl.edu 37 5 446345 446345 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007277.4 +1 reviewed p.V9I 0.997 79 0% 61 39.3% 8 37.5% possibly_damaging(0.882) tolerated(0.08) deleterious(0.644) NULL BRD9 65980 genome.wustl.edu 37 5 864601 864601 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_023924.4 -1 validated p.A496 0.001 58 0% 67 40.3% 30 43.3% - - - NULL SLC12A7 10723 genome.wustl.edu 37 5 1084051 1084051 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006598.2 -1 validated p.R313H 1.000 73 0% 17 47.1% 19 57.8% probably_damaging(0.962) tolerated(0.19) neutral(0.455) HMMPfam_AA_permease C5orf38 153571 genome.wustl.edu 37 5 2752740 2752740 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178569.2 +1 provisional p.V69M 0.002 39 0% 30 16.7% 1 0% unknown(0) - - NULL IRX1 79192 genome.wustl.edu 37 5 3600266 3600266 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024337.3 +1 validated p.H402Y 1.000 21 0% 14 28.6% 5 80% benign(0.184) tolerated(0.07) neutral(0.336) NULL NSUN2 54888 genome.wustl.edu 37 5 6604732 6604732 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017755.4 -1 validated p.R602W 1.000 163 0% 188 39.4% 42 40.4% probably_damaging(1) deleterious(0) deleterious(0.945) NULL PAPD7 11044 genome.wustl.edu 37 5 6750613 6750613 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006999.4 +1 reviewed p.D369 1.000 80 0% 47 40.4% 22 45.4% - - - NULL DNAH5 1767 genome.wustl.edu 37 5 13766225 13766225 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001369.2 -1 reviewed p.R3321W 1.000 92 0% 88 37.5% 0 - probably_damaging(1) deleterious(0.02) deleterious(0.883) NULL DNAH5 1767 genome.wustl.edu 37 5 13829795 13829795 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001369.2 -1 reviewed p.R2090W 0.885 109 0% 82 39% 1 100% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_AAA,superfamily_SSF52540 CDH10 1008 genome.wustl.edu 37 5 24509706 24509706 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006727.2 -1 reviewed p.R409G 0.972 184 0% 227 35.7% 0 - probably_damaging(0.995) tolerated(0.08) deleterious(0.758) HMMPfam_Cadherin,HMMSmart_CA,superfamily_Cadherin DROSHA 29102 genome.wustl.edu 37 5 31511260 31511260 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000512076 -1 known p.R143Q 0.990 155 0% 187 39.6% 13 61.5% - - - NULL MIR579 693164 genome.wustl.edu 37 5 32394537 32394537 + RNA SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000385221 -1 known NULL 0.328 48 0% 61 34.4% 0 - - - - - RXFP3 51289 genome.wustl.edu 37 5 33937425 33937425 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016568.3 +1 validated p.R194* 1.000 66 0% 24 29.2% 0 - - - - HMMPfam_7tm_1,superfamily_SSF81321 BRIX1 55299 genome.wustl.edu 37 5 34915850 34915850 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018321.3 +1 validated p.A3T 0.960 74 0% 44 45.5% 18 33.3% probably_damaging(1) deleterious(0) deleterious(0.945) NULL AGXT2 64902 genome.wustl.edu 37 5 35047909 35047909 + Splice_Site SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031900.3 -1 reviewed e1+1 0.982 89 0% 76 40.8% 0 - - - - - NIPBL 25836 genome.wustl.edu 37 5 36976100 36976100 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_133433.3 +1 reviewed p.R364H 1.000 151 0% 206 44.7% 5 60% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_ARM repeat NIPBL 25836 genome.wustl.edu 37 5 37052625 37052625 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_133433.3 +1 reviewed p.R2407Q 1.000 142 0% 190 45.3% 26 53.8% probably_damaging(1) tolerated(0.16) deleterious(0.559) superfamily_ARM repeat NUP155 9631 genome.wustl.edu 37 5 37333695 37333695 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153485.1 -1 reviewed p.A463V 1.000 125 0% 185 46.5% 2 0% benign(0.29) tolerated(0.08) neutral(0.389) HMMPfam_Nucleoporin GDNF 2668 genome.wustl.edu 37 5 37815796 37815796 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000514.2 -1 reviewed p.H198R 1.000 103 0% 85 29.4% 5 40% probably_damaging(1) tolerated(0.14) deleterious(0.750) HMMPfam_TGF_beta,HMMSmart_SM00204,superfamily_Cystine-knot cytokines RICTOR 253260 genome.wustl.edu 37 5 39002712 39002712 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152756.3 -1 validated p.A106V 1.000 109 0% 172 36.6% 1 0% benign(0.097) tolerated(0.27) neutral(0.041) superfamily_ARM repeat PTGER4 5734 genome.wustl.edu 37 5 40681327 40681327 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000958.2 +1 reviewed p.A78T 1.000 42 0% 16 43.8% 4 25% possibly_damaging(0.756) tolerated(0.08) deleterious(0.579) HMMPfam_7tm_1,superfamily_SSF81321 GHR 2690 genome.wustl.edu 37 5 42719274 42719274 + Missense_Mutation SNP C C G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000163.2 +1 reviewed p.H555Q 0.000 152 0% 127 44.9% 0 - benign(0.01) tolerated(0.59) neutral(0.005) NULL IL31RA 133396 genome.wustl.edu 37 5 55212787 55212787 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_139017.4 +1 validated p.R712C 0.000 66 0% 88 30.7% 0 - benign(0) tolerated(0.12) neutral(0.261) NULL ZSWIM6 57688 genome.wustl.edu 37 5 60821800 60821800 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020928.1 +1 provisional p.H563Y 1.000 111 0% 87 32.2% 8 25% possibly_damaging(0.916) tolerated(0.54) neutral(0.374) NULL PPWD1 23398 genome.wustl.edu 37 5 64872779 64872779 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015342.2 +1 validated p.R348H 1.000 182 0% 257 23.3% 19 26.3% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_WD40_like ENC1 8507 genome.wustl.edu 37 5 73931012 73931012 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003633.2 -1 validated p.G433 0.035 32 0% 22 27.3% 12 41.6% - - - HMMPfam_Kelch_1,HMMSmart_SM00612,superfamily_Galactose oxidase central domain SV2C 22987 genome.wustl.edu 37 5 75505675 75505675 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014979.1 +1 provisional p.Y292 0.993 98 0% 86 39.5% 0 - - - - HMMPfam_MFS_1,superfamily_MFS_gen_substrate_transporter CRHBP 1393 genome.wustl.edu 37 5 76264611 76264611 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001882.3 +1 reviewed p.H290 0.765 150 0% 177 36.2% 0 - - - - HMMPfam_CRF-BP AGGF1 55109 genome.wustl.edu 37 5 76344787 76344787 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018046.3 +1 validated p.R447Q 0.997 108 0% 270 40% 16 37.5% possibly_damaging(0.657) tolerated(0.31) neutral(0.259) HMMPfam_FHA,HMMSmart_SM00240,superfamily_SMAD/FHA domain CMYA5 202333 genome.wustl.edu 37 5 79058906 79058906 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153610.3 +1 validated p.R3810H 0.003 56 0% 33 57.6% 0 - probably_damaging(0.998) tolerated(0.8) deleterious(0.475) HMMPfam_fn3,HMMSmart_FN3,superfamily_FN_III-like CMYA5 202333 genome.wustl.edu 37 5 79058953 79058953 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153610.3 +1 validated p.R3826W 1.000 59 0% 31 29% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_fn3,HMMSmart_FN3,superfamily_FN_III-like VCAN 1462 genome.wustl.edu 37 5 82836874 82836874 + Silent SNP C C T rs184452501 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004385.4 +1 reviewed p.D2684 0.000 112 0% 116 34.5% 0 - - - - NULL VCAN 1462 genome.wustl.edu 37 5 82876228 82876228 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004385.4 +1 reviewed p.R3389Q 1.000 124 0% 156 40.4% 8 0% possibly_damaging(0.951) deleterious(0.01) deleterious(0.800) NULL GPR98 84059 genome.wustl.edu 37 5 90046431 90046431 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032119.3 +1 reviewed p.R3680C 1.000 127 0% 234 35% 1 100% probably_damaging(1) deleterious(0) deleterious(0.945) NULL GPR98 84059 genome.wustl.edu 37 5 90073861 90073861 + Splice_Site SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032119.3 +1 reviewed e62+1 1.000 86 0% 106 12.3% 0 - - - - - ERAP1 51752 genome.wustl.edu 37 5 96139325 96139325 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016442.3 -1 validated p.I102T 0.151 252 0% 208 34.1% 14 71.4% possibly_damaging(0.922) deleterious(0) deleterious(0.816) HMMPfam_Peptidase_M1,superfamily_SSF63737 PAM 5066 genome.wustl.edu 37 5 102237087 102237087 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000919.3 +1 reviewed p.R80* 0.995 272 0% 372 40.3% 92 11.9% - - - HMMPfam_Cu2_monooxygen,superfamily_PHM_PNGase_F DCP2 167227 genome.wustl.edu 37 5 112339653 112339653 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152624.4 +1 validated p.R274H 1.000 95 0% 132 37.9% 2 50% benign(0.047) deleterious(0.03) neutral(0.367) NULL SNCAIP 9627 genome.wustl.edu 37 5 121786663 121786663 + Silent SNP C C T rs146249796 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005460.2 +1 reviewed p.S707 0.013 59 0% 48 41.7% 9 55.5% - - - NULL MEGF10 84466 genome.wustl.edu 37 5 126783312 126783312 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032446.2 +1 validated p.H931R 1.000 106 0% 80 26.3% 0 - benign(0.021) deleterious(0.02) neutral(0.384) NULL CTXN3 613212 genome.wustl.edu 37 5 126993361 126993361 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001048252.2 +1 validated p.R50W 1.000 119 0% 116 35.3% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL ISOC1 51015 genome.wustl.edu 37 5 128430716 128430716 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016048.2 +1 validated p.G86D 1.000 35 0% 18 38.9% 38 42.1% probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL ADAMTS19 171019 genome.wustl.edu 37 5 129037269 129037269 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_133638.3 +1 reviewed p.A1042V 0.996 51 0% 40 35% 0 - probably_damaging(1) tolerated(0.45) deleterious(0.512) HMMPfam_TSP_1,HMMSmart_SM00209,superfamily_TSP-1 type 1 repeat FNIP1 96459 genome.wustl.edu 37 5 131039917 131039917 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000513722 -1 known p.A113V 0.959 59 0% 141 30.5% 1 0% - - - NULL P4HA2 8974 genome.wustl.edu 37 5 131545991 131545991 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001142599.1 -1 reviewed p.R232H 1.000 99 0% 59 40.7% 79 54.4% probably_damaging(0.987) deleterious(0.02) deleterious(0.820) NULL PDLIM4 8572 genome.wustl.edu 37 5 131607781 131607781 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001131027.1 +1 reviewed p.A245V 1.000 74 0% 43 37.2% 7 0% probably_damaging(0.974) deleterious(0) deleterious(0.861) NULL CCNI2 645121 genome.wustl.edu 37 5 132086672 132086672 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001039780.2 +1 provisional p.L253 0.938 197 0% 196 15.3% 1 0% - - - NULL PHF15 23338 genome.wustl.edu 37 5 133873756 133873756 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015288.4 +1 provisional p.E46K 1.000 74 0% 55 36.4% 5 20% possibly_damaging(0.598) tolerated(0.29) neutral(0.236) HMMPfam_EPL1 TRPC7 57113 genome.wustl.edu 37 5 135651309 135651309 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000503275 -1 known p.R313C 0.995 146 0% 146 34.9% 0 - - - - NULL SPOCK1 6695 genome.wustl.edu 37 5 136324158 136324158 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004598.3 -1 reviewed p.G294D 1.000 151 0% 120 11.7% 0 - probably_damaging(1) deleterious(0.04) deleterious(0.849) HMMPfam_SPARC_Ca_bdg,superfamily_SSF47473 CTNNA1 1495 genome.wustl.edu 37 5 138221974 138221974 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001903.2 +1 validated p.R379H 1.000 180 0% 261 44.1% 158 46.8% probably_damaging(0.969) deleterious(0) deleterious(0.856) HMMPfam_Vinculin,superfamily_alpha-catenin/vinculin PCDHA7 56141 genome.wustl.edu 37 5 140215744 140215744 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018910.2 +1 reviewed p.A592 0.556 112 0% 59 35.6% 3 66.6% - - - HMMPfam_Cadherin,superfamily_Cadherin-like PCDHA9 9752 genome.wustl.edu 37 5 140230270 140230270 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031857.1 +1 reviewed p.G730 0.586 38 0% 21 33.3% 0 - - - - NULL PCDHB5 26167 genome.wustl.edu 37 5 140515306 140515306 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015669.2 +1 reviewed p.G97E 0.738 50 0% 57 40.4% 0 - possibly_damaging(0.671) tolerated(0.13) deleterious(0.490) HMMPfam_Cadherin_2,superfamily_Cadherin PCDHB16 57717 genome.wustl.edu 37 5 140563036 140563036 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020957.1 +1 reviewed p.V301A 0.872 65 0% 54 11.1% 1 0% benign(0.028) deleterious(0) neutral(0.446) HMMPfam_Cadherin,HMMSmart_CA,superfamily_Cadherin PCDHB10 56126 genome.wustl.edu 37 5 140572512 140572512 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018930.3 +1 reviewed p.H129 0.774 167 0% 171 38.6% 1 0% - - - PatternScan_CADHERIN_1,superfamily_Cadherin PCDHB12 56124 genome.wustl.edu 37 5 140590576 140590576 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018932.3 +1 reviewed p.S699 0.667 58 0% 26 61.5% 0 - - - - NULL PCDHB15 56121 genome.wustl.edu 37 5 140625619 140625619 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018935.2 +1 reviewed p.R158Q 0.537 39 0% 54 11.1% 1 0% benign(0.001) tolerated(1) - HMMPfam_Cadherin,HMMSmart_CA,superfamily_Cadherin PCDHGA1 56114 genome.wustl.edu 37 5 140712234 140712234 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018912.2 +1 reviewed p.T661 0.000 91 0% 47 34% 1 100% - - - HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like PCDHGB2 56103 genome.wustl.edu 37 5 140739912 140739912 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018923.2 +1 reviewed p.A70 0.009 75 0% 50 30% 0 - - - - HMMSmart_SM00112,HMMPfam_Cadherin_2,superfamily_Cadherin-like PCDHGB3 56102 genome.wustl.edu 37 5 140751311 140751311 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018924.2 +1 reviewed p.P450 0.000 42 0% 31 32.3% 0 - - - - HMMSmart_SM00112,PatternScan_CADHERIN_1,superfamily_Cadherin-like PCDHGA8 9708 genome.wustl.edu 37 5 140774124 140774124 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032088.1 +1 reviewed p.A582T 0.975 68 0% 38 42.1% 0 - possibly_damaging(0.757) tolerated(0.09) deleterious(0.576) HMMPfam_Cadherin,superfamily_Cadherin-like PCDHGB6 56100 genome.wustl.edu 37 5 140789535 140789535 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018926.2 +1 reviewed p.T589I 1.000 37 0% 11 45.5% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Cadherin,superfamily_Cadherin-like PCDHGA10 56106 genome.wustl.edu 37 5 140794537 140794537 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018913.2 +1 reviewed p.D599Y 1.000 73 0% 37 35.1% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like PCDHGC3 5098 genome.wustl.edu 37 5 140856667 140856667 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002588.2 +1 reviewed p.G328 0.964 57 0% 24 29.2% 0 - - - - HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like ABLIM3 22885 genome.wustl.edu 37 5 148577927 148577927 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014945.2 +1 validated p.R99 1.000 96 0% 47 44.7% 1 0% - - - HMMPfam_LIM,HMMSmart_SM00132,PatternScan_LIM_DOMAIN_1,superfamily_Glucocorticoid receptor-like (DNA-binding domain) ABLIM3 22885 genome.wustl.edu 37 5 148586680 148586680 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014945.2 +1 validated p.T186 0.288 95 0% 34 35.3% 1 0% - - - HMMPfam_LIM,HMMSmart_SM00132,superfamily_Glucocorticoid receptor-like (DNA-binding domain) PCYOX1L 78991 genome.wustl.edu 37 5 148745526 148745526 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024028.3 +1 validated p.H164 0.240 100 0% 69 42% 4 50% - - - HMMPfam_Prenylcys_lyase,superfamily_FAD/NAD(P)-binding domain ARHGEF37 389337 genome.wustl.edu 37 5 148996252 148996252 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001001669.2 +1 validated p.P194H 0.012 143 0% 92 13% 5 40% benign(0.296) tolerated(0.11) neutral(0.363) HMMPfam_RhoGEF,HMMSmart_RhoGEF,superfamily_DH-domain LOC100287940 100287940 genome.wustl.edu 37 5 149677926 149677926 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002342566.1 +1 model p.A259T 0.391 101 0% 39 28.2% 0 - - - - NULL SYNPO 11346 genome.wustl.edu 37 5 150028955 150028955 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007286.5 +1 validated p.R373H 1.000 20 0% 16 56.2% 6 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL FAT2 2196 genome.wustl.edu 37 5 150922048 150922048 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001447.2 -1 reviewed p.H2880 0.997 153 0% 83 39.8% 19 89.4% - - - HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Concanavalin A-like lectins/glucanases,superfamily_Cadherin-like FAT2 2196 genome.wustl.edu 37 5 150923451 150923451 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001447.2 -1 reviewed p.R2413C 0.001 75 0% 55 36.4% 7 14.2% probably_damaging(0.986) deleterious(0.05) deleterious(0.780) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Concanavalin A-like lectins/glucanases,superfamily_Cadherin-like FAT2 2196 genome.wustl.edu 37 5 150945591 150945591 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001447.2 -1 reviewed p.A968T 0.020 56 0% 30 50% 4 100% benign(0.065) tolerated(0.75) neutral(0.006) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like GALNT10 55568 genome.wustl.edu 37 5 153709262 153709262 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198321.3 +1 reviewed p.A178T 1.000 125 0% 84 36.9% 11 36.3% possibly_damaging(0.437) tolerated(0.22) neutral(0.184) HMMPfam_Glycos_transf_2,superfamily_Nucleotide-diphospho-sugar transferases THG1L 54974 genome.wustl.edu 37 5 157166390 157166390 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017872.3 +1 provisional p.A266V 0.987 47 0% 75 26.7% 8 50% benign(0) tolerated(0.28) neutral(0.032) HMMPfam_Thg1 CLINT1 9685 genome.wustl.edu 37 5 157218790 157218790 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014666.2 -1 validated p.M434T 1.000 109 0% 85 40% 37 40.5% unknown(0) deleterious(0.01) - NULL ODZ2 57451 genome.wustl.edu 37 5 167655079 167655079 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001122679.1 +1 inferred p.R1813C 1.000 80 0% 51 13.7% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_Concanavalin A-like lectins/glucanases ODZ2 57451 genome.wustl.edu 37 5 167671562 167671562 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001122679.1 +1 inferred p.S1877 0.988 65 0% 38 60.5% 0 - - - - superfamily_Concanavalin A-like lectins/glucanases WWC1 23286 genome.wustl.edu 37 5 167851015 167851015 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015238.2 +1 reviewed p.S584 0.004 50 0% 31 35.5% 15 46.6% - - - NULL SLIT3 6586 genome.wustl.edu 37 5 168093539 168093539 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003062.2 -1 validated p.V1498I 1.000 65 0% 25 40% 4 0% benign(0.122) tolerated(0.24) neutral(0.048) HMMSmart_SM00041,PatternScan_CTCK_1 HRH2 3274 genome.wustl.edu 37 5 175110610 175110610 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001131055.1 +1 reviewed p.R125Q 1.000 147 0% 91 35.2% 0 - possibly_damaging(0.76) tolerated(0.08) deleterious(0.581) HMMPfam_7tm_1,superfamily_SSF81321 ARL10 285598 genome.wustl.edu 37 5 175795965 175795965 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_173664.4 +1 validated p.V181I 0.995 82 0% 62 38.7% 0 - unknown(0) - - HMMPfam_Arf,superfamily_SSF52540 FGFR4 2264 genome.wustl.edu 37 5 176518689 176518689 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002011.3 +1 reviewed p.R203C 1.000 87 0% 29 44.8% 3 33.3% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_I-set,superfamily_Immunoglobulin FGFR4 2264 genome.wustl.edu 37 5 176523068 176523068 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002011.3 +1 reviewed p.R611Q 1.000 63 0% 46 41.3% 1 0% probably_damaging(0.993) deleterious(0) deleterious(0.895) HMMPfam_Pkinase_Tyr,HMMSmart_SM00219,HMMSmart_SM00220,PatternScan_PROTEIN_KINASE_TYR,superfamily_Protein kinase-like (PK-like) NSD1 64324 genome.wustl.edu 37 5 176662842 176662842 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022455.4 +1 reviewed p.R1273C 1.000 56 0% 107 34.6% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) NULL PRELID1 27166 genome.wustl.edu 37 5 176733521 176733521 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013237.2 +1 provisional p.A204T 1.000 36 2.8% 20 45% 234 40.1% benign(0) deleterious(0.03) neutral(0.364) NULL FAM193B 54540 genome.wustl.edu 37 5 176959445 176959445 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019057.3 -1 validated p.A312V 1.000 25 0% 13 30.8% 23 30.4% benign(0.264) tolerated(0.1) neutral(0.314) NULL PROP1 5626 genome.wustl.edu 37 5 177419968 177419968 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006261.4 -1 reviewed p.A141 0.431 213 0% 182 39% 0 - - - - NULL MAPK9 5601 genome.wustl.edu 37 5 179674412 179674412 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001135044.1 -1 reviewed p.A239T 0.989 107 0% 100 14% 4 0% unknown(0) deleterious(0.04) - NULL ZFP62 643836 genome.wustl.edu 37 5 180277551 180277551 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152283.4 -1 validated p.G255V 1.000 155 0% 196 40.3% 6 66.6% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers BTNL3 10917 genome.wustl.edu 37 5 180431746 180431746 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_197975.1 +1 validated p.D282 0.017 210 0% 142 34.5% 0 - - - - NULL TUBB2B 347733 genome.wustl.edu 37 6 3225096 3225096 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178012.4 -1 reviewed p.T409 1.000 82 0% 55 38.2% 259 6.9% - - - superfamily_Tubulin C-terminal domain-like DSP 1832 genome.wustl.edu 37 6 7579588 7579588 + Missense_Mutation SNP C C G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004415.2 +1 reviewed p.N1055K 1.000 52 0% 66 36.4% 22 40.9% benign(0.235) tolerated(0.16) neutral(0.083) NULL DSP 1832 genome.wustl.edu 37 6 7585418 7585418 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004415.2 +1 reviewed p.I2641 0.145 43 0% 29 37.9% 100 48% - - - HMMSmart_SM00250,superfamily_Plakin repeat GCNT2 2651 genome.wustl.edu 37 6 10586308 10586308 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145655.3 +1 reviewed p.P29L 0.000 173 0% 229 39.3% 1 100% benign(0) tolerated(0.24) neutral(0.037) NULL ERVFRD-1 405754 genome.wustl.edu 37 6 11104151 11104151 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_207582.2 -1 validated p.R465* 0.680 105 0% 72 41.7% 0 - - - - HMMPfam_TLV_coat NEDD9 4739 genome.wustl.edu 37 6 11185649 11185649 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001142393.1 -1 validated p.L751I 1.000 221 0% 133 13.5% 32 34.3% probably_damaging(0.999) tolerated(0.14) deleterious(0.740) NULL HIVEP1 3096 genome.wustl.edu 37 6 12123354 12123354 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002114.2 +1 validated p.S1109L 0.789 66 0% 54 48.1% 2 100% benign(0.013) deleterious(0.01) neutral(0.406) NULL HIVEP1 3096 genome.wustl.edu 37 6 12164274 12164274 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002114.2 +1 validated p.C2579 0.000 151 0% 117 57.3% 32 59.3% - - - NULL KDM1B 221656 genome.wustl.edu 37 6 18222178 18222178 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000449850 +1 known p.H626R 0.992 205 0% 307 39.1% 5 40% - - - HMMPfam_Amino_oxidase,superfamily_FAD/NAD(P)-binding domain HIST1H2BA 255626 genome.wustl.edu 37 6 25727310 25727310 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_170610.2 +1 reviewed p.S58 0.341 479 0% 458 36.2% 0 - - - - HMMSmart_SM00427,HMMPfam_Histone,superfamily_Histone-fold BTN3A3 10384 genome.wustl.edu 37 6 26451963 26451963 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006994.4 +1 validated p.R360M 0.000 218 0% 162 38.3% 14 57.1% probably_damaging(0.999) tolerated(0.15) deleterious(0.732) HMMSmart_PRY PRSS16 10279 genome.wustl.edu 37 6 27222907 27222907 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005865.3 +1 reviewed p.R491 1.000 116 0% 67 19.4% 11 9% - - - HMMPfam_Peptidase_S28 ZSCAN12 9753 genome.wustl.edu 37 6 28366080 28366080 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000361028 -1 known p.R35C 0.002 251 0% 315 36.2% 0 - possibly_damaging(0.451) deleterious(0.01) deleterious(0.553) NULL HLA-F 3134 genome.wustl.edu 37 6 29692903 29692903 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001098479.1 +1 reviewed p.L236 0.776 77 0% 45 44.4% 40 15% - - - HMMPfam_C1-set,HMMSmart_IGc1,superfamily_SSF48726 TRIM10 10107 genome.wustl.edu 37 6 30128271 30128271 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006778.3 -1 validated p.R122Q 0.810 86 0% 38 18.4% 0 - probably_damaging(0.999) tolerated(0.15) deleterious(0.732) HMMPfam_zf-B_box,HMMSmart_SM00336 MDC1 9656 genome.wustl.edu 37 6 30673800 30673800 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014641.2 -1 reviewed p.N1054D 0.000 122 0% 86 39.5% 2 0% possibly_damaging(0.642) tolerated(0.65) neutral(0.228) NULL IER3 8870 genome.wustl.edu 37 6 30711944 30711944 + Splice_Site SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000376382 -1 novel e3-1 0.400 26 0% 16 25% 43 0% unknown(0) tolerated(0.12) - - SKIV2L 6499 genome.wustl.edu 37 6 31928234 31928234 + Missense_Mutation SNP C C T rs140350010 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006929.4 +1 reviewed p.S127L 0.990 87 0% 58 41.4% 8 62.5% probably_damaging(0.969) deleterious(0.02) deleterious(0.794) NULL BTNL2 56244 genome.wustl.edu 37 6 32362771 32362771 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019602.1 -1 provisional p.E370D 0.005 143 0% 62 33.9% 0 - possibly_damaging(0.68) deleterious(0.02) deleterious(0.625) HMMPfam_C2-set_2,superfamily_Immunoglobulin ITPR3 3710 genome.wustl.edu 37 6 33645385 33645385 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002224.2 +1 validated p.L1209 1.000 54 1.9% 28 46.4% 24 33.3% - - - HMMPfam_RYDR_ITPR PACSIN1 29993 genome.wustl.edu 37 6 34500262 34500262 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020804.2 +1 validated p.S430 0.998 42 0% 23 43.5% 0 - - - - HMMPfam_SH3_1,HMMSmart_SM00326,superfamily_SH3-domain SCUBE3 222663 genome.wustl.edu 37 6 35195408 35195408 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152753.2 +1 provisional p.C46Y 1.000 126 0% 68 48.5% 4 75% probably_damaging(0.999) deleterious(0) deleterious(0.935) PatternScan_ASX_HYDROXYL,HMMSmart_SM00179,HMMSmart_SM00181,HMMPfam_EGF_CA,PatternScan_EGF_CA,superfamily_EGF/Laminin ZNF76 7629 genome.wustl.edu 37 6 35254164 35254164 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003427.3 +1 provisional p.R74C 1.000 77 0% 67 43.3% 9 33.3% possibly_damaging(0.795) deleterious(0) deleterious(0.743) NULL MDGA1 266727 genome.wustl.edu 37 6 37622627 37622627 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153487.3 -1 validated p.V221M 1.000 134 0% 95 47.4% 4 0% probably_damaging(0.996) deleterious(0.01) deleterious(0.867) HMMSmart_SM00408,HMMSmart_SM00409,superfamily_Immunoglobulin KCNK5 8645 genome.wustl.edu 37 6 39162068 39162068 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003740.3 -1 reviewed p.V171I 1.000 87 0% 73 39.7% 1 0% possibly_damaging(0.637) tolerated(0.09) deleterious(0.519) HMMPfam_Ion_trans_2,superfamily_SSF81324 TREM1 54210 genome.wustl.edu 37 6 41243962 41243962 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000334475 -1 known p.R138Q 0.000 121 0% 120 40.8% 7 0% benign(0.032) tolerated(0.47) neutral(0.012) NULL TAF8 129685 genome.wustl.edu 37 6 42034111 42034111 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138572.2 +1 reviewed p.R184H 1.000 80 0% 48 35.4% 1 0% probably_damaging(1) tolerated(0.05) deleterious(0.845) HMMPfam_TAF8_C KIAA0240 23506 genome.wustl.edu 37 6 42796577 42796577 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015349.1 +1 validated p.T169M 1.000 93 0% 62 40.3% 5 20% probably_damaging(0.999) tolerated(0.07) deleterious(0.809) NULL PPP2R5D 5528 genome.wustl.edu 37 6 42974956 42974956 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006245.2 +1 reviewed p.T182M 1.000 107 0% 64 43.8% 16 62.5% probably_damaging(0.991) deleterious(0.01) deleterious(0.850) HMMPfam_B56 MRPL2 51069 genome.wustl.edu 37 6 43024149 43024149 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015950.3 -1 reviewed p.H100 1.000 109 0% 85 24.7% 35 34.2% - - - HMMPfam_Ribosomal_L2,superfamily_Nucleic_acid_OB CUL9 23113 genome.wustl.edu 37 6 43192121 43192121 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015089.2 +1 validated p.L2498M 1.000 166 0% 145 37.2% 37 45.9% probably_damaging(0.99) deleterious(0.01) deleterious(0.847) NULL GTPBP2 54676 genome.wustl.edu 37 6 43590428 43590428 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019096.3 -1 validated p.R470Q 1.000 50 0% 19 36.8% 24 25% possibly_damaging(0.687) deleterious(0.04) deleterious(0.595) HMMPfam_GTP_EFTU_D2,superfamily_Translation proteins CAPN11 11131 genome.wustl.edu 37 6 44140064 44140064 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007058.3 +1 reviewed p.I145 0.929 81 0% 55 40% 0 - - - - HMMPfam_Peptidase_C2,HMMSmart_CysPc,superfamily_SSF54001 EFHC1 114327 genome.wustl.edu 37 6 52303388 52303388 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018100.3 +1 reviewed p.Q191R 1.000 57 0% 58 13.8% 0 - benign(0.001) tolerated(1) - HMMSmart_SM00676 FAM135A 57579 genome.wustl.edu 37 6 71248051 71248051 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001105531.2 +1 validated p.R1196Q 1.000 104 0% 161 41% 10 30% possibly_damaging(0.796) deleterious(0.04) deleterious(0.648) HMMPfam_DUF676,superfamily_SSF53474 KCNQ5 56479 genome.wustl.edu 37 6 73904416 73904416 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019842.3 +1 reviewed p.T693M 1.000 115 0.9% 73 37% 0 - possibly_damaging(0.945) deleterious(0) deleterious(0.834) NULL COL12A1 1303 genome.wustl.edu 37 6 75866132 75866132 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004370.5 -1 reviewed p.R1031C 0.770 407 0% 519 43.4% 3 0% probably_damaging(0.989) - - HMMPfam_fn3,HMMSmart_SM00060,superfamily_Fibronectin type III FILIP1 27145 genome.wustl.edu 37 6 76124490 76124490 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015687.2 -1 validated p.R67* 0.005 152 0% 248 41.9% 0 - - - - HMMPfam_CortBP2 DOPEY1 23033 genome.wustl.edu 37 6 83863319 83863319 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015018.2 +1 validated p.V2073 0.978 305 0% 700 41.6% 7 71.4% - - - NULL RARS2 57038 genome.wustl.edu 37 6 88239365 88239365 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020320.3 -1 reviewed p.R258H 1.000 81 0% 165 38.2% 12 41.6% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_tRNA-synt_1d,superfamily_Nucleotidylyl transferase MDN1 23195 genome.wustl.edu 37 6 90388392 90388392 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014611.1 -1 provisional p.R4113Q 0.685 194 0% 243 35.4% 3 33.3% possibly_damaging(0.898) tolerated(0.06) deleterious(0.677) NULL MDN1 23195 genome.wustl.edu 37 6 90403821 90403821 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014611.1 -1 provisional p.V3285I 0.000 158 0% 151 41.7% 3 33.3% benign(0) tolerated(1) - NULL MDN1 23195 genome.wustl.edu 37 6 90410463 90410463 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014611.1 -1 provisional p.R2847H 0.997 146 0% 112 10.7% 0 - probably_damaging(0.995) tolerated(0.11) deleterious(0.729) NULL MAP3K7 6885 genome.wustl.edu 37 6 91263240 91263240 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145331.1 -1 reviewed p.R225C 1.000 107 0% 117 27.4% 21 52.3% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase MAP3K7 6885 genome.wustl.edu 37 6 91278305 91278305 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145331.1 -1 reviewed p.V90A 1.000 117 0% 218 42.7% 7 71.4% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase MANEA 79694 genome.wustl.edu 37 6 96054060 96054060 + Missense_Mutation SNP C C G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024641.2 +1 validated p.L390V 0.631 77 0% 100 17% 2 0% benign(0.078) tolerated(0.16) neutral(0.065) NULL FUT9 10690 genome.wustl.edu 37 6 96651546 96651546 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006581.3 +1 validated p.T172M 0.033 76 0% 57 12.3% 0 - benign(0) tolerated(0.05) neutral(0.345) HMMPfam_Glyco_transf_10 PRDM1 639 genome.wustl.edu 37 6 106553111 106553111 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001198.3 +1 reviewed p.T359M 0.853 39 0% 22 54.5% 2 0% possibly_damaging(0.44) deleterious(0) deleterious(0.588) NULL HS3ST5 222537 genome.wustl.edu 37 6 114383949 114383949 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153612.3 -1 validated p.V21I 0.981 137 0% 119 25.2% 0 - benign(0) tolerated(0.4) neutral(0.016) NULL DCBLD1 285761 genome.wustl.edu 37 6 117859847 117859847 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_173674.1 +1 provisional p.S275 0.991 125 0% 119 52.1% 9 22.2% - - - HMMPfam_F5_F8_type_C,HMMSmart_SM00231,superfamily_Galactose-binding domain-like CTAGE9 643854 genome.wustl.edu 37 6 132030107 132030107 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001145659.1 -1 provisional p.A684V 0.000 128 0% 160 5.6% 23 0% benign(0.029) tolerated(0.12) neutral(0.262) NULL ALDH8A1 64577 genome.wustl.edu 37 6 135254073 135254073 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022568.2 -1 reviewed p.T230 0.053 58 0% 28 39.3% 0 - - - - HMMPfam_Aldedh,superfamily_ALDH-like PDE7B 27115 genome.wustl.edu 37 6 136512835 136512835 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018945.3 +1 reviewed p.G404C 0.915 42 0% 29 48.3% 2 0% possibly_damaging(0.504) deleterious(0.02) deleterious(0.551) HMMPfam_PDEase_I,superfamily_HD-domain/PDEase-like SLC35D3 340146 genome.wustl.edu 37 6 137245251 137245251 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001008783.1 +1 provisional p.P223L 0.999 55 0% 22 36.4% 0 - probably_damaging(1) tolerated(0.43) deleterious(0.513) HMMPfam_UAA HIVEP2 3097 genome.wustl.edu 37 6 143095286 143095286 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006734.3 -1 provisional p.A197V 1.000 201 0% 167 40.1% 2 50% probably_damaging(0.999) tolerated(0.08) deleterious(0.790) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2 PLAGL1 5325 genome.wustl.edu 37 6 144269215 144269215 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080951.1 -1 reviewed p.T20M 1.000 79 0% 72 37.5% 1 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers UTRN 7402 genome.wustl.edu 37 6 144759958 144759958 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007124.2 +1 reviewed p.R440H 1.000 91 0% 102 42.2% 0 - probably_damaging(1) deleterious(0.04) deleterious(0.849) HMMPfam_Spectrin,HMMSmart_SPEC,superfamily_Spectrin UTRN 7402 genome.wustl.edu 37 6 145069599 145069599 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007124.2 +1 reviewed p.P2719 0.068 113 0% 97 48.5% 5 60% - - - HMMPfam_Spectrin,HMMSmart_SPEC,superfamily_Spectrin ADGB 79747 genome.wustl.edu 37 6 147012388 147012388 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024694.3 +1 provisional p.R483H 0.997 151 0.7% 190 42.6% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00230 SASH1 23328 genome.wustl.edu 37 6 148840977 148840977 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015278.3 +1 validated p.R386H 1.000 37 0% 26 38.5% 2 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL SYNE1 23345 genome.wustl.edu 37 6 152640109 152640109 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_182961.2 -1 reviewed p.T5426 1.000 214 0% 340 43.5% 0 - - - - NULL OPRM1 4988 genome.wustl.edu 37 6 154410980 154410980 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001145279.1 +1 reviewed p.A197T 1.000 83 0% 63 20.6% 0 - probably_damaging(0.965) deleterious(0.04) deleterious(0.756) HMMPfam_7tm_1,superfamily_SSF81321 SLC22A1 6580 genome.wustl.edu 37 6 160543205 160543205 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003057.2 +1 reviewed p.A80T 0.000 56 0% 30 36.7% 0 - benign(0) tolerated(0.51) neutral(0.009) NULL MAP3K4 4216 genome.wustl.edu 37 6 161513118 161513118 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005922.2 +1 reviewed p.R1071Q 1.000 153 0% 253 15% 12 16.6% benign(0.07) tolerated(0.37) neutral(0.024) NULL WDR27 253769 genome.wustl.edu 37 6 170064343 170064343 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_182552.3 -1 validated p.R275C 0.933 128 0% 101 40.6% 8 25% benign(0.002) tolerated(0.08) neutral(0.300) NULL PDGFA 5154 genome.wustl.edu 37 7 552067 552067 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000400761 -1 known p.P69S 0.563 34 0% 21 19% 20 55% - - - HMMPfam_PDGF_N ELFN1 392617 genome.wustl.edu 37 7 1784464 1784464 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001128636.2 +1 validated p.A78T 1.000 80 0% 42 33.3% 0 - - - - superfamily_L domain-like SNX8 29886 genome.wustl.edu 37 7 2296539 2296539 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013321.1 -1 provisional p.F418 1.000 116 0% 61 34.4% 65 38.4% - - - NULL ACTB 60 genome.wustl.edu 37 7 5568086 5568086 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001101.3 -1 reviewed p.R210C 1.000 68 0% 42 42.9% 4871 45.2% probably_damaging(0.974) - - HMMPfam_Actin,HMMSmart_SM00268,superfamily_Actin-like ATPase domain EIF2AK1 27102 genome.wustl.edu 37 7 6077078 6077078 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014413.3 -1 reviewed p.G437R 1.000 288 0% 354 32.2% 57 54.3% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase MIOS 54468 genome.wustl.edu 37 7 7613140 7613140 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019005.3 +1 validated p.R345Q 1.000 69 0% 71 36.6% 5 0% probably_damaging(0.98) tolerated(0.36) neutral(0.444) superfamily_WD40 repeat-like THSD7A 221981 genome.wustl.edu 37 7 11521471 11521471 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015204.2 -1 validated p.T654M 1.000 178 0% 124 41.9% 5 20% probably_damaging(0.999) deleterious(0.03) deleterious(0.855) HMMPfam_TSP_1,HMMSmart_SM00209,superfamily_TSP-1 type 1 repeat ETV1 2115 genome.wustl.edu 37 7 13971370 13971370 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004956.4 -1 validated p.R187C 1.000 158 0% 113 46.9% 0 - probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_ETS_PEA3_N AHR 196 genome.wustl.edu 37 7 17367383 17367383 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001621.4 +1 validated p.A121T 1.000 212 0% 572 39.5% 9 22.2% probably_damaging(1) deleterious(0.02) deleterious(0.883) HMMSmart_SM00091,HMMPfam_PAS,superfamily_PYP-like sensor domain (PAS domain) STK31 56164 genome.wustl.edu 37 7 23776635 23776635 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031414.3 +1 reviewed p.A319T 0.922 94 0% 211 42.7% 0 - benign(0.002) deleterious(0.02) neutral(0.383) NULL HOXA11 3207 genome.wustl.edu 37 7 27224700 27224700 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005523.5 -1 reviewed p.V22I 1.000 89 0% 53 41.5% 4 25% possibly_damaging(0.86) deleterious(0.03) deleterious(0.697) NULL SCRN1 9805 genome.wustl.edu 37 7 29966080 29966080 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001145514.1 -1 reviewed p.I378 0.992 124 0% 82 35.4% 20 30% - - - NULL SCRN1 9805 genome.wustl.edu 37 7 29983652 29983652 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001145514.1 -1 reviewed p.R182H 0.998 188 0% 157 42% 17 47% probably_damaging(0.996) deleterious(0.04) deleterious(0.810) NULL NOD1 10392 genome.wustl.edu 37 7 30491063 30491063 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006092.2 -1 reviewed p.R657H 1.000 79 0% 43 16.3% 4 0% probably_damaging(1) deleterious(0) deleterious(0.945) NULL GARS 2617 genome.wustl.edu 37 7 30655597 30655597 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002047.2 +1 reviewed p.L373I 0.625 123 0.8% 129 36.4% 30 26.6% benign(0) tolerated(0.15) neutral(0.241) HMMPfam_tRNA-synt_2b,superfamily_Class II aaRS and biotin synthetases EEPD1 80820 genome.wustl.edu 37 7 36278593 36278593 + Splice_Site SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_030636.2 +1 validated e2-1 1.000 178 0% 254 24% 0 - - - - - TRGV5 6978 genome.wustl.edu 37 7 38389074 38389074 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000390344 -1 known p.S79L 0.003 138 0% 161 10.6% 0 - probably_damaging(0.999) tolerated(0.33) deleterious(0.514) HMMPfam_V-set,superfamily_Immunoglobulin POU6F2 11281 genome.wustl.edu 37 7 39504001 39504001 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007252.3 +1 reviewed p.E598K 1.000 102 0% 53 17% 0 - probably_damaging(0.992) tolerated(0.06) deleterious(0.770) NULL GLI3 2737 genome.wustl.edu 37 7 42005226 42005226 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000168.5 -1 reviewed p.P1149S 0.507 55 0% 32 34.4% 5 80% benign(0.007) tolerated(0.15) neutral(0.241) NULL MRPL32 64983 genome.wustl.edu 37 7 42974676 42974676 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031903.2 +1 reviewed p.R85C 1.000 121 0% 132 36.4% 80 48.7% benign(0.019) deleterious(0) neutral(0.446) NULL NACAD 23148 genome.wustl.edu 37 7 45124308 45124308 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000258775 -1 known p.A491T 0.011 80 0% 45 35.6% 0 - possibly_damaging(0.888) deleterious(0) deleterious(0.792) NULL ZNF117 51351 genome.wustl.edu 37 7 64439613 64439613 + Missense_Mutation SNP T T A rs3807068 byCluster;byFrequency;byHapMap;by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015852.3 -1 validated p.K112N 0.000 97 0% 253 42.3% 4 50% benign(0.126) tolerated(0.52) neutral(0.019) HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers LOC442572 442572 genome.wustl.edu 37 7 66751332 66751332 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_499314.5 +1 model p.R353C 0.529 305 0% 273 31.9% 0 - - - - NULL POM121 9883 genome.wustl.edu 37 7 72411054 72411054 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_172020.1 +1 reviewed p.S290 0.001 215 0% 180 22.8% 5 0% - - - NULL ELN 2006 genome.wustl.edu 37 7 73470731 73470731 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000501.2 +1 reviewed p.P427 0.164 301 0% 212 39.2% 18 16.6% - - - PatternScan_ENDONUCLEASE_III_2 CLIP2 7461 genome.wustl.edu 37 7 73814755 73814755 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003388.4 +1 reviewed p.S979L 0.097 55 0% 22 40.9% 3 33.3% benign(0.059) tolerated(0.17) neutral(0.063) NULL GTF2IRD1 9569 genome.wustl.edu 37 7 74015406 74015406 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016328.1 +1 reviewed p.R904W 0.994 137 0% 122 38.5% 42 47.6% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) NULL STYXL1 51657 genome.wustl.edu 37 7 75625796 75625796 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016086.2 -1 validated p.P311L 0.553 228 0% 160 34.4% 63 36.5% probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL LOC100288807 100288807 genome.wustl.edu 37 7 76689804 76689804 + Missense_Mutation SNP C C T rs184595508 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002342739.1 -1 model p.R9H 0.008 99 0% 67 40.3% 3 100% - - - NULL SEMA3D 223117 genome.wustl.edu 37 7 84628893 84628893 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152754.2 -1 validated p.Q733* 1.000 291 0% 245 40% 13 61.5% - - - NULL KIAA1324L 222223 genome.wustl.edu 37 7 86521131 86521131 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001142749.2 -1 validated p.C980F 1.000 160 0% 253 39.1% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL ABCB4 5244 genome.wustl.edu 37 7 87069628 87069628 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018849.2 -1 reviewed p.S483P 1.000 201 0% 237 23.2% 0 - benign(0.162) deleterious(0.01) neutral(0.420) HMMPfam_ABC_tran,HMMSmart_SM00382,superfamily_P-loop containing nucleoside triphosphate hydrolases ABCB1 5243 genome.wustl.edu 37 7 87179322 87179322 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000927.3 -1 reviewed p.R467W 1.000 201 0% 167 47.3% 2 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_ABC_tran,HMMSmart_SM00382,superfamily_P-loop containing nucleoside triphosphate hydrolases AKAP9 10142 genome.wustl.edu 37 7 91729000 91729000 + Splice_Site SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005751.4 +1 reviewed e44-1 0.996 114 0% 145 34.5% 0 - - - - - TRRAP 8295 genome.wustl.edu 37 7 98547176 98547176 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003496.2 +1 validated p.R1617H 1.000 59 0% 30 43.3% 3 66.6% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) superfamily_ARM repeat ARPC1A 10552 genome.wustl.edu 37 7 98951704 98951704 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006409.2 +1 reviewed p.D225N 1.000 125 0% 65 27.7% 228 45.6% benign(0.316) tolerated(0.13) neutral(0.352) HMMSmart_SM00320,superfamily_WD40 repeat-like PTCD1 26024 genome.wustl.edu 37 7 99032633 99032633 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015545.2 -1 validated p.T78M 0.000 96 0% 54 16.7% 4 0% benign(0.013) tolerated(0.22) neutral(0.043) NULL C7orf43 55262 genome.wustl.edu 37 7 99752784 99752784 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000456769 -1 known p.G437R 0.003 55 0% 21 33.3% 19 47.3% - - - NULL SPDYE3 441272 genome.wustl.edu 37 7 99909552 99909552 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000332397 +1 known p.V242M 0.052 73 0% 75 41.3% 0 - unknown(0) deleterious(0) - NULL ZAN 7455 genome.wustl.edu 37 7 100358107 100358107 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003386.1 +1 reviewed p.G1264S 1.000 302 0% 188 44.1% 0 - probably_damaging(0.999) - - HMMPfam_VWD,HMMSmart_SM00216 SLC12A9 56996 genome.wustl.edu 37 7 100459099 100459099 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020246.2 +1 validated p.A477T 0.981 82 0% 27 40.7% 28 35.7% benign(0.033) tolerated(0.1) neutral(0.288) HMMPfam_AA_permease SRRT 51593 genome.wustl.edu 37 7 100482557 100482557 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015908.5 +1 validated p.R352Q 1.000 130 0% 90 43.3% 93 46.2% possibly_damaging(0.516) tolerated(0.4) neutral(0.190) NULL FIS1 51024 genome.wustl.edu 37 7 100883107 100883107 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016068.2 -1 validated p.V147M 0.994 29 0% 19 52.6% 153 32% unknown(0) - - NULL MLL5 55904 genome.wustl.edu 37 7 104741995 104741995 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018682.3 +1 reviewed p.C616R 1.000 89 0% 184 38% 5 40% unknown(0) deleterious(0.01) - NULL DLD 1738 genome.wustl.edu 37 7 107545882 107545882 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000108.3 +1 reviewed p.Q172R 1.000 115 0% 209 34.9% 35 37.1% benign(0.001) tolerated(0.17) neutral(0.059) HMMPfam_Pyr_redox_2,superfamily_SSF51905 LAMB4 22798 genome.wustl.edu 37 7 107669621 107669621 + Missense_Mutation SNP T T G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007356.2 -1 validated p.K1671N 0.052 264 0% 431 20.4% 0 - benign(0.004) tolerated(0.36) neutral(0.020) NULL LAMB4 22798 genome.wustl.edu 37 7 107748134 107748134 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007356.2 -1 validated p.V178A 0.995 154 0% 207 45.4% 0 - probably_damaging(0.998) deleterious(0.03) deleterious(0.839) HMMPfam_Laminin_N,HMMSmart_SM00136 DOCK4 9732 genome.wustl.edu 37 7 111449434 111449434 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000445943 -1 known p.S1034L 0.927 167 0% 258 34.9% 0 - - - - NULL TMEM168 64418 genome.wustl.edu 37 7 112407412 112407412 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022484.4 -1 validated p.R645H 0.993 106 0% 113 31.9% 16 18.7% benign(0.083) tolerated(0.06) neutral(0.329) NULL MDFIC 29969 genome.wustl.edu 37 7 114655851 114655851 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000393486 +1 known p.C201 1.000 242 0% 287 42.2% 28 10.7% - - - PatternScan_EGF_1 SLC13A1 6561 genome.wustl.edu 37 7 122809310 122809310 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022444.3 -1 validated p.P149S 1.000 166 0% 133 39.8% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Na_sulph_symp SND1 27044 genome.wustl.edu 37 7 127326727 127326727 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014390.2 +1 validated p.R47W 1.000 100 0% 62 37.1% 46 60.8% benign(0.145) tolerated(0.12) neutral(0.273) HMMSmart_SNc,superfamily_Staphylococal_nuclease_OB-fold SMO 6608 genome.wustl.edu 37 7 128845459 128845459 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005631.3 +1 provisional p.F252 1.000 102 0% 58 32.8% 16 56.2% - - - HMMPfam_Frizzled PLXNA4 91584 genome.wustl.edu 37 7 132192961 132192961 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020911.1 -1 validated p.N164 0.911 103 0% 54 48.1% 1 0% - - - HMMPfam_Sema,HMMSmart_SM00630,superfamily_Sema domain NUP205 23165 genome.wustl.edu 37 7 135320364 135320364 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015135.2 +1 validated p.G1699W 1.000 83 0% 226 40.7% 20 55% probably_damaging(0.991) deleterious(0.02) deleterious(0.827) NULL ZC3HAV1 56829 genome.wustl.edu 37 7 138764688 138764688 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020119.3 -1 reviewed p.N333 0.001 79 0% 55 36.4% 10 40% - - - NULL TTC26 79989 genome.wustl.edu 37 7 138822665 138822665 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024926.2 +1 validated p.D72N 1.000 234 0% 534 40.4% 2 50% benign(0.241) tolerated(0.24) neutral(0.062) superfamily_SSF48452 TBXAS1 6916 genome.wustl.edu 37 7 139653238 139653238 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001061.4 +1 reviewed p.D175 0.000 101 0% 126 27.8% 1 0% - - - HMMPfam_p450,superfamily_Cytochrome P450 PARP12 64761 genome.wustl.edu 37 7 139756694 139756694 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022750.2 -1 provisional p.S241N 0.000 83 0% 75 53.3% 10 40% probably_damaging(0.962) tolerated(0.09) deleterious(0.702) NULL SLC37A3 84255 genome.wustl.edu 37 7 140080091 140080091 + Silent SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_207113.1 -1 validated p.L63 0.998 149 0% 167 40.1% 9 66.6% - - - HMMPfam_MFS_1,superfamily_MFS general substrate transporter DENND2A 27147 genome.wustl.edu 37 7 140266989 140266989 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015689.3 -1 validated p.Y559C 0.997 76 0% 42 42.9% 8 62.5% probably_damaging(0.994) deleterious(0.01) deleterious(0.858) NULL ADCK2 90956 genome.wustl.edu 37 7 140386857 140386857 + Missense_Mutation SNP G G C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_052853.3 +1 validated p.G458A 0.000 131 0% 79 22.8% 77 33.7% benign(0.002) tolerated(0.53) neutral(0.007) NULL TRPV5 56302 genome.wustl.edu 37 7 142605757 142605757 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019841.4 -1 reviewed p.R705C 0.996 137 0% 119 35.3% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL KEL 3792 genome.wustl.edu 37 7 142658564 142658564 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000420.2 -1 reviewed p.V36M 0.000 42 0% 36 30.6% 0 - possibly_damaging(0.525) deleterious(0.04) deleterious(0.526) NULL GSTK1 373156 genome.wustl.edu 37 7 142962282 142962282 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001143679.1 +1 reviewed p.G161W 0.000 171 0% 125 43.2% 24 29.1% benign(0.038) deleterious(0) neutral(0.447) HMMPfam_DSBA NOBOX 135935 genome.wustl.edu 37 7 144098372 144098372 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080413.2 -1 provisional p.G204V 0.000 111 0% 86 40.7% 0 - possibly_damaging(0.828) deleterious(0) deleterious(0.758) NULL CNTNAP2 26047 genome.wustl.edu 37 7 147336243 147336243 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014141.5 +1 reviewed p.T648M 0.999 121 0% 122 45.1% 0 - possibly_damaging(0.859) tolerated(0.06) deleterious(0.655) superfamily_Concanavalin A-like lectins/glucanases ZNF425 155054 genome.wustl.edu 37 7 148801228 148801228 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001001661.2 -1 validated p.E579K 0.422 62 0% 21 42.9% 3 66.6% probably_damaging(0.994) deleterious(0.02) deleterious(0.835) superfamily_SSF57667 ZNF746 155061 genome.wustl.edu 37 7 149171567 149171567 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152557.4 -1 validated p.A615T 0.923 82 0% 42 42.9% 17 41.1% benign(0.036) deleterious(0) neutral(0.447) NULL KRBA1 84626 genome.wustl.edu 37 7 149416750 149416750 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000255992 +1 known p.T7 0.277 80 0% 68 38.2% 4 50% - - - NULL ZNF467 168544 genome.wustl.edu 37 7 149462099 149462099 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_207336.1 -1 provisional p.R498C 1.000 24 0% 18 33.3% 7 71.4% possibly_damaging(0.923) deleterious(0.04) deleterious(0.722) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 SSPO 23145 genome.wustl.edu 37 7 149485878 149485878 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000378016 +1 known p.G1366V 0.074 174 0.6% 85 14.1% 0 - - - - NULL SLC4A2 6522 genome.wustl.edu 37 7 150772569 150772569 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003040.3 +1 validated p.T1092M 1.000 162 0% 79 51.9% 76 42.1% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_HCO3_cotransp AGAP3 116988 genome.wustl.edu 37 7 150840531 150840531 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031946.4 +1 validated p.V793M 1.000 101 0% 61 23% 32 53.1% probably_damaging(0.953) deleterious(0) deleterious(0.841) superfamily_Ankyrin repeat CHPF2 54480 genome.wustl.edu 37 7 150935601 150935601 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019015.1 +1 provisional p.R718Q 1.000 108 0% 42 40.5% 88 51.1% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_CHGN GALNTL5 168391 genome.wustl.edu 37 7 151664434 151664434 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145292.3 +1 validated p.W35R 0.000 132 0% 166 30.7% 0 - benign(0) tolerated(0.6) neutral(0.004) NULL MLL3 58508 genome.wustl.edu 37 7 151845972 151845972 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_170606.2 -1 reviewed p.P4347L 0.997 159 0% 136 31.6% 10 50% unknown(0) - - NULL MLL3 58508 genome.wustl.edu 37 7 151879229 151879229 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_170606.2 -1 reviewed p.R1906* 0.956 69 0% 68 42.6% 3 100% - - - NULL CSMD1 64478 genome.wustl.edu 37 8 3141766 3141766 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033225.5 -1 validated p.S1352 0.000 138 0% 88 38.6% 0 - - - - HMMPfam_CUB,HMMSmart_SM00042,superfamily_Spermadhesin CUB domain CSMD1 64478 genome.wustl.edu 37 8 3165982 3165982 + Silent SNP G G A rs146926975 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033225.5 -1 validated p.Y1226 0.998 157 0% 123 44.7% 0 - - - - HMMPfam_Sushi,HMMSmart_SM00032,superfamily_Complement control module/SCR domain CSMD1 64478 genome.wustl.edu 37 8 3265578 3265578 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033225.5 -1 validated p.L639 0.001 104 1% 101 45.5% 0 - - - - HMMPfam_CUB,HMMSmart_SM00042,superfamily_Spermadhesin CUB domain SOX7 83595 genome.wustl.edu 37 8 10583400 10583400 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031439.2 -1 reviewed p.P339S 1.000 164 0% 93 38.7% 2 0% probably_damaging(0.999) tolerated(1) deleterious(0.490) NULL DLC1 10395 genome.wustl.edu 37 8 13357421 13357421 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_182643.2 -1 reviewed p.R54C 0.998 122 0% 109 48.6% 0 - benign(0.029) deleterious(0.01) neutral(0.407) NULL XPO7 23039 genome.wustl.edu 37 8 21824469 21824469 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001100161.1 +1 validated p.S40R 1.000 71 0% 82 37.8% 5 20% possibly_damaging(0.573) deleterious(0.01) deleterious(0.602) HMMPfam_IBN_N,superfamily_ARM repeat XPO7 23039 genome.wustl.edu 37 8 21849470 21849470 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001100161.1 +1 validated p.N720 0.987 71 0% 76 34.2% 25 40% - - - superfamily_ARM repeat BMP1 649 genome.wustl.edu 37 8 22052301 22052301 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006129.4 +1 reviewed p.S503N 1.000 60 0% 40 35% 26 34.6% possibly_damaging(0.6) deleterious(0) deleterious(0.652) HMMPfam_CUB,HMMSmart_SM00042,superfamily_Spermadhesin CUB domain SLC39A14 23516 genome.wustl.edu 37 8 22273296 22273296 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001128431.2 +1 validated p.H255 0.998 75 0% 37 43.2% 3 66.6% - - - HMMPfam_Zip KIAA1967 57805 genome.wustl.edu 37 8 22475027 22475027 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021174.4 +1 validated p.A647V 1.000 401 0% 387 43.7% 59 47.4% benign(0.076) deleterious(0.02) neutral(0.389) NULL EGR3 1960 genome.wustl.edu 37 8 22548283 22548283 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004430.2 -1 reviewed p.S289 0.998 78 0% 26 34.6% 5 20% - - - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers TNFRSF10B 8795 genome.wustl.edu 37 8 22887129 22887129 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003842.4 -1 reviewed p.R157H 0.000 64 1.6% 38 44.7% 21 61.9% benign(0.324) tolerated(0.18) neutral(0.158) HMMPfam_TNFR_c6,HMMSmart_SM00208,PatternScan_TNFR_NGFR_1,superfamily_TNF receptor-like CDCA2 157313 genome.wustl.edu 37 8 25365030 25365030 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152562.2 +1 validated p.M950V 0.000 119 0% 100 41% 13 61.5% benign(0.013) tolerated(0.59) neutral(0.005) NULL EBF2 64641 genome.wustl.edu 37 8 25718576 25718576 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022659.2 -1 validated p.G444V 1.000 212 0% 250 33.2% 0 - benign(0.016) deleterious(0.03) neutral(0.365) NULL ADRA1A 148 genome.wustl.edu 37 8 26722358 26722358 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033303.3 -1 reviewed p.G43 0.963 127 0.8% 80 45% 0 - - - - HMMPfam_7tm_1,superfamily_SSF81321 SCARA3 51435 genome.wustl.edu 37 8 27516175 27516175 + Missense_Mutation SNP C C G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016240.2 +1 reviewed p.T163S 1.000 80 0% 56 23.2% 15 46.6% benign(0) tolerated(0.93) - NULL SCARA3 51435 genome.wustl.edu 37 8 27516477 27516477 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016240.2 +1 reviewed p.G264S 0.717 50 0% 25 52% 23 56.5% benign(0) tolerated(0.8) neutral(0.001) NULL C8orf80 389643 genome.wustl.edu 37 8 27886852 27886852 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001010906.1 -1 provisional p.D695E 0.996 146 0% 68 13.2% 0 - benign(0.001) tolerated(0.56) neutral(0.006) NULL EXTL3 2137 genome.wustl.edu 37 8 28575164 28575164 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001440.2 +1 provisional p.V530M 0.802 61 0% 31 71% 9 44.4% benign(0.264) tolerated(0.1) neutral(0.314) NULL KIF13B 23303 genome.wustl.edu 37 8 29006170 29006170 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015254.3 -1 validated p.S579 0.976 224 0% 235 40.4% 11 36.3% - - - NULL GTF2E2 2961 genome.wustl.edu 37 8 30469933 30469933 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002095.4 -1 validated p.N144 1.000 188 0% 251 37.5% 43 46.5% - - - HMMPfam_TFIIE_beta,superfamily_SSF46785 BRF2 55290 genome.wustl.edu 37 8 37702418 37702418 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018310.2 -1 reviewed p.R284* 0.173 58 0% 26 42.3% 20 25% - - - NULL ASH2L 9070 genome.wustl.edu 37 8 37986395 37986395 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004674.3 +1 validated p.V485I 0.555 71 0% 122 18.9% 27 40.7% benign(0) tolerated(0.31) neutral(0.027) HMMPfam_SPRY,HMMSmart_SM00449 TM2D2 83877 genome.wustl.edu 37 8 38851086 38851086 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_078473.2 -1 validated p.R137* 1.000 83 0% 94 35.1% 27 29.6% - - - NULL AP3M2 10947 genome.wustl.edu 37 8 42022668 42022668 + Silent SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001134296.1 +1 reviewed p.S221 1.000 123 0% 122 11.5% 3 33.3% - - - HMMPfam_Adap_comp_sub,superfamily_Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor IKBKB 3551 genome.wustl.edu 37 8 42166476 42166476 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001556.1 +1 validated p.G209S 1.000 55 0% 40 55% 18 33.3% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) superfamily_Kinase_like,HMMPfam_Pkinase HOOK3 84376 genome.wustl.edu 37 8 42812295 42812295 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032410.3 +1 validated p.R176H 1.000 163 0% 349 39.3% 3 33.3% benign(0.003) tolerated(0.16) neutral(0.059) HMMPfam_HOOK HGSNAT 138050 genome.wustl.edu 37 8 43048942 43048942 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152419.2 +1 reviewed p.L474M 0.950 201 0% 252 41.7% 16 56.2% probably_damaging(0.995) tolerated(0.15) deleterious(0.699) HMMPfam_DUF2261 KIAA0146 23514 genome.wustl.edu 37 8 48641984 48641984 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080394.1 +1 predicted p.R854H 0.022 75 0% 42 38.1% 61 39.3% possibly_damaging(0.938) tolerated(0.12) deleterious(0.644) NULL RP1 6101 genome.wustl.edu 37 8 55534067 55534067 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006269.1 +1 reviewed p.E181K 1.000 81 0% 37 40.5% 0 - possibly_damaging(0.822) deleterious(0.01) deleterious(0.717) HMMPfam_DCX,HMMSmart_DCX,superfamily_SSF89837 TGS1 96764 genome.wustl.edu 37 8 56686269 56686269 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024831.6 +1 validated p.A31V 0.998 121 0% 124 36.3% 5 20% probably_damaging(1) deleterious(0) deleterious(0.945) NULL ASPH 444 genome.wustl.edu 37 8 62596634 62596634 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004318.3 -1 reviewed p.V73I 0.996 183 0% 247 39.3% 31 38.7% benign(0.431) deleterious(0) deleterious(0.585) HMMPfam_Asp-B-Hydro_N ENSG00000237810 0 genome.wustl.edu 37 8 63057194 63057194 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000433538 -1 known p.R14H 1.000 20 0% 15 46.7% 0 - - - - superfamily_Protein kinase-like (PK-like) SULF1 23213 genome.wustl.edu 37 8 70536423 70536423 + Missense_Mutation SNP T T A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001128204.1 +1 validated p.V614E 1.000 58 0% 23 26.1% 6 0% probably_damaging(1) tolerated(0.1) deleterious(0.786) superfamily_Alkaline_phosphatase_core LRRC69 100130742 genome.wustl.edu 37 8 92136765 92136765 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001129890.1 +1 provisional p.P76 0.998 88 0% 166 43.4% 0 - - - - HMMPfam_LRR_1,HMMSmart_SM00369,HMMSmart_SM00364,superfamily_L domain-like FAM92A1 137392 genome.wustl.edu 37 8 94722047 94722047 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145269.3 +1 predicted p.R163C 1.000 124 0% 199 40.7% 19 36.8% probably_damaging(0.997) deleterious(0) deleterious(0.911) HMMPfam_DUF1208 INTS8 55656 genome.wustl.edu 37 8 95888460 95888460 + Missense_Mutation SNP T T A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017864.2 +1 provisional p.M925K 1.000 197 0% 393 38.9% 50 44% possibly_damaging(0.837) deleterious(0) deleterious(0.764) NULL PLEKHF2 79666 genome.wustl.edu 37 8 96166877 96166877 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024613.3 +1 validated p.R202Q 1.000 124 0% 102 37.3% 9 11.1% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_FYVE,HMMSmart_FYVE,superfamily_FYVE_PHD_ZnF VPS13B 157680 genome.wustl.edu 37 8 100587891 100587891 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017890.3 +1 reviewed p.R1677Q 0.863 139 0% 262 41.2% 1 0% benign(0.006) tolerated(0.5) neutral(0.010) NULL VPS13B 157680 genome.wustl.edu 37 8 100654448 100654448 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017890.3 +1 reviewed p.R1902M 1.000 106 0% 105 45.7% 3 100% benign(0.001) tolerated(0.11) neutral(0.272) NULL POLR2K 5440 genome.wustl.edu 37 8 101165540 101165540 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005034.3 +1 reviewed p.R58Q 0.997 329 0% 607 41.8% 141 49.6% possibly_damaging(0.463) tolerated(0.09) neutral(0.449) HMMSmart_SM00659,superfamily_RNA polymerase subunits ODF1 4956 genome.wustl.edu 37 8 103572937 103572937 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024410.3 +1 reviewed p.G193D 1.000 100 0% 67 41.8% 0 - benign(0.176) tolerated(0.07) neutral(0.335) superfamily_HSP20_chap CSMD3 114788 genome.wustl.edu 37 8 113237046 113237046 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198123.1 -1 validated p.A3693V 1.000 456 0.2% 413 37.8% 0 - benign(0.008) deleterious(0.02) neutral(0.383) NULL WDR67 93594 genome.wustl.edu 37 8 124140710 124140710 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145647.3 +1 validated p.R692* 0.984 93 0% 126 39.7% 2 0% - - - NULL MTSS1 9788 genome.wustl.edu 37 8 125568477 125568477 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014751.4 -1 validated p.T467N 1.000 107 0% 72 33.3% 1 100% benign(0.009) tolerated(0.36) neutral(0.021) NULL GSDMC 56169 genome.wustl.edu 37 8 130789815 130789815 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031415.2 -1 validated p.R7C 0.000 128 0% 130 41.5% 1 0% benign(0.351) tolerated(0.18) neutral(0.167) HMMPfam_Gasdermin TG 7038 genome.wustl.edu 37 8 134144148 134144148 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003235.4 +1 reviewed p.S2652L 0.941 190 0% 187 42.2% 1 100% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_COesterase,superfamily_alpha/beta-Hydrolases WISP1 8840 genome.wustl.edu 37 8 134239766 134239766 + Missense_Mutation SNP A A T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003882.2 +1 reviewed p.D306V 0.998 169 0% 109 45% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00041,HMMPfam_Cys_knot ST3GAL1 6482 genome.wustl.edu 37 8 134478194 134478194 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003033.3 -1 reviewed p.G149D 1.000 57 0% 42 50% 1 0% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_Glyco_transf_29 ZFAT 57623 genome.wustl.edu 37 8 135614246 135614246 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020863.3 -1 reviewed p.L572 0.009 37 0% 16 25% 4 0% - - - NULL ZFAT 57623 genome.wustl.edu 37 8 135614923 135614923 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020863.3 -1 reviewed p.R347* 1.000 117 0% 48 14.6% 3 0% - - - PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers COL22A1 169044 genome.wustl.edu 37 8 139767401 139767401 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152888.1 -1 validated p.R677Q 0.945 66 0% 55 41.8% 0 - unknown(0) tolerated(0.38) - NULL DENND3 22898 genome.wustl.edu 37 8 142161751 142161751 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014957.2 +1 validated p.V217I 0.997 115 0% 44 38.6% 5 20% probably_damaging(1) tolerated(0.1) deleterious(0.786) HMMPfam_DENN,HMMSmart_SM00799 CYP11B1 1584 genome.wustl.edu 37 8 143956376 143956376 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000497.3 -1 reviewed p.H465 1.000 38 0% 26 38.5% 0 - - - - HMMPfam_p450,superfamily_Cytochrome_P450 SCRIB 23513 genome.wustl.edu 37 8 144887544 144887544 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_182706.3 -1 validated p.A803V 0.981 19 0.000 5 0.800 36 50% possibly_damaging(0.838) deleterious(0.01) deleterious(0.726) HMMPfam_PDZ,HMMSmart_SM00228,superfamily_PDZ domain-like EPPK1 83481 genome.wustl.edu 37 8 144941616 144941616 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031308.1 -1 validated p.A1936T 1.000 47 0% 23 43.5% 1 0% probably_damaging(0.98) deleterious(0.01) deleterious(0.830) HMMPfam_Plectin,HMMSmart_SM00250,superfamily_Plakin repeat EPPK1 83481 genome.wustl.edu 37 8 144941990 144941990 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031308.1 -1 validated p.R1811Q 0.000 256 0% 235 40.4% 0 - probably_damaging(0.982) tolerated(0.41) neutral(0.442) NULL EPPK1 83481 genome.wustl.edu 37 8 144945533 144945533 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031308.1 -1 validated p.R630Q 0.000 75 0% 27 44.4% 1 100% probably_damaging(0.982) deleterious(0.02) deleterious(0.809) HMMPfam_Plectin,HMMSmart_SM00250,superfamily_Plakin repeat PLEC 5339 genome.wustl.edu 37 8 145001159 145001159 + Missense_Mutation SNP T T A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_201380.2 -1 reviewed p.S1448C 1.000 150 0% 56 10.7% 43 2.3% unknown(0) - - HMMSmart_SM00150,superfamily_Spectrin repeat OPLAH 26873 genome.wustl.edu 37 8 145108232 145108232 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000426825 -1 known p.H917 0.960 58 0% 34 11.8% 21 9.5% - - - HMMPfam_Hydantoinase_B VPS28 51160 genome.wustl.edu 37 8 145650340 145650340 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_183057.1 -1 reviewed p.R97C 1.000 144 0% 64 17.2% 195 24.1% probably_damaging(0.991) deleterious(0.01) deleterious(0.850) HMMPfam_VPS28 KANK1 23189 genome.wustl.edu 37 9 732558 732558 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015158.2 +1 reviewed p.R1062 0.997 81 0% 69 56.5% 4 50% - - - superfamily_ANK SMARCA2 6595 genome.wustl.edu 37 9 2086961 2086961 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003070.3 +1 reviewed p.K887E 1.000 97 0% 80 10% 7 42.8% unknown(0) deleterious(0.01) - HMMPfam_SNF2_N,HMMSmart_SM00487,superfamily_P-loop containing nucleoside triphosphate hydrolases SMARCA2 6595 genome.wustl.edu 37 9 2123881 2123881 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003070.3 +1 reviewed p.R1309C 1.000 78 1.3% 39 82.1% 13 46.1% possibly_damaging(0.936) deleterious(0) deleterious(0.826) NULL KDM4C 23081 genome.wustl.edu 37 9 7049119 7049119 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015061.3 +1 reviewed p.A781 0.010 133 0% 83 67.5% 7 85.7% - - - NULL PTPRD 5789 genome.wustl.edu 37 9 8518020 8518020 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002839.3 -1 reviewed p.M457I 1.000 367 0.3% 258 56.6% 0 - benign(0.221) tolerated(0.19) neutral(0.072) HMMPfam_fn3,HMMSmart_SM00060,superfamily_Fibronectin type III TEK 7010 genome.wustl.edu 37 9 27190556 27190556 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000459.3 +1 reviewed p.V453M 0.913 147 0% 154 66.9% 4 0% possibly_damaging(0.822) deleterious(0.04) deleterious(0.660) HMMPfam_fn3,HMMSmart_FN3,superfamily_FN_III-like FANCG 2189 genome.wustl.edu 37 9 35074941 35074941 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004629.1 -1 reviewed p.S540N 0.945 86 0% 48 75% 19 78.9% benign(0.097) tolerated(0.21) neutral(0.051) HMMSmart_SM00028,superfamily_TPR-like UNC13B 10497 genome.wustl.edu 37 9 35398997 35398997 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006377.3 +1 reviewed p.V1265I 1.000 96 0% 27 55.6% 8 100% benign(0.201) tolerated(0.37) neutral(0.038) HMMPfam_Membr_traf_MHD RUSC2 9853 genome.wustl.edu 37 9 35548531 35548531 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001135999.1 +1 validated p.D671 0.998 54 0% 23 60.9% 0 - - - - NULL CD72 971 genome.wustl.edu 37 9 35611808 35611808 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001782.2 -1 validated p.R315C 0.000 170 0% 118 43.2% 5 20% benign(0.025) tolerated(0.18) neutral(0.057) HMMPfam_Lectin_C,HMMSmart_SM00034,superfamily_C-type lectin-like PGM5 5239 genome.wustl.edu 37 9 71098928 71098928 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021965.3 +1 validated p.Y481 0.652 156 0% 79 62% 0 - - - - HMMPfam_PGM_PMM_IV,superfamily_Phosphoglucomutase C-terminal domain TMEM2 23670 genome.wustl.edu 37 9 74349777 74349777 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013390.2 -1 validated p.E446D 1.000 174 0% 130 56.2% 3 66.6% probably_damaging(0.998) deleterious(0.02) deleterious(0.857) NULL FAM108B1 51104 genome.wustl.edu 37 9 74489860 74489860 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016014.2 -1 validated p.W46* 1.000 155 0% 118 65.3% 5 80% - - - superfamily_SSF53474 ALDH1A1 216 genome.wustl.edu 37 9 75531961 75531961 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000689.3 -1 reviewed p.I304V 0.998 147 0% 113 58.4% 151 90.7% benign(0.001) tolerated(0.22) neutral(0.042) HMMPfam_Aldedh,PatternScan_ALDEHYDE_DEHYDR_CYS,superfamily_ALDH-like ZNF367 195828 genome.wustl.edu 37 9 99150565 99150565 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153695.3 -1 validated p.A336V 1.000 49 0% 22 77.3% 1 100% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL TSTD2 158427 genome.wustl.edu 37 9 100367838 100367838 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_139246.4 -1 validated p.R347K 0.992 102 0% 46 52.2% 5 40% benign(0) tolerated(0.6) neutral(0.004) HMMPfam_Rhodanese,HMMSmart_SM00450,superfamily_Rhodanese/Cell cycle control phosphatase NCBP1 4686 genome.wustl.edu 37 9 100417219 100417219 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002486.4 +1 reviewed p.V410I 1.000 100 0% 65 72.3% 8 75% benign(0.001) tolerated(1) - HMMPfam_MIF4G_like,superfamily_ARM-type_fold MRPL50 54534 genome.wustl.edu 37 9 104153019 104153019 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019051.2 -1 reviewed p.R69H 0.384 161 0% 90 68.9% 24 66.6% possibly_damaging(0.871) deleterious(0.03) deleterious(0.703) HMMPfam_Ribosomal_S39 SVEP1 79987 genome.wustl.edu 37 9 113173344 113173344 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153366.3 -1 validated p.E2216G 1.000 89 0% 48 77.1% 0 - probably_damaging(0.957) tolerated(0.33) neutral(0.425) HMMPfam_Sushi,HMMSmart_SM00032,superfamily_Complement control module/SCR domain LPAR1 1902 genome.wustl.edu 37 9 113704010 113704010 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001401.3 -1 reviewed p.R162W 1.000 133 0% 72 65.3% 4 50% benign(0.07) tolerated(0.19) neutral(0.054) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like DBC1 1620 genome.wustl.edu 37 9 121930269 121930269 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014618.2 -1 validated p.R460H 1.000 115 0% 37 64.9% 0 - probably_damaging(0.969) tolerated(0.55) neutral(0.418) NULL ENG 2022 genome.wustl.edu 37 9 130592018 130592018 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001114753.1 -1 reviewed p.S103N 0.000 112 0% 30 43.3% 31 0% benign(0.153) deleterious(0.03) neutral(0.378) NULL SPTAN1 6709 genome.wustl.edu 37 9 131349933 131349933 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001130438.1 +1 validated p.G943S 1.000 144 0% 54 68.5% 18 77.7% possibly_damaging(0.666) deleterious(0.04) deleterious(0.585) HMMPfam_Spectrin,HMMSmart_SPEC,superfamily_Spectrin PPAPDC3 84814 genome.wustl.edu 37 9 134165667 134165667 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032728.3 +1 validated p.R95W 1.000 33 0% 15 73.3% 0 - probably_damaging(1) deleterious(0.02) deleterious(0.883) NULL UCK1 83549 genome.wustl.edu 37 9 134404542 134404542 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031432.2 -1 validated p.D161N 0.998 45 0.000 9 0.778 14 64.2% probably_damaging(0.997) deleterious(0) deleterious(0.911) HMMPfam_PRK,superfamily_SSF52540 KCNT1 57582 genome.wustl.edu 37 9 138651534 138651534 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020822.2 +1 validated p.G288 0.939 72 0% 21 52.4% 0 - - - - HMMPfam_Ion_trans_2,superfamily_SSF81324 NOTCH1 4851 genome.wustl.edu 37 9 139391144 139391144 + Silent SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017617.3 -1 reviewed p.P2349 0.007 62 0% 18 55.6% 17 58.8% - - - NULL NOTCH1 4851 genome.wustl.edu 37 9 139413167 139413167 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017617.3 -1 reviewed p.N325 0.927 69 0% 14 50% 4 75% - - - HMMSmart_EGF_CA,PatternScan_EGF_1,PatternScan_EGF_2,HMMPfam_EGF_CA,superfamily_SSF57196 LCN10 414332 genome.wustl.edu 37 9 139636438 139636438 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001001712.2 -1 validated p.T51I 0.130 47 0% 23 52.2% 0 - possibly_damaging(0.901) deleterious(0.01) deleterious(0.762) superfamily_Calycin LCN6 158062 genome.wustl.edu 37 9 139639702 139639702 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198946.2 -1 validated p.A111V 0.998 100 0% 32 56.2% 0 - benign(0.071) tolerated(0.05) neutral(0.350) superfamily_Calycin LARP4B 23185 genome.wustl.edu 37 10 860687 860687 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015155.1 -1 provisional p.A642T 0.993 61 0% 43 11.6% 22 13.6% probably_damaging(0.955) deleterious(0) deleterious(0.843) NULL ADARB2 105 genome.wustl.edu 37 10 1262947 1262947 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018702.2 -1 reviewed p.D542 0.272 65 0% 34 38.2% 0 - - - - HMMPfam_A_deamin,HMMSmart_ADEAMc FBXO18 84893 genome.wustl.edu 37 10 5948287 5948287 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032807.3 +1 reviewed p.R200W 0.000 48 0% 15 40% 23 43.4% benign(0) tolerated(0.09) neutral(0.296) NULL FBXO18 84893 genome.wustl.edu 37 10 5960424 5960424 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032807.3 +1 reviewed p.V746I 1.000 90 0% 46 34.8% 33 42.4% benign(0.002) tolerated(0.58) neutral(0.005) superfamily_SSF52540 PRPF18 8559 genome.wustl.edu 37 10 13656080 13656080 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003675.3 +1 reviewed p.Y262 0.993 91 0% 204 29.9% 17 64.7% - - - HMMPfam_Prp18,superfamily_Functional domain of the splicing factor Prp18 PTER 9317 genome.wustl.edu 37 10 16553050 16553050 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001001484.1 +1 validated p.R282H 0.995 152 0% 187 40.6% 18 66.6% benign(0.006) tolerated(0.56) neutral(0.006) HMMPfam_PTE,superfamily_Metallo-dependent hydrolases C10orf140 387640 genome.wustl.edu 37 10 21804401 21804401 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_207371.3 -1 validated p.L784P 1.000 230 0% 263 41.1% 0 - probably_damaging(0.999) tolerated(0.27) deleterious(0.524) NULL SPAG6 9576 genome.wustl.edu 37 10 22676871 22676871 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012443.2 +1 reviewed p.Y266 0.619 162 0% 210 29.5% 0 - - - - HMMPfam_Arm,HMMSmart_SM00185,superfamily_ARM repeat KIAA1462 57608 genome.wustl.edu 37 10 30336528 30336528 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020848.2 -1 validated p.R72C 0.000 71 0% 37 35.1% 1 0% possibly_damaging(0.744) deleterious(0.01) deleterious(0.679) NULL ZNF438 220929 genome.wustl.edu 37 10 31138707 31138707 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001143766.1 -1 validated p.N209 0.000 217 0% 164 42.1% 1 0% - - - NULL ZWINT 11130 genome.wustl.edu 37 10 58119784 58119784 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007057.3 -1 reviewed p.T84M 0.013 56 0% 18 38.9% 32 56.2% probably_damaging(0.994) deleterious(0.02) deleterious(0.835) NULL ANK3 288 genome.wustl.edu 37 10 61829879 61829879 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020987.2 -1 reviewed p.T3587M 1.000 370 0% 330 39.4% 0 - probably_damaging(0.999) - - NULL JMJD1C 221037 genome.wustl.edu 37 10 64946091 64946091 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032776.1 -1 validated p.A2208V 0.998 146 0% 195 41% 9 55.5% possibly_damaging(0.494) deleterious(0.02) deleterious(0.547) NULL JMJD1C 221037 genome.wustl.edu 37 10 64968886 64968886 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032776.1 -1 validated p.P935L 1.000 146 0% 239 49.8% 4 0% probably_damaging(0.953) deleterious(0.03) deleterious(0.761) NULL HERC4 26091 genome.wustl.edu 37 10 69750942 69750942 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022079.2 -1 validated p.T429M 1.000 18 0% 89 44.9% 5 40% possibly_damaging(0.668) deleterious(0.01) deleterious(0.642) NULL MYPN 84665 genome.wustl.edu 37 10 69881901 69881901 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032578.2 +1 validated p.R236C 0.096 63 0% 46 39.1% 0 - possibly_damaging(0.736) deleterious(0.02) deleterious(0.652) NULL NEUROG3 50674 genome.wustl.edu 37 10 71332479 71332479 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020999.3 -1 reviewed p.R107 0.890 44 0% 30 26.7% 0 - - - - HMMPfam_HLH,HMMSmart_HLH,superfamily_HLH_basic KAT6B 23522 genome.wustl.edu 37 10 76788301 76788301 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012330.2 +1 validated p.E1240G 1.000 69 0% 96 37.5% 14 42.8% probably_damaging(0.996) deleterious(0.02) deleterious(0.845) NULL SFTPA1 653509 genome.wustl.edu 37 10 81373717 81373717 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001093770.2 +1 reviewed p.R199C 0.020 201 0% 123 10.6% 0 - possibly_damaging(0.771) tolerated(0.18) neutral(0.342) HMMPfam_Lectin_C,HMMSmart_SM00034,superfamily_C-type lectin-like LDB3 11155 genome.wustl.edu 37 10 88492709 88492709 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007078.2 +1 reviewed p.K720 1.000 53 0% 32 43.8% 0 - - - - HMMPfam_LIM,HMMSmart_SM00132,superfamily_Glucocorticoid receptor-like (DNA-binding domain) PTEN 5728 genome.wustl.edu 37 10 89711900 89711900 + Missense_Mutation SNP G G A rs121913294 TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000371953 +1 known p.R173H 1.000 164 0% 345 41.4% 27 70.3% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMSmart_SM00404,superfamily_(Phosphotyrosine protein) phosphatases II PTEN 5728 genome.wustl.edu 37 10 89717672 89717672 + Nonsense_Mutation SNP C C T rs121909219 byCluster TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000371953 +1 known p.R233* 0.984 169 0% 174 52.3% 44 27.2% - - - superfamily_C2 domain (Calcium/lipid-binding domain CaLB),HMMPfam_PTEN_C2 LIPK 643414 genome.wustl.edu 37 10 90497465 90497465 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080518.1 +1 provisional p.R248Q 0.000 281 0% 344 44.8% 0 - benign(0.002) tolerated(0.67) neutral(0.003) HMMPfam_Abhydrolase_1,superfamily_SSF53474 LIPM 340654 genome.wustl.edu 37 10 90576576 90576576 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001128215.1 +1 validated p.R288* 1.000 158 0% 179 41.9% 0 - - - - HMMPfam_Abhydrolase_1,superfamily_SSF53474 KIF20B 9585 genome.wustl.edu 37 10 91469785 91469785 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016195.2 +1 validated p.Y151 0.998 70 1.4% 184 37.5% 0 - - - - HMMPfam_Kinesin,HMMSmart_SM00129,superfamily_P-loop containing nucleoside triphosphate hydrolases RPP30 10556 genome.wustl.edu 37 10 92655664 92655664 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001104546.1 +1 validated p.V203M 0.959 134 0% 300 39.7% 35 37.1% probably_damaging(0.991) deleterious(0) deleterious(0.889) HMMPfam_RNase_P_p30,superfamily_PHP domain-like ANKRD1 27063 genome.wustl.edu 37 10 92675538 92675538 + Splice_Site SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014391.2 -1 reviewed e7+1 1.000 66 0% 42 45.2% 0 - - - - - MYOF 26509 genome.wustl.edu 37 10 95070330 95070330 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013451.3 -1 reviewed p.R1987Q 1.000 222 0% 225 16% 304 20.3% probably_damaging(0.979) tolerated(0.23) neutral(0.463) NULL TM9SF3 56889 genome.wustl.edu 37 10 98287919 98287919 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020123.3 -1 validated p.T470 0.002 79 0% 81 42% 82 41.4% - - - HMMPfam_EMP70 PIK3AP1 118788 genome.wustl.edu 37 10 98416609 98416609 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152309.2 -1 validated p.T171 0.002 106 0% 52 32.7% 2 0% - - - NULL RRP12 23223 genome.wustl.edu 37 10 99118724 99118724 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015179.3 -1 validated p.M1228I 0.000 54 0% 51 11.8% 35 2.8% benign(0) tolerated(0.2) neutral(0.049) NULL RRP12 23223 genome.wustl.edu 37 10 99133361 99133361 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015179.3 -1 validated p.R666H 1.000 66 0% 28 28.6% 11 45.4% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_NUC173,superfamily_ARM repeat RRP12 23223 genome.wustl.edu 37 10 99133590 99133590 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015179.3 -1 validated p.W620* 1.000 143 0% 67 38.8% 12 0% - - - HMMPfam_NUC173,superfamily_ARM repeat MMS19 64210 genome.wustl.edu 37 10 99219025 99219025 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000444411 -1 known p.P33L 0.766 96 0% 64 35.9% 86 37.2% - - - NULL MMS19 64210 genome.wustl.edu 37 10 99220454 99220454 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022362.4 -1 validated p.R823W 0.897 144 0% 162 33.3% 45 46.6% probably_damaging(0.981) deleterious(0.01) deleterious(0.831) superfamily_ARM repeat NDUFB8 4714 genome.wustl.edu 37 10 102286732 102286732 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005004.2 -1 validated p.P104 1.000 124 0% 118 39% 327 41.5% - - - HMMPfam_NDUF_B8 FAM178A 55719 genome.wustl.edu 37 10 102683848 102683848 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001136123.1 +1 validated p.R364C 1.000 49 0% 73 39.7% 4 25% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL PPRC1 23082 genome.wustl.edu 37 10 103908158 103908158 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015062.3 +1 reviewed p.R1477Q 0.997 223 0% 193 43.5% 41 48.7% unknown(0) tolerated(0.61) - NULL SUFU 51684 genome.wustl.edu 37 10 104359302 104359302 + Splice_Site SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016169.3 +1 reviewed e8+1 1.000 53 0% 36 33.3% 1 100% - - - - PDCD11 22984 genome.wustl.edu 37 10 105194696 105194696 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014976.1 +1 validated p.T1270M 0.000 54 0% 46 41.3% 18 38.8% possibly_damaging(0.861) tolerated(0.1) deleterious(0.619) superfamily_Nucleic_acid_OB,HMMSmart_S1 PDCD11 22984 genome.wustl.edu 37 10 105202060 105202060 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014976.1 +1 validated p.R1600W 0.228 54 0% 52 50% 31 54.8% possibly_damaging(0.753) tolerated(0.07) deleterious(0.596) HMMSmart_HAT,superfamily_SSF48452 TACC2 10579 genome.wustl.edu 37 10 124013558 124013558 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_206862.2 +1 reviewed p.M2945T 1.000 125 0% 210 38.6% 76 38.1% probably_damaging(0.959) deleterious(0) deleterious(0.847) HMMPfam_TACC DMBT1 1755 genome.wustl.edu 37 10 124348687 124348687 + Missense_Mutation SNP T T A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007329.2 +1 reviewed p.C671S 0.990 226 0% 110 16.4% 1 0% probably_damaging(0.988) deleterious(0) deleterious(0.882) HMMPfam_SRCR,HMMSmart_SM00202,superfamily_SRCR-like DMBT1 1755 genome.wustl.edu 37 10 124390630 124390630 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007329.2 +1 reviewed p.R1931H 0.000 194 0% 125 44.8% 9 33.3% benign(0.412) tolerated(0.33) neutral(0.157) HMMPfam_SRCR,HMMSmart_SM00202,superfamily_SRCR-like DMBT1 1755 genome.wustl.edu 37 10 124395560 124395560 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007329.2 +1 reviewed p.R2072H 0.000 212 0% 178 38.8% 19 0% benign(0.001) tolerated(0.55) neutral(0.007) HMMPfam_CUB,HMMSmart_SM00042,superfamily_Spermadhesin CUB domain CPXM2 119587 genome.wustl.edu 37 10 125528083 125528083 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198148.2 -1 validated p.P420T 1.000 75 0% 37 21.6% 5 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Peptidase_M14,superfamily_Zn-dependent exopeptidases FAM196A 642938 genome.wustl.edu 37 10 128973601 128973601 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001039762.2 -1 validated p.T353 0.019 120 0% 74 41.9% 0 - - - - NULL KNDC1 85442 genome.wustl.edu 37 10 135020652 135020652 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152643.6 +1 validated p.A1197 0.751 24 0% 13 46.2% 0 - - - - NULL PTDSS2 81490 genome.wustl.edu 37 11 488255 488255 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_030783.1 +1 provisional p.F226 1.000 85 0% 40 35% 21 52.3% - - - HMMPfam_PSS LRRC56 115399 genome.wustl.edu 37 11 550080 550080 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198075.3 +1 validated p.Y144 0.939 88 0% 46 50% 1 0% - - - HMMPfam_LRR_1,superfamily_SSF52075 C11orf35 256329 genome.wustl.edu 37 11 557447 557447 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_173573.2 -1 validated p.R222H 0.003 104 0% 65 41.5% 15 33.3% benign(0.001) tolerated(0.36) neutral(0.020) NULL PNPLA2 57104 genome.wustl.edu 37 11 822402 822402 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020376.2 +1 provisional p.Y164 0.492 97 0% 42 35.7% 162 27.1% - - - HMMPfam_Patatin,superfamily_FabD/lysophospholipase-like MUC2 4583 genome.wustl.edu 37 11 1093846 1093846 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002457.2 +1 reviewed p.A1885T 0.000 185 0% 85 45.9% 0 - unknown(0) tolerated(1) - NULL MUC2 4583 genome.wustl.edu 37 11 1097284 1097284 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002457.2 +1 reviewed p.V2230I 0.016 67 0% 48 14.6% 0 - possibly_damaging(0.58) tolerated(0.12) neutral(0.460) HMMPfam_VWD,HMMSmart_SM00216 TOLLIP 54472 genome.wustl.edu 37 11 1309893 1309893 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019009.3 -1 validated p.D160 0.180 81 0% 37 29.7% 65 35.3% - - - superfamily_C2 domain (Calcium/lipid-binding domain CaLB) LOC100287770 100287770 genome.wustl.edu 37 11 1776063 1776063 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002343068.1 +1 model p.G42R 0.000 31 0% 20 45% 1 100% - - - NULL TRPM5 29850 genome.wustl.edu 37 11 2432869 2432869 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014555.3 -1 validated p.R868H 0.986 64 0% 29 20.7% 0 - probably_damaging(0.996) deleterious(0) deleterious(0.906) HMMPfam_Ion_trans CARS 833 genome.wustl.edu 37 11 3069109 3069109 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001014437.1 -1 reviewed p.A50T 0.998 66 0% 26 50% 3 33.3% benign(0.017) tolerated(0.15) neutral(0.241) NULL OSBPL5 114879 genome.wustl.edu 37 11 3141705 3141705 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020896.3 -1 reviewed p.D184 1.000 32 0% 13 30.8% 6 66.6% - - - HMMPfam_PH,HMMSmart_PH,superfamily_SSF50729 SMPD1 6609 genome.wustl.edu 37 11 6415528 6415528 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000543.3 +1 reviewed p.P529 0.004 72 0% 44 40.9% 44 34% - - - superfamily_Metallo-dependent phosphatases TRIM3 10612 genome.wustl.edu 37 11 6477399 6477399 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006458.2 -1 reviewed p.R479H 0.992 115 0% 66 33.3% 16 50% benign(0.182) deleterious(0.04) neutral(0.365) superfamily_NHL repeat OR6A2 8590 genome.wustl.edu 37 11 6816048 6816048 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003696.2 -1 provisional p.R298C 0.810 120 0% 124 38.7% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_SSF81321 EIF4G2 1982 genome.wustl.edu 37 11 10822544 10822544 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000429377 -1 known p.Q575* 1.000 344 0% 386 36.3% 206 2.9% - - - NULL GALNTL4 374378 genome.wustl.edu 37 11 11362477 11362477 + Silent SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198516.2 -1 validated p.P389 1.000 179 0% 88 31.8% 16 12.5% - - - superfamily_Nucleotide-diphospho-sugar transferases GALNTL4 374378 genome.wustl.edu 37 11 11454230 11454230 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198516.2 -1 validated p.M178T 0.998 143 0% 99 52.5% 7 42.8% benign(0.007) deleterious(0) neutral(0.445) HMMPfam_Glycos_transf_2,superfamily_Nucleotide-diphospho-sugar transferases ARNTL 406 genome.wustl.edu 37 11 13402764 13402764 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001030272.1 +1 reviewed p.T526M 1.000 78 0% 83 38.6% 11 54.5% probably_damaging(0.999) deleterious(0.02) deleterious(0.873) NULL PLEKHA7 144100 genome.wustl.edu 37 11 16810798 16810798 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_175058.4 -1 validated p.R1068* 1.000 43 0% 20 30% 17 47% - - - NULL ABCC8 6833 genome.wustl.edu 37 11 17483186 17483186 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000352.3 -1 reviewed p.A256T 1.000 122 0% 60 45% 0 - probably_damaging(0.988) tolerated(0.47) neutral(0.449) NULL PTPN5 84867 genome.wustl.edu 37 11 18751285 18751285 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006906.1 -1 validated p.P470 0.951 37 0% 29 37.9% 0 - - - - HMMPfam_Y_phosphatase,HMMSmart_SM00194,HMMSmart_SM00404,superfamily_(Phosphotyrosine protein) phosphatases II PTPN5 84867 genome.wustl.edu 37 11 18764922 18764922 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006906.1 -1 validated p.A116T 0.412 135 0% 95 33.7% 0 - benign(0) tolerated(1) - NULL E2F8 79733 genome.wustl.edu 37 11 19251172 19251172 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024680.2 -1 validated p.S574 0.003 158 0.6% 100 38% 5 20% - - - NULL NAV2 89797 genome.wustl.edu 37 11 20070582 20070582 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_182964.5 +1 validated p.V1404A 0.622 80 0% 34 14.7% 2 50% benign(0.119) deleterious(0.01) neutral(0.415) NULL LUZP2 338645 genome.wustl.edu 37 11 24750780 24750780 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001009909.2 +1 validated p.R43H 0.988 58 0% 51 39.2% 0 - benign(0) deleterious(0) neutral(0.445) NULL DCDC5 100506627 genome.wustl.edu 37 11 30944050 30944050 + Missense_Mutation SNP C C G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002343054.1 -1 model p.V196L 0.849 190 0% 413 43.1% 0 - benign(0.001) tolerated(0.11) neutral(0.272) NULL ELP4 26610 genome.wustl.edu 37 11 31653855 31653855 + Missense_Mutation SNP A A C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019040.3 +1 reviewed p.N277T 0.001 117 0% 155 39.4% 7 28.5% benign(0) tolerated(0.45) neutral(0.012) HMMPfam_PAXNEB NAT10 55226 genome.wustl.edu 37 11 34158212 34158212 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024662.2 +1 validated p.V684 0.275 105 0% 84 22.6% 40 55% - - - NULL ABTB2 25841 genome.wustl.edu 37 11 34186275 34186275 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145804.1 -1 provisional p.E463G 1.000 107 0% 39 46.2% 15 66.6% benign(0.002) tolerated(0.45) neutral(0.012) HMMSmart_ANK,superfamily_ANK PAMR1 25891 genome.wustl.edu 37 11 35456329 35456329 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015430.2 -1 validated p.T470A 0.026 85 0% 56 46.4% 7 28.5% benign(0) tolerated(0.78) neutral(0.001) HMMSmart_Tryp_SPc,superfamily_Pept_Ser_Cys TRAF6 7189 genome.wustl.edu 37 11 36516569 36516569 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004620.2 -1 reviewed p.N212S 0.965 91 0% 198 35.9% 10 20% benign(0) tolerated(0.47) neutral(0.011) HMMPfam_zf-TRAF,superfamily_Traf_like PHF21A 51317 genome.wustl.edu 37 11 45955585 45955585 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001101802.1 -1 validated p.T659 0.998 102 1% 74 40.5% 19 42.1% - - - NULL LOC100289572 100289572 genome.wustl.edu 37 11 47470533 47470533 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002343082.1 +1 model p.C213Y 0.000 141 0% 81 19.8% 0 - - - - NULL FAM180B 399888 genome.wustl.edu 37 11 47608204 47608204 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000356737 +1 known p.R3C 0.002 56 0% 27 33.3% 0 - unknown(0) - - NULL FAM180B 399888 genome.wustl.edu 37 11 47609656 47609656 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000356737 +1 known p.A115 0.081 69 0% 23 47.8% 0 - - - - NULL FNBP4 23360 genome.wustl.edu 37 11 47754204 47754204 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015308.2 -1 validated p.R569W 1.000 391 0.8% 560 43.2% 11 45.4% probably_damaging(1) deleterious(0) deleterious(0.945) NULL OR5M1 390168 genome.wustl.edu 37 11 56380654 56380654 + Missense_Mutation SNP T T A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001004740.1 -1 provisional p.I109F 0.005 201 0% 156 37.2% 0 - probably_damaging(0.976) tolerated(0.29) neutral(0.447) HMMPfam_7tm_1,superfamily_SSF81321 ZDHHC5 25921 genome.wustl.edu 37 11 57466283 57466283 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015457.2 +1 validated p.L459M 1.000 66 0% 40 10% 81 2.4% possibly_damaging(0.885) deleterious(0.01) deleterious(0.752) NULL OR9Q2 219957 genome.wustl.edu 37 11 57958228 57958228 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001005283.2 +1 validated p.G89D 0.004 107 0% 68 11.8% 0 - probably_damaging(1) tolerated(0.83) deleterious(0.500) HMMPfam_7tm_1,superfamily_SSF81321 OR1S1 219959 genome.wustl.edu 37 11 57982864 57982864 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001004458.1 +1 validated p.G216 0.000 275 0% 259 13.1% 0 - - - - HMMPfam_7tm_1,superfamily_SSF81321 FAM111B 374393 genome.wustl.edu 37 11 58893036 58893036 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198947.3 +1 validated p.R489Q 0.001 39 0% 31 48.4% 22 50% probably_damaging(0.994) tolerated(0.21) deleterious(0.496) superfamily_Trypsin-like serine proteases CD5 921 genome.wustl.edu 37 11 60889355 60889355 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014207.3 +1 validated p.C360R 0.998 60 0% 30 33.3% 1 0% probably_damaging(1) deleterious(0.02) deleterious(0.883) HMMPfam_SRCR,HMMSmart_SM00202,superfamily_SRCR-like VWCE 220001 genome.wustl.edu 37 11 61053874 61053874 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152718.2 -1 validated p.C151 0.860 40 0% 33 30.3% 1 100% - - - HMMSmart_SM00179,HMMSmart_SM00181,HMMPfam_EGF_CA,PatternScan_EGF_CA,superfamily_EGF/Laminin PPP1R32 220004 genome.wustl.edu 37 11 61252164 61252164 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145017.2 +1 validated p.R129Q 1.000 31 0% 23 30.4% 1 0% probably_damaging(0.985) tolerated(0.12) deleterious(0.693) NULL SCGB1D4 404552 genome.wustl.edu 37 11 62064965 62064965 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_206998.1 -1 provisional p.R74Q 0.003 146 0% 229 34.1% 0 - unknown(0) tolerated(0.07) - superfamily_Uteroglobin-like LOC100287678 100287678 genome.wustl.edu 37 11 62563574 62563574 + Missense_Mutation SNP G G A rs191034414 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002343090.1 +1 model p.V69I 0.836 193 0% 141 40.4% 111 43.2% - - - NULL SLC22A8 9376 genome.wustl.edu 37 11 62760810 62760810 + Splice_Site SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004254.3 -1 reviewed e10-2 0.925 127 0% 75 18.7% 0 - - - - - NRXN2 9379 genome.wustl.edu 37 11 64390267 64390267 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015080.2 -1 reviewed p.T1377 0.231 59 0% 30 33.3% 2 50% - - - NULL MEN1 4221 genome.wustl.edu 37 11 64572650 64572650 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000417021 -1 known p.P401L 0.992 63 0% 35 34.3% 24 37.5% - - - HMMPfam_Menin MEN1 4221 genome.wustl.edu 37 11 64575419 64575419 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000244.3 -1 reviewed p.G205S 1.000 53 0% 42 11.9% 13 30.7% probably_damaging(0.996) deleterious(0.01) deleterious(0.867) HMMPfam_Menin MRPL49 740 genome.wustl.edu 37 11 64893016 64893016 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004927.2 +1 reviewed p.V96I 1.000 194 1% 155 43.9% 16 43.7% probably_damaging(0.991) tolerated(0.06) deleterious(0.766) HMMPfam_Img2 PCNXL3 399909 genome.wustl.edu 37 11 65385142 65385142 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032223.2 +1 validated p.R181Q 0.991 106 0.9% 62 38.7% 6 50% possibly_damaging(0.907) tolerated(0.3) neutral(0.389) NULL FOSL1 8061 genome.wustl.edu 37 11 65660407 65660407 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005438.3 -1 reviewed p.G256R 1.000 99 0% 37 43.2% 11 27.2% unknown(0) deleterious(0.01) - NULL SART1 9092 genome.wustl.edu 37 11 65733558 65733558 + Missense_Mutation SNP G G C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005146.4 +1 reviewed p.E284Q 1.000 176 0% 92 25% 39 28.2% possibly_damaging(0.915) deleterious(0.01) deleterious(0.772) HMMPfam_SART-1 CD248 57124 genome.wustl.edu 37 11 66082378 66082378 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020404.2 -1 validated p.I707 0.803 43 0% 34 52.9% 14 0% - - - NULL RBM14 10432 genome.wustl.edu 37 11 66392817 66392817 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006328.3 +1 validated p.S490 0.991 27 0% 10 60% 31 38.7% - - - NULL SPTBN2 6712 genome.wustl.edu 37 11 66457571 66457571 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006946.2 -1 reviewed p.R1917W 1.000 160 0% 82 36.6% 11 27.2% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Spectrin,HMMSmart_SM00150,superfamily_Spectrin repeat ANKRD13D 338692 genome.wustl.edu 37 11 67067470 67067470 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_207354.2 +1 validated p.V230M 0.996 65 0% 37 40.5% 57 33.3% benign(0.151) tolerated(0.28) neutral(0.045) NULL GPR152 390212 genome.wustl.edu 37 11 67219785 67219785 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_206997.1 -1 validated p.H137 0.000 17 0.000 6 0.667 0 - - - - HMMPfam_7tm_1,superfamily_SSF81321 CABP2 51475 genome.wustl.edu 37 11 67287376 67287376 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016366.2 -1 reviewed p.G175 0.002 32 0% 22 50% 0 - - - - HMMSmart_SM00054,PatternScan_EF_HAND_1,HMMPfam_efhand,superfamily_EF-hand TBX10 347853 genome.wustl.edu 37 11 67400523 67400523 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005995.3 -1 provisional p.V201M 1.000 200 0% 160 45.6% 0 - probably_damaging(0.953) tolerated(0.06) deleterious(0.719) HMMPfam_T-box,HMMSmart_TBOX,superfamily_P53_like_DNA_bnd ALDH3B2 222 genome.wustl.edu 37 11 67432918 67432918 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000695.3 -1 reviewed p.A182T 0.998 90 0% 39 35.9% 9 33.3% possibly_damaging(0.864) tolerated(0.19) neutral(0.384) HMMPfam_Aldedh,superfamily_ALDH-like MRGPRD 116512 genome.wustl.edu 37 11 68748320 68748320 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198923.2 -1 validated p.S46G 0.014 64 0% 33 42.4% 0 - benign(0.003) tolerated(0.4) neutral(0.016) HMMPfam_7tm_1,superfamily_SSF81321 ANO1 55107 genome.wustl.edu 37 11 70007354 70007354 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018043.5 +1 validated p.V556M 0.601 116 0% 65 43.1% 145 42% benign(0.107) tolerated(0.1) neutral(0.295) NULL SHANK2 22941 genome.wustl.edu 37 11 70319250 70319250 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012309.3 -1 reviewed p.A1163 0.457 197 0% 103 39.8% 6 50% - - - NULL NUMA1 4926 genome.wustl.edu 37 11 71718270 71718270 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006185.2 -1 validated p.R1810C 1.000 38 0% 18 50% 217 40% probably_damaging(1) deleterious(0) deleterious(0.945) NULL C11orf51 25906 genome.wustl.edu 37 11 71822259 71822259 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014042.2 -1 validated p.R22* 1.000 120 0% 76 31.6% 44 20.4% - - - NULL INPPL1 3636 genome.wustl.edu 37 11 71948267 71948267 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001567.3 +1 reviewed p.P993 0.548 36 0% 28 57.1% 101 59.4% - - - NULL INPPL1 3636 genome.wustl.edu 37 11 71949110 71949110 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001567.3 +1 reviewed p.A1193T 0.987 52 0% 23 30.4% 91 26.3% benign(0.008) tolerated(0.51) neutral(0.009) HMMSmart_SAM,superfamily_SAM_homology ATG16L2 89849 genome.wustl.edu 37 11 72537220 72537220 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033388.1 +1 validated p.R369C 1.000 41 0% 24 45.8% 23 47.8% possibly_damaging(0.939) deleterious(0.01) deleterious(0.790) HMMSmart_SM00320,superfamily_WD40 repeat-like FCHSD2 9873 genome.wustl.edu 37 11 72549849 72549849 + Missense_Mutation SNP A A T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014824.2 -1 validated p.I737N 1.000 100 0% 86 43% 15 60% possibly_damaging(0.92) deleterious(0) deleterious(0.816) NULL PGM2L1 283209 genome.wustl.edu 37 11 74058231 74058231 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_173582.3 -1 validated p.V301I 1.000 94 0% 230 33.9% 7 28.5% probably_damaging(0.976) tolerated(0.07) deleterious(0.737) HMMPfam_PGM_PMM_II,superfamily_Phosphoglucomutase first 3 domains LRRC32 2615 genome.wustl.edu 37 11 76370731 76370731 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001128922.1 -1 reviewed p.L636 0.301 148 0% 106 37.7% 3 0% - - - NULL MYO7A 4647 genome.wustl.edu 37 11 76893595 76893595 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000260.3 +1 reviewed p.G1079S 1.000 48 0% 41 31.7% 0 - probably_damaging(0.959) deleterious(0.05) deleterious(0.748) HMMSmart_SM00139 MYO7A 4647 genome.wustl.edu 37 11 76901163 76901163 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000260.3 +1 reviewed p.P1243 0.000 39 0% 12 50% 0 - - - - HMMPfam_MyTH4,HMMSmart_SM00139 GAB2 9846 genome.wustl.edu 37 11 77936200 77936200 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080491.2 -1 reviewed p.A419V 0.690 134 0% 105 38.1% 4 25% benign(0.052) tolerated(0.13) neutral(0.256) NULL FAT3 120114 genome.wustl.edu 37 11 92523334 92523334 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001008781.2 +1 validated p.A1521T 0.906 68 0% 52 42.3% 0 - benign(0.047) tolerated(0.99) neutral(0.003) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Concanavalin A-like lectins/glucanases,superfamily_Cadherin-like SESN3 143686 genome.wustl.edu 37 11 94918577 94918577 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_144665.2 -1 provisional p.A202V 1.000 76 0% 92 33.7% 5 20% probably_damaging(0.991) deleterious(0.01) deleterious(0.850) HMMPfam_PA26 MAML2 84441 genome.wustl.edu 37 11 95712721 95712721 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032427.1 -1 validated p.N954 0.024 464 0% 505 39.8% 10 60% - - - NULL ARHGAP42 143872 genome.wustl.edu 37 11 100730331 100730331 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152432.2 +1 provisional p.R120Q 1.000 140 0% 319 43.3% 3 33.3% probably_damaging(1) deleterious(0) deleterious(0.945) NULL PGR 5241 genome.wustl.edu 37 11 100909953 100909954 + Frame_Shift_Ins INS - - G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000926.4 -1 reviewed p.R899fs 1.000:1.000 - - - - - - - - - HMMPfam_Hormone_recep,superfamily_Nuclear receptor ligand-binding domain MMP13 4322 genome.wustl.edu 37 11 102816439 102816439 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002427.3 -1 reviewed p.P417 0.184 204 0% 492 42.5% 0 - - - - superfamily_Hemopexin,HMMPfam_Hemopexin,HMMSmart_HX DYNC2H1 79659 genome.wustl.edu 37 11 103058206 103058206 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080463.1 +1 reviewed p.R2344H 1.000 120 0% 142 41.5% 0 - probably_damaging(0.996) deleterious(0.01) deleterious(0.867) HMMSmart_SM00382,superfamily_P-loop containing nucleoside triphosphate hydrolases DDI1 414301 genome.wustl.edu 37 11 103907980 103907980 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001001711.2 +1 validated p.A144T 0.075 47 0% 13 30.8% 0 - possibly_damaging(0.946) tolerated(0.32) neutral(0.414) NULL SIK2 23235 genome.wustl.edu 37 11 111575824 111575824 + Missense_Mutation SNP G G C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015191.1 +1 validated p.Q354H 1.000 136 0% 126 31% 4 50% probably_damaging(0.998) deleterious(0.01) deleterious(0.880) superfamily_Protein kinase-like (PK-like) DRD2 1813 genome.wustl.edu 37 11 113295287 113295287 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000795.3 -1 reviewed p.A29 0.007 135 0% 102 46.1% 0 - - - - superfamily_Family A G protein-coupled receptor-like ZBTB16 7704 genome.wustl.edu 37 11 114117961 114117961 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001018011.1 +1 reviewed p.R556W 1.000 57 0% 33 42.4% 0 - probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers FAM55A 120400 genome.wustl.edu 37 11 114401367 114401367 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000424269 -1 known p.L121 0.754 407 0% 368 29.6% 0 - - - - superfamily_E set domains SIK3 23387 genome.wustl.edu 37 11 116717125 116717125 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_025164.3 -1 validated p.Q1260R 1.000 151 0% 104 42.3% 34 29.4% probably_damaging(0.996) deleterious(0) deleterious(0.906) NULL MLL 4297 genome.wustl.edu 37 11 118350938 118350938 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005933.2 +1 validated p.Q1207* 1.000 190 0.5% 384 39.3% 2 50% - - - NULL HYOU1 10525 genome.wustl.edu 37 11 118918968 118918968 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001130991.1 -1 reviewed p.T790A 1.000 80 0% 43 11.6% 81 6.1% benign(0.008) tolerated(0.69) neutral(0.002) superfamily_Heat shock protein 70kD (HSP70) C-terminal subdomain VPS11 55823 genome.wustl.edu 37 11 118951995 118951995 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000300793 +1 known p.R877* 1.000 92 0% 70 11.4% 68 7.3% - - - NULL ENSG00000245385 0 genome.wustl.edu 37 11 119205772 119205772 + RNA SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000501918 -1 known NULL 0.003 112 0% 82 42.7% 9 44.4% - - - - USP2 9099 genome.wustl.edu 37 11 119228771 119228771 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004205.4 -1 validated p.R448* 1.000 149 0% 134 41% 3 0% - - - HMMPfam_UCH,superfamily_Cysteine proteinases ARHGEF12 23365 genome.wustl.edu 37 11 120352127 120352127 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015313.1 +1 reviewed p.A1466T 0.820 154 0% 103 35% 25 40% benign(0.167) tolerated(0.09) neutral(0.311) NULL SORL1 6653 genome.wustl.edu 37 11 121491775 121491775 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003105.4 +1 reviewed p.L1964 0.048 135 0% 152 32.2% 33 39.3% - - - HMMPfam_fn3,HMMSmart_SM00060,superfamily_Fibronectin type III ZNF202 7753 genome.wustl.edu 37 11 123601309 123601309 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003455.2 -1 validated p.T96 0.138 156 0% 86 39.5% 3 0% - - - HMMPfam_SCAN,HMMSmart_SM00431 ZNF202 7753 genome.wustl.edu 37 11 123601477 123601477 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003455.2 -1 validated p.P40 0.998 124 0% 71 42.3% 2 50% - - - HMMPfam_SCAN OR8B8 26493 genome.wustl.edu 37 11 124310427 124310427 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012378.1 -1 provisional p.L185 0.000 124 0.8% 92 38% 0 - - - - HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like OR8A1 390275 genome.wustl.edu 37 11 124440111 124440111 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001005194.1 +1 provisional p.L49 0.001 175 0% 148 40.5% 0 - - - - superfamily_SSF81321 PKNOX2 63876 genome.wustl.edu 37 11 125255525 125255525 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022062.2 +1 validated p.S102 0.542 170 0% 121 37.2% 4 50% - - - NULL ARHGAP32 9743 genome.wustl.edu 37 11 128855932 128855932 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001142685.1 -1 validated p.D484N 1.000 193 0% 166 44.6% 3 33.3% possibly_damaging(0.768) deleterious(0.02) deleterious(0.668) HMMPfam_RhoGAP,HMMSmart_SM00324,superfamily_GTPase activation domain GAP APLP2 334 genome.wustl.edu 37 11 129993532 129993532 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001642.2 +1 validated p.T316 1.000 108 0% 73 37% 84 25% - - - HMMPfam_Kunitz_BPTI,HMMSmart_SM00131,superfamily_BPTI-like ST14 6768 genome.wustl.edu 37 11 130066582 130066582 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021978.3 +1 reviewed p.Y447 0.737 119 0% 80 41.2% 215 45.5% - - - HMMSmart_CUB,superfamily_CUB,superfamily_LDL_rcpt_classA_cys-rich SNX19 399979 genome.wustl.edu 37 11 130784395 130784395 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014758.2 -1 validated p.P480 0.042 167 0% 124 44.4% 9 44.4% - - - NULL IQSEC3 440073 genome.wustl.edu 37 12 266295 266295 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015232.1 +1 validated p.R450Q 1.000 53 0% 30 26.7% 0 - unknown(0) deleterious(0) - HMMPfam_Sec7,HMMSmart_Sec7,superfamily_Sec7 WNK1 65125 genome.wustl.edu 37 12 995171 995171 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018979.3 +1 reviewed p.V1734A 0.000 144 0% 123 13.8% 26 0% unknown(0) tolerated(0.47) - NULL ERC1 23085 genome.wustl.edu 37 12 1137086 1137086 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178040.2 +1 reviewed p.R6H 1.000 50 0% 35 34.3% 5 40% unknown(0) deleterious(0) - NULL ADIPOR2 79602 genome.wustl.edu 37 12 1863600 1863600 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024551.2 +1 validated p.R31* 0.004 104 0% 126 42.9% 7 57.1% - - - NULL TEAD4 7004 genome.wustl.edu 37 12 3129822 3129822 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003213.2 +1 reviewed p.P202 0.000 43 0% 26 26.9% 18 38.8% - - - HMMPfam_TEA C12orf4 57102 genome.wustl.edu 37 12 4609418 4609418 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020374.2 -1 predicted p.N442 1.000 114 0% 104 34.6% 18 72.2% - - - HMMPfam_DUF2362 AKAP3 10566 genome.wustl.edu 37 12 4736731 4736731 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006422.2 -1 reviewed p.A446V 0.001 168 0% 184 38.6% 0 - benign(0.003) tolerated(0.09) neutral(0.296) HMMPfam_AKAP_110,HMMSmart_SM00807 KCNA6 3742 genome.wustl.edu 37 12 4920613 4920613 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002235.3 +1 reviewed p.T469M 1.000 174 0% 107 41.1% 0 - possibly_damaging(0.866) deleterious(0.04) deleterious(0.684) superfamily_SSF81324 VWF 7450 genome.wustl.edu 37 12 6122773 6122773 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000552.3 -1 reviewed p.D1832N 0.950 103 0% 104 45.2% 33 6% benign(0.095) tolerated(0.05) neutral(0.352) HMMPfam_VWA,HMMSmart_SM00327,superfamily_vWA-like SCNN1A 6337 genome.wustl.edu 37 12 6458129 6458129 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001038.5 -1 reviewed p.V514I 0.873 199 1% 119 31.9% 86 33.7% benign(0) tolerated(1) - HMMPfam_ASC GAPDH 2597 genome.wustl.edu 37 12 6647106 6647106 + Silent SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002046.3 +1 reviewed p.T294 1.000 68 0% 52 19.2% 8037 22.6% - - - HMMPfam_Gp_dh_C,superfamily_Glyceraldehyde-3-phosphate dehydrogenase-like C-terminal domain LEPREL2 10536 genome.wustl.edu 37 12 6939163 6939163 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014262.3 +1 validated p.R213H 0.003 65 0% 26 34.6% 0 - - - - NULL FOXJ2 55810 genome.wustl.edu 37 12 8201982 8201982 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018416.2 +1 validated p.A451V 1.000 57 0% 40 37.5% 7 42.8% possibly_damaging(0.915) deleterious(0) deleterious(0.811) NULL CLEC1A 51267 genome.wustl.edu 37 12 10226001 10226001 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016511.2 -1 reviewed p.A185T 1.000 64 0% 72 41.7% 1 0% benign(0.001) tolerated(0.58) neutral(0.005) HMMPfam_Lectin_C,HMMSmart_CLECT,superfamily_C-type_lectin_fold DUSP16 80824 genome.wustl.edu 37 12 12629997 12629997 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_030640.2 -1 reviewed p.C590R 0.235 97 0% 48 12.5% 11 0% possibly_damaging(0.465) tolerated(0.06) deleterious(0.476) NULL DDX47 51202 genome.wustl.edu 37 12 12980280 12980280 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016355.3 +1 reviewed p.V403I 1.000 156 0% 149 40.9% 77 40.2% possibly_damaging(0.865) tolerated(0.07) deleterious(0.654) superfamily_P-loop containing nucleoside triphosphate hydrolases KIAA1467 57613 genome.wustl.edu 37 12 13224245 13224245 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020853.1 +1 validated p.T480M 0.002 141 0% 83 33.7% 5 20% benign(0.046) tolerated(0.1) neutral(0.289) NULL PTPRO 5800 genome.wustl.edu 37 12 15677851 15677851 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_030667.1 +1 reviewed p.M665I 1.000 119 0% 128 37.5% 0 - benign(0.104) tolerated(0.17) neutral(0.067) HMMSmart_SM00060,superfamily_Fibronectin type III PDE3A 5139 genome.wustl.edu 37 12 20833173 20833173 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000921.3 +1 validated p.E1132K 1.000 72 0% 72 34.7% 6 66.6% benign(0.043) deleterious(0) neutral(0.447) NULL CCDC91 55297 genome.wustl.edu 37 12 28702092 28702092 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018318.3 +1 validated p.V438I 0.029 65 0% 112 27.7% 12 58.3% possibly_damaging(0.465) tolerated(0.66) neutral(0.155) NULL FGD4 121512 genome.wustl.edu 37 12 32777596 32777596 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000381025 +1 known p.R268* 0.002 17 0% 14 42.9% 0 - - - - HMMSmart_PH PKP2 5318 genome.wustl.edu 37 12 32949098 32949098 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004572.3 -1 reviewed p.D812N 0.990 226 0.4% 180 37.2% 21 33.3% possibly_damaging(0.801) tolerated(0.66) neutral(0.304) HMMSmart_SM00185,superfamily_ARM repeat KIF21A 55605 genome.wustl.edu 37 12 39703541 39703541 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017641.3 -1 validated p.V1362A 1.000 107 0% 155 40% 4 75% probably_damaging(1) tolerated(0.43) deleterious(0.513) superfamily_WD40 repeat-like NELL2 4753 genome.wustl.edu 37 12 44915950 44915950 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001145107.1 -1 reviewed p.V720I 1.000 94 0% 100 39% 0 - benign(0.254) tolerated(0.62) neutral(0.030) HMMPfam_VWC,HMMSmart_VWC,PatternScan_EGF_2 FAM113B 91523 genome.wustl.edu 37 12 47630009 47630009 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138371.1 +1 predicted p.R388H 0.000 151 0% 97 22.7% 4 0% probably_damaging(0.985) tolerated(0.56) neutral(0.439) NULL VDR 7421 genome.wustl.edu 37 12 48240127 48240127 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000376.2 -1 reviewed p.V339I 0.994 30 0% 12 50% 1 100% benign(0.017) deleterious(0.02) neutral(0.384) HMMPfam_Hormone_recep,HMMSmart_SM00430,superfamily_Nuclear receptor ligand-binding domain TMEM106C 79022 genome.wustl.edu 37 12 48361002 48361002 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001143842.1 +1 validated p.T205M 0.993 151 0% 137 43.8% 129 44.9% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_DUF1356 PFKM 5213 genome.wustl.edu 37 12 48526828 48526828 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000289.5 +1 reviewed p.L139I 1.000 62 0% 52 38.5% 3 0% probably_damaging(0.978) deleterious(0) deleterious(0.865) HMMPfam_PFK,superfamily_Phosphofructokinase ASB8 140461 genome.wustl.edu 37 12 48543244 48543244 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024095.3 -1 validated p.V258M 1.000 85 0% 43 44.2% 22 45.4% probably_damaging(0.99) deleterious(0) deleterious(0.886) HMMPfam_SOCS_box ASB8 140461 genome.wustl.edu 37 12 48543596 48543596 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024095.3 -1 validated p.S140 0.507 79 0% 45 51.1% 12 33.3% - - - HMMPfam_Ank,HMMSmart_ANK,superfamily_ANK ADCY6 112 genome.wustl.edu 37 12 49168816 49168816 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015270.3 -1 reviewed p.R668C 1.000 118 0% 63 44.4% 24 58.3% probably_damaging(0.998) deleterious(0.03) deleterious(0.839) HMMPfam_DUF1053 ADCY6 112 genome.wustl.edu 37 12 49177198 49177198 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015270.3 -1 reviewed p.L7P 1.000 46 0% 28 21.4% 4 0% possibly_damaging(0.496) deleterious(0.01) deleterious(0.571) NULL FMNL3 91010 genome.wustl.edu 37 12 50042123 50042123 + Silent SNP G G A rs190548710 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_175736.4 -1 validated p.N843 0.964 81 0% 46 41.3% 3 33.3% - - - HMMSmart_FH2,HMMPfam_FH2,superfamily_FH2_actin_bd SMARCD1 6602 genome.wustl.edu 37 12 50484057 50484057 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003076.4 +1 reviewed p.R303* 1.000 130 0% 104 29.8% 23 13% - - - HMMPfam_SWIB,superfamily_SWIB/MDM2 domain,HMMSmart_SM00151 KRT85 3891 genome.wustl.edu 37 12 52760899 52760899 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002283.3 -1 reviewed p.T97 0.009 168 0% 96 44.8% 0 - - - - NULL KRT6B 3854 genome.wustl.edu 37 12 52845391 52845391 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005555.3 -1 reviewed p.R158W 0.423 383 0% 311 25.1% 3 0% possibly_damaging(0.494) deleterious(0.03) deleterious(0.529) NULL KRT6B 3854 genome.wustl.edu 37 12 52845620 52845620 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005555.3 -1 reviewed p.G81 0.000 229 0% 131 19.1% 3 0% - - - NULL KRT8 3856 genome.wustl.edu 37 12 53293667 53293667 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002273.3 -1 reviewed p.S291 0.000 51 0% 27 33.3% 1727 42.6% - - - superfamily_Prefoldin,HMMPfam_Filament SOAT2 8435 genome.wustl.edu 37 12 53515135 53515135 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003578.3 +1 reviewed p.V396M 1.000 144 0% 82 47.6% 0 - possibly_damaging(0.862) tolerated(0.06) deleterious(0.655) HMMPfam_MBOAT PPP1R1A 5502 genome.wustl.edu 37 12 54975889 54975889 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006741.3 -1 validated p.L92M 1.000 139 0% 73 30.1% 35 42.8% probably_damaging(0.998) deleterious(0.04) deleterious(0.823) HMMPfam_DARPP-32 ERBB3 2065 genome.wustl.edu 37 12 56487277 56487277 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001982.2 +1 reviewed p.R475W 1.000 114 0% 96 38.5% 14 42.8% probably_damaging(0.999) deleterious(0.02) deleterious(0.873) superfamily_L domain-like SMARCC2 6601 genome.wustl.edu 37 12 56558157 56558157 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003075.3 -1 reviewed p.A1166 1.000 49 0% 34 47.1% 37 29.7% - - - NULL ANKRD52 283373 genome.wustl.edu 37 12 56641949 56641949 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_173595.3 -1 validated p.D612 0.938 53 0% 32 31.2% 1 100% - - - HMMPfam_Ank,HMMSmart_ANK,superfamily_ANK ZBTB39 9880 genome.wustl.edu 37 12 57397300 57397300 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014830.1 -1 provisional p.R468W 1.000 45 0% 28 32.1% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers STAT6 6778 genome.wustl.edu 37 12 57502012 57502012 + Missense_Mutation SNP C C T rs188884452 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003153.4 -1 reviewed p.R17Q 1.000 72 0% 38 47.4% 20 50% probably_damaging(0.976) tolerated(0.19) neutral(0.467) HMMPfam_STAT_int,superfamily_Transcription factor STAT-4 N-domain SHMT2 6472 genome.wustl.edu 37 12 57627675 57627675 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005412.5 +1 reviewed p.G423S 1.000 112 0% 59 40.7% 121 47.9% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_SHMT,superfamily_PyrdxlP-dep_Trfase_major ARHGAP9 64333 genome.wustl.edu 37 12 57870700 57870700 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032496.2 -1 reviewed p.A306V 0.021 114 0% 63 19% 2 0% benign(0.4) tolerated(0.19) neutral(0.178) NULL MBD6 114785 genome.wustl.edu 37 12 57920359 57920359 + Silent SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_052897.3 +1 validated p.A477 1.000 26 0% 12 33.3% 35 62.8% - - - NULL ENSG00000247039 0 genome.wustl.edu 37 12 58014923 58014923 + RNA SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000501036 -1 known NULL 0.000 33 0% 11 36.4% 0 - - - - - MON2 23041 genome.wustl.edu 37 12 62929491 62929491 + Splice_Site SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015026.2 +1 validated e14+2 1.000 99 0% 140 30% 0 - - - - - SRGAP1 57522 genome.wustl.edu 37 12 64536136 64536136 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020762.2 +1 validated p.T981I 1.000 71 0% 52 15.4% 4 0% benign(0.011) deleterious(0.04) neutral(0.349) NULL GNS 2799 genome.wustl.edu 37 12 65136988 65136988 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002076.3 -1 reviewed p.P242H 1.000 130 0% 115 27.8% 36 25% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_Sulfatase,superfamily_Alkaline_phosphatase_core PTPRB 5787 genome.wustl.edu 37 12 70983761 70983761 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001109754.1 -1 reviewed p.R678H 1.000 77 0% 49 44.9% 0 - benign(0.321) tolerated(0.45) neutral(0.113) superfamily_Fibronectin type III OTOGL 283310 genome.wustl.edu 37 12 80760409 80760409 + Missense_Mutation SNP A A T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002343203.1 +1 model p.Y2005F 1.000 123 0% 312 45.5% 0 - possibly_damaging(0.945) tolerated(0.61) neutral(0.394) NULL SLC6A15 55117 genome.wustl.edu 37 12 85267023 85267023 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_182767.4 -1 validated p.I318V 1.000 156 0% 118 39.8% 0 - possibly_damaging(0.796) deleterious(0) deleterious(0.744) HMMPfam_SNF RASSF9 9182 genome.wustl.edu 37 12 86198960 86198960 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005447.3 -1 reviewed p.Y276 0.958 136 0% 183 16.4% 13 7.6% - - - NULL DCN 1634 genome.wustl.edu 37 12 91546957 91546957 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001920.3 -1 reviewed p.P221H 0.876 204 0% 277 32.5% 36 0% possibly_damaging(0.893) tolerated(0.1) deleterious(0.638) HMMSmart_SM00369,HMMSmart_SM00364,superfamily_L domain-like TMCC3 57458 genome.wustl.edu 37 12 94972270 94972270 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020698.2 -1 validated p.T344M 1.000 84 0% 55 45.5% 2 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Tmemb_cc2 ENSG00000227825 0 genome.wustl.edu 37 12 98849258 98849258 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000370696 -1 known p.R214* 0.530 98 0% 99 39.4% 0 - - - - NULL NT5DC3 51559 genome.wustl.edu 37 12 104171772 104171772 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000447799 -1 known p.R68H 0.001 132 0% 74 36.5% 1 100% - - - HMMPfam_5_nucleotid APPL2 55198 genome.wustl.edu 37 12 105600920 105600920 + Missense_Mutation SNP C C G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018171.3 -1 validated p.Q180H 1.000 60 0% 32 43.8% 15 53.3% probably_damaging(0.996) tolerated(0.76) neutral(0.463) NULL POLR3B 55703 genome.wustl.edu 37 12 106897896 106897896 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018082.5 +1 validated p.R1046C 1.000 309 0.3% 337 45.4% 23 47.8% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_RNA_pol_Rpb2_7,superfamily_beta and beta-prime subunits of DNA dependent RNA-polymerase SART3 9733 genome.wustl.edu 37 12 108920247 108920247 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014706.3 -1 reviewed p.A667T 0.000 102 0% 68 44.1% 12 50% unknown(0) - - NULL SVOP 55530 genome.wustl.edu 37 12 109354798 109354798 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000299134 -1 known p.T95I 1.000 45 0% 40 60% 0 - benign(0.013) tolerated(0.59) neutral(0.005) HMMPfam_MFS_1,superfamily_MFS general substrate transporter ALKBH2 121642 genome.wustl.edu 37 12 109527945 109527945 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001001655.2 -1 validated p.G116 0.476 95 0% 68 32.4% 35 31.4% - - - NULL TRPV4 59341 genome.wustl.edu 37 12 110232161 110232161 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021625.4 -1 reviewed p.T488 0.353 92 0% 45 55.6% 20 25% - - - NULL C12orf76 400073 genome.wustl.edu 37 12 110480187 110480187 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_207435.1 -1 predicted p.A126V 1.000 73 0% 45 46.7% 5 20% unknown(0) - - NULL ALDH2 217 genome.wustl.edu 37 12 112227678 112227678 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000690.2 +1 reviewed p.D164 0.966 121 0% 138 40.6% 111 36.9% - - - HMMPfam_Aldedh,superfamily_Aldehyde_DH/Histidinol_DH ERP29 10961 genome.wustl.edu 37 12 112457613 112457613 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006817.3 +1 reviewed p.Y66 0.982 120 0% 111 33.3% 205 20% - - - superfamily_Thiordxn-like_fd,HMMPfam_ERp29_N C12orf51 283450 genome.wustl.edu 37 12 112630871 112630871 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001109662.2 -1 validated p.R2605H 1.000 66 0% 107 37.4% 9 55.5% probably_damaging(1) - - NULL C12orf51 283450 genome.wustl.edu 37 12 112669480 112669480 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001109662.2 -1 validated p.A1591T 1.000 63 0% 38 10.5% 5 20% probably_damaging(0.98) - - NULL C12orf51 283450 genome.wustl.edu 37 12 112702994 112702994 + Silent SNP G G C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000311694 -1 known p.S331C 1.000 115 0% 269 40.9% 0 - - - - NULL DDX54 79039 genome.wustl.edu 37 12 113618785 113618785 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001111322.1 -1 reviewed p.V85M 1.000 102 0% 54 48.1% 10 60% - - - NULL CIT 11113 genome.wustl.edu 37 12 120171983 120171983 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007174.1 -1 validated p.T1070 0.067 152 0% 90 40% 4 0% - - - NULL CCDC64 92558 genome.wustl.edu 37 12 120530859 120530859 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_207311.2 +1 validated p.R539Q 0.999 49 0% 23 30.4% 11 63.6% benign(0) tolerated(0.53) neutral(0.007) NULL GCN1L1 10985 genome.wustl.edu 37 12 120568532 120568532 + Missense_Mutation SNP C C T rs145712872 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006836.1 -1 validated p.R2530Q 1.000 59 0% 44 29.5% 68 48.5% probably_damaging(0.991) deleterious(0.01) deleterious(0.850) superfamily_ARM repeat RPLP0 6175 genome.wustl.edu 37 12 120638562 120638562 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001002.3 -1 reviewed p.W9R 1.000 51 0% 25 36% 649 39.7% benign(0.319) tolerated(0.41) neutral(0.115) HMMPfam_Ribosomal_L10 DYNLL1 8655 genome.wustl.edu 37 12 120934294 120934294 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001037494.1 +1 reviewed p.C24R 1.000 51 0% 38 26.3% 1342 49.4% benign(0) tolerated(0.09) neutral(0.296) HMMPfam_Dynein_light,superfamily_DLC ORAI1 84876 genome.wustl.edu 37 12 122079406 122079406 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032790.3 +1 reviewed p.V255I 1.000 67 0% 20 45% 75 36% possibly_damaging(0.744) tolerated(1) neutral(0.273) HMMPfam_DUF1650 KNTC1 9735 genome.wustl.edu 37 12 123060104 123060104 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014708.4 +1 reviewed p.A799 0.864 152 0% 108 38% 5 20% - - - NULL HIP1R 9026 genome.wustl.edu 37 12 123340696 123340696 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003959.1 +1 validated p.R433H 0.248 51 0% 17 35.3% 32 43.7% possibly_damaging(0.771) tolerated(0.52) neutral(0.295) NULL ABCB9 23457 genome.wustl.edu 37 12 123444460 123444460 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019625.3 -1 reviewed p.R108H 1.000 26 0% 14 50% 5 80% probably_damaging(0.995) tolerated(0.05) deleterious(0.803) NULL OGFOD2 79676 genome.wustl.edu 37 12 123461261 123461261 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024623.1 +1 provisional p.L24I 0.998 62 0% 12 50% 13 61.5% benign(0.176) tolerated(0.31) neutral(0.043) NULL SNRNP35 11066 genome.wustl.edu 37 12 123950369 123950369 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_180699.2 +1 reviewed p.Y99 0.916 92 0% 67 35.8% 40 60% - - - HMMPfam_RRM_1,HMMSmart_RRM,superfamily_SSF54928 DHX37 57647 genome.wustl.edu 37 12 125449129 125449129 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032656.2 -1 reviewed p.A619V 1.000 62 0% 46 56.5% 9 22.2% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) HMMPfam_Helicase_C,HMMSmart_HELICc,superfamily_SSF52540 TMEM132C 92293 genome.wustl.edu 37 12 129154049 129154049 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001136103.2 +1 provisional p.V353M 0.990 86 1.2% 101 39.6% 4 50% probably_damaging(0.996) deleterious(0.01) deleterious(0.867) NULL EP400 57634 genome.wustl.edu 37 12 132490715 132490715 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015409.3 +1 validated p.S997 0.000 82 0% 55 25.5% 8 75% - - - superfamily_SSF52540 EP400 57634 genome.wustl.edu 37 12 132528834 132528834 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015409.3 +1 validated p.T2187M 1.000 27 0% 18 38.9% 14 50% unknown(0) - - NULL EP400 57634 genome.wustl.edu 37 12 132554090 132554090 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015409.3 +1 validated p.Y2974 0.980 51 0% 21 61.9% 25 44% - - - NULL GALNT9 50614 genome.wustl.edu 37 12 132839192 132839192 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000328957 -1 known p.A147T 0.082 63 0% 28 46.4% 0 - benign(0) tolerated(0.08) neutral(0.300) superfamily_Nucleotide-diphospho-sugar transferases POLE 5426 genome.wustl.edu 37 12 133233976 133233976 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006231.2 -1 validated p.A1140T 1.000 87 0% 38 44.7% 11 18.1% benign(0.002) tolerated(0.61) neutral(0.004) HMMPfam_DNA_pol_B,superfamily_SSF56672 ANKLE2 23141 genome.wustl.edu 37 12 133303854 133303854 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015114.1 -1 validated p.R931C 0.004 34 0% 12 50% 41 31.7% unknown(0) deleterious(0) - NULL IFT88 8100 genome.wustl.edu 37 13 21215490 21215490 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_175605.3 +1 reviewed p.H554 0.010 154 0% 122 71.3% 5 100% - - - HMMPfam_TPR_1,HMMSmart_SM00028,superfamily_TPR-like MTUS2 23281 genome.wustl.edu 37 13 29600832 29600832 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001033602.2 +1 validated p.G676V 0.969 68 0% 32 18.8% 0 - probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL SLC7A1 6541 genome.wustl.edu 37 13 30091888 30091888 + Silent SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003045.4 -1 validated p.A444 1.000 203 0% 131 11.5% 3 33.3% - - - NULL HMGB1 3146 genome.wustl.edu 37 13 31037463 31037463 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002128.4 -1 validated p.K59 1.000 181 0% 192 16.1% 335 9.2% - - - HMMPfam_HMG_box,HMMSmart_SM00398,superfamily_HMG-box AKAP11 11215 genome.wustl.edu 37 13 42876607 42876607 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016248.2 +1 reviewed p.S1242L 0.031 60 0% 42 54.8% 2 100% benign(0.005) tolerated(0.83) neutral(0.001) NULL CPB2 1361 genome.wustl.edu 37 13 46656596 46656596 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001872.3 -1 reviewed p.Q122* 0.675 185 0% 129 63.6% 0 - - - - superfamily_Zn-dependent exopeptidases RB1 5925 genome.wustl.edu 37 13 48954198 48954198 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000321.2 +1 reviewed p.R467* 1.000 8 0.000 24 0.542 1 0% - - - HMMPfam_RB_A,superfamily_Cyclin-like LOC121981 121981 genome.wustl.edu 37 13 53394895 53394895 + RNA SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XR_017783.1 +1 model NULL 0.999 31 0% 14 64.3% 0 - - - - - PCDH17 27253 genome.wustl.edu 37 13 58207485 58207485 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001040429.2 +1 reviewed p.D269N 1.000 22 0.000 7 0.714 3 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like PCDH9 5101 genome.wustl.edu 37 13 67801808 67801808 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_203487.2 -1 reviewed p.G255 1.000 128 0% 65 56.9% 0 - - - - superfamily_Cadherin-like RBM26 64062 genome.wustl.edu 37 13 79943050 79943050 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022118.3 -1 validated p.S237L 0.999 172 0% 166 58.4% 6 66.6% benign(0.006) tolerated(0.06) neutral(0.323) NULL KDELC1 79070 genome.wustl.edu 37 13 103441381 103441381 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024089.2 -1 reviewed p.A425V 1.000 223 0% 146 70.5% 5 80% benign(0.168) deleterious(0.01) neutral(0.421) HMMSmart_CAP10,HMMPfam_DUF821 LIG4 3981 genome.wustl.edu 37 13 108862645 108862645 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001098268.1 -1 reviewed p.Q324 0.000 84 0% 66 19.7% 7 14.2% - - - HMMPfam_DNA_ligase_A_M,superfamily_SSF56091 ING1 3621 genome.wustl.edu 37 13 111371713 111371713 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005537.3 +1 reviewed p.V235M 1.000 36 0% 10 90% 47 95.7% possibly_damaging(0.871) deleterious(0) deleterious(0.783) NULL ADPRHL1 113622 genome.wustl.edu 37 13 114083298 114083298 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138430.3 -1 validated p.E205 0.949 50 0% 17 47.1% 1 100% - - - HMMPfam_ADP_ribosyl_GH,superfamily_ADP-ribosylglycohydrolase CDC16 8881 genome.wustl.edu 37 13 115037712 115037712 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001078645.1 +1 reviewed p.K553E 1.000 46 0% 58 12.1% 66 4.5% possibly_damaging(0.767) deleterious(0.04) deleterious(0.633) NULL OR4N2 390429 genome.wustl.edu 37 14 20296476 20296476 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001004723.1 +1 provisional p.R290H 0.519 65 0% 45 20% 0 - benign(0.233) deleterious(0.01) neutral(0.429) superfamily_SSF81321 CHD8 57680 genome.wustl.edu 37 14 21863239 21863239 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020920.3 -1 reviewed p.P1462L 1.000 70 0% 78 46.2% 24 54.1% benign(0.382) deleterious(0.03) deleterious(0.486) superfamily_P-loop containing nucleoside triphosphate hydrolases MMP14 4323 genome.wustl.edu 37 14 23313910 23313910 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004995.2 +1 reviewed p.R408* 0.997 169 0% 143 38.5% 112 4.4% - - - superfamily_Hemopexin-like domain,HMMPfam_Hemopexin,HMMSmart_SM00120 C14orf93 60686 genome.wustl.edu 37 14 23457182 23457182 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001130706.1 -1 validated p.R376H 1.000 126 0% 148 39.2% 22 68.1% probably_damaging(0.998) tolerated(0.07) deleterious(0.793) NULL MYH7 4625 genome.wustl.edu 37 14 23896866 23896866 + Missense_Mutation SNP C C T rs121913627 TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000257.2 -1 reviewed p.V606M 1.000 147 0% 82 41.5% 0 - probably_damaging(0.968) deleterious(0) deleterious(0.855) HMMPfam_Myosin_head,HMMSmart_SM00242,superfamily_P-loop containing nucleoside triphosphate hydrolases TGM1 7051 genome.wustl.edu 37 14 24724444 24724444 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000359.2 -1 reviewed p.R554Q 1.000 82 0% 32 50% 0 - probably_damaging(0.985) deleterious(0.01) deleterious(0.838) superfamily_SSF54001 RABGGTA 5875 genome.wustl.edu 37 14 24734963 24734963 + Missense_Mutation SNP T T G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004581.3 -1 validated p.Q521P 0.993 79 0% 47 38.3% 49 22.4% benign(0.001) tolerated(0.29) neutral(0.029) superfamily_SSF52058 NYNRIN 57523 genome.wustl.edu 37 14 24878570 24878570 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_025081.2 +1 validated p.V524M 0.000 47 0% 36 38.9% 1 0% benign(0) deleterious(0.02) neutral(0.383) NULL CTSG 1511 genome.wustl.edu 37 14 25042968 25042968 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001911.2 -1 reviewed p.V215I 0.992 99 0% 103 36.9% 0 - benign(0.084) deleterious(0.01) neutral(0.412) HMMPfam_Trypsin,HMMSmart_Tryp_SPc,superfamily_Pept_Ser_Cys PRKD1 5587 genome.wustl.edu 37 14 30135356 30135356 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002742.2 -1 validated p.Y154 0.810 137 0% 150 10.7% 1 0% - - - HMMPfam_C1_1,HMMSmart_C1,PatternScan_ZF_DAG_PE_1,superfamily_SSF57889 LRR1 122769 genome.wustl.edu 37 14 50074337 50074337 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152329.3 +1 reviewed p.R168* 0.991 93 0% 148 10.8% 5 0% - - - superfamily_L domain-like TRIM9 114088 genome.wustl.edu 37 14 51489583 51489583 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015163.5 -1 reviewed p.R337 0.009 171 0% 118 41.5% 2 100% - - - HMMSmart_SM00502 NID2 22795 genome.wustl.edu 37 14 52495455 52495455 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007361.3 -1 validated p.R839W 0.076 75 0% 88 38.6% 0 - probably_damaging(0.985) deleterious(0.02) deleterious(0.815) HMMSmart_SM00179,HMMSmart_SM00181,PatternScan_EGF_2,HMMPfam_EGF_CA,superfamily_EGF/Laminin DACT1 51339 genome.wustl.edu 37 14 59113157 59113157 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016651.5 +1 validated p.R606W 0.265 30 0% 22 27.3% 1 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL DACT1 51339 genome.wustl.edu 37 14 59113772 59113772 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016651.5 +1 validated p.K811E 1.000 148 0% 163 31.3% 1 0% probably_damaging(0.991) deleterious(0.01) deleterious(0.850) NULL JKAMP 51528 genome.wustl.edu 37 14 59967913 59967913 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016475.3 +1 validated p.Y215 1.000 374 0% 622 38.6% 22 36.3% - - - HMMPfam_DUF766 PIGH 5283 genome.wustl.edu 37 14 68059436 68059436 + Splice_Site SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004569.3 -1 reviewed e3-1 1.000 136 0% 167 10.8% 2 50% - - - - PAPLN 89932 genome.wustl.edu 37 14 73732131 73732131 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_173462.3 +1 validated p.R1033Q 0.664 30 0% 16 31.2% 3 66.6% benign(0.272) tolerated(0.51) neutral(0.038) HMMSmart_IGc2,HMMPfam_I-set,superfamily_SSF48726 HEATR4 399671 genome.wustl.edu 37 14 73945407 73945407 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_203309.1 -1 provisional p.S948 0.000 132 0% 170 35.9% 0 - - - - NULL HEATR4 399671 genome.wustl.edu 37 14 73978785 73978785 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_203309.1 -1 provisional p.R448W 0.554 217 0% 147 43.5% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_ARM-type_fold C14orf43 91748 genome.wustl.edu 37 14 74203773 74203773 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001043318.1 -1 validated p.A559 0.000 93 0% 50 24% 6 0% - - - NULL LTBP2 4053 genome.wustl.edu 37 14 74995342 74995342 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000428.2 -1 reviewed p.R738C 1.000 36 0% 12 33.3% 1 100% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_TB module/8-cys domain KIAA0317 9870 genome.wustl.edu 37 14 75137544 75137544 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001039479.1 -1 validated p.W510L 1.000 116 0% 120 38.3% 8 75% possibly_damaging(0.812) deleterious(0.05) deleterious(0.651) HMMSmart_SM00119,superfamily_Hect E3 ligase catalytic domain YLPM1 56252 genome.wustl.edu 37 14 75265410 75265410 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019589.2 +1 validated p.R1137Q 0.000 89 0% 54 40.7% 12 41.6% benign(0.002) tolerated(0.39) neutral(0.016) NULL RPS6KL1 83694 genome.wustl.edu 37 14 75388007 75388007 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031464.3 -1 validated p.V80M 0.999 78 0% 41 36.6% 0 - probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_MIT,HMMSmart_MIT ANGEL1 23357 genome.wustl.edu 37 14 77274437 77274437 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015305.3 -1 validated p.L235P 1.000 88 0% 46 34.8% 2 50% benign(0.109) tolerated(0.23) neutral(0.050) NULL KIAA1737 85457 genome.wustl.edu 37 14 77580248 77580248 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033426.2 +1 validated p.A263T 0.504 79 0% 55 25.5% 10 60% possibly_damaging(0.786) tolerated(0.28) neutral(0.326) NULL POMT2 29954 genome.wustl.edu 37 14 77769269 77769269 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013382.5 -1 reviewed p.L189 0.985 105 0% 77 40.3% 9 55.5% - - - HMMPfam_PMT GSTZ1 2954 genome.wustl.edu 37 14 77794296 77794296 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145870.2 +1 reviewed p.P86 0.000 68 0% 48 18.8% 13 0% - - - superfamily_Thioredoxin-like GALC 2581 genome.wustl.edu 37 14 88450795 88450795 + Silent SNP G G A rs181066089 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000153.2 -1 reviewed p.V175 0.991 89 0% 80 41.2% 4 50% - - - HMMPfam_Glyco_hydro_59,superfamily_(Trans)glycosidases RPS6KA5 9252 genome.wustl.edu 37 14 91356876 91356876 + Silent SNP G G A rs139792854 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004755.2 -1 validated p.N597 0.000 93 0% 104 35.6% 3 33.3% - - - HMMSmart_S_TKc,superfamily_Kinase_like,HMMPfam_Pkinase CPSF2 53981 genome.wustl.edu 37 14 92625382 92625382 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017437.1 +1 validated p.A626V 1.000 187 0% 292 37% 19 57.8% benign(0.002) deleterious(0.01) neutral(0.406) NULL ASB2 51676 genome.wustl.edu 37 14 94417515 94417515 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016150.3 -1 reviewed p.R189H 0.995 91 0% 34 52.9% 0 - probably_damaging(1) tolerated(0.15) deleterious(0.741) HMMPfam_Ank,HMMSmart_SM00248,superfamily_Ankyrin repeat EVL 51466 genome.wustl.edu 37 14 100563838 100563838 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016337.2 +1 validated p.I67 1.000 123 0% 110 41.8% 34 44.1% - - - HMMPfam_WH1,HMMSmart_WH1,superfamily_SSF50729 DLK1 8788 genome.wustl.edu 37 14 101201221 101201221 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003836.5 +1 reviewed p.D380 0.000 49 0% 28 35.7% 0 - - - - NULL DYNC1H1 1778 genome.wustl.edu 37 14 102463379 102463379 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001376.4 +1 reviewed p.R1191H 1.000 66 0% 46 34.8% 6 66.6% benign(0.058) deleterious(0.02) neutral(0.387) NULL DYNC1H1 1778 genome.wustl.edu 37 14 102477092 102477092 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001376.4 +1 reviewed p.V2141I 1.000 53 0% 53 30.2% 19 36.8% benign(0.009) tolerated(0.44) neutral(0.013) superfamily_SSF52540 DYNC1H1 1778 genome.wustl.edu 37 14 102515904 102515904 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001376.4 +1 reviewed p.G4500 0.422 88 0% 25 44% 367 44.1% - - - HMMPfam_Dynein_heavy TECPR2 9895 genome.wustl.edu 37 14 102880980 102880980 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014844.3 +1 validated p.C163Y 1.000 108 0% 122 45.1% 1 0% probably_damaging(1) tolerated(0.14) deleterious(0.750) superfamily_WD40_like CDC42BPB 9578 genome.wustl.edu 37 14 103410637 103410637 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006035.3 -1 reviewed p.T1333 0.000 70 0% 40 37.5% 53 28.3% - - - HMMPfam_CNH,HMMSmart_CNH ASPG 374569 genome.wustl.edu 37 14 104559028 104559028 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080464.1 +1 provisional p.D47 0.090 35 0% 13 46.2% 0 - - - - HMMPfam_Asparaginase,superfamily_Glutaminase/Asparaginase AHNAK2 113146 genome.wustl.edu 37 14 105415167 105415167 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138420.2 -1 validated p.S2207 0.000 211 0% 152 36.2% 0 - - - - NULL BRF1 2972 genome.wustl.edu 37 14 105683938 105683938 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001519.2 -1 reviewed p.R572Q 0.979 66 0% 30 23.3% 32 31.2% probably_damaging(0.999) tolerated(0.56) deleterious(0.497) NULL BRF1 2972 genome.wustl.edu 37 14 105693076 105693076 + Silent SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001519.2 -1 reviewed p.T270 0.074 76 0% 66 40.9% 13 38.4% - - - superfamily_Cyclin-like PACS2 23241 genome.wustl.edu 37 14 105856326 105856326 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001100913.1 +1 validated p.I677V 1.000 206 0% 158 41.8% 45 42.2% benign(0.002) tolerated(0.9) - HMMPfam_Pacs-1 MTA1 9112 genome.wustl.edu 37 14 105933070 105933070 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004689.3 +1 reviewed p.P602S 1.000 34 0% 23 21.7% 72 38.8% benign(0.031) deleterious(0.03) neutral(0.366) NULL IGHG4 3503 genome.wustl.edu 37 14 106092171 106092171 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000390543 -1 known p.T78M 0.000 473 0% 348 28.4% 113 0.8% probably_damaging(0.962) deleterious(0.01) deleterious(0.810) HMMPfam_C1-set,HMMSmart_IGc1,superfamily_SSF48726 IGHM 3507 genome.wustl.edu 37 14 106320670 106320670 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000390558 -1 known p.A376V 0.000 59 0% 28 17.9% 862 0.1% - - - HMMPfam_C1-set,HMMSmart_SM00407,superfamily_Immunoglobulin HERC2 8924 genome.wustl.edu 37 15 28356990 28356990 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004667.4 -1 reviewed p.D4808 0.417 179 0% 88 34.1% 62 38.7% - - - NULL HERC2 8924 genome.wustl.edu 37 15 28447622 28447622 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004667.4 -1 reviewed p.R2451C 1.000 52 0% 23 34.8% 2 0% benign(0.061) deleterious(0.02) neutral(0.387) NULL HERC2 8924 genome.wustl.edu 37 15 28491985 28491985 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004667.4 -1 reviewed p.T1098 0.114 56 0% 55 47.3% 0 - - - - NULL TJP1 7082 genome.wustl.edu 37 15 30000833 30000833 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003257.3 -1 validated p.S1594P 1.000 160 0% 234 37.2% 36 44.4% benign(0.313) deleterious(0) deleterious(0.542) NULL ENSG00000215302 0 genome.wustl.edu 37 15 30771224 30771224 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000399971 +1 known p.T11I 1.000 50 0% 74 14.9% 1 0% - - - NULL C15orf55 256646 genome.wustl.edu 37 15 34646692 34646692 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_175741.1 +1 validated p.R346Q 1.000 144 0% 156 39.7% 0 - probably_damaging(1) tolerated(0.22) deleterious(0.542) NULL AQR 9716 genome.wustl.edu 37 15 35198874 35198874 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014691.2 -1 validated p.R568H 1.000 159 0% 215 33.5% 8 100% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) NULL AQR 9716 genome.wustl.edu 37 15 35212575 35212575 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014691.2 -1 validated p.N393 0.991 143 0% 261 34.9% 1 100% - - - NULL FSIP1 161835 genome.wustl.edu 37 15 39910156 39910156 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152597.4 -1 validated p.M493I 0.000 214 0.5% 241 43.2% 0 - benign(0.235) deleterious(0) neutral(0.468) NULL DISP2 85455 genome.wustl.edu 37 15 40657441 40657441 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033510.1 +1 reviewed p.D271 0.836 41 0% 29 55.2% 0 - - - - NULL BAHD1 22893 genome.wustl.edu 37 15 40750789 40750789 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014952.3 +1 validated p.P42 0.136 39 0% 28 35.7% 8 25% - - - NULL DNAJC17 55192 genome.wustl.edu 37 15 41065955 41065955 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018163.2 -1 validated p.A254 0.000 42 0% 24 41.7% 52 34.6% - - - NULL NDUFAF1 51103 genome.wustl.edu 37 15 41680690 41680690 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016013.2 -1 validated p.R264* 0.996 53 0% 80 12.5% 34 5.8% - - - HMMPfam_CIA30 MGA 23269 genome.wustl.edu 37 15 42003059 42003059 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080541.2 +1 validated p.R866* 0.923 151 0% 184 45.1% 2 50% - - - NULL MGA 23269 genome.wustl.edu 37 15 42058859 42058859 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080541.2 +1 validated p.R2909Q 0.314 75 0% 74 40.5% 4 50% benign(0.124) tolerated(0.91) neutral(0.010) NULL JMJD7-PLA2G4B 8681 genome.wustl.edu 37 15 42132762 42132762 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005090.3 +1 validated p.T272 0.967 65 0% 32 40.6% 12 16.6% - - - HMMPfam_C2,HMMSmart_SM00239,HMMSmart_SM00558,superfamily_C2 domain (Calcium/lipid-binding domain CaLB) SPTBN5 51332 genome.wustl.edu 37 15 42158671 42158671 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016642.2 -1 validated p.A2132 0.610 49 0% 32 12.5% 0 - - - - HMMPfam_Spectrin,HMMSmart_SM00150,superfamily_Spectrin repeat PLA2G4F 255189 genome.wustl.edu 37 15 42434214 42434214 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_213600.3 -1 validated p.R840W 0.041 70 0% 28 35.7% 0 - probably_damaging(0.993) deleterious(0) deleterious(0.895) superfamily_FabD/lysophospholipase-like HAUS2 55142 genome.wustl.edu 37 15 42858878 42858878 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018097.2 +1 validated p.R191H 0.994 108 0% 185 42.7% 13 38.4% probably_damaging(0.982) deleterious(0) deleterious(0.871) NULL TMEM62 80021 genome.wustl.edu 37 15 43452973 43452973 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024956.3 +1 provisional p.R426H 1.000 207 0% 334 12.6% 13 0% possibly_damaging(0.598) deleterious(0.01) deleterious(0.613) NULL DUOX1 53905 genome.wustl.edu 37 15 45440614 45440614 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017434.3 +1 reviewed p.S929 0.452 143 0% 88 34.1% 32 21.8% - - - superfamily_EF-hand SLC24A5 283652 genome.wustl.edu 37 15 48413290 48413290 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_205850.2 +1 reviewed p.G17S 0.002 102 0% 58 36.2% 0 - benign(0.003) tolerated(0.06) neutral(0.323) NULL SECISBP2L 9728 genome.wustl.edu 37 15 49320863 49320863 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014701.2 -1 provisional p.I227 0.731 142 0% 130 43.1% 2 50% - - - NULL C15orf33 196951 genome.wustl.edu 37 15 49800506 49800506 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152647.2 -1 validated p.L305P 0.427 254 0% 560 40.7% 1 100% probably_damaging(0.998) deleterious(0.01) deleterious(0.880) NULL TRPM7 54822 genome.wustl.edu 37 15 50929677 50929677 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017672.4 -1 reviewed p.A258 1.000 130 0% 161 28.6% 2 50% - - - NULL WDR72 256764 genome.wustl.edu 37 15 54008802 54008802 + Splice_Site SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_182758.2 -1 validated e3+2 1.000 206 0% 144 43.1% 0 - - - - - UNC13C 440279 genome.wustl.edu 37 15 54306109 54306109 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080534.1 +1 provisional p.V337M 0.991 89 0% 138 40.6% 0 - possibly_damaging(0.437) deleterious(0) deleterious(0.587) NULL NEDD4 4734 genome.wustl.edu 37 15 56142856 56142856 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198400.2 -1 validated p.Q758* 0.038 140 0% 153 11.1% 1 0% - - - NULL HSP90AB4P 664618 genome.wustl.edu 37 15 58984641 58984641 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000380522 -1 known p.S228 0.977 15 0% 68 32.4% 1 0% - - - HMMPfam_HSP90 RNF111 54778 genome.wustl.edu 37 15 59373219 59373219 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017610.6 +1 reviewed p.P678L 0.989 373 0.5% 355 42% 8 75% probably_damaging(1) deleterious(0) deleterious(0.945) NULL RORA 6095 genome.wustl.edu 37 15 60850430 60850430 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_134260.2 -1 reviewed p.G71 1.000 75 0% 88 31.8% 0 - - - - NULL TLN2 83660 genome.wustl.edu 37 15 63054637 63054637 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015059.2 +1 reviewed p.L1649P 1.000 157 0% 93 35.5% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) NULL HERC1 8925 genome.wustl.edu 37 15 63972916 63972916 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003922.3 -1 reviewed p.W2095* 1.000 201 0% 203 22.2% 4 50% - - - HMMPfam_SPRY,HMMSmart_SM00449 IGDCC4 57722 genome.wustl.edu 37 15 65676468 65676468 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020962.1 -1 provisional p.P1211L 0.000 40 0% 15 33.3% 1 0% benign(0.178) deleterious(0) neutral(0.461) NULL SMAD3 4088 genome.wustl.edu 37 15 67477141 67477141 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005902.3 +1 reviewed p.Q316 1.000 133 0% 87 40.2% 23 30.4% - - - HMMPfam_MH2,HMMSmart_SM00524,superfamily_SMAD/FHA domain SKOR1 390598 genome.wustl.edu 37 15 68118409 68118409 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001031807.1 +1 provisional p.S72 0.997 43 0% 18 44.4% 1 0% - - - HMMPfam_Ski_Sno,superfamily_Putativ_DNA_bind MYO9A 4649 genome.wustl.edu 37 15 72189995 72189995 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006901.2 -1 validated p.V1617I 0.000 217 0% 241 38.6% 2 50% benign(0.008) tolerated(0.43) neutral(0.013) NULL CYP1A1 1543 genome.wustl.edu 37 15 75015038 75015038 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000499.3 -1 reviewed p.R134H 0.998 25 0% 17 29.4% 0 - probably_damaging(0.999) tolerated(0.47) deleterious(0.501) HMMPfam_p450,superfamily_Cytochrome P450 CYP1A2 1544 genome.wustl.edu 37 15 75042488 75042488 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000761.3 +1 reviewed p.R137W 0.690 58 0% 26 38.5% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_p450,superfamily_Cytochrome_P450 COMMD4 54939 genome.wustl.edu 37 15 75631414 75631414 + Silent SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017828.3 +1 validated p.S90 1.000 81 0% 43 18.6% 154 33.7% - - - HMMPfam_HCaRG SIN3A 25942 genome.wustl.edu 37 15 75684745 75684745 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001145357.1 -1 reviewed p.R897* 1.000 305 0% 299 46.5% 7 28.5% - - - NULL PSTPIP1 9051 genome.wustl.edu 37 15 77317660 77317660 + Splice_Site SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003978.3 +1 reviewed e4+1 1.000 196 0% 128 13.3% 0 - - - - - SGK269 79834 genome.wustl.edu 37 15 77425652 77425652 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024776.2 -1 validated p.R1258C 0.997 145 0% 125 44% 3 66.6% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL IDH3A 3419 genome.wustl.edu 37 15 78454689 78454689 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005530.2 +1 reviewed p.A197 0.244 80 0% 45 35.6% 16 50% - - - HMMPfam_Iso_dh,superfamily_Isocitrate/Isopropylmalate dehydrogenase-like RASGRF1 5923 genome.wustl.edu 37 15 79282566 79282566 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002891.4 -1 reviewed p.P1077T 1.000 235 0% 291 41.6% 2 0% probably_damaging(0.998) deleterious(0.01) deleterious(0.880) HMMPfam_RasGEF,HMMSmart_SM00147,superfamily_Ras GEF TMC3 342125 genome.wustl.edu 37 15 81664945 81664945 + Missense_Mutation SNP G G C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080532.1 -1 provisional p.L75V 1.000 170 0% 156 41% 0 - probably_damaging(0.996) deleterious(0.01) deleterious(0.867) NULL WHAMM 123720 genome.wustl.edu 37 15 83485473 83485473 + Silent SNP T T G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080435.1 +1 provisional p.P271 0.825 121 0% 154 39.6% 12 33.3% - - - NULL ALPK3 57538 genome.wustl.edu 37 15 85406808 85406808 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020778.4 +1 validated p.R1681Q 0.964 90 0% 83 36.1% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Alpha_kinase,HMMSmart_SM00811,superfamily_Protein kinase-like (PK-like) AKAP13 11214 genome.wustl.edu 37 15 86270435 86270435 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006738.4 +1 reviewed p.R2325* 0.998 76 0% 100 30% 8 25% - - - HMMPfam_PH,HMMSmart_PH,superfamily_SSF50729 KIF7 374654 genome.wustl.edu 37 15 90189143 90189143 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198525.2 -1 validated p.R635W 0.101 107 0% 61 37.7% 2 50% benign(0.174) deleterious(0.01) neutral(0.422) NULL BLM 641 genome.wustl.edu 37 15 91306240 91306240 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000057.2 +1 reviewed p.R643C 0.633 97 0% 185 39.5% 0 - probably_damaging(0.997) deleterious(0) deleterious(0.911) superfamily_SSF52540 MAN2A2 4122 genome.wustl.edu 37 15 91456175 91456175 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000431652 +1 known p.R846H 0.000 197 0.5% 116 40.5% 21 33.3% - - - superfamily_Galactose mutarotase-like,HMMPfam_Glyco_hydro_38C SLCO3A1 28232 genome.wustl.edu 37 15 92706125 92706125 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013272.3 +1 validated p.I631 0.994 91 0% 58 31% 2 0% - - - superfamily_MFS general substrate transporter CHSY1 22856 genome.wustl.edu 37 15 101718804 101718804 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000254190 -1 known p.A400T 0.976 103 0% 62 41.9% 12 33.3% benign(0.003) tolerated(0.34) neutral(0.023) HMMPfam_CHGN TARSL2 123283 genome.wustl.edu 37 15 102252083 102252083 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152334.2 -1 validated p.R271I 1.000 85 0% 82 31.7% 2 0% benign(0.125) deleterious(0.05) neutral(0.356) superfamily_ThrRS/AlaRS common domain LOC100129478 100129478 genome.wustl.edu 37 16 281177 281177 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_001719774.2 +1 model p.P15 0.067 47 0% 29 27.6% 1 0% - - - NULL AXIN1 8312 genome.wustl.edu 37 16 396844 396844 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003502.2 -1 reviewed p.P61L 1.000 81 0% 40 45% 16 50% probably_damaging(1) deleterious(0.01) deleterious(0.905) NULL MRPL28 10573 genome.wustl.edu 37 16 419091 419091 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006428.3 -1 reviewed p.G140R 1.000 129 0% 76 36.8% 71 35.2% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_P53_like_DNA_bnd WDR90 197335 genome.wustl.edu 37 16 708904 708904 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145294.4 +1 provisional p.I968 0.990 80 0% 30 30% 15 33.3% - - - HMMSmart_SM00320,superfamily_WD40 repeat-like,HMMPfam_WD40 BAIAP3 8938 genome.wustl.edu 37 16 1394519 1394519 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003933.3 +1 reviewed p.R586Q 0.917 140 0% 51 37.3% 0 - benign(0.17) tolerated(0.33) neutral(0.040) HMMPfam_DUF1041 TELO2 9894 genome.wustl.edu 37 16 1547439 1547439 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016111.3 +1 reviewed p.R254C 1.000 31 0.000 8 0.625 20 25% probably_damaging(1) deleterious(0.01) deleterious(0.905) NULL MAPK8IP3 23162 genome.wustl.edu 37 16 1817646 1817646 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015133.3 +1 reviewed p.R1106C 1.000 26 0.000 9 0.667 45 51.1% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_WD40 repeat-like CASKIN1 57524 genome.wustl.edu 37 16 2233912 2233912 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020764.3 -1 validated p.A483T 1.000 40 0% 16 62.5% 2 50% benign(0) tolerated(0.32) neutral(0.024) HMMPfam_SAM_1,HMMSmart_SAM,superfamily_SAM_homology ABCA3 21 genome.wustl.edu 37 16 2327666 2327666 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001089.2 -1 reviewed p.V1639I 0.450 43 0% 23 65.2% 7 14.2% benign(0.002) tolerated(0.21) neutral(0.044) NULL CCNF 899 genome.wustl.edu 37 16 2495557 2495557 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001761.2 +1 reviewed p.R343Q 0.888 47 0% 24 50% 9 33.3% benign(0.095) tolerated(0.33) neutral(0.031) HMMSmart_CYCLIN,HMMPfam_Cyclin_N,superfamily_Cyclin_like SRRM2 23524 genome.wustl.edu 37 16 2806558 2806558 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016333.3 +1 validated p.R65C 1.000 33 0% 14 50% 33 39.3% unknown(0) - - HMMPfam_cwf21 NAA60 79903 genome.wustl.edu 37 16 3532568 3532568 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001083600.1 +1 validated p.V103I 1.000 78 0% 54 38.9% 37 43.2% probably_damaging(0.987) deleterious(0) deleterious(0.881) HMMPfam_Acetyltransf_1,superfamily_Acyl_CoA_acyltransferase ADCY9 115 genome.wustl.edu 37 16 4164999 4164999 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001116.2 -1 reviewed p.A149T 0.073 60 0% 47 36.2% 12 41.6% benign(0) tolerated(0.51) neutral(0.009) NULL ZNF500 26048 genome.wustl.edu 37 16 4802848 4802848 + Silent SNP C C T rs182699514 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021646.1 -1 validated p.P324 0.025 80 0% 38 42.1% 8 12.5% - - - superfamily_SSF57667 LOC100132944 100132944 genome.wustl.edu 37 16 8941640 8941640 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_001716801.2 -1 model p.R181C 0.000 42 0% 11 36.4% 26 26.9% - - - NULL USP7 7874 genome.wustl.edu 37 16 8995051 8995051 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003470.2 -1 validated p.T696 0.860 161 0% 201 10.9% 33 27.2% - - - NULL CIITA 4261 genome.wustl.edu 37 16 10998611 10998611 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000246.3 +1 reviewed p.T316 0.000 168 0% 120 36.7% 4 50% - - - NULL CIITA 4261 genome.wustl.edu 37 16 11004117 11004117 + Splice_Site SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000246.3 +1 reviewed e13+1 1.000 53 0% 47 46.8% 0 - - - - - CIITA 4261 genome.wustl.edu 37 16 11016049 11016049 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000246.3 +1 reviewed p.V1059M 0.000 124 0.8% 74 41.9% 5 0% possibly_damaging(0.944) tolerated(0.1) deleterious(0.675) HMMSmart_SM00368,superfamily_RNI-like BFAR 51283 genome.wustl.edu 37 16 14743705 14743705 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016561.2 +1 validated p.H171 0.030 122 0% 108 35.2% 50 46% - - - NULL NOMO1 23420 genome.wustl.edu 37 16 14951455 14951455 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014287.3 +1 reviewed p.T388M 0.061 553 0% 555 35.1% 37 43.2% possibly_damaging(0.598) tolerated(0.1) deleterious(0.493) superfamily_Starch-binding domain-like KIAA0430 9665 genome.wustl.edu 37 16 15706550 15706550 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014647.3 -1 validated p.S1113N 0.895 130 0% 116 12.1% 13 15.3% benign(0.081) tolerated(0.48) neutral(0.017) NULL ABCC6 368 genome.wustl.edu 37 16 16255324 16255324 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001171.5 -1 reviewed p.V1202M 1.000 48 0% 24 25% 0 - possibly_damaging(0.887) deleterious(0.02) deleterious(0.730) HMMPfam_ABC_membrane,superfamily_Multidrug resistance ABC transporter MsbA N-terminal domain NOMO3 408050 genome.wustl.edu 37 16 16345870 16345870 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001004067.2 +1 reviewed p.D262 0.983 395 0% 372 22.6% 21 4.7% - - - superfamily_Carboxypeptidase regulatory domain NOMO3 408050 genome.wustl.edu 37 16 16346331 16346331 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001004067.2 +1 reviewed p.A305 1.000 516 0% 610 18% 22 9% - - - NULL C16orf62 57020 genome.wustl.edu 37 16 19584516 19584516 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020314.4 +1 predicted p.R121W 1.000 108 0% 118 39% 8 62.5% probably_damaging(1) deleterious(0) deleterious(0.945) NULL GPRC5B 51704 genome.wustl.edu 37 16 19873179 19873179 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016235.1 -1 reviewed p.V383I 1.000 118 0% 90 36.7% 26 34.6% possibly_damaging(0.793) tolerated(0.26) neutral(0.332) NULL ACSM2B 348158 genome.wustl.edu 37 16 20570624 20570624 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001105069.1 -1 validated p.R108H 0.988 229 0% 139 15.8% 0 - possibly_damaging(0.824) tolerated(0.09) deleterious(0.609) HMMPfam_AMP-binding,superfamily_Acetyl-CoA synthetase-like DNAH3 55567 genome.wustl.edu 37 16 21110029 21110029 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017539.1 -1 provisional p.R810C 0.981 185 0% 261 36.4% 0 - probably_damaging(0.989) tolerated(0.17) deleterious(0.498) NULL EEF2K 29904 genome.wustl.edu 37 16 22256034 22256034 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013302.3 +1 reviewed p.E110 0.027 108 0% 48 16.7% 7 0% - - - superfamily_Kinase_like POLR3E 55718 genome.wustl.edu 37 16 22337236 22337236 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018119.2 +1 validated p.P501 0.000 38 0% 22 36.4% 14 57.1% - - - NULL USP31 57478 genome.wustl.edu 37 16 23091330 23091330 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020718.3 -1 validated p.Y705H 1.000 116 0% 73 16.4% 8 12.5% benign(0.382) tolerated(0.1) neutral(0.408) HMMPfam_UCH,superfamily_Cysteine proteinases ERN2 10595 genome.wustl.edu 37 16 23706594 23706594 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033266.3 -1 validated p.R624H 1.000 57 0% 15 46.7% 0 - probably_damaging(0.996) deleterious(0) deleterious(0.906) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase CACNG3 10368 genome.wustl.edu 37 16 24268157 24268157 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006539.2 +1 reviewed p.V28M 1.000 261 0% 291 44.3% 0 - probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_PMP22_Claudin RBBP6 5930 genome.wustl.edu 37 16 24567769 24567769 + Splice_Site SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006910.4 +1 reviewed e7+1 1.000 107 0% 166 44% 10 90% - - - - TNRC6A 27327 genome.wustl.edu 37 16 24788506 24788506 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014494.2 +1 reviewed p.R139Q 1.000 83 0% 79 46.8% 4 25% possibly_damaging(0.691) deleterious(0) deleterious(0.692) NULL CLN3 1201 genome.wustl.edu 37 16 28502865 28502865 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000086.2 -1 reviewed p.P21 0.000 35 2.9% 24 37.5% 26 53.8% - - - superfamily_MFS general substrate transporter CCDC101 112869 genome.wustl.edu 37 16 28602114 28602114 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138414.2 +1 validated p.R208H 0.314 68 0% 44 36.4% 36 41.6% probably_damaging(1) deleterious(0.02) deleterious(0.883) HMMPfam_DUF1325 TUFM 7284 genome.wustl.edu 37 16 28856095 28856095 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003321.4 -1 reviewed p.R203L 1.000 252 0% 162 44.4% 227 43.6% probably_damaging(0.967) deleterious(0.01) deleterious(0.815) HMMPfam_GTP_EFTU,superfamily_P-loop containing nucleoside triphosphate hydrolases ATP2A1 487 genome.wustl.edu 37 16 28895913 28895913 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_173201.2 +1 reviewed p.A161T 1.000 50 0% 24 25% 2 50% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_E1-E2_ATPase,superfamily_Calcium ATPase transduction domain A,superfamily_Calcium ATPase transmembrane domain M ITGAL 3683 genome.wustl.edu 37 16 30531228 30531228 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002209.2 +1 reviewed p.Y1093 0.032 93 0% 56 33.9% 5 0% - - - NULL SETD1A 9739 genome.wustl.edu 37 16 30976119 30976119 + Silent SNP T T G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014712.1 +1 provisional p.S352 0.107 236 0% 192 37.5% 6 16.6% - - - NULL KAT8 84148 genome.wustl.edu 37 16 31131791 31131791 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_182958.2 +1 validated p.R140C 1.000 28 0% 23 34.8% 16 56.2% probably_damaging(1) deleterious(0) deleterious(0.945) NULL ITGAM 3684 genome.wustl.edu 37 16 31338185 31338185 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000632.3 +1 reviewed p.F879 0.023 192 0% 291 39.2% 0 - - - - HMMPfam_Integrin_alpha2,superfamily_SSF69179 PHKB 5257 genome.wustl.edu 37 16 47733210 47733210 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000293.2 +1 reviewed p.A1072V 0.896 191 0% 216 33.3% 85 48.2% benign(0) tolerated(0.18) neutral(0.056) HMMPfam_PHK_AB SIAH1 6477 genome.wustl.edu 37 16 48395868 48395868 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001006610.1 -1 reviewed p.L189I 1.000 177 0% 160 36.9% 40 35% possibly_damaging(0.471) tolerated(0.08) neutral(0.456) superfamily_Traf_like,HMMPfam_Sina CYLD 1540 genome.wustl.edu 37 16 50825539 50825539 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015247.2 +1 reviewed p.V727I 1.000 122 0% 302 39.1% 11 36.3% benign(0.016) deleterious(0.04) neutral(0.349) HMMPfam_UCH,superfamily_Cysteine proteinases SALL1 6299 genome.wustl.edu 37 16 51172902 51172902 + Silent SNP G G A rs148808830 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002968.2 -1 reviewed p.P1077 1.000 161 0.6% 112 40.2% 17 35.2% - - - NULL RPGRIP1L 23322 genome.wustl.edu 37 16 53726041 53726041 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015272.2 -1 reviewed p.R156C 1.000 479 0% 704 29.8% 2 100% probably_damaging(1) deleterious(0) deleterious(0.945) NULL GNAO1 2775 genome.wustl.edu 37 16 56385325 56385325 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020988.2 +1 validated p.F251 1.000 172 0% 152 42.1% 0 - - - - HMMPfam_G-alpha,HMMSmart_SM00275,superfamily_P-loop containing nucleoside triphosphate hydrolases CPNE2 221184 genome.wustl.edu 37 16 57155032 57155032 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152727.4 +1 reviewed p.G237R 1.000 100 0% 49 49% 147 53.7% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_C2,HMMSmart_C2,superfamily_C2_CaLB CPNE2 221184 genome.wustl.edu 37 16 57171156 57171156 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152727.4 +1 reviewed p.R422W 0.995 113 0% 39 33.3% 330 44.2% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_VWA,HMMPfam_Copine,superfamily_SSF53300 GPR114 221188 genome.wustl.edu 37 16 57601914 57601914 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153837.1 +1 provisional p.Y323C 0.447 88 0% 33 39.4% 1 0% probably_damaging(0.974) deleterious(0) deleterious(0.861) HMMPfam_7tm_2 GPR97 222487 genome.wustl.edu 37 16 57710204 57710204 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_170776.4 +1 validated p.S100N 0.981 125 0% 119 44.5% 0 - benign(0.01) tolerated(0.34) neutral(0.024) NULL CDH5 1003 genome.wustl.edu 37 16 66426080 66426080 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001795.3 +1 reviewed p.V337 0.188 115 0% 94 45.7% 13 15.3% - - - HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like CDH16 1014 genome.wustl.edu 37 16 66947474 66947474 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004062.2 -1 reviewed p.H275N 1.000 85 0% 65 33.8% 0 - benign(0) tolerated(0.44) neutral(0.013) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like PLEKHG4 25894 genome.wustl.edu 37 16 67316195 67316195 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001129727.1 +1 reviewed p.R399Q 0.002 48 0% 11 54.5% 2 50% benign(0.014) tolerated(0.38) neutral(0.018) NULL CENPT 80152 genome.wustl.edu 37 16 67867693 67867693 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_025082.3 -1 validated p.D24N 0.003 11 0.000 8 0.625 14 42.8% probably_damaging(0.99) tolerated(0.08) deleterious(0.742) NULL PSKH1 5681 genome.wustl.edu 37 16 67961448 67961448 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006742.2 +1 validated p.R393H 1.000 45 0% 16 31.2% 8 50% benign(0.003) tolerated(0.13) neutral(0.253) NULL DPEP3 64180 genome.wustl.edu 37 16 68011841 68011841 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022357.3 -1 reviewed p.E277 1.000 113 0% 57 35.1% 0 - - - - HMMPfam_Peptidase_M19,superfamily_Metallo-dependent hydrolases DPEP3 64180 genome.wustl.edu 37 16 68014043 68014043 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022357.3 -1 reviewed p.R106W 0.000 58 0% 24 41.7% 0 - benign(0.012) deleterious(0.01) neutral(0.406) superfamily_Metallo-dependent hydrolases FUK 197258 genome.wustl.edu 37 16 70512547 70512547 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145059.2 +1 reviewed p.R975C 0.986 52 0% 18 50% 17 47% possibly_damaging(0.596) tolerated(0.07) deleterious(0.525) HMMPfam_GHMP_kinases_C,superfamily_GHMP Kinase C-terminal domain PMFBP1 83449 genome.wustl.edu 37 16 72198801 72198801 + Missense_Mutation SNP G G C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031293.2 -1 validated p.D9E 1.000 95 0% 56 33.9% 0 - possibly_damaging(0.948) deleterious(0) deleterious(0.836) NULL CLEC18B 497190 genome.wustl.edu 37 16 74446297 74446297 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000425714 -1 known p.V203M 0.000 73 0% 24 20.8% 0 - unknown(0) tolerated(0.14) - NULL LOC100132346 100132346 genome.wustl.edu 37 16 74646658 74646658 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_001726790.2 -1 model p.A49T 0.987 12 0% 24 25% 0 - - - - HMMPfam_Cpn10,superfamily_GroES-like LDHD 197257 genome.wustl.edu 37 16 75148067 75148067 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153486.2 -1 reviewed p.R232H 0.031 35 0% 28 39.3% 0 - unknown(0) deleterious(0.03) - superfamily_FAD-binding domain PLCG2 5336 genome.wustl.edu 37 16 81954830 81954830 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002661.2 +1 validated p.V755I 0.998 91 0% 117 34.2% 8 12.5% benign(0.021) tolerated(0.26) neutral(0.035) superfamily_SH3,superfamily_PLC-like_Pdiesterase_TIM-brl,superfamily_SSF50729,superfamily_SSF55550 DNAAF1 123872 genome.wustl.edu 37 16 84209746 84209746 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178452.4 +1 reviewed p.R636* 0.000 51 0% 40 35% 4 25% - - - NULL ATP2C2 9914 genome.wustl.edu 37 16 84438776 84438776 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014861.2 +1 validated p.R85C 1.000 89 0% 62 50% 30 30% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Cation_ATPase_N,superfamily_Calcium ATPase transmembrane domain M USP10 9100 genome.wustl.edu 37 16 84806270 84806270 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005153.2 +1 reviewed p.V708M 1.000 147 0% 171 10.5% 16 12.5% possibly_damaging(0.889) deleterious(0.01) deleterious(0.755) HMMPfam_UCH,superfamily_SSF54001 MAP1LC3B 81631 genome.wustl.edu 37 16 87432441 87432441 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022818.4 +1 reviewed p.R21* 0.929 168 0% 200 27% 54 9.2% - - - HMMPfam_MAP1_LC3,superfamily_Ubiquitin-like ZNF469 84627 genome.wustl.edu 37 16 88498258 88498258 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001127464.1 +1 reviewed p.P1432 0.004 75 1.3% 47 34% 0 - - - - NULL ZC3H18 124245 genome.wustl.edu 37 16 88697553 88697553 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000289509 +1 known p.R729* 1.000 40 0% 30 16.7% 74 6.7% - - - NULL PIEZO1 9780 genome.wustl.edu 37 16 88788766 88788766 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000451779 -1 known p.D1142 0.000 46 2.2% 15 66.7% 19 36.8% - - - NULL ZNF778 197320 genome.wustl.edu 37 16 89293467 89293467 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_182531.2 +1 validated p.P229 0.237 65 0% 69 36.2% 5 60% - - - superfamily_C2H2 and C2HC zinc fingers C16orf7 9605 genome.wustl.edu 37 16 89785542 89785542 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000261625 -1 known p.P52H 0.170 108 0% 93 37.6% 2 50% unknown(0) - - NULL ZNF276 92822 genome.wustl.edu 37 16 89789731 89789731 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001113525.1 +1 validated p.A207V 0.938 41 0% 15 26.7% 7 28.5% unknown(0) - - NULL TCF25 22980 genome.wustl.edu 37 16 89965240 89965240 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014972.2 +1 validated p.R394Q 0.994 103 0% 62 16.1% 111 17.1% possibly_damaging(0.525) tolerated(0.05) deleterious(0.522) HMMPfam_DUF654 LOC100288617 100288617 genome.wustl.edu 37 17 1481549 1481549 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002343497.1 +1 model p.S271G 0.399 64 1.6% 33 30.3% 44 43.1% - - - NULL PRPF8 10594 genome.wustl.edu 37 17 1560022 1560022 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006445.3 -1 reviewed p.A1847T 1.000 102 0% 90 43.3% 104 46.1% possibly_damaging(0.582) deleterious(0) deleterious(0.645) NULL RPA1 6117 genome.wustl.edu 37 17 1775775 1775775 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002945.3 +1 validated p.A137T 0.000 47 0% 29 48.3% 22 36.3% benign(0) tolerated(0.59) neutral(0.004) NULL SGSM2 9905 genome.wustl.edu 37 17 2265508 2265508 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014853.2 +1 validated p.T134 0.860 50 0% 35 34.3% 20 70% - - - HMMPfam_RUN,HMMSmart_RUN KIAA0664 23277 genome.wustl.edu 37 17 2597492 2597492 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015229.3 -1 validated p.V967M 1.000 134 0% 80 41.2% 55 50.9% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) NULL ITGAE 3682 genome.wustl.edu 37 17 3680864 3680864 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002208.4 -1 reviewed p.L42P 1.000 61 0% 31 48.4% 3 0% probably_damaging(0.998) deleterious(0) deleterious(0.919) superfamily_SSF69318 C17orf85 55421 genome.wustl.edu 37 17 3719475 3719475 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001114118.1 -1 provisional p.R467Q 1.000 201 0% 274 42% 37 32.4% benign(0.139) deleterious(0.04) neutral(0.361) NULL ATP2A3 489 genome.wustl.edu 37 17 3833681 3833681 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_174953.1 -1 reviewed p.I886 0.025 97 0% 76 35.5% 78 76.9% - - - HMMPfam_Cation_ATPase_C,superfamily_Calcium ATPase transmembrane domain M ATP2A3 489 genome.wustl.edu 37 17 3850927 3850927 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_174953.1 -1 reviewed p.G285S 1.000 8 0.000 6 0.667 39 56.4% probably_damaging(0.994) tolerated(0.07) deleterious(0.771) HMMPfam_E1-E2_ATPase,superfamily_Calcium ATPase transmembrane domain M MYBBP1A 10514 genome.wustl.edu 37 17 4455262 4455262 + Silent SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001105538.1 -1 validated p.A312 0.995 65 0% 23 43.5% 22 59% - - - HMMPfam_DNA_pol_phi,superfamily_ARM-type_fold SMTNL2 342527 genome.wustl.edu 37 17 4496467 4496467 + Splice_Site SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001114974.1 +1 validated e3+1 0.999 53 0% 17 41.2% 0 - - - - - DLG4 1742 genome.wustl.edu 37 17 7100327 7100327 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001365.3 -1 reviewed p.L321M 1.000 61 0% 28 53.6% 10 40% possibly_damaging(0.918) tolerated(0.2) neutral(0.417) HMMPfam_PDZ_assoc PLSCR3 57048 genome.wustl.edu 37 17 7296826 7296826 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020360.2 -1 provisional p.I82 1.000 82 0% 86 44.2% 17 41.1% - - - HMMPfam_Scramblase KDM6B 23135 genome.wustl.edu 37 17 7755570 7755570 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080424.1 +1 provisional p.V1462M 1.000 127 0% 93 34.4% 45 42.2% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00558,HMMPfam_JmjC CHD3 1107 genome.wustl.edu 37 17 7797535 7797535 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001005271.2 +1 reviewed p.R402C 0.966 76 0% 68 45.6% 36 41.6% probably_damaging(0.999) - - NULL CHD3 1107 genome.wustl.edu 37 17 7802419 7802419 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001005271.2 +1 reviewed p.R807C 1.000 72 0% 46 45.7% 47 38.2% possibly_damaging(0.945) - - HMMPfam_SNF2_N,HMMSmart_SM00487,superfamily_P-loop containing nucleoside triphosphate hydrolases NDEL1 81565 genome.wustl.edu 37 17 8349093 8349093 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_030808.3 +1 reviewed p.L51 1.000 156 0% 206 15.5% 21 4.7% - - - NULL MYH10 4628 genome.wustl.edu 37 17 8383800 8383800 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005964.1 -1 validated p.A1739T 1.000 94 0% 43 46.5% 22 50% benign(0.008) tolerated(0.22) neutral(0.042) HMMPfam_Myosin_tail_1,superfamily_Prefoldin MYH10 4628 genome.wustl.edu 37 17 8448828 8448828 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005964.1 -1 validated p.T447A 1.000 119 0% 140 36.4% 3 0% probably_damaging(0.979) deleterious(0) deleterious(0.867) HMMPfam_Myosin_head,HMMSmart_SM00242,superfamily_P-loop containing nucleoside triphosphate hydrolases USP43 124739 genome.wustl.edu 37 17 9604628 9604628 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000436020 +1 known p.R53H 0.000 56 0% 23 39.1% 0 - - - - NULL PIRT 644139 genome.wustl.edu 37 17 10728776 10728776 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001101387.1 -1 validated p.G63S 0.331 123 0% 71 38% 0 - benign(0.004) tolerated(0.2) neutral(0.049) NULL MAP2K4 6416 genome.wustl.edu 37 17 11984691 11984691 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003010.2 +1 reviewed p.H79 1.000 70 0% 92 27.2% 5 0% - - - NULL TEKT3 64518 genome.wustl.edu 37 17 15231347 15231347 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031898.2 -1 reviewed p.D209N 0.999 249 0% 281 28.1% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Tektin CDRT1 374286 genome.wustl.edu 37 17 15496799 15496799 + Missense_Mutation SNP C C T rs148254995 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006382.3 -1 provisional p.D620N 0.016 160 0% 141 36.9% 0 - benign(0.261) tolerated(0.14) neutral(0.277) HMMSmart_SM00320,superfamily_WD40 repeat-like,HMMPfam_WD40 TNFRSF13B 23495 genome.wustl.edu 37 17 16875331 16875331 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012452.2 -1 reviewed p.R20H 0.000 118 0% 69 30.4% 1 0% probably_damaging(0.974) deleterious(0) deleterious(0.861) NULL RAI1 10743 genome.wustl.edu 37 17 17697400 17697400 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_030665.3 +1 reviewed p.G380R 0.995 63 0% 38 39.5% 13 30.7% probably_damaging(1) deleterious(0) deleterious(0.945) NULL DRG2 1819 genome.wustl.edu 37 17 18001619 18001619 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001388.3 +1 reviewed p.S87 0.997 225 0% 148 43.9% 23 56.5% - - - HMMPfam_MMR_HSR1,superfamily_P-loop containing nucleoside triphosphate hydrolases MYO15A 51168 genome.wustl.edu 37 17 18030435 18030435 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016239.3 +1 reviewed p.R1330C 1.000 48 0% 37 16.2% 0 - probably_damaging(1) - - HMMPfam_Myosin_head,HMMSmart_SM00242,superfamily_P-loop containing nucleoside triphosphate hydrolases LLGL1 3996 genome.wustl.edu 37 17 18141458 18141458 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004140.3 +1 reviewed p.R661H 0.998 74 0% 43 34.9% 12 41.6% probably_damaging(1) deleterious(0) deleterious(0.945) NULL SHMT1 6470 genome.wustl.edu 37 17 18250892 18250892 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004169.3 -1 reviewed p.G146V 1.000 125 0% 103 35% 55 52.7% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_SHMT,superfamily_PLP-dependent transferases ALDH3A1 218 genome.wustl.edu 37 17 19642905 19642905 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000691.4 -1 reviewed p.C344 0.457 58 0% 39 23.1% 46 36.9% - - - HMMPfam_Aldedh,superfamily_ALDH-like SPECC1 92521 genome.wustl.edu 37 17 20135719 20135719 + Splice_Site SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001033553.1 +1 validated e6+1 0.000 22 0% 18 50% 32 37.5% - - - - CCDC144NL 339184 genome.wustl.edu 37 17 20799092 20799092 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001004306.1 -1 provisional p.L81P 0.007 79 0% 48 37.5% 0 - benign(0.05) tolerated(0.1) neutral(0.289) NULL WSB1 26118 genome.wustl.edu 37 17 25628876 25628876 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015626.8 +1 reviewed p.R35C 1.000 342 0.3% 385 35.6% 30 43.3% benign(0.001) tolerated(0.11) neutral(0.272) superfamily_WD40 repeat-like KSR1 8844 genome.wustl.edu 37 17 25909854 25909854 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014238.1 +1 validated p.A98T 0.000 48 0% 23 34.8% 1 100% benign(0) tolerated(0.7) neutral(0.002) NULL SUPT6H 6830 genome.wustl.edu 37 17 27009813 27009813 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003170.3 +1 validated p.R556W 1.000 56 0% 64 29.7% 34 44.1% probably_damaging(1) deleterious(0) deleterious(0.945) NULL TLCD1 116238 genome.wustl.edu 37 17 27051602 27051602 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138463.3 -1 validated p.R224C 1.000 128 0% 111 44.1% 49 42.8% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_TRAM_LAG1_CLN8,HMMSmart_TLC C17orf63 55731 genome.wustl.edu 37 17 27086045 27086045 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001077498.1 -1 validated p.S311L 1.000 116 0% 53 28.3% 22 40.9% benign(0.273) deleterious(0.03) neutral(0.394) NULL NF1 4763 genome.wustl.edu 37 17 29559121 29559121 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001042492.2 +1 reviewed p.V1076 0.420 64 0% 87 34.5% 6 33.3% - - - NULL NF1 4763 genome.wustl.edu 37 17 29587516 29587516 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001042492.2 +1 reviewed p.Q1520 1.000 191 0% 249 41% 5 20% - - - HMMSmart_SM00323,superfamily_GTPase activation domain GAP NLE1 54475 genome.wustl.edu 37 17 33464163 33464163 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018096.3 -1 validated p.R229W 0.995 63 0% 26 42.3% 8 37.5% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00320,superfamily_WD40 repeat-like,PatternScan_WD_REPEATS_1,HMMPfam_WD40 CCL5 6352 genome.wustl.edu 37 17 34205610 34205610 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002985.2 -1 reviewed p.Y37C 0.992 212 0.5% 128 46.9% 57 1.7% probably_damaging(0.999) deleterious(0) deleterious(0.935) PatternScan_SMALL_CYTOKINES_CC,HMMPfam_IL8,HMMSmart_SCY,superfamily_Chemokine_IL8 SYNRG 11276 genome.wustl.edu 37 17 35937659 35937659 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007247.4 -1 reviewed p.G214 1.000 188 0% 266 40.2% 0 - - - - NULL SOCS7 30837 genome.wustl.edu 37 17 36533624 36533624 + Missense_Mutation SNP C C G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014598.1 +1 validated p.S482C 1.000 149 0% 249 30.9% 1 0% probably_damaging(1) deleterious(0.05) deleterious(0.845) HMMSmart_SM00252,superfamily_SH2 domain ARHGAP23 57636 genome.wustl.edu 37 17 36623439 36623439 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020876.1 +1 provisional p.P411 0.000 27 0% 18 55.6% 5 40% - - - NULL MLLT6 4302 genome.wustl.edu 37 17 36868143 36868143 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005937.3 +1 validated p.G199E 0.040 215 0% 91 45.1% 14 57.1% benign(0.005) tolerated(0.31) neutral(0.027) NULL CDC6 990 genome.wustl.edu 37 17 38451609 38451609 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001254.3 +1 reviewed p.V362A 0.371 162 0% 234 26.1% 18 22.2% benign(0) tolerated(0.43) neutral(0.013) HMMPfam_AAA,superfamily_SSF52540 CCR7 1236 genome.wustl.edu 37 17 38711130 38711130 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001838.2 -1 reviewed p.R334H 1.000 130 0% 61 62.3% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_Family A G protein-coupled receptor-like KRT12 3859 genome.wustl.edu 37 17 39019568 39019568 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000223.3 -1 reviewed p.E375K 0.999 25 0.000 9 0.556 0 - probably_damaging(0.996) deleterious(0) deleterious(0.906) HMMPfam_Filament LOC100287618 100287618 genome.wustl.edu 37 17 39092876 39092876 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002343552.1 +1 model p.D42 0.000 38 0% 17 58.8% 26 34.6% - - - NULL KRT39 390792 genome.wustl.edu 37 17 39115079 39115079 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_213656.3 -1 reviewed p.E417G 0.433 115 0% 72 27.8% 0 - possibly_damaging(0.654) tolerated(0.16) neutral(0.289) NULL KRTAP9-2 83899 genome.wustl.edu 37 17 39383021 39383021 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031961.2 +1 reviewed p.Q39* 1.000 285 0% 196 25% 0 - - - - HMMPfam_Keratin_B2 KRT34 3885 genome.wustl.edu 37 17 39538417 39538417 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021013.3 -1 reviewed p.G70S 0.000 127 0% 54 31.5% 0 - benign(0.002) tolerated(0.3) neutral(0.029) NULL KRT14 3861 genome.wustl.edu 37 17 39740083 39740083 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000526.4 -1 reviewed p.E286K 0.979 142 0% 99 38.4% 2 0% possibly_damaging(0.521) deleterious(0.01) deleterious(0.581) superfamily_Prefoldin,HMMPfam_Filament KRT14 3861 genome.wustl.edu 37 17 39740609 39740609 + Missense_Mutation SNP C C T rs68005964 TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000526.4 -1 reviewed p.R222H 1.000 127 0% 102 37.3% 1 0% probably_damaging(1) deleterious(0.04) deleterious(0.849) HMMPfam_Filament KLHL10 317719 genome.wustl.edu 37 17 40004192 40004192 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152467.3 +1 validated p.G487D 1.000 88 0% 73 38.4% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Kelch_1,HMMSmart_Kelch,superfamily_Gal_oxid_central KCNH4 23415 genome.wustl.edu 37 17 40328103 40328103 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012285.2 -1 reviewed p.S266 0.212 29 0% 23 47.8% 0 - - - - HMMPfam_Ion_trans,superfamily_SSF81324 STAT5B 6777 genome.wustl.edu 37 17 40370267 40370267 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012448.3 -1 reviewed p.G357 0.955 111 0% 62 29% 6 16.6% - - - superfamily_P53_like_DNA_bnd,HMMPfam_STAT_bind PTRF 284119 genome.wustl.edu 37 17 40556950 40556950 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012232.5 -1 reviewed p.R310C 1.000 104 0% 56 44.6% 77 36.3% probably_damaging(1) deleterious(0.01) deleterious(0.905) NULL FAM134C 162427 genome.wustl.edu 37 17 40734098 40734098 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178126.3 -1 validated p.A378 0.173 41 0% 34 50% 16 37.5% - - - NULL CNTNAP1 8506 genome.wustl.edu 37 17 40835877 40835877 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003632.2 +1 reviewed p.R36C 0.905 57 0% 33 18.2% 0 - probably_damaging(0.994) tolerated(0.05) deleterious(0.797) HMMSmart_FA58C,superfamily_Gal_bind_like MPP2 4355 genome.wustl.edu 37 17 41957260 41957260 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005374.3 -1 reviewed p.R415C 0.981 69 0% 35 37.1% 1 100% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_Guanylate_kin,HMMSmart_SM00072,superfamily_P-loop containing nucleoside triphosphate hydrolases UBTF 7343 genome.wustl.edu 37 17 42289093 42289093 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014233.2 -1 validated p.A310T 1.000 71 0% 40 27.5% 82 46.3% possibly_damaging(0.435) tolerated(0.24) neutral(0.179) HMMPfam_HMG_box,HMMSmart_SM00398,superfamily_HMG-box FZD2 2535 genome.wustl.edu 37 17 42636266 42636266 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001466.2 +1 reviewed p.V404I 1.000 69 0% 16 50% 13 46.1% possibly_damaging(0.892) deleterious(0) deleterious(0.796) HMMPfam_Frizzled EFTUD2 9343 genome.wustl.edu 37 17 42962638 42962638 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004247.3 -1 validated p.T112 0.022 232 0% 335 43.9% 19 73.6% - - - NULL MAPT 4137 genome.wustl.edu 37 17 44101347 44101347 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001123066.3 +1 validated p.R714H 1.000 38 0% 38 10.5% 0 - possibly_damaging(0.858) deleterious(0) deleterious(0.776) NULL LRRC37A2 474170 genome.wustl.edu 37 17 44623637 44623637 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001006607.2 +1 validated p.M1024V 0.214 493 0% 654 11.5% 6 0% possibly_damaging(0.94) deleterious(0.01) deleterious(0.790) NULL ENSG00000249872 0 genome.wustl.edu 37 17 44627893 44627893 + RNA SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000510581 -1 novel NULL 0.004 521 0% 1093 12.1% 4 25% - - - - SCRN2 90507 genome.wustl.edu 37 17 45915665 45915665 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138355.3 -1 validated p.A364T 0.158 43 0% 22 27.3% 35 34.2% benign(0.036) tolerated(0.59) neutral(0.006) NULL LOC100131693 100131693 genome.wustl.edu 37 17 47502275 47502275 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_001726582.1 -1 model p.V4I 1.000 108 0% 176 44.3% 0 - - - - HMMPfam_IF4E,superfamily_Translation initiation factor eIF4e MYCBPAP 84073 genome.wustl.edu 37 17 48602332 48602332 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032133.4 +1 validated p.P620H 0.420 44 0% 15 40% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL ANKFN1 162282 genome.wustl.edu 37 17 54559765 54559765 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153228.2 +1 validated p.N717D 1.000 172 0% 190 14.7% 0 - possibly_damaging(0.824) tolerated(1) neutral(0.312) NULL AKAP1 8165 genome.wustl.edu 37 17 55183077 55183077 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003488.3 +1 reviewed p.T84 0.000 64 0% 33 39.4% 10 50% - - - NULL EPX 8288 genome.wustl.edu 37 17 56277066 56277066 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000502.4 +1 reviewed p.R483H 1.000 186 0% 70 44.3% 0 - probably_damaging(0.987) deleterious(0) deleterious(0.881) HMMPfam_An_peroxidase,superfamily_Peroxidase_super MPO 4353 genome.wustl.edu 37 17 56356801 56356801 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000340482 -1 known p.V211I 0.000 42 0% 11 45.5% 0 - unknown(0) tolerated(0.39) - NULL BZRAP1 9256 genome.wustl.edu 37 17 56389719 56389719 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004758.2 -1 validated p.H821 0.000 34 0% 12 50% 2 50% - - - HMMPfam_fn3,HMMSmart_SM00060,superfamily_Fibronectin type III TEX14 56155 genome.wustl.edu 37 17 56676846 56676846 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198393.2 -1 reviewed p.F620 0.366 82 0% 81 16% 0 - - - - NULL PPM1E 22843 genome.wustl.edu 37 17 56833464 56833464 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014906.3 +1 reviewed p.E36K 0.995 47 0% 17 29.4% 0 - unknown(0) deleterious(0) - NULL RPS6KB1 6198 genome.wustl.edu 37 17 58011822 58011822 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003161.2 +1 reviewed p.G269 1.000 247 0% 242 38.8% 10 30% - - - HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase CSHL1 1444 genome.wustl.edu 37 17 61988216 61988216 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022579.1 -1 reviewed p.V27I 0.051 100 0% 60 36.7% 0 - benign(0.011) deleterious(0.02) neutral(0.384) HMMPfam_Hormone_1,superfamily_4-helical cytokines SCN4A 6329 genome.wustl.edu 37 17 62019284 62019284 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000334.4 -1 reviewed p.A1453V 0.999 91 0% 85 41.2% 0 - benign(0.135) tolerated(0.11) neutral(0.283) HMMPfam_Ion_trans,superfamily_Voltage-gated potassium channels SCN4A 6329 genome.wustl.edu 37 17 62045437 62045437 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000334.4 -1 reviewed p.A328T 0.000 232 0% 172 35.5% 0 - benign(0) tolerated(0.7) neutral(0.002) HMMPfam_Ion_trans,superfamily_Voltage-gated potassium channels C17orf72 92340 genome.wustl.edu 37 17 62078502 62078502 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000425164 +1 known p.R101Q 0.000 214 0% 141 34% 3 33.3% benign(0) tolerated(0.5) neutral(0.010) NULL ICAM2 3384 genome.wustl.edu 37 17 62082473 62082473 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000873.3 -1 reviewed p.V108M 0.329 49 0% 42 14.3% 5 0% probably_damaging(0.998) tolerated(0.06) deleterious(0.797) HMMPfam_ICAM_N,superfamily_Immunoglobulin PRKCA 5578 genome.wustl.edu 37 17 64683344 64683344 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002737.2 +1 reviewed p.I215 1.000 210 0% 239 14.6% 1 0% - - - HMMPfam_C2,HMMSmart_SM00239,superfamily_C2 domain (Calcium/lipid-binding domain CaLB) ENSG00000154251 0 genome.wustl.edu 37 17 66124329 66124329 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000284414 -1 known p.P19L 0.005 84 0% 109 37.6% 67 50.7% - - - NULL ABCA9 10350 genome.wustl.edu 37 17 67004274 67004274 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080283.3 -1 reviewed p.L1084 0.041 68 0% 149 39.6% 0 - - - - NULL ABCA9 10350 genome.wustl.edu 37 17 67039671 67039671 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080283.3 -1 reviewed p.T253 0.001 53 0% 79 40.5% 0 - - - - NULL KCNJ2 3759 genome.wustl.edu 37 17 68171552 68171552 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000891.2 +1 reviewed p.S124 0.518 121 0% 68 47.1% 0 - - - - HMMPfam_IRK,superfamily_Voltage-gated potassium channels C17orf80 55028 genome.wustl.edu 37 17 71232543 71232543 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017941.4 +1 validated p.G308W 0.011 77 0% 83 39.8% 1 0% probably_damaging(1) deleterious(0.02) deleterious(0.883) NULL SDK2 54549 genome.wustl.edu 37 17 71361467 71361467 + Missense_Mutation SNP T T G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001144952.1 -1 provisional p.E1745D 0.983 47 0% 34 32.4% 1 100% benign(0) tolerated(1) - HMMPfam_fn3,HMMSmart_SM00060,superfamily_Fibronectin type III SDK2 54549 genome.wustl.edu 37 17 71420062 71420062 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001144952.1 -1 provisional p.R585* 1.000 18 0% 10 50% 0 - - - - HMMSmart_SM00409,superfamily_Fibronectin type III,superfamily_Immunoglobulin GPRC5C 55890 genome.wustl.edu 37 17 72443156 72443156 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022036.2 +1 reviewed p.V484M 0.181 52 0% 32 40.6% 70 30% benign(0.174) deleterious(0) neutral(0.461) NULL FDXR 2232 genome.wustl.edu 37 17 72861891 72861891 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004110.3 -1 reviewed p.V187M 1.000 45 0% 20 50% 52 42.3% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Pyr_redox_2,superfamily_SSF51905,superfamily_SSF51971 CASKIN2 57513 genome.wustl.edu 37 17 73501904 73501904 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020753.3 -1 validated p.R278Q 1.000 118 0% 64 39.1% 11 27.2% probably_damaging(1) deleterious(0.02) deleterious(0.883) superfamily_Ankyrin repeat LLGL2 3993 genome.wustl.edu 37 17 73567858 73567858 + Nonsense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001031803.1 +1 reviewed p.E763* 1.000 35 0% 13 30.8% 69 28.9% - - - NULL ITGB4 3691 genome.wustl.edu 37 17 73723531 73723531 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000213.3 +1 reviewed p.A70V 0.000 36 0% 21 38.1% 30 60% benign(0.006) tolerated(0.36) neutral(0.020) HMMPfam_Integrin_beta,HMMSmart_SM00187,HMMSmart_SM00423 EVPL 2125 genome.wustl.edu 37 17 74005000 74005000 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001988.2 -1 validated p.R1429H 0.165 61 0% 27 37% 2 100% possibly_damaging(0.922) tolerated(0.13) deleterious(0.624) NULL SPHK1 8877 genome.wustl.edu 37 17 74383387 74383387 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_182965.2 +1 validated p.A378V 0.873 102 0% 43 20.9% 33 45.4% probably_damaging(0.968) tolerated(0.07) deleterious(0.729) NULL SEPT9 10801 genome.wustl.edu 37 17 75484369 75484369 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001113491.1 +1 reviewed p.P364S 1.000 84 0% 64 34.4% 290 43.4% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Septin,superfamily_P-loop containing nucleoside triphosphate hydrolases DNAH17 8632 genome.wustl.edu 37 17 76440722 76440722 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000389840 -1 known p.R3817H 0.985 66 0% 33 51.5% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Dynein_heavy RNF213 57674 genome.wustl.edu 37 17 78298873 78298873 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000508628 +1 known p.R1023Q 0.000 204 0% 225 36.4% 3 33.3% benign(0.148) tolerated(0.62) neutral(0.017) NULL RNF213 57674 genome.wustl.edu 37 17 78319974 78319974 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000508628 +1 known p.R2613 0.000 85 0% 42 33.3% 3 66.6% - - - NULL SLC38A10 124565 genome.wustl.edu 37 17 79234132 79234132 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001037984.1 -1 validated p.S398 0.028 40 0% 19 36.8% 31 45.1% - - - NULL BAHCC1 57597 genome.wustl.edu 37 17 79414527 79414527 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000436173 +1 known p.P1210L 0.002 28 0% 13 46.2% 1 100% benign(0.004) deleterious(0) neutral(0.445) NULL NPLOC4 55666 genome.wustl.edu 37 17 79575810 79575810 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017921.2 -1 validated p.P158 0.020 104 0% 83 34.9% 15 40% - - - HMMPfam_zf-NPL4 NOTUM 147111 genome.wustl.edu 37 17 79914809 79914809 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178493.5 -1 validated p.C279 0.171 64 0% 48 47.9% 0 - - - - HMMPfam_PAE GPS1 2873 genome.wustl.edu 37 17 80011759 80011759 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_212492.1 +1 reviewed p.A88T 0.996 38 0% 23 34.8% 76 47.3% benign(0.052) tolerated(0.17) neutral(0.062) NULL TBCD 6904 genome.wustl.edu 37 17 80890603 80890603 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005993.4 +1 reviewed p.T1061 0.000 76 1.3% 50 44% 205 49.7% - - - superfamily_ARM repeat LOC441806 441806 genome.wustl.edu 37 18 856775 856775 + Silent SNP T T G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002344135.1 +1 model p.L54 0.998 42 0% 51 31.4% 0 - - - - HMMPfam_SAC3_GANP NDC80 10403 genome.wustl.edu 37 18 2610795 2610795 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006101.2 +1 validated p.R576* 0.995 90 0% 130 41.5% 11 27.2% - - - NULL DLGAP1 9229 genome.wustl.edu 37 18 3879898 3879898 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004746.2 -1 provisional p.C57 0.987 32 0% 16 56.2% 0 - - - - NULL SOGA2 23255 genome.wustl.edu 37 18 8720395 8720395 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015210.3 +1 predicted p.R86 0.095 79 0% 70 38.6% 1 100% - - - NULL AFG3L2 10939 genome.wustl.edu 37 18 12344172 12344172 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006796.1 -1 reviewed p.V580I 0.998 90 0% 53 34% 67 61.1% possibly_damaging(0.492) tolerated(0.5) neutral(0.174) HMMPfam_Peptidase_M41,superfamily_SSF52540 TMEM241 85019 genome.wustl.edu 37 18 20889660 20889660 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032933.4 -1 validated p.S272G 0.325 160 0% 137 29.9% 5 60% benign(0.006) tolerated(0.13) neutral(0.253) superfamily_Multidrug resistance efflux transporter EmrE ZNF521 25925 genome.wustl.edu 37 18 22805887 22805887 + Silent SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015461.2 -1 validated p.T665 1.000 66 0% 51 49% 1 0% - - - HMMPfam_zf-C2H2,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers CDH2 1000 genome.wustl.edu 37 18 25585947 25585947 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001792.3 -1 reviewed p.H238R 1.000 124 0% 128 36.7% 4 50% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like NOL4 8715 genome.wustl.edu 37 18 31803068 31803068 + Missense_Mutation SNP G G C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003787.3 -1 validated p.N50K 1.000 94 0% 66 43.9% 0 - benign(0.133) tolerated(0.51) neutral(0.020) NULL SETBP1 26040 genome.wustl.edu 37 18 42281739 42281739 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015559.2 +1 validated p.R143H 0.981 25 0% 40 47.5% 1 0% probably_damaging(0.99) tolerated(0.06) deleterious(0.764) NULL SLC14A1 6563 genome.wustl.edu 37 18 43311041 43311041 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001128588.3 +1 reviewed p.F127 0.888 96 0% 77 35.1% 4 25% - - - HMMPfam_UT CTIF 9811 genome.wustl.edu 37 18 46287773 46287773 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001142397.1 +1 validated p.V364M 1.000 40 0% 19 31.6% 6 50% possibly_damaging(0.915) deleterious(0.01) deleterious(0.772) NULL MYO5B 4645 genome.wustl.edu 37 18 47379828 47379828 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080467.2 -1 reviewed p.N1404 0.960 101 0% 78 38.5% 33 45.4% - - - NULL MEX3C 51320 genome.wustl.edu 37 18 48703613 48703613 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016626.4 -1 reviewed p.P363L 1.000 103 0% 114 49.1% 11 36.3% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMSmart_KH,HMMPfam_KH_1,superfamily_SSF54791 FECH 2235 genome.wustl.edu 37 18 55221537 55221537 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001012515.2 -1 reviewed p.T350 0.199 215 0% 219 35.6% 18 38.8% - - - HMMPfam_Ferrochelatase,superfamily_Chelatase SEC11C 90701 genome.wustl.edu 37 18 56819823 56819823 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033280.2 +1 provisional p.R85W 1.000 138 0% 173 34.1% 206 49.5% possibly_damaging(0.732) deleterious(0.01) deleterious(0.673) superfamily_LexA/Signal peptidase,HMMPfam_Peptidase_S24 SERPINB12 89777 genome.wustl.edu 37 18 61225619 61225619 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080474.1 +1 provisional p.S68N 0.000 95 0% 135 33.3% 0 - benign(0.039) tolerated(0.6) neutral(0.006) HMMPfam_Serpin,HMMSmart_SERPIN,superfamily_Prot_inh_serpin CDH7 1005 genome.wustl.edu 37 18 63525098 63525098 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004361.2 +1 reviewed p.D428Y 1.000 145 0% 117 47.9% 0 - probably_damaging(0.992) deleterious(0.05) deleterious(0.793) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like CDH7 1005 genome.wustl.edu 37 18 63547797 63547797 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004361.2 +1 reviewed p.N675 0.913 94 0% 115 19.1% 0 - - - - HMMPfam_Cadherin_C CDH19 28513 genome.wustl.edu 37 18 64172494 64172494 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021153.2 -1 reviewed p.I625T 0.916 51 0% 51 51% 0 - benign(0) tolerated(0.46) neutral(0.012) HMMPfam_Cadherin_C CNDP1 84735 genome.wustl.edu 37 18 72251796 72251796 + Nonstop_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032649.5 +1 reviewed p.*508Q 0.000 222 0% 341 36.4% 0 - - - - NULL ZNF236 7776 genome.wustl.edu 37 18 74617269 74617269 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007345.3 +1 validated p.R730Q 0.744 63 0% 68 45.6% 1 100% probably_damaging(0.998) tolerated(0.09) deleterious(0.771) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers RBFA 79863 genome.wustl.edu 37 18 77804233 77804233 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024805.2 +1 validated p.A200T 0.964 274 0% 295 43.1% 44 50% probably_damaging(0.999) tolerated(0.07) deleterious(0.809) NULL ABCA7 10347 genome.wustl.edu 37 19 1045074 1045074 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019112.3 +1 reviewed p.A430V 0.866 45 0% 16 37.5% 12 33.3% benign(0.023) tolerated(0.07) neutral(0.320) NULL ATP8B3 148229 genome.wustl.edu 37 19 1808241 1808241 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138813.2 -1 reviewed p.L166I 1.000 104 0% 62 43.5% 0 - probably_damaging(1) deleterious(0.01) deleterious(0.905) NULL AP3D1 8943 genome.wustl.edu 37 19 2129135 2129135 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003938.5 -1 validated p.R254W 0.696 63 0% 41 12.2% 39 28.2% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Adaptin_N,superfamily_ARM repeat ZNF57 126295 genome.wustl.edu 37 19 2917527 2917527 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_173480.2 +1 validated p.T303M 0.018 107 0% 96 37.5% 5 100% probably_damaging(1) deleterious(0.01) deleterious(0.905) superfamily_C2H2 and C2HC zinc fingers TLE2 7089 genome.wustl.edu 37 19 3005537 3005537 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003260.4 -1 validated p.S598 0.721 119 0% 52 36.5% 83 43.3% - - - HMMSmart_WD40,superfamily_WD40_like,HMMPfam_WD40 TLE2 7089 genome.wustl.edu 37 19 3019723 3019723 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003260.4 -1 validated p.V115M 1.000 48 0% 17 29.4% 23 34.7% benign(0) tolerated(1) - HMMPfam_TLE_N ENSG00000226800 0 genome.wustl.edu 37 19 3612056 3612056 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000447295 +1 known p.R110W 0.973 90 0% 43 58.1% 24 58.3% benign(0.001) tolerated(0.15) neutral(0.241) NULL C19orf29 58509 genome.wustl.edu 37 19 3612132 3612132 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080543.1 -1 validated p.R689H 1.000 74 0% 36 52.8% 24 29.1% possibly_damaging(0.93) tolerated(0.84) neutral(0.377) HMMPfam_CactinC_cactus PIP5K1C 23396 genome.wustl.edu 37 19 3661081 3661081 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012398.1 -1 reviewed p.S117 0.969 131 0% 97 45.4% 37 35.1% - - - HMMSmart_PIPKc,superfamily_SSF56104 STAP2 55620 genome.wustl.edu 37 19 4325250 4325250 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017720.2 -1 reviewed p.P345 0.000 98 0% 72 11.1% 201 4.9% - - - NULL SH3GL1 6455 genome.wustl.edu 37 19 4365495 4365495 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003025.2 -1 provisional p.G105 0.039 74 0% 27 44.4% 64 31.2% - - - HMMPfam_BAR,HMMSmart_SM00721 HDGFRP2 84717 genome.wustl.edu 37 19 4475475 4475475 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001001520.1 +1 reviewed p.Y61 0.990 81 0% 83 43.4% 57 35% - - - HMMPfam_PWWP,HMMSmart_SM00293,superfamily_Tudor/PWWP/MBT DPP9 91039 genome.wustl.edu 37 19 4714260 4714260 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_139159.4 -1 reviewed p.P49L 0.547 22 0% 11 63.6% 8 87.5% benign(0.007) tolerated(0.31) neutral(0.027) NULL DUS3L 56931 genome.wustl.edu 37 19 5788368 5788368 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020175.2 -1 validated p.T314 1.000 51 0% 25 40% 16 0% - - - HMMPfam_Dus,superfamily_FMN-linked oxidoreductases KHSRP 8570 genome.wustl.edu 37 19 6416804 6416804 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003685.2 -1 validated p.G424 0.000 29 0% 20 35% 64 34.3% - - - HMMSmart_SM00322,superfamily_Eukaryotic type KH-domain (KH-domain type I) TUBB4A 10382 genome.wustl.edu 37 19 6495338 6495338 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006087.2 -1 provisional p.R391H 1.000 61 0% 44 47.7% 16 0% probably_damaging(0.99) - - superfamily_Tubulin C-terminal domain-like VAV1 7409 genome.wustl.edu 37 19 6825376 6825376 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005428.2 +1 reviewed p.G262 0.004 62 0% 36 44.4% 2 0% - - - HMMPfam_RhoGEF,HMMSmart_RhoGEF,superfamily_DH-domain PNPLA6 10908 genome.wustl.edu 37 19 7620212 7620212 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006702.4 +1 reviewed p.T927 0.003 35 0% 20 55% 21 33.3% - - - superfamily_Acyl_Trfase/lysoPlipase CAMSAP3 57662 genome.wustl.edu 37 19 7676675 7676675 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080429.2 +1 validated p.S459 0.042 21 0% 11 36.4% 5 20% - - - NULL TIMM44 10469 genome.wustl.edu 37 19 8006005 8006005 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006351.3 -1 validated p.P41 0.000 93 0% 56 28.6% 8 50% - - - NULL ELAVL1 1994 genome.wustl.edu 37 19 8046013 8046013 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001419.2 -1 reviewed p.A77V 1.000 144 0% 133 29.3% 115 30.4% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_RRM_1,HMMSmart_SM00360,superfamily_RNA-binding domain RBD FBN3 84467 genome.wustl.edu 37 19 8197949 8197949 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032447.3 -1 reviewed p.V545M 0.998 56 0% 19 26.3% 8 12.5% benign(0.017) tolerated(1) neutral(0.001) HMMSmart_SM00179,HMMSmart_SM00181,HMMPfam_EGF_CA,PatternScan_EGF_CA,superfamily_EGF/Laminin HNRNPM 4670 genome.wustl.edu 37 19 8528547 8528547 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005968.3 +1 validated p.G139R 1.000 171 0% 219 42% 193 45.5% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_RRM_1,HMMSmart_SM00360,superfamily_RNA-binding domain RBD MYO1F 4542 genome.wustl.edu 37 19 8604848 8604848 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012335.3 -1 validated p.A559T 0.998 65 0% 40 32.5% 3 0% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_Myosin_head,HMMSmart_SM00242,superfamily_P-loop containing nucleoside triphosphate hydrolases MYO1F 4542 genome.wustl.edu 37 19 8615468 8615468 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012335.3 -1 validated p.Y294 0.553 179 0% 117 38.5% 3 0% - - - HMMPfam_Myosin_head,HMMSmart_SM00242,superfamily_P-loop containing nucleoside triphosphate hydrolases MUC16 94025 genome.wustl.edu 37 19 9018486 9018486 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024690.2 -1 validated p.R12563H 0.000 358 0% 371 35% 8 25% benign(0.044) - - HMMPfam_SEA,superfamily_SEA domain MUC16 94025 genome.wustl.edu 37 19 9087133 9087133 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024690.2 -1 validated p.T1561M 0.100 460 0% 393 43.3% 0 - unknown(0) - - NULL LOC100132973 100132973 genome.wustl.edu 37 19 9293164 9293165 + Splice_Site INS - - TTTATTTATTTATTTA novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_001726567.1 -1 model e2-1 1.000:1.000 - - - - - - - - - - KRI1 65095 genome.wustl.edu 37 19 10671868 10671868 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_023008.3 -1 validated p.R194C 0.987 85 0% 38 39.5% 23 34.7% probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL ILF3 3609 genome.wustl.edu 37 19 10794629 10794629 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017620.2 +1 reviewed p.S685L 1.000 240 0% 118 44.1% 191 46.5% unknown(0) deleterious(0) - NULL SMARCA4 6597 genome.wustl.edu 37 19 11132542 11132542 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001128849.1 +1 reviewed p.E920K 1.000 68 0% 24 29.2% 65 30.7% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_SNF2_N,HMMSmart_DEXDc,superfamily_SSF52540 SMARCA4 6597 genome.wustl.edu 37 19 11135079 11135079 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001128849.1 +1 reviewed p.V1016M 1.000 33 0% 25 36% 75 44% probably_damaging(0.995) tolerated(0.16) deleterious(0.517) HMMPfam_SNF2_N DOCK6 57572 genome.wustl.edu 37 19 11313258 11313258 + Splice_Site SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020812.2 -1 validated e42+2 0.990 59 0% 37 51.4% 1 0% - - - - SWSAP1 126074 genome.wustl.edu 37 19 11486417 11486417 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_175871.3 +1 validated p.V139M 0.699 76 0% 42 28.6% 6 33.3% probably_damaging(0.96) deleterious(0.01) deleterious(0.808) NULL RGL3 57139 genome.wustl.edu 37 19 11516069 11516069 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001035223.2 -1 validated p.R344C 0.943 59 0% 51 51% 44 34% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_RasGEF,HMMSmart_SM00147,superfamily_Ras GEF ZNF440 126070 genome.wustl.edu 37 19 11941167 11941167 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152357.2 +1 validated p.Q25K 0.676 232 0% 341 46.3% 5 60% probably_damaging(0.992) deleterious(0) deleterious(0.892) HMMPfam_KRAB,HMMSmart_KRAB,superfamily_Krueppel-associated_box ZNF878 729747 genome.wustl.edu 37 19 12155237 12155237 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080404.1 -1 inferred p.R374C 0.001 134 0% 161 14.9% 0 - possibly_damaging(0.715) deleterious(0) deleterious(0.704) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers ZNF490 57474 genome.wustl.edu 37 19 12691496 12691496 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020714.2 -1 validated p.E465K 0.452 170 0% 184 39.7% 3 66.6% possibly_damaging(0.702) tolerated(0.42) neutral(0.267) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 GCDH 2639 genome.wustl.edu 37 19 13007031 13007031 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000159.2 +1 reviewed p.S216 0.138 156 0% 100 40% 19 0% - - - HMMPfam_Acyl-CoA_dh_M,superfamily_Acyl-CoA dehydrogenase NM domain-like NFIX 4784 genome.wustl.edu 37 19 13136046 13136046 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002501.2 +1 validated p.R80H 1.000 53 0% 19 63.2% 19 36.8% probably_damaging(0.972) deleterious(0) deleterious(0.859) HMMPfam_MH1,HMMSmart_DWA TRMT1 55621 genome.wustl.edu 37 19 13218619 13218619 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001136035.2 -1 validated p.N484 0.984 161 0% 120 33.3% 54 46.2% - - - HMMPfam_TRM NOTCH3 4854 genome.wustl.edu 37 19 15289922 15289922 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000435.2 -1 reviewed p.S1211L 0.235 27 0% 16 37.5% 39 53.8% possibly_damaging(0.747) deleterious(0) deleterious(0.719) HMMSmart_SM00179,HMMSmart_SM00181 OR10H5 284433 genome.wustl.edu 37 19 15905562 15905562 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001004466.1 +1 provisional p.R235Q 0.001 243 0% 163 45.4% 0 - benign(0.36) tolerated(0.12) neutral(0.375) HMMPfam_7tm_1,superfamily_SSF81321 CPAMD8 27151 genome.wustl.edu 37 19 17122405 17122405 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015692.2 -1 validated p.R191* 1.000 91 0% 50 46% 4 0% - - - HMMPfam_A2M_N ANO8 57719 genome.wustl.edu 37 19 17441667 17441667 + Missense_Mutation SNP T T G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020959.2 -1 validated p.E321D 0.884 85 0% 44 52.3% 18 16.6% benign(0.142) tolerated(0.26) neutral(0.046) NULL SLC27A1 376497 genome.wustl.edu 37 19 17611111 17611111 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198580.1 +1 provisional p.R411C 1.000 54 0% 32 40.6% 26 42.3% probably_damaging(0.998) deleterious(0.01) deleterious(0.880) HMMPfam_AMP-binding,superfamily_SSF56801 GLT25D1 79709 genome.wustl.edu 37 19 17678282 17678282 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024656.2 +1 provisional p.T186M 1.000 90 0% 66 43.9% 56 33.9% probably_damaging(1) deleterious(0.03) deleterious(0.865) NULL UNC13A 23025 genome.wustl.edu 37 19 17769067 17769067 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001080421.2 -1 validated p.D279N 1.000 187 0% 150 47.3% 0 - probably_damaging(0.976) tolerated(0.05) deleterious(0.763) NULL SLC5A5 6528 genome.wustl.edu 37 19 17988625 17988625 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000453.2 +1 reviewed p.A264 0.325 173 0% 109 47.7% 2 100% - - - NULL LSM4 25804 genome.wustl.edu 37 19 18420491 18420491 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012321.3 -1 validated p.R109* 0.990 20 0% 14 28.6% 115 2.6% - - - superfamily_Sm-like ribonucleoproteins CRTC1 23373 genome.wustl.edu 37 19 18870863 18870863 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001098482.1 +1 validated p.P253 0.216 70 0% 30 50% 13 69.2% - - - NULL ZNF101 94039 genome.wustl.edu 37 19 19790744 19790744 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033204.2 +1 provisional p.A316T 0.991 65 0% 71 35.2% 15 20% benign(0.023) deleterious(0.03) neutral(0.365) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2 TSHZ3 57616 genome.wustl.edu 37 19 31767826 31767826 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020856.2 -1 validated p.R958Q 1.000 103 1% 64 50% 2 50% probably_damaging(0.987) deleterious(0) deleterious(0.881) HMMPfam_Homeobox,HMMSmart_HOX,superfamily_Homeodomain_like FXYD5 53827 genome.wustl.edu 37 19 35660478 35660478 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014164.5 +1 reviewed p.C166Y 0.465 86 0% 75 13.3% 75 1.3% possibly_damaging(0.952) deleterious(0) deleterious(0.840) HMMPfam_ATP1G1_PLM_MAT8 CD22 933 genome.wustl.edu 37 19 35836592 35836592 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001771.3 +1 validated p.R766C 0.077 122 0% 81 39.5% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL HAUS5 23354 genome.wustl.edu 37 19 36110955 36110955 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015302.1 +1 validated p.L483P 1.000 81 0% 34 14.7% 11 0% benign(0.046) tolerated(0.08) neutral(0.302) NULL RBM42 79171 genome.wustl.edu 37 19 36128377 36128377 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024321.3 +1 provisional p.R455H 1.000 140 0% 84 42.9% 170 40.5% unknown(0) deleterious(0.01) - HMMSmart_SM00360,superfamily_RNA-binding domain RBD MLL4 9757 genome.wustl.edu 37 19 36217157 36217157 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014727.1 +1 reviewed p.R1302 0.998 85 0% 40 57.5% 8 50% - - - superfamily_FYVE/PHD zinc finger,HMMPfam_PHD MLL4 9757 genome.wustl.edu 37 19 36221279 36221279 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014727.1 +1 reviewed p.R1705* 1.000 258 0% 208 40.4% 20 50% - - - NULL COX7A1 1346 genome.wustl.edu 37 19 36642592 36642592 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000437291 -1 known p.A57V 0.000 47 0% 20 20% 14 7.1% - - - HMMPfam_COX7a,superfamily_Mitochondrial cytochrome c oxidase subunit VIIa ZNF565 147929 genome.wustl.edu 37 19 36674278 36674278 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001042474.1 -1 validated p.C197Y 0.991 149 0% 141 34% 0 - probably_damaging(1) deleterious(0.02) deleterious(0.883) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 ZNF607 84775 genome.wustl.edu 37 19 38189321 38189321 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032689.4 -1 validated p.R571C 0.007 50 0% 76 36.8% 1 100% benign(0.149) tolerated(0.21) neutral(0.057) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers SUPT5H 6829 genome.wustl.edu 37 19 39965175 39965175 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001111020.2 +1 validated p.P947 0.942 75 0% 31 41.9% 170 50% - - - NULL DYRK1B 9149 genome.wustl.edu 37 19 40321075 40321075 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004714.1 -1 reviewed p.G104 1.000 124 0.8% 103 32% 42 28.5% - - - superfamily_Protein kinase-like (PK-like) PSMC4 5704 genome.wustl.edu 37 19 40486241 40486241 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006503.2 +1 reviewed p.R323W 1.000 166 0% 102 44.1% 184 46.7% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00382,HMMPfam_AAA,PatternScan_AAA,superfamily_P-loop containing nucleoside triphosphate hydrolases CYP2F1 1572 genome.wustl.edu 37 19 41633947 41633947 + Missense_Mutation SNP A A T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000774.3 +1 reviewed p.N479I 0.222 56 0% 31 48.4% 0 - probably_damaging(0.998) deleterious(0.03) deleterious(0.839) HMMPfam_p450,superfamily_Cytochrome P450 POU2F2 5452 genome.wustl.edu 37 19 42599759 42599759 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002698.2 -1 validated p.R282C 1.000 45 0% 26 26.9% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Homeobox,HMMSmart_HOX,superfamily_Homeodomain_like MEGF8 1954 genome.wustl.edu 37 19 42858864 42858864 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001410.2 +1 validated p.A1312V 1.000 62 0% 36 27.8% 2 0% probably_damaging(0.999) deleterious(0.02) deleterious(0.873) NULL LIPE 3991 genome.wustl.edu 37 19 42930446 42930446 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005357.2 -1 reviewed p.R286W 0.110 163 0% 146 43.8% 2 50% possibly_damaging(0.938) deleterious(0) deleterious(0.828) NULL XRCC1 7515 genome.wustl.edu 37 19 44055786 44055786 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006297.2 -1 reviewed p.R379H 1.000 38 0% 22 18.2% 52 3.8% probably_damaging(0.978) tolerated(0.09) deleterious(0.717) HMMPfam_BRCT,HMMSmart_SM00292,superfamily_BRCT domain SMG9 56006 genome.wustl.edu 37 19 44254813 44254813 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019108.2 -1 validated p.G27 0.994 64 0% 29 34.5% 10 30% - - - NULL KCNN4 3783 genome.wustl.edu 37 19 44271813 44271813 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002250.2 -1 reviewed p.H389R 0.014 177 0% 98 13.3% 102 25.4% probably_damaging(0.991) tolerated(0.24) deleterious(0.481) NULL ZNF296 162979 genome.wustl.edu 37 19 45575248 45575248 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145288.1 -1 provisional p.P347T 0.026 46 0% 22 31.8% 6 66.6% probably_damaging(0.995) deleterious(0.03) deleterious(0.822) NULL GPR4 2828 genome.wustl.edu 37 19 46094629 46094629 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005282.2 -1 validated p.T166A 1.000 18 0% 11 45.5% 2 0% possibly_damaging(0.663) tolerated(0.65) neutral(0.237) HMMPfam_7tm_1,superfamily_SSF81321 PPP5C 5536 genome.wustl.edu 37 19 46878978 46878978 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006247.2 +1 provisional p.V161M 0.279 52 0% 31 45.2% 48 41.6% possibly_damaging(0.822) deleterious(0.04) deleterious(0.660) HMMPfam_PPP5 ARHGAP35 2909 genome.wustl.edu 37 19 47422063 47422063 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004491.4 +1 reviewed p.R44H 1.000 145 0% 133 35.3% 5 20% probably_damaging(0.996) deleterious(0) deleterious(0.906) superfamily_P-loop containing nucleoside triphosphate hydrolases ARHGAP35 2909 genome.wustl.edu 37 19 47422424 47422424 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004491.4 +1 reviewed p.I164 0.465 140 0% 175 26.9% 1 0% - - - superfamily_P-loop containing nucleoside triphosphate hydrolases ARHGAP35 2909 genome.wustl.edu 37 19 47424093 47424093 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004491.4 +1 reviewed p.G721C 1.000 106 0.9% 116 26.7% 5 80% probably_damaging(1) deleterious(0) deleterious(0.945) NULL ARHGAP35 2909 genome.wustl.edu 37 19 47492845 47492845 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004491.4 +1 reviewed p.V1317M 1.000 134 0% 100 42% 13 61.5% probably_damaging(0.985) deleterious(0) deleterious(0.877) HMMPfam_RhoGAP,HMMSmart_SM00324,superfamily_GTPase activation domain GAP DHX34 9704 genome.wustl.edu 37 19 47863315 47863315 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014681.5 +1 reviewed p.V455I 0.987 121 0% 95 40% 14 42.8% possibly_damaging(0.67) deleterious(0.04) deleterious(0.587) HMMPfam_Helicase_C,HMMSmart_SM00490,superfamily_P-loop containing nucleoside triphosphate hydrolases ZNF114 163071 genome.wustl.edu 37 19 48789376 48789376 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_153608.1 +1 provisional p.N165 0.000 61 0% 59 20.3% 4 0% - - - NULL GRIN2D 2906 genome.wustl.edu 37 19 48925132 48925132 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000836.2 +1 reviewed p.D728N 1.000 67 0% 34 47.1% 0 - benign(0.218) tolerated(0.21) neutral(0.066) HMMPfam_Lig_chan,HMMSmart_PBPe,superfamily_SSF53850 KCNJ14 3770 genome.wustl.edu 37 19 48967677 48967677 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013348.2 +1 reviewed p.S318 0.097 155 0% 66 39.4% 5 20% - - - HMMPfam_IRK,superfamily_Ig_E-set FUT2 2524 genome.wustl.edu 37 19 49206962 49206962 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000511.5 +1 reviewed p.R250Q 0.956 108 0% 60 55% 7 42.8% possibly_damaging(0.691) deleterious(0.04) deleterious(0.597) HMMPfam_Glyco_transf_11 PLEKHA4 57664 genome.wustl.edu 37 19 49363622 49363622 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020904.2 -1 validated p.A154V 0.839 34 0% 28 46.4% 1 0% benign(0.107) tolerated(1) neutral(0.009) HMMSmart_SM00233 CGB2 114336 genome.wustl.edu 37 19 49536324 49536324 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033378.1 +1 reviewed p.R113H 0.527 123 0% 69 31.9% 0 - possibly_damaging(0.88) deleterious(0) deleterious(0.788) HMMSmart_GHB,HMMPfam_Cys_knot,PatternScan_GLYCO_HORMONE_BETA_2,superfamily_SSF57501 SNORD33 26818 genome.wustl.edu 37 19 49993878 49993878 + RNA SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NR_000020.1 +1 provisional NULL 0.031 25 0% 19 36.8% 3 100% - - - - MYH14 79784 genome.wustl.edu 37 19 50783320 50783320 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001077186.1 +1 reviewed p.A1320 0.006 96 0% 60 38.3% 102 39.2% - - - HMMPfam_Myosin_tail_1 POLD1 5424 genome.wustl.edu 37 19 50906786 50906786 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002691.2 +1 validated p.V392M 0.999 178 0% 117 30.8% 15 40% benign(0.327) deleterious(0.03) neutral(0.467) HMMPfam_DNA_pol_B_exo,HMMSmart_POLBc,superfamily_RNaseH_fold SHANK1 50944 genome.wustl.edu 37 19 51189537 51189537 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016148.2 -1 validated p.A845V 0.942 133 0% 66 10.6% 1 0% benign(0.195) deleterious(0.03) neutral(0.383) NULL KLK2 3817 genome.wustl.edu 37 19 51380242 51380242 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005551.3 +1 validated p.T203I 0.636 242 0% 185 51.4% 0 - benign(0.205) deleterious(0.04) neutral(0.369) HMMPfam_Trypsin,HMMSmart_SM00020,superfamily_Trypsin-like serine proteases KLK4 9622 genome.wustl.edu 37 19 51410258 51410258 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004917.3 -1 reviewed p.V233M 0.000 96 0% 86 41.9% 0 - possibly_damaging(0.677) tolerated(0.06) deleterious(0.564) HMMPfam_Trypsin,HMMSmart_SM00020,superfamily_Trypsin-like serine proteases KLK8 11202 genome.wustl.edu 37 19 51503939 51503939 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_144505.1 -1 reviewed p.A36T 0.000 69 0% 36 41.7% 0 - benign(0.036) - - NULL SIGLEC10 89790 genome.wustl.edu 37 19 51918270 51918270 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033130.4 -1 validated p.R475C 0.527 33 0% 15 26.7% 0 - benign(0.07) tolerated(0.13) neutral(0.258) superfamily_Immunoglobulin ZNF534 147658 genome.wustl.edu 37 19 52941131 52941131 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001143939.1 +1 validated p.S153G 0.017 140 0% 218 36.2% 0 - possibly_damaging(0.663) tolerated(0.35) neutral(0.255) superfamily_SSF57667 ZNF525 170958 genome.wustl.edu 37 19 53884068 53884068 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000474037 +1 known p.R79H 0.012 64 0% 179 40.2% 3 0% possibly_damaging(0.598) deleterious(0.05) deleterious(0.552) NULL LILRA6 79168 genome.wustl.edu 37 19 54745947 54745947 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024318.2 -1 validated p.A104T 0.000 484 0.2% 525 28.4% 1 0% probably_damaging(0.999) tolerated(0.52) deleterious(0.499) superfamily_SSF48726 LAIR1 3903 genome.wustl.edu 37 19 54868121 54868121 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002287.3 -1 reviewed p.R188C 0.000 176 0% 174 39.1% 8 0% possibly_damaging(0.493) deleterious(0) deleterious(0.609) NULL KIR3DL2 3812 genome.wustl.edu 37 19 55363598 55363598 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006737.2 +1 reviewed p.H72 0.000 201 0% 226 44.7% 0 - - - - HMMSmart_IG,HMMPfam_ig,superfamily_SSF48726 PPP1R12C 54776 genome.wustl.edu 37 19 55606125 55606125 + Nonsense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017607.2 -1 provisional p.S499* 0.000 107 0% 62 40.3% 28 21.4% - - - NULL U2AF2 11338 genome.wustl.edu 37 19 56175097 56175097 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007279.2 +1 reviewed p.S243 0.992 94 0% 62 22.6% 177 51.4% - - - superfamily_RNA-binding domain RBD EPN1 29924 genome.wustl.edu 37 19 56200686 56200686 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001130072.1 +1 validated p.D209 0.932 43 0% 21 33.3% 14 7.1% - - - HMMPfam_UIM,HMMSmart_UIM NLRP4 147945 genome.wustl.edu 37 19 56369488 56369488 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_134444.4 +1 validated p.P243 0.000 94 0% 56 35.7% 0 - - - - HMMPfam_NACHT ZNF787 126208 genome.wustl.edu 37 19 56600191 56600191 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000270459 -1 known p.T117M 0.993 27 0% 19 47.4% 80 55% probably_damaging(1) deleterious(0.01) deleterious(0.905) superfamily_C2H2 and C2HC zinc fingers ZNF583 147949 genome.wustl.edu 37 19 56934277 56934277 + Nonsense_Mutation SNP A A T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152478.2 +1 validated p.K84* 0.000 41 0% 62 51.6% 0 - - - - NULL ZNF583 147949 genome.wustl.edu 37 19 56935167 56935167 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152478.2 +1 validated p.Y380 0.008 166 0% 223 36.3% 1 100% - - - HMMPfam_zf-C2H2,HMMSmart_ZnF_C2H2,superfamily_SSF57667 ZFP28 140612 genome.wustl.edu 37 19 57066189 57066189 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020828.1 +1 provisional p.G679S 1.000 156 0% 143 41.3% 3 100% probably_damaging(1) deleterious(0.02) deleterious(0.883) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 ZNF71 58491 genome.wustl.edu 37 19 57133900 57133900 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021216.4 +1 validated p.C415 0.996 82 0% 34 38.2% 4 25% - - - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 ZNF419 79744 genome.wustl.edu 37 19 58002923 58002923 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001098491.1 +1 validated p.R54C 0.001 240 0% 183 41.5% 3 66.6% benign(0.008) tolerated(0.2) neutral(0.049) HMMPfam_KRAB,HMMSmart_SM00349,superfamily_KRAB domain (Kruppel-associated box Pfam 01352) ZNF530 348327 genome.wustl.edu 37 19 58118416 58118416 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020880.3 +1 validated p.R508Q 0.000 130 0% 149 42.3% 5 60% benign(0.246) tolerated(0.68) neutral(0.027) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 ZNF776 284309 genome.wustl.edu 37 19 58265198 58265198 + Nonsense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_173632.3 +1 validated p.G234* 0.002 49 0% 58 12.1% 2 50% - - - superfamily_C2H2 and C2HC zinc fingers ZNF606 80095 genome.wustl.edu 37 19 58489786 58489786 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_025027.3 -1 validated p.H754 0.993 184 0% 293 13.7% 6 16.6% - - - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers ZNF274 10782 genome.wustl.edu 37 19 58718307 58718307 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000424679 +1 known p.A159 0.000 59 0% 39 43.6% 5 40% - - - HMMPfam_SCAN,HMMSmart_SM00431 ZNF324 25799 genome.wustl.edu 37 19 58983056 58983056 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014347.1 +1 provisional p.C399 0.533 27 0% 14 42.9% 2 50% - - - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers CHMP2A 27243 genome.wustl.edu 37 19 59063080 59063080 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014453.2 -1 validated p.A202V 0.998 46 0% 39 41% 274 45.9% benign(0.264) tolerated(0.16) neutral(0.087) NULL RBCK1 10616 genome.wustl.edu 37 20 409217 409217 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031229.2 +1 reviewed p.T431M 1.000 62 0% 24 16.7% 62 8% probably_damaging(1) tolerated(0.06) deleterious(0.823) NULL SRXN1 140809 genome.wustl.edu 37 20 629465 629465 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080725.1 -1 provisional p.A103T 0.996 110 0% 67 41.8% 6 50% benign(0.081) tolerated(0.08) neutral(0.306) HMMSmart_SM00470 SIRPD 128646 genome.wustl.edu 37 20 1532544 1532544 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178460.2 -1 validated p.R72W 0.000 244 0% 286 35.7% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_IG,HMMPfam_V-set,superfamily_SSF48726 SIRPG 55423 genome.wustl.edu 37 20 1629948 1629948 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_018556.3 -1 reviewed p.P60 0.010 300 0% 330 40.3% 0 - - - - HMMSmart_SM00406,HMMSmart_SM00409,HMMPfam_V-set,superfamily_Immunoglobulin STK35 140901 genome.wustl.edu 37 20 2097362 2097362 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080836.3 +1 reviewed p.M182V 1.000 252 0% 257 12.5% 2 0% possibly_damaging(0.598) deleterious(0) deleterious(0.651) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase CPXM1 56265 genome.wustl.edu 37 20 2775282 2775282 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019609.4 -1 reviewed p.R622C 1.000 66 0% 53 35.8% 22 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMSmart_SM00631,superfamily_Zn-dependent exopeptidases FAM113A 64773 genome.wustl.edu 37 20 2820434 2820434 + Splice_Site SNP C C G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022760.3 -1 predicted e1+1 1.000 81 0% 41 34.1% 3 66.6% - - - - ADAM33 80332 genome.wustl.edu 37 20 3654720 3654720 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_025220.2 -1 reviewed p.Y243 0.693 136 0% 79 49.4% 1 0% - - - "HMMPfam_Reprolysin,superfamily_Metalloproteases (""zincins"") catalytic domain" SIGLEC1 6614 genome.wustl.edu 37 20 3677914 3677914 + Missense_Mutation SNP C C T rs148161998 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_023068.3 -1 reviewed p.R733Q 0.006 106 0% 66 47% 4 0% benign(0.031) tolerated(0.7) neutral(0.004) HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_ig,superfamily_Immunoglobulin C20orf27 54976 genome.wustl.edu 37 20 3734842 3734842 + Silent SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000405186 -1 known p.G5 0.011 40 0% 15 46.7% 0 - - - - NULL PLCB1 23236 genome.wustl.edu 37 20 8639183 8639183 + Splice_Site SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015192.2 +1 reviewed e9-2 0.998 79 0% 106 40.6% 0 - - - - - PAX1 5075 genome.wustl.edu 37 20 21695332 21695332 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006192.3 +1 validated p.P499Q 0.000 31 0% 23 39.1% 0 - probably_damaging(0.989) deleterious(0) deleterious(0.884) NULL GGTLC1 92086 genome.wustl.edu 37 20 23966580 23966580 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178311.2 -1 reviewed p.T112 0.993 119 0% 57 40.4% 13 0% - - - HMMPfam_G_glu_transpept ENTPD6 955 genome.wustl.edu 37 20 25190494 25190494 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001247.2 +1 reviewed p.T129M 0.995 267 0% 278 30.6% 35 48.5% probably_damaging(0.968) tolerated(0.24) neutral(0.447) HMMPfam_GDA1_CD39 PYGB 5834 genome.wustl.edu 37 20 25255252 25255252 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002862.3 +1 reviewed p.R185C 1.000 52 0% 24 20.8% 33 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_Phosphorylase,superfamily_SSF53756 ZNF337 26152 genome.wustl.edu 37 20 25657650 25657650 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015655.2 -1 validated p.R92W 0.000 119 0% 97 40.2% 9 22.2% probably_damaging(0.999) deleterious(0.03) deleterious(0.855) NULL POFUT1 23509 genome.wustl.edu 37 20 30818818 30818818 + Missense_Mutation SNP A A C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015352.1 +1 reviewed p.D311A 1.000 144 0% 95 28.4% 28 42.8% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_O-FucT SUN5 140732 genome.wustl.edu 37 20 31592111 31592111 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080675.3 -1 validated p.G12 0.000 73 0% 58 32.8% 0 - - - - NULL MYH7B 57644 genome.wustl.edu 37 20 33567264 33567264 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020884.3 +1 reviewed p.G97R 1.000 52 0% 22 50% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Myosin_N,superfamily_P-loop containing nucleoside triphosphate hydrolases MYH7B 57644 genome.wustl.edu 37 20 33570346 33570346 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020884.3 +1 reviewed p.P246 0.990 47 0% 35 31.4% 0 - - - - HMMPfam_Myosin_head,HMMSmart_SM00242,superfamily_P-loop containing nucleoside triphosphate hydrolases CEP250 11190 genome.wustl.edu 37 20 34067203 34067203 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007186.3 +1 reviewed p.V748M 0.403 45 0% 40 40% 8 50% benign(0.011) tolerated(0.15) neutral(0.241) NULL DLGAP4 22839 genome.wustl.edu 37 20 35128934 35128934 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014902.4 +1 reviewed p.L808P 1.000 27 0% 17 29.4% 78 17.9% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_GKAP TGM2 7052 genome.wustl.edu 37 20 36766595 36766595 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004613.2 -1 reviewed p.R512H 0.998 141 0% 64 34.4% 19 15.7% possibly_damaging(0.903) tolerated(0.16) neutral(0.417) HMMPfam_Transglut_C,superfamily_Transglutaminase two C-terminal domains FAM83D 81610 genome.wustl.edu 37 20 37580570 37580570 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_030919.2 +1 validated p.A419T 0.656 62 1.6% 23 39.1% 18 27.7% benign(0.048) deleterious(0.04) neutral(0.352) NULL LPIN3 64900 genome.wustl.edu 37 20 39981281 39981281 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022896.1 +1 validated p.L467I 0.879 133 0.8% 120 40.8% 1 0% benign(0.378) tolerated(0.06) neutral(0.443) NULL LOC100287031 100287031 genome.wustl.edu 37 20 42143816 42143816 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002343705.1 -1 model p.C32 0.000 43 0% 27 59.3% 0 - - - - NULL L3MBTL1 26013 genome.wustl.edu 37 20 42168905 42168905 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015478.5 +1 reviewed p.A673V 0.997 92 0% 35 54.3% 1 100% possibly_damaging(0.819) tolerated(0.18) neutral(0.365) NULL GDAP1L1 78997 genome.wustl.edu 37 20 42885867 42885867 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000445952 +1 known p.G32R 1.000 35 0% 28 25% 0 - - - - HMMPfam_GST_N,superfamily_Thioredoxin-like TTPAL 79183 genome.wustl.edu 37 20 43118137 43118137 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001039199.1 +1 validated p.D328 0.724 84 0% 44 54.5% 4 50% - - - NULL UBE2C 11065 genome.wustl.edu 37 20 44444140 44444140 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_181799.1 +1 reviewed p.L110 0.000 73 0% 52 40.4% 1 0% - - - HMMSmart_SM00212,superfamily_UBC-like PLTP 5360 genome.wustl.edu 37 20 44533712 44533712 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006227.2 -1 reviewed p.R251W 0.249 72 0% 38 39.5% 21 0% possibly_damaging(0.768) tolerated(0.12) deleterious(0.545) HMMPfam_LBP_BPI_CETP_C,superfamily_Bactericidal permeability-increasing protein BPI EYA2 2139 genome.wustl.edu 37 20 45771717 45771717 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005244.4 +1 reviewed p.R303H 1.000 214 0% 193 39.9% 187 39.5% probably_damaging(1) tolerated(0.11) deleterious(0.772) HMMPfam_Hydrolase SULF2 55959 genome.wustl.edu 37 20 46294839 46294839 + Missense_Mutation SNP T T C rs184990645 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000371978 -1 known p.T19A 1.000 269 0% 117 10.3% 38 0% probably_damaging(0.999) deleterious(0.02) deleterious(0.873) NULL ZNFX1 57169 genome.wustl.edu 37 20 47865471 47865471 + Missense_Mutation SNP A A T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021035.2 -1 validated p.S1364T 1.000 76 0% 52 38.5% 20 75% possibly_damaging(0.912) tolerated(0.39) neutral(0.380) NULL ZNFX1 57169 genome.wustl.edu 37 20 47869320 47869320 + Silent SNP A A T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021035.2 -1 validated p.L1051 1.000 131 0% 93 44.1% 9 22.2% - - - superfamily_P-loop containing nucleoside triphosphate hydrolases SNORD12B 100113393 genome.wustl.edu 37 20 47896922 47896922 + RNA SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NR_003695.1 +1 provisional NULL 1.000 263 0% 254 32.3% 2 100% - - - - LOC100128598 100128598 genome.wustl.edu 37 20 49626579 49626579 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_001716142.1 +1 model p.V489I 0.997 52 0% 20 55% 0 - - - - NULL ATP9A 10079 genome.wustl.edu 37 20 50221454 50221454 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006045.1 -1 validated p.A970V 1.000 36 0% 13 30.8% 25 44% benign(0.043) tolerated(0.1) neutral(0.289) NULL ZFP64 55734 genome.wustl.edu 37 20 50701141 50701141 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_199427.2 -1 validated p.S631 0.011 33 0% 25 28% 4 75% - - - NULL GNAS 2778 genome.wustl.edu 37 20 57485819 57485819 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080425.2 +1 reviewed p.R1017C 1.000 151 0% 82 36.6% 7504 34.1% probably_damaging(1) tolerated(0.1) deleterious(0.786) HMMPfam_G-alpha,HMMSmart_SM00275,superfamily_P-loop containing nucleoside triphosphate hydrolases ZNF831 128611 genome.wustl.edu 37 20 57766659 57766659 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_178457.1 +1 provisional p.T195 0.000 18 0.000 9 0.667 0 - - - - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 GATA5 140628 genome.wustl.edu 37 20 61048518 61048518 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080473.4 -1 reviewed p.G214S 1.000 25 0% 20 50% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_GATA,HMMSmart_ZnF_GATA,superfamily_SSF57716 KCNQ2 3785 genome.wustl.edu 37 20 62070998 62070998 + Missense_Mutation SNP C C G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_172107.2 -1 reviewed p.A294P 1.000 88 0% 41 36.6% 0 - probably_damaging(0.997) deleterious(0) deleterious(0.911) HMMPfam_Ion_trans,superfamily_Voltage-gated potassium channels PRIC285 85441 genome.wustl.edu 37 20 62192178 62192178 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001037335.2 -1 reviewed p.D2417 0.011 78 0% 30 26.7% 24 29.1% - - - superfamily_P-loop containing nucleoside triphosphate hydrolases PRPF6 24148 genome.wustl.edu 37 20 62654141 62654141 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012469.3 +1 reviewed p.R560Q 1.000 81 0% 37 27% 108 23.1% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_HAT,superfamily_SSF48452 GABPA 2551 genome.wustl.edu 37 21 27124342 27124342 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002040.3 +1 validated p.A117V 1.000 137 0% 215 13.5% 3 33.3% benign(0) tolerated(0.72) neutral(0.002) NULL N6AMT1 29104 genome.wustl.edu 37 21 30248795 30248795 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013240.3 -1 reviewed p.M186T 1.000 239 0% 285 40% 4 25% possibly_damaging(0.851) deleterious(0) deleterious(0.772) HMMPfam_MTS,superfamily_S-adenosyl-L-methionine-dependent methyltransferases KRTAP19-4 337971 genome.wustl.edu 37 21 31869296 31869296 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_181610.1 -1 provisional p.G45R 0.011 223 0% 183 40.4% 0 - unknown(0) - - NULL TIAM1 7074 genome.wustl.edu 37 21 32639166 32639166 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003253.2 -1 validated p.H41 1.000 64 0% 43 25.6% 3 33.3% - - - NULL SETD4 54093 genome.wustl.edu 37 21 37417981 37417981 + Missense_Mutation SNP C C T rs145926295 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017438.3 -1 validated p.V209M 0.999 32 0% 20 45% 28 57.1% probably_damaging(0.993) deleterious(0.01) deleterious(0.856) HMMPfam_SET,superfamily_SET domain TTC3 7267 genome.wustl.edu 37 21 38494133 38494133 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001001894.1 +1 validated p.C306Y 1.000 97 0% 205 38% 14 57.1% probably_damaging(0.991) deleterious(0) deleterious(0.889) HMMPfam_TPR_1,superfamily_SSF48452 BRWD1 54014 genome.wustl.edu 37 21 40608668 40608668 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000455867 -1 known p.H541Y 0.996 191 0% 243 38.7% 1 0% - - - NULL DSCAM 1826 genome.wustl.edu 37 21 41648061 41648061 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001389.3 -1 validated p.G773 1.000 104 0% 108 38% 0 - - - - HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_I-set,superfamily_Immunoglobulin FAM3B 54097 genome.wustl.edu 37 21 42718976 42718976 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_058186.3 +1 validated p.A145V 0.220 232 0% 241 18.7% 1 0% benign(0.001) tolerated(0.2) neutral(0.049) NULL PDE9A 5152 genome.wustl.edu 37 21 44181017 44181017 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002606.2 +1 reviewed p.T362M 1.000 65 0% 60 43.3% 20 25% probably_damaging(0.999) tolerated(0.06) deleterious(0.813) HMMPfam_PDEase_I,PatternScan_PDEASE_I,HMMSmart_SM00471,superfamily_HD-domain/PDEase-like LRRC3 81543 genome.wustl.edu 37 21 45876938 45876938 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_030891.3 +1 validated p.S137 0.002 34 0% 12 41.7% 0 - - - - superfamily_SSF52058 KRTAP10-7 386675 genome.wustl.edu 37 21 46021557 46021557 + Missense_Mutation SNP C C T rs180786399 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000380102 +1 known p.R346C 1.000 142 0% 59 40.7% 0 - unknown(0) tolerated(0.13) - HMMPfam_Keratin_B2 ITGB2 3689 genome.wustl.edu 37 21 46326847 46326847 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000211.3 -1 reviewed p.T104M 0.000 71 0% 49 40.8% 12 8.3% probably_damaging(0.988) tolerated(0.09) deleterious(0.734) HMMPfam_Integrin_beta,HMMSmart_INB POFUT2 23275 genome.wustl.edu 37 21 46702294 46702294 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_133635.4 -1 validated p.A203V 0.994 62 0% 36 41.7% 12 58.3% benign(0.008) tolerated(0.56) neutral(0.006) HMMPfam_O-FucT MCM3AP 8888 genome.wustl.edu 37 21 47697505 47697505 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003906.3 -1 reviewed p.T598 0.000 117 0% 64 29.7% 12 50% - - - NULL DIP2A 23181 genome.wustl.edu 37 21 47987311 47987311 + Missense_Mutation SNP G G C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015151.3 +1 reviewed p.V1498L 1.000 85 0% 59 44.1% 21 47.6% probably_damaging(0.999) tolerated(0.11) deleterious(0.762) superfamily_Acetyl-CoA synthetase-like IL17RA 23765 genome.wustl.edu 37 22 17583194 17583194 + Splice_Site SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014339.4 +1 reviewed e7+2 1.000 140 0% 121 43.8% 19 100% - - - - PRODH 5625 genome.wustl.edu 37 22 18918537 18918537 + Missense_Mutation SNP G G T rs60404632 TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_016335.3 -1 reviewed p.L150M 1.000 77 0% 46 41.3% 1 100% probably_damaging(0.988) deleterious(0.01) deleterious(0.843) superfamily_FAD-linked oxidoreductase RIMBP3 85376 genome.wustl.edu 37 22 20458195 20458195 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015672.1 -1 validated p.A1036V 0.006 294 0% 156 11.5% 0 - benign(0.328) deleterious(0.01) deleterious(0.509) superfamily_Fibronectin type III LZTR1 8216 genome.wustl.edu 37 22 21345975 21345975 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006767.3 +1 reviewed p.R284C 1.000 37 0% 20 30% 9 44.4% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Kelch_1,HMMSmart_SM00612,superfamily_Galactose oxidase central domain LZTR1 8216 genome.wustl.edu 37 22 21346043 21346043 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006767.3 +1 reviewed p.T306 0.005 33 0% 28 25% 17 41.1% - - - HMMPfam_Kelch_1,HMMSmart_SM00612,superfamily_Galactose oxidase central domain LOC100288305 100288305 genome.wustl.edu 37 22 24944944 24944944 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_002343772.1 +1 model p.G47R 0.067 47 0% 16 25% 19 52.6% - - - NULL SGSM1 129049 genome.wustl.edu 37 22 25243763 25243763 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001039948.2 +1 validated p.A101V 0.962 27 0% 12 41.7% 0 - benign(0.004) tolerated(0.27) neutral(0.034) HMMPfam_RUN MYO18B 84700 genome.wustl.edu 37 22 26194050 26194050 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032608.5 +1 reviewed p.A836V 0.965 51 0% 26 57.7% 0 - probably_damaging(1) tolerated(0.34) deleterious(0.523) HMMSmart_SM00242,superfamily_P-loop containing nucleoside triphosphate hydrolases CRYBB1 1414 genome.wustl.edu 37 22 27012128 27012128 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001887.3 -1 reviewed p.A52 0.012 169 0% 60 26.7% 0 - - - - NULL TTC28 23331 genome.wustl.edu 37 22 28394928 28394928 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001145418.1 -1 validated p.F1573 0.604 85 0% 37 51.4% 10 50% - - - NULL KREMEN1 83999 genome.wustl.edu 37 22 29533398 29533398 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_032045.4 +1 reviewed p.D234N 1.000 71 0% 39 41% 7 42.8% possibly_damaging(0.952) tolerated(0.08) deleterious(0.696) HMMPfam_CUB,HMMSmart_CUB,superfamily_CUB RFPL1 5988 genome.wustl.edu 37 22 29834903 29834903 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021026.2 +1 validated p.P41 0.162 216 0% 169 45.6% 0 - - - - HMMSmart_RING,HMMPfam_zf-C3HC4,superfamily_SSF57850 GAL3ST1 9514 genome.wustl.edu 37 22 30951209 30951209 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004861.1 -1 reviewed p.R335C 1.000 17 0% 12 75% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Gal-3-0_sulfotr SMTN 6525 genome.wustl.edu 37 22 31500430 31500430 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_134270.1 +1 reviewed p.R934H 1.000 38 0% 27 48.1% 62 43.5% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL LOC100133224 100133224 genome.wustl.edu 37 22 31552503 31552503 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 XM_001716151.1 -1 model p.C188 0.988 56 0% 122 42.6% 1 0% - - - HMMPfam_LSM,HMMSmart_SM00651,superfamily_Sm-like ribonucleoproteins FBXO7 25793 genome.wustl.edu 37 22 32894334 32894334 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012179.3 +1 reviewed p.S462 0.812 97 0% 84 31% 128 51.5% - - - NULL RBFOX2 23543 genome.wustl.edu 37 22 36161512 36161512 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001082578.1 -1 reviewed p.R259C 1.000 119 0% 200 30.5% 18 55.5% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_SSF54928 RBFOX2 23543 genome.wustl.edu 37 22 36236240 36236240 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001031695.2 -1 reviewed p.Q9R 1.000 112 0% 158 12% 3 0% benign(0.014) tolerated(0.25) neutral(0.037) NULL APOL1 8542 genome.wustl.edu 37 22 36653179 36653179 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145343.2 +1 reviewed p.A48V 0.000 151 0% 143 42% 23 39.1% unknown(0) tolerated(0.06) - NULL EIF3D 8664 genome.wustl.edu 37 22 36907688 36907688 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003753.3 -1 reviewed p.M499V 1.000 157 0.6% 109 35.8% 358 39.3% benign(0.413) deleterious(0.01) deleterious(0.539) HMMPfam_eIF-3_zeta SSTR3 6753 genome.wustl.edu 37 22 37603480 37603480 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001051.2 -1 reviewed p.A121 0.003 50 0% 27 37% 0 - - - - HMMPfam_7tm_1,superfamily_SSF81321 DMC1 11144 genome.wustl.edu 37 22 38934571 38934571 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007068.2 -1 reviewed p.H211 1.000 67 0% 96 40.6% 2 50% - - - HMMSmart_AAA,HMMPfam_Rad51,superfamily_SSF52540 SUN2 25777 genome.wustl.edu 37 22 39141702 39141702 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015374.1 -1 validated p.S267L 0.003 52 0% 32 15.6% 22 0% benign(0.156) tolerated(0.08) neutral(0.314) NULL MGAT3 4248 genome.wustl.edu 37 22 39884801 39884801 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001098270.1 +1 reviewed p.A483 0.878 55 1.8% 29 44.8% 5 60% - - - HMMPfam_Glyco_transf_17 CACNA1I 8911 genome.wustl.edu 37 22 40066136 40066136 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021096.3 +1 reviewed p.V1430M 1.000 450 0% 336 41.1% 0 - possibly_damaging(0.893) deleterious(0) deleterious(0.796) HMMPfam_Ion_trans,superfamily_Voltage-gated potassium channels DNAJB7 150353 genome.wustl.edu 37 22 41257994 41257994 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_145174.1 -1 provisional p.V2A 1.000 91 0% 205 40.5% 0 - possibly_damaging(0.922) tolerated(0.32) neutral(0.396) HMMSmart_DnaJ,superfamily_DnaJ_N L3MBTL2 83746 genome.wustl.edu 37 22 41625569 41625569 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_031488.4 +1 validated p.T638 0.951 97 0% 87 36.8% 28 39.2% - - - NULL ACO2 50 genome.wustl.edu 37 22 41903905 41903905 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001098.2 +1 reviewed p.R95H 1.000 46 0% 18 44.4% 93 39.7% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Aconitase,superfamily_Aconitase_N TCF20 6942 genome.wustl.edu 37 22 42606436 42606436 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005650.1 -1 reviewed p.A1626T 0.950 336 0.3% 394 37.6% 10 60% benign(0.002) deleterious(0.01) neutral(0.406) NULL BIK 638 genome.wustl.edu 37 22 43524622 43524622 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001197.3 +1 reviewed p.P127 0.000 91 0% 76 34.2% 26 50% - - - NULL TTLL12 23170 genome.wustl.edu 37 22 43575882 43575882 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015140.3 -1 validated p.T224M 1.000 28 0.000 9 0.667 21 23.8% probably_damaging(0.992) deleterious(0) deleterious(0.892) NULL SCUBE1 80274 genome.wustl.edu 37 22 43654225 43654225 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_173050.2 -1 validated p.E243K 1.000 87 0% 62 33.9% 1 0% benign(0.224) deleterious(0.02) neutral(0.405) superfamily_SSF57196 EFCAB6 64800 genome.wustl.edu 37 22 44063071 44063071 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022785.2 -1 validated p.I632M 0.043 365 0% 562 14.6% 2 0% probably_damaging(0.998) tolerated(0.23) deleterious(0.516) superfamily_EF-hand NUP50 10762 genome.wustl.edu 37 22 45579383 45579383 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_007172.3 +1 reviewed p.R396W 1.000 148 0% 207 44% 11 54.5% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Ran_BP1,HMMSmart_SM00160,superfamily_PH domain-like KIAA0930 23313 genome.wustl.edu 37 22 45601701 45601701 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015264.1 -1 validated p.S108 1.000 41 0% 38 52.6% 26 23% - - - HMMPfam_DUF2045 FAM19A5 25817 genome.wustl.edu 37 22 49103590 49103590 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001082967.1 +1 validated p.C108 0.661 84 0% 47 31.9% 17 100% - - - NULL PANX2 56666 genome.wustl.edu 37 22 50615406 50615406 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_052839.3 +1 reviewed p.R89C 1.000 39 0% 25 48% 8 37.5% probably_damaging(0.999) tolerated(0.19) deleterious(0.540) NULL TUBGCP6 85378 genome.wustl.edu 37 22 50664611 50664611 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020461.3 -1 reviewed p.L567 0.019 122 0% 89 42.7% 15 60% - - - HMMPfam_Spc97_Spc98 SBF1 6305 genome.wustl.edu 37 22 50905770 50905770 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_002972.2 -1 validated p.S182 0.075 62 0% 30 46.7% 13 30.7% - - - HMMPfam_DENN,HMMSmart_SM00799 KLHDC7B 113730 genome.wustl.edu 37 22 50987954 50987954 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138433.3 +1 validated p.Y453 0.920 21 0% 22 31.8% 3 0% - - - HMMPfam_Kelch_1,HMMSmart_SM00612,superfamily_Galactose oxidase central domain PPP2R3B 28227 genome.wustl.edu 37 X 306304 306304 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013239.4 -1 reviewed p.T328M 0.998 158 0% 119 39.5% 17 23.5% possibly_damaging(0.85) deleterious(0.04) deleterious(0.676) superfamily_EF-hand PPP2R3B 28227 genome.wustl.edu 37 X 306335 306335 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013239.4 -1 reviewed p.V318I 1.000 168 0% 133 35.3% 23 69.5% probably_damaging(0.994) deleterious(0) deleterious(0.897) superfamily_EF-hand ZBED1 9189 genome.wustl.edu 37 X 2408502 2408502 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004729.3 -1 reviewed p.R87C 0.999 217 0% 161 36.6% 9 55.5% probably_damaging(1) deleterious(0.01) deleterious(0.905) NULL HDHD1 8226 genome.wustl.edu 37 X 6995418 6995418 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001135565.1 -1 reviewed p.A141V 0.000 75 0% 50 36% 6 33.3% benign(0) tolerated(0.33) neutral(0.024) HMMPfam_Hydrolase,superfamily_HAD-like KAL1 3730 genome.wustl.edu 37 X 8504916 8504916 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000216.2 -1 reviewed p.R506Q 0.523 285 0% 296 35.5% 5 100% benign(0.393) tolerated(0.52) neutral(0.135) HMMSmart_FN3 FAM9A 171482 genome.wustl.edu 37 X 8763336 8763336 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_174951.3 -1 validated p.A205V 0.125 255 0.4% 202 40.6% 0 - unknown(0) - - NULL FAM9A 171482 genome.wustl.edu 37 X 8767124 8767124 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_174951.3 -1 validated p.A35T 0.002 235 0% 141 44% 0 - possibly_damaging(0.93) deleterious(0) deleterious(0.821) NULL GPR143 4935 genome.wustl.edu 37 X 9707712 9707712 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000447366 -1 known p.R247W 0.840 106 0% 79 34.2% 11 100% - - - HMMPfam_Ocular_alb SHROOM2 357 genome.wustl.edu 37 X 9907350 9907350 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001649.2 +1 reviewed p.Q1419* 1.000 94 0% 44 47.7% 5 0% - - - HMMPfam_ASD2 TLR8 51311 genome.wustl.edu 37 X 12937667 12937667 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138636.4 +1 reviewed p.I170V 0.000 51 0% 84 15.5% 0 - benign(0.005) tolerated(0.3) neutral(0.029) superfamily_SSF52047 ASB11 140456 genome.wustl.edu 37 X 15306084 15306084 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080873.1 -1 reviewed p.R256C 0.001 134 0% 104 32.7% 0 - benign(0) tolerated(0.24) neutral(0.037) HMMPfam_Ank,HMMSmart_ANK,superfamily_ANK PIR 8544 genome.wustl.edu 37 X 15497927 15497927 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001018109.1 -1 reviewed p.P38 0.850 146 0% 260 36.9% 28 100% - - - HMMPfam_Pirin,superfamily_RmlC_like_cupin NHS 4810 genome.wustl.edu 37 X 17743974 17743974 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_198270.2 +1 reviewed p.R562H 0.275 84 0% 34 38.2% 3 0% probably_damaging(0.999) tolerated(0.07) deleterious(0.809) NULL MAP3K15 389840 genome.wustl.edu 37 X 19433334 19433334 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000338883 -1 known p.R494H 1.000 102 0% 142 47.2% 0 - benign(0.008) tolerated(0.58) neutral(0.005) NULL MAP7D2 256714 genome.wustl.edu 37 X 20033417 20033417 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152780.3 -1 validated p.E517G 1.000 330 0% 316 43.4% 0 - probably_damaging(0.995) deleterious(0) deleterious(0.902) HMMPfam_MAP7 MAP7D2 256714 genome.wustl.edu 37 X 20043896 20043896 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152780.3 -1 validated p.G353 0.000 220 0.5% 190 22.1% 0 - - - - NULL FAM48B2 170067 genome.wustl.edu 37 X 24330195 24330195 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001136233.1 -1 provisional p.Q413R 0.000 293 0% 198 29.8% 0 - - - - NULL MAGEB6 158809 genome.wustl.edu 37 X 26212133 26212133 + Missense_Mutation SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_173523.2 +1 reviewed p.D57G 0.000 124 0.8% 126 27% 0 - benign(0) tolerated(0.52) neutral(0.009) NULL CXorf30 645090 genome.wustl.edu 37 X 36385108 36385108 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001098843.3 +1 validated p.C463 0.002 238 0% 301 38.2% 4 75% - - - NULL XK 7504 genome.wustl.edu 37 X 37545300 37545300 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021083.2 +1 reviewed p.R29H 0.671 30 0% 12 66.7% 7 0% benign(0.183) tolerated(0.32) neutral(0.041) HMMPfam_XK-related BCOR 54880 genome.wustl.edu 37 X 39913588 39913588 + Splice_Site SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001123385.1 -1 reviewed e12-2 1.000 70 0% 70 12.9% 0 - - - - - BCOR 54880 genome.wustl.edu 37 X 39933843 39933843 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001123385.1 -1 reviewed p.Y252 1.000 50 0% 27 48.1% 8 0% - - - NULL BCOR 54880 genome.wustl.edu 37 X 39934080 39934080 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001123385.1 -1 reviewed p.S173 0.588 127 1.6% 114 45.6% 5 0% - - - NULL MED14 9282 genome.wustl.edu 37 X 40556323 40556323 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004229.3 -1 reviewed p.K535E 1.000 264 0% 454 37.2% 9 100% benign(0.001) tolerated(0.15) neutral(0.241) NULL USP9X 8239 genome.wustl.edu 37 X 41073934 41073934 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001039590.2 +1 reviewed p.A1768V 1.000 142 0% 282 13.5% 19 15.7% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_UCH,superfamily_Cysteine proteinases CHST7 56548 genome.wustl.edu 37 X 46433936 46433936 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_019886.2 +1 reviewed p.A190 0.968 27 0.000 8 0.625 4 0% - - - HMMPfam_Sulfotransfer_1,superfamily_SSF52540 RP2 6102 genome.wustl.edu 37 X 46737004 46737004 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006915.2 +1 reviewed p.N316 0.015 391 0% 886 37.5% 8 75% - - - superfamily_NDK RGN 9104 genome.wustl.edu 37 X 46949305 46949305 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004683.4 +1 reviewed p.S159 0.978 148 0% 127 50.4% 0 - - - - HMMPfam_SGL,superfamily_Calcium-dependent phosphotriesterase USP11 8237 genome.wustl.edu 37 X 47100807 47100807 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004651.3 +1 reviewed p.A369 0.013 101 0% 63 12.7% 24 4.1% - - - HMMPfam_UCH,superfamily_SSF54001 PORCN 64840 genome.wustl.edu 37 X 48372702 48372702 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_203475.1 +1 reviewed p.T265M 0.999 106 0% 87 37.9% 10 0% probably_damaging(0.965) deleterious(0.03) deleterious(0.771) HMMPfam_MBOAT USP27X 389856 genome.wustl.edu 37 X 49645861 49645861 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001145073.1 +1 provisional p.A317 0.993 138 0% 149 35.6% 3 0% - - - HMMPfam_UCH,superfamily_SSF54001 SHROOM4 57477 genome.wustl.edu 37 X 50377833 50377833 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020717.3 -1 reviewed p.E414K 1.000 82 0% 54 51.9% 0 - probably_damaging(0.971) deleterious(0.04) deleterious(0.762) NULL SMC1A 8243 genome.wustl.edu 37 X 53430550 53430550 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_006306.2 -1 reviewed p.R790W 1.000 474 0% 432 40.3% 23 39.1% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_SMC_N,superfamily_SSF52540 FGD1 2245 genome.wustl.edu 37 X 54482182 54482182 + Silent SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004463.2 -1 reviewed p.L626 1.000 171 0% 108 38.9% 7 100% - - - HMMPfam_PH,HMMSmart_PH,superfamily_SSF50729 FAM123B 139285 genome.wustl.edu 37 X 63412635 63412635 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152424.3 -1 reviewed p.R178C 0.995 91 0% 48 35.4% 0 - probably_damaging(1) deleterious(0.02) deleterious(0.883) HMMPfam_WTX IGBP1 3476 genome.wustl.edu 37 X 69368658 69368658 + Silent SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001551.2 +1 reviewed p.P242 1.000 101 0% 133 24.1% 53 0% - - - HMMPfam_TAP42 TAF1 6872 genome.wustl.edu 37 X 70608222 70608222 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004606.3 +1 reviewed p.R875C 1.000 106 0% 130 37.7% 1 100% probably_damaging(1) deleterious(0) deleterious(0.945) NULL KIAA2022 340533 genome.wustl.edu 37 X 73961905 73961905 + Silent SNP A A G novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001008537.2 -1 validated p.S829 0.977 153 0% 144 38.9% 1 0% - - - NULL ATP7A 538 genome.wustl.edu 37 X 77254125 77254125 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000052.4 +1 reviewed p.G496D 1.000 133 0% 168 41.7% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_HMA,superfamily_HMA heavy metal-associated domain,PatternScan_HMA_1 POU3F4 5456 genome.wustl.edu 37 X 82764003 82764003 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000307.3 +1 reviewed p.G224V 1.000 51 0% 33 36.4% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Pou,HMMSmart_POU,superfamily_Lambda_like_DNA RPS6KA6 27330 genome.wustl.edu 37 X 83319304 83319304 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_014496.4 -1 reviewed p.R740Q 1.000 185 0% 211 47.4% 0 - benign(0.222) tolerated(0.63) neutral(0.025) NULL ZNF711 7552 genome.wustl.edu 37 X 84526279 84526279 + Silent SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021998.4 +1 reviewed p.L577 1.000 117 0% 108 42.6% 1 0% - - - HMMPfam_zf-C2H2,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers NAP1L3 4675 genome.wustl.edu 37 X 92927569 92927569 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_004538.4 -1 reviewed p.T245 0.004 182 0% 390 36.9% 0 - - - - HMMPfam_NAP RPA4 29935 genome.wustl.edu 37 X 96139732 96139732 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_013347.4 +1 reviewed p.E141D 0.000 143 0% 150 35.3% 0 - benign(0.177) deleterious(0.01) neutral(0.422) HMMPfam_tRNA_anti,superfamily_Nucleic_acid_OB PCDH19 57526 genome.wustl.edu 37 X 99661886 99661886 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001105243.1 -1 reviewed p.N570 0.967 199 0.5% 106 47.2% 6 0% - - - superfamily_Cadherin PCDH19 57526 genome.wustl.edu 37 X 99662368 99662368 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001105243.1 -1 reviewed p.R410W 0.368 159 0% 104 38.5% 2 100% probably_damaging(1) tolerated(0.18) deleterious(0.556) HMMPfam_Cadherin,HMMSmart_CA,superfamily_Cadherin TSPAN6 7105 genome.wustl.edu 37 X 99887531 99887531 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003270.2 -1 reviewed p.S207L 1.000 122 0% 197 42.1% 147 88.4% possibly_damaging(0.795) deleterious(0.02) deleterious(0.681) superfamily_Tetraspanin,HMMPfam_Tetraspannin NXF3 56000 genome.wustl.edu 37 X 102339643 102339643 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_022052.1 -1 reviewed p.Y66C 0.968 137 0% 145 15.9% 0 - probably_damaging(1) deleterious(0.01) deleterious(0.905) NULL RAB40A 142684 genome.wustl.edu 37 X 102755443 102755443 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_080879.2 -1 reviewed p.R81H 1.000 211 0% 140 33.6% 0 - probably_damaging(0.997) deleterious(0.01) deleterious(0.872) HMMSmart_RAB,HMMPfam_Ras,superfamily_SSF52540 TBC1D8B 54885 genome.wustl.edu 37 X 106083996 106083996 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_017752.2 +1 validated p.R534H 1.000 127 0% 95 37.9% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_TBC,HMMSmart_SM00164,superfamily_Ypt/Rab-GAP domain of gyp1p RGAG1 57529 genome.wustl.edu 37 X 109693940 109693940 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_020769.2 +1 validated p.M32T 0.001 128 0% 129 46.5% 0 - benign(0) deleterious(0.02) neutral(0.383) NULL AMOT 154796 genome.wustl.edu 37 X 112022635 112022635 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001113490.1 -1 reviewed p.A916V 0.966 103 0% 38 65.8% 2 0% unknown(0) deleterious(0.03) - NULL KLHL13 90293 genome.wustl.edu 37 X 117043861 117043861 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033495.3 -1 reviewed p.L257F 1.000 54 0% 48 27.1% 14 0% probably_damaging(0.997) deleterious(0.01) deleterious(0.872) HMMPfam_BACK KLHL13 90293 genome.wustl.edu 37 X 117054291 117054291 + Missense_Mutation SNP T T C novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_033495.3 -1 reviewed p.T95A 0.997 175 0% 124 29.8% 17 0% benign(0.269) tolerated(0.06) neutral(0.351) HMMSmart_SM00225,superfamily_POZ domain,HMMPfam_BTB SEPT6 23157 genome.wustl.edu 37 X 118809625 118809625 + Missense_Mutation SNP C C A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_015129.5 -1 reviewed p.G13C 1.000 63 0% 37 37.8% 3 0% benign(0.247) tolerated(0.05) neutral(0.370) superfamily_P-loop containing nucleoside triphosphate hydrolases GRIA3 2892 genome.wustl.edu 37 X 122598815 122598815 + Nonsense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 ENST00000264357 +1 known p.R726* 1.000 92 1.1% 78 39.7% 0 - - - - HMMPfam_Lig_chan,HMMSmart_SM00079,superfamily_Periplasmic binding protein-like II SMARCA1 6594 genome.wustl.edu 37 X 128657270 128657270 + Silent SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_003069.3 -1 reviewed p.D26 0.981 98 0% 103 36.9% 2 0% - - - NULL BCORL1 63035 genome.wustl.edu 37 X 129171432 129171432 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_021946.3 +1 reviewed p.R1466W 0.993 72 0% 41 12.2% 3 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Ank,HMMSmart_SM00248,superfamily_Ankyrin repeat ZNF449 203523 genome.wustl.edu 37 X 134494444 134494444 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_152695.5 +1 reviewed p.R334W 0.005 63 0% 74 48.6% 1 100% probably_damaging(1) tolerated(0.07) deleterious(0.819) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers MAP7D3 79649 genome.wustl.edu 37 X 135313107 135313107 + Nonsense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_024597.3 -1 reviewed p.Q478* 0.001 193 0% 217 40.6% 1 0% - - - NULL BRS3 680 genome.wustl.edu 37 X 135572636 135572636 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001727.1 +1 validated p.R260H 0.996 51 0% 62 33.9% 0 - benign(0.085) deleterious(0.01) neutral(0.412) HMMPfam_7tm_1,superfamily_SSF81321 MAGEC3 139081 genome.wustl.edu 37 X 140953312 140953312 + Missense_Mutation SNP G G T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_138702.1 +1 reviewed p.R60M 0.000 276 0% 263 30.8% 0 - unknown(0) - - NULL MAGEC1 9947 genome.wustl.edu 37 X 140995710 140995710 + Silent SNP G G A rs191655529 by1000genomes TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005462.4 +1 reviewed p.S840 0.017 199 0% 204 45.1% 0 - - - - NULL MAGEA6 4105 genome.wustl.edu 37 X 151869696 151869696 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005363.2 +1 reviewed p.P129L 0.001 286 0% 257 43.6% 0 - benign(0.092) tolerated(1) neutral(0.007) HMMPfam_MAGE PLXNB3 5365 genome.wustl.edu 37 X 153037412 153037412 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_005393.2 +1 reviewed p.V871M 0.876 45 0% 19 36.8% 1 100% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_TIG,HMMSmart_IPT,superfamily_Ig_E-set L1CAM 3897 genome.wustl.edu 37 X 153132122 153132122 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_000425.3 -1 reviewed p.G805S 1.000 83 0% 48 35.4% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_Fibronectin type III ARHGAP4 393 genome.wustl.edu 37 X 153175478 153175478 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001666.4 -1 reviewed p.A740T 0.000 55 1.8% 32 37.5% 10 0% benign(0) tolerated(1) - superfamily_SH3 OPN1MW2 728458 genome.wustl.edu 37 X 153490518 153490518 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001048181.2 +1 reviewed p.R85H 0.999 104 0% 57 33.3% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_7tm_1,superfamily_SSF81321 TKTL1 8277 genome.wustl.edu 37 X 153556272 153556272 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_012253.3 +1 validated p.R529Q 0.056 198 0% 203 40.4% 0 - possibly_damaging(0.64) tolerated(0.16) neutral(0.283) HMMPfam_Transketolase_C,superfamily_TK C-terminal domain-like FLNA 2316 genome.wustl.edu 37 X 153593246 153593246 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001110556.1 -1 reviewed p.V591I 0.999 72 0% 22 45.5% 35 94.2% benign(0.356) - - HMMSmart_SM00557,superfamily_E set domains,HMMPfam_Filamin SLC10A3 8273 genome.wustl.edu 37 X 153716640 153716640 + Missense_Mutation SNP C C T novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_001142392.1 -1 reviewed p.E214K 0.987 44 0% 18 55.6% 39 0% benign(0.001) tolerated(0.19) neutral(0.050) HMMPfam_SBF FUNDC2 65991 genome.wustl.edu 37 X 154255274 154255274 + Missense_Mutation SNP G G A novel TCGA-A5-A0VP-01A-21D-A10B-09 TCGA-A5-A0VP-10A-01D-A10B-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 7f64eba0-afa7-4612-9db2-edafa21b5564 b91ef015-ee09-4caa-9177-519a83c24230 NM_023934.3 +1 validated p.A21T 0.000 20 0% 13 30.8% 16 0% benign(0) tolerated(0.16) neutral(0.059) NULL