Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_file Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID transcript_name strand transcript_status amino_acid_change ucsc_cons normal_depth normal_vaf tumor_depth tumor_vaf rna_depth rna_vaf polyphen sift condel domain KLHL17 339451 genome.wustl.edu 37 1 900462 900462 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_198317.1 +1 provisional p.A607V 0.847 73 0% 70 11.4% 5 0% benign(0) tolerated(0.71) neutral(0.002) HMMPfam_Kelch_1,HMMSmart_Kelch PARK7 11315 genome.wustl.edu 37 1 8030993 8030993 + Missense_Mutation SNP C C T rs182164240 by1000genomes TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001123377.1 +1 reviewed p.R98W 0.097 333 0.3% 349 24.1% 555 38.1% probably_damaging(0.986) deleterious(0.01) deleterious(0.840) HMMPfam_DJ-1_PfpI,superfamily_Class I glutamine amidotransferase-like RERE 473 genome.wustl.edu 37 1 8418863 8418863 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001042681.1 -1 reviewed p.P1244 0.000 141 0% 216 25.9% 34 41.1% - - - HMMPfam_Atrophin-1 PRAMEF7 441871 genome.wustl.edu 37 1 12979720 12979720 + Silent SNP G G C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001012277.1 +1 provisional p.L304 0.001 360 0% 306 15% 0 - - - - superfamily_RNI-like CROCC 9696 genome.wustl.edu 37 1 17273358 17273358 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014675.3 +1 validated p.E796K 1.000 48 0% 28 14.3% 11 18.1% unknown(0) deleterious(0.04) - NULL PADI3 51702 genome.wustl.edu 37 1 17603144 17603144 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_016233.2 +1 reviewed p.A480T 1.000 281 0% 273 23.1% 0 - benign(0.007) tolerated(0.75) neutral(0.002) HMMPfam_PAD,superfamily_SSF55909 PLA2G2E 30814 genome.wustl.edu 37 1 20249177 20249177 + Nonsense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014589.1 -1 provisional p.Q38* 1.000 101 0% 85 20% 0 - - - - HMMPfam_Phospholip_A2_1,HMMSmart_PA2c,superfamily_PhospholipaseA2 USP48 84196 genome.wustl.edu 37 1 22078004 22078004 + Nonsense_Mutation SNP A A T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_032236.5 -1 reviewed p.L257* 1.000 290 0% 346 23.4% 6 0% - - - HMMPfam_UCH,superfamily_Cysteine proteinases HSPG2 3339 genome.wustl.edu 37 1 22181416 22181416 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000374695 -1 known p.A2020T 0.987 180 0% 142 29.6% 16 6.2% benign(0.235) tolerated(0.08) neutral(0.324) HMMSmart_SM00406,HMMSmart_SM00408,HMMSmart_SM00409,superfamily_Concanavalin A-like lectins/glucanases,HMMPfam_I-set,superfamily_Immunoglobulin LUZP1 7798 genome.wustl.edu 37 1 23418889 23418889 + Silent SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001142546.1 -1 reviewed p.S622 0.000 222 0% 160 16.9% 7 42.8% - - - NULL NIPAL3 57185 genome.wustl.edu 37 1 24775979 24775979 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020448.4 +1 validated p.V135I 0.003 140 0% 114 14% 11 45.4% benign(0.002) tolerated(0.51) neutral(0.009) HMMPfam_DUF803 ARID1A 8289 genome.wustl.edu 37 1 27107151 27107151 + Nonsense_Mutation SNP C C G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_006015.4 +1 reviewed p.Y2254* 0.857 71 0% 79 25.3% 58 41.3% - - - NULL PTAFR 5724 genome.wustl.edu 37 1 28477310 28477310 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000952.4 -1 validated p.V75I 0.037 268 0% 319 24.1% 7 0% benign(0.002) tolerated(0.93) - HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like SRSF4 6429 genome.wustl.edu 37 1 29486987 29486987 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005626.4 -1 reviewed p.D50 1.000 257 0% 316 24.7% 37 40.5% - - - HMMPfam_RRM_1,HMMSmart_RRM,superfamily_SSF54928 PHC2 1912 genome.wustl.edu 37 1 33820474 33820474 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_198040.2 -1 reviewed p.A453T 0.995 133 0% 127 21.3% 0 - benign(0.002) tolerated(0.25) neutral(0.037) NULL CSMD2 114784 genome.wustl.edu 37 1 34312506 34312506 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_052896.3 -1 validated p.G298R 1.000 80 0% 65 21.5% 0 - probably_damaging(0.997) deleterious(0.01) deleterious(0.872) HMMPfam_CUB,HMMSmart_SM00042,superfamily_Spermadhesin CUB domain ZMYM1 79830 genome.wustl.edu 37 1 35580267 35580267 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_024772.3 +1 validated p.D946N 0.016 29 0% 20 30% 0 - probably_damaging(1) deleterious(0.03) deleterious(0.865) NULL KLF17 128209 genome.wustl.edu 37 1 44596414 44596414 + Missense_Mutation SNP G G C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_173484.3 +1 validated p.A386P 0.015 100 0% 138 25.4% 0 - probably_damaging(0.981) tolerated(0.47) neutral(0.436) NULL AGL 178 genome.wustl.edu 37 1 100346326 100346326 + Missense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000028.2 +1 reviewed p.T625K 1.000 641 0% 717 25.5% 3 0% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_(Trans)glycosidases LOC126987 126987 genome.wustl.edu 37 1 106623395 106623395 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 XM_002342097.1 -1 model p.R222W 0.761 39 0% 37 13.5% 0 - - - - NULL MAGI3 260425 genome.wustl.edu 37 1 114123198 114123198 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001142782.1 +1 validated p.P156 1.000 201 0% 244 18.4% 3 33.3% - - - HMMPfam_Guanylate_kin,HMMSmart_GuKc,PatternScan_GUANYLATE_KINASE_1,superfamily_SSF52540 CLK2 1196 genome.wustl.edu 37 1 155233072 155233072 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003993.2 -1 reviewed p.F478 0.798 149 0% 117 35% 49 32.6% - - - HMMSmart_S_TKc,superfamily_Kinase_like,HMMPfam_Pkinase DCAF8 50717 genome.wustl.edu 37 1 160209729 160209729 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_015726.3 -1 reviewed p.R161W 1.000 83 0% 70 30% 27 29.6% probably_damaging(0.999) deleterious(0) deleterious(0.935) superfamily_WD40 repeat-like DUSP27 92235 genome.wustl.edu 37 1 167096221 167096221 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001080426.1 +1 provisional p.A618V 0.018 80 0% 125 17.6% 0 - benign(0.007) tolerated(0.08) neutral(0.300) NULL RASAL2 9462 genome.wustl.edu 37 1 178421771 178421771 + Missense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_170692.2 +1 reviewed p.L647M 1.000 292 0% 283 23% 0 - probably_damaging(0.979) deleterious(0) deleterious(0.867) HMMPfam_RasGAP,HMMSmart_RasGAP,superfamily_Rho_GAP CACNA1S 779 genome.wustl.edu 37 1 201019592 201019592 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000069.2 -1 reviewed p.R1389Q 1.000 218 0% 292 26% 0 - probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL IGFN1 91156 genome.wustl.edu 37 1 201184862 201184862 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000451870 +1 known p.R607Q 0.974 36 0% 42 35.7% 0 - probably_damaging(0.979) tolerated(0.36) neutral(0.442) HMMSmart_SM00409,HMMPfam_I-set,superfamily_Immunoglobulin NFASC 23114 genome.wustl.edu 37 1 204945872 204945872 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_015090.3 +1 reviewed p.A605T 0.987 112 0% 76 21.1% 5 0% benign(0.052) deleterious(0.04) neutral(0.352) HMMSmart_IGc2,HMMPfam_I-set,superfamily_SSF48726 SLC26A9 115019 genome.wustl.edu 37 1 205896680 205896680 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_134325.2 -1 reviewed p.H385 0.496 255 0% 312 26% 0 - - - - HMMPfam_Sulfate_transp CR1 1378 genome.wustl.edu 37 1 207793370 207793370 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000651.4 +1 reviewed p.A2404 0.000 276 0% 291 23.7% 1 0% - - - HMMPfam_Sushi,HMMSmart_SM00032,superfamily_Complement control module/SCR domain PTPN14 5784 genome.wustl.edu 37 1 214557322 214557322 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005401.4 -1 reviewed p.E626K 1.000 43 0% 45 26.7% 4 25% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) NULL HIST3H2BB 128312 genome.wustl.edu 37 1 228646034 228646034 + Silent SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_175055.2 +1 reviewed p.N68 1.000 249 0.4% 274 27.4% 0 - - - - HMMSmart_SM00427,HMMPfam_Histone,superfamily_Histone-fold TRIM67 440730 genome.wustl.edu 37 1 231344781 231344781 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001004342.3 +1 validated p.D636 0.987 121 0% 109 29.4% 0 - - - - superfamily_Concanavalin A-like lectins/glucanases ZP4 57829 genome.wustl.edu 37 1 238050795 238050795 + Missense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_021186.2 -1 reviewed p.P207Q 0.018 187 0.5% 180 29.4% 0 - probably_damaging(0.993) tolerated(0.11) deleterious(0.722) HMMPfam_Zona_pellucida,HMMSmart_SM00241 ZP4 57829 genome.wustl.edu 37 1 238051724 238051724 + Missense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_021186.2 -1 reviewed p.D163Y 0.314 216 0% 237 18.6% 0 - probably_damaging(0.976) deleterious(0.02) deleterious(0.801) HMMPfam_Trefoil,HMMSmart_SM00018,superfamily_Trefoil,PatternScan_P_TREFOIL ADAM17 6868 genome.wustl.edu 37 2 9676879 9676879 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003183.4 -1 reviewed p.N103 0.602 502 0% 576 22.6% 8 25% - - - NULL TAF1B 9014 genome.wustl.edu 37 2 10008496 10008496 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005680.2 +1 reviewed p.A164V 0.676 167 0% 210 21.9% 6 33.3% benign(0) deleterious(0) neutral(0.445) NULL GREB1 9687 genome.wustl.edu 37 2 11725319 11725319 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014668.3 +1 reviewed p.R312C 1.000 236 0% 261 23.8% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL APOB 338 genome.wustl.edu 37 2 21230830 21230830 + Silent SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000384.2 -1 reviewed p.V2970 0.219 285 0% 268 31.3% 0 - - - - NULL OTOF 9381 genome.wustl.edu 37 2 26705407 26705407 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_194248.2 -1 reviewed p.V482 0.042 101 0% 84 22.6% 0 - - - - HMMPfam_C2,HMMSmart_SM00239,superfamily_C2 domain (Calcium/lipid-binding domain CaLB) MAPRE3 22924 genome.wustl.edu 37 2 27247085 27247085 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_012326.2 +1 reviewed p.R130Q 0.999 143 0% 149 23.5% 24 8.3% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_Calponin-homology domain CH-domain ENSG00000181250 0 genome.wustl.edu 37 2 33952650 33952650 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000322472 -1 known p.V65I 1.000 79 0% 45 11.1% 0 - - - - HMMPfam_MARVEL MSH2 4436 genome.wustl.edu 37 2 47703672 47703672 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000251.1 +1 reviewed p.T724 0.117 244 0% 282 29.8% 20 40% - - - HMMPfam_MutS_V,HMMSmart_MUTSac,superfamily_SSF52540 C2orf73 129852 genome.wustl.edu 37 2 54587506 54587506 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001100396.1 +1 validated p.C224Y 0.995 99 0% 135 25.9% 1 0% probably_damaging(0.996) deleterious(0) deleterious(0.906) NULL ALMS1 7840 genome.wustl.edu 37 2 73827898 73827898 + Missense_Mutation SNP A A C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_015120.4 +1 reviewed p.E3920A 0.999 312 0% 413 26.2% 18 55.5% possibly_damaging(0.454) deleterious(0.01) deleterious(0.554) NULL DQX1 165545 genome.wustl.edu 37 2 74752202 74752202 + Missense_Mutation SNP G G C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_133637.2 -1 validated p.T122S 0.678 75 0% 49 12.2% 0 - benign(0) tolerated(0.55) neutral(0.007) HMMSmart_SM00487,superfamily_P-loop containing nucleoside triphosphate hydrolases CCDC138 165055 genome.wustl.edu 37 2 109489908 109489908 + Missense_Mutation SNP A A T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_144978.1 +1 provisional p.K565N 0.369 194 0% 161 31.1% 8 50% benign(0.001) tolerated(0.39) neutral(0.016) NULL TMEM177 80775 genome.wustl.edu 37 2 120439078 120439078 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001105198.1 +1 validated p.A217T 0.455 54 0% 22 18.2% 27 37% benign(0.001) tolerated(0.39) neutral(0.016) NULL CNTNAP5 129684 genome.wustl.edu 37 2 125192250 125192250 + Missense_Mutation SNP T T A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_130773.2 +1 reviewed p.L240Q 0.996 97 0% 121 14.9% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_LamG,superfamily_ConA_like_lec_gl,HMMPfam_Laminin_G_2 GPR39 2863 genome.wustl.edu 37 2 133402882 133402882 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001508.2 +1 validated p.F355 0.638 49 0% 33 27.3% 5 0% - - - superfamily_Family A G protein-coupled receptor-like LRP2 4036 genome.wustl.edu 37 2 170038097 170038097 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004525.2 -1 reviewed p.A3344T 0.948 284 0% 280 27.9% 0 - possibly_damaging(0.922) deleterious(0.02) deleterious(0.754) HMMPfam_Ldl_recept_b,HMMSmart_LY,superfamily_SSF63825 TTN 7273 genome.wustl.edu 37 2 179460304 179460304 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_133378.4 -1 reviewed p.R16691Q 0.978 233 0% 242 24% 0 - - - - NULL TTN 7273 genome.wustl.edu 37 2 179643731 179643731 + Nonsense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_133379.3 -1 reviewed p.G1360* 1.000 247 0% 232 17.2% 0 - - - - HMMSmart_IGc2,HMMPfam_I-set,superfamily_SSF48726 IGFBP2 3485 genome.wustl.edu 37 2 217528687 217528687 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000597.2 +1 validated p.R280C 1.000 136 0% 87 16.1% 155 3.2% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Thyroglobulin_1,HMMSmart_SM00211,PatternScan_THYROGLOBULIN_1_1,superfamily_Thyroglobulin type-1 domain CCDC108 255101 genome.wustl.edu 37 2 219888026 219888026 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_194302.2 -1 provisional p.R908H 0.431 121 0% 115 21.7% 7 0% probably_damaging(0.992) deleterious(0.01) deleterious(0.853) superfamily_PapD-like AGAP1 116987 genome.wustl.edu 37 2 236708037 236708037 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001037131.1 +1 validated p.S276 0.991 87 2.3% 91 24.2% 2 0% - - - NULL ITPR1 3708 genome.wustl.edu 37 3 4859885 4859885 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001099952.2 +1 reviewed p.E2615K 1.000 268 0% 341 25.8% 0 - probably_damaging(0.985) deleterious(0) deleterious(0.877) NULL OSBPL10 114884 genome.wustl.edu 37 3 31712319 31712319 + Nonsense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000429492 -1 known p.R397* 1.000 236 0% 162 23.5% 13 53.8% probably_damaging(0.995) deleterious(0) deleterious(0.902) HMMPfam_Oxysterol_BP ARPP21 10777 genome.wustl.edu 37 3 35725305 35725305 + Nonsense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_016300.4 +1 validated p.Q87* 1.000 248 0% 248 23% 0 - - - - NULL GORASP1 64689 genome.wustl.edu 37 3 39142560 39142560 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_031899.2 -1 reviewed p.G128S 1.000 127 0% 137 32.1% 16 31.2% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_PDZ domain-like,HMMPfam_GRASP55_65 ZNF662 389114 genome.wustl.edu 37 3 42956105 42956105 + Silent SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001134656.1 +1 validated p.G206 0.000 159 0% 213 26.8% 1 100% - - - NULL ALS2CL 259173 genome.wustl.edu 37 3 46729621 46729622 + In_Frame_Ins INS - - GCA novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_147129.2 -1 validated p.90in_frame_insL 0.021:0.057 - - - - - - - - - NULL VPRBP 9730 genome.wustl.edu 37 3 51458310 51458310 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014703.2 -1 validated p.G652D 1.000 251 0% 257 22.2% 6 50% probably_damaging(0.989) deleterious(0) deleterious(0.884) superfamily_ARM repeat SEMA3G 56920 genome.wustl.edu 37 3 52474033 52474033 + Nonsense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020163.1 -1 provisional p.R409* 1.000 112 0% 70 28.6% 10 0% - - - HMMPfam_Sema,HMMSmart_Sema,superfamily_Sema IL17RB 55540 genome.wustl.edu 37 3 53889340 53889340 + Missense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_018725.3 +1 reviewed p.M167I 1.000 142 0.7% 174 15.5% 0 - possibly_damaging(0.891) tolerated(0.25) neutral(0.387) NULL LRIG1 26018 genome.wustl.edu 37 3 66463324 66463324 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_015541.2 -1 validated p.A254 0.650 257 0% 239 22.2% 59 32.2% - - - HMMPfam_LRR_1,HMMSmart_SM00369,superfamily_L domain-like CNTN3 5067 genome.wustl.edu 37 3 74347150 74347150 + Nonsense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020872.1 -1 validated p.G787* 1.000 386 0% 409 23.5% 2 0% - - - HMMPfam_fn3,HMMSmart_SM00060,superfamily_Fibronectin type III GPR15 2838 genome.wustl.edu 37 3 98251449 98251449 + Missense_Mutation SNP T T A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005290.1 +1 provisional p.I191N 0.000 361 0% 333 23.1% 0 - benign(0) tolerated(0.3) neutral(0.029) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like GTPBP8 29083 genome.wustl.edu 37 3 112718408 112718408 + Missense_Mutation SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014170.2 +1 validated p.V261A 1.000 231 0% 268 24.3% 5 60% probably_damaging(0.998) deleterious(0.05) deleterious(0.820) superfamily_P-loop containing nucleoside triphosphate hydrolases PIK3R4 30849 genome.wustl.edu 37 3 130452955 130452955 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014602.2 -1 validated p.R296H 0.987 22 0% 30 23.3% 3 33.3% benign(0.389) tolerated(0.14) neutral(0.374) HMMPfam_Pkinase_Tyr,superfamily_Kinase_like,superfamily_ARM-type_fold ATR 545 ucsc.edu 37 3 142261554 142261555 + Frame_Shift_Ins INS - A A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001184.3 -1 reviewed p.N1134fs 1.000:1.000 - - - - - - - - - HMMPfam_UME,HMMSmart_SM00802,superfamily_ARM repeat FAM194A 131831 genome.wustl.edu 37 3 150421680 150421680 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_152394.3 -1 validated p.A2 0.003 109 0% 93 24.7% 0 - - - - NULL CCNL1 57018 genome.wustl.edu 37 3 156866320 156866320 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020307.2 -1 validated p.R431C 1.000 510 0% 487 24.8% 30 23.3% probably_damaging(0.994) tolerated(0.09) deleterious(0.748) NULL KCNMB3 27094 genome.wustl.edu 37 3 178962353 178962353 + Missense_Mutation SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014407.3 -1 reviewed p.V130A 1.000 148 0% 187 21.4% 4 25% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_CaKB VPS8 23355 genome.wustl.edu 37 3 184714201 184714201 + Missense_Mutation SNP G G C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001009921.2 +1 validated p.G1250R 1.000 156 0% 201 25.4% 10 30% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL DGKQ 1609 genome.wustl.edu 37 4 961568 961568 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000509465 -1 known p.T225M 0.001 38 0% 28 21.4% 3 66.6% - - - NULL CYTL1 54360 genome.wustl.edu 37 4 5021020 5021020 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000509419 -1 known p.R50Q 0.949 52 0% 27 22.2% 2 0% - - - NULL NCAPG 64151 genome.wustl.edu 37 4 17839254 17839254 + Missense_Mutation SNP A A T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_022346.3 +1 validated p.N766Y 0.995 263 0% 305 28.2% 8 25% probably_damaging(0.982) deleterious(0.03) deleterious(0.791) NULL CCDC149 91050 genome.wustl.edu 37 4 24838064 24838064 + Frame_Shift_Del DEL T T - novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001130726.1 -1 validated p.K243fs 0.995 - - - - - - - - - HMMPfam_DUF2353 N4BP2 55728 genome.wustl.edu 37 4 40123257 40123257 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_018177.3 +1 reviewed p.V1176M 0.000 73 0% 73 20.5% 1 0% benign(0.001) deleterious(0) neutral(0.445) NULL AASDH 132949 genome.wustl.edu 37 4 57250442 57250442 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_181806.2 -1 validated p.H8 0.032 170 0% 183 24.6% 3 33.3% - - - superfamily_Acetyl-CoA synthetase-like HTN1 3346 genome.wustl.edu 37 4 70918824 70918824 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002159.2 +1 validated p.A11T 0.008 602 0% 734 22.5% 0 - possibly_damaging(0.507) deleterious(0) deleterious(0.614) NULL ANKRD50 57182 genome.wustl.edu 37 4 125591377 125591377 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020337.2 -1 validated p.A1019T 1.000 84 0% 80 21.2% 3 66.6% probably_damaging(0.997) deleterious(0.01) deleterious(0.872) HMMPfam_Ank,HMMSmart_ANK,superfamily_ANK FAT4 79633 genome.wustl.edu 37 4 126240343 126240343 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_024582.4 +1 validated p.G926D 1.000 102 0% 85 22.4% 0 - probably_damaging(0.998) tolerated(0.17) deleterious(0.533) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like IRF2 3660 genome.wustl.edu 37 4 185320080 185320080 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002199.3 -1 reviewed p.S228F 1.000 113 0% 109 30.3% 24 12.5% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL ADAMTS16 170690 genome.wustl.edu 37 5 5209340 5209340 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_139056.2 +1 reviewed p.C529Y 1.000 180 0% 256 32% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL PIK3R1 5295 genome.wustl.edu 37 5 67569797 67569798 + Frame_Shift_Del DEL AG AG - novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 AG AG Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_181523.1 +1 reviewed p.S154fs 1.000:1.000 - - - - - - - - - HMMPfam_RhoGAP,HMMSmart_SM00324,superfamily_GTPase activation domain GAP HEXB 3074 genome.wustl.edu 37 5 73981173 73981173 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000521.3 +1 reviewed p.L30 0.026 18 0% 11 36.4% 9 22.2% - - - NULL ANKRD31 256006 genome.wustl.edu 37 5 74443141 74443141 + Missense_Mutation SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000274361 -1 known p.S699P 0.304 611 0% 651 25.7% 0 - probably_damaging(0.996) deleterious(0) deleterious(0.906) superfamily_ANK BHMT 635 genome.wustl.edu 37 5 78417160 78417160 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001713.2 +1 reviewed p.G199 0.996 144 0% 135 31.1% 0 - - - - HMMPfam_S-methyl_trans,superfamily_S_methyl_trans THBS4 7060 genome.wustl.edu 37 5 79354054 79354054 + Missense_Mutation SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003248.4 +1 reviewed p.V189A 1.000 116 0% 111 27% 0 - benign(0.198) tolerated(0.33) neutral(0.043) HMMSmart_TSPN THBS4 7060 genome.wustl.edu 37 5 79355623 79355623 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003248.4 +1 reviewed p.P294 0.196 91 0% 94 26.6% 3 33.3% - - - HMMSmart_EGF,superfamily_SSF57196 HARS 3035 genome.wustl.edu 37 5 140057274 140057274 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002109.3 -1 reviewed p.R232H 1.000 422 0% 548 22.4% 44 36.3% benign(0.152) deleterious(0.02) neutral(0.397) HMMPfam_tRNA-synt_2b,superfamily_SSF55681 PCDHA12 56137 genome.wustl.edu 37 5 140255227 140255227 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_018903.2 +1 reviewed p.A57V 0.000 85 0% 66 22.7% 0 - benign(0.002) tolerated(0.06) neutral(0.323) HMMSmart_SM00112,HMMPfam_Cadherin_2,superfamily_Cadherin-like CCNJL 79616 genome.wustl.edu 37 5 159682576 159682576 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_024565.5 -1 validated p.T289 0.023 218 0.5% 192 32.8% 0 - - - - HMMPfam_Cyclin_C,HMMSmart_SM00385,superfamily_Cyclin-like ENSG00000241956 0 genome.wustl.edu 37 5 164028094 164028094 + RNA SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000486913 +1 known NULL 1.000 80 0% 47 25.5% 0 - - - - - STC2 8614 genome.wustl.edu 37 5 172745050 172745050 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003714.2 -1 reviewed p.A237T 0.000 143 0% 96 24% 4 0% benign(0) tolerated(0.64) neutral(0.003) HMMPfam_Stanniocalcin HK3 3101 genome.wustl.edu 37 5 176310838 176310838 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002115.2 -1 reviewed p.N662 1.000 141 0% 118 32.2% 3 0% - - - HMMPfam_Hexokinase_1,superfamily_SSF53067 C5orf60 285679 genome.wustl.edu 37 5 179069426 179069426 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001142306.1 -1 provisional p.A250T 0.006 376 0% 447 26.4% 0 - probably_damaging(0.965) - - NULL EXOC2 55770 genome.wustl.edu 37 6 497476 497476 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_018303.4 -1 reviewed p.S817F 1.000 150 0% 157 26.8% 9 33.3% possibly_damaging(0.908) deleterious(0) deleterious(0.806) NULL CAGE1 285782 genome.wustl.edu 37 6 7387403 7387403 + Missense_Mutation SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000502583 -1 known p.N2D 0.455 172 0% 159 24.5% 0 - possibly_damaging(0.763) deleterious(0) deleterious(0.728) NULL FAM65B 9750 genome.wustl.edu 37 6 24843671 24843671 + Missense_Mutation SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014722.2 -1 validated p.S447P 0.024 303 0% 332 25.3% 4 0% benign(0) tolerated(0.29) neutral(0.029) NULL HIST1H1B 3009 genome.wustl.edu 37 6 27834630 27834632 + In_Frame_Del DEL CTT CTT - novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 CTT CTT Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005322.2 -1 reviewed p.K226in_frame_del 1.000:1.000:1.000 - - - - - - - - - NULL FAM83B 222584 genome.wustl.edu 37 6 54805185 54805185 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001010872.1 +1 validated p.N472 1.000 127 0% 106 25.5% 0 - - - - NULL SMAP1 60682 genome.wustl.edu 37 6 71464755 71464755 + Frame_Shift_Del DEL C C - novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001044305.1 +1 reviewed p.P109fs 1.000 - - - - - - - - - HMMPfam_ArfGap,HMMSmart_SM00105,superfamily_Pyk2-associated protein beta ARF-GAP domain UFL1 23376 genome.wustl.edu 37 6 96986508 96986508 + Missense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_015323.4 +1 validated p.P327H 1.000 142 0% 155 23.9% 9 44.4% possibly_damaging(0.943) deleterious(0) deleterious(0.832) NULL SIM1 6492 genome.wustl.edu 37 6 100897473 100897473 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005068.2 -1 reviewed p.V151M 1.000 157 0% 148 25.7% 0 - benign(0.382) deleterious(0.04) deleterious(0.471) superfamily_SSF55785 SESN1 27244 genome.wustl.edu 37 6 109319816 109319816 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014454.1 -1 provisional p.T291I 1.000 119 0.8% 173 21.4% 16 18.7% probably_damaging(0.972) tolerated(0.3) neutral(0.443) HMMPfam_PA26 CEP85L 387119 genome.wustl.edu 37 6 118886824 118886824 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001042475.2 -1 validated p.T296 1.000 270 0% 306 23.2% 0 - - - - NULL MED23 9439 genome.wustl.edu 37 6 131931365 131931365 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004830.2 -1 reviewed p.L300 1.000 144 0% 150 24.7% 11 9% - - - NULL MYB 4602 genome.wustl.edu 37 6 135514982 135514982 + Missense_Mutation SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001130173.1 +1 reviewed p.S257G 1.000 594 0% 556 26.1% 1 100% benign(0) tolerated(0.35) neutral(0.021) NULL AKAP12 9590 genome.wustl.edu 37 6 151674461 151674461 + Missense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005100.3 +1 reviewed p.E1645D 0.000 195 0% 261 17.6% 12 41.6% benign(0.147) tolerated(0.45) neutral(0.025) NULL FNDC1 84624 genome.wustl.edu 37 6 159654584 159654584 + Missense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_032532.2 +1 validated p.Q1014K 0.000 30 0% 35 25.7% 4 0% unknown(0) deleterious(0.02) - NULL RADIL 55698 genome.wustl.edu 37 7 4874346 4874346 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_018059.4 -1 validated p.P436 0.028 22 0% 16 31.2% 0 - - - - NULL FERD3L 222894 genome.wustl.edu 37 7 19184670 19184670 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_152898.2 -1 validated p.A106T 1.000 207 0% 146 22.6% 0 - probably_damaging(0.983) deleterious(0.01) deleterious(0.835) HMMPfam_HLH,superfamily_HLH_basic NPC1L1 29881 genome.wustl.edu 37 7 44579498 44579498 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_013389.2 -1 reviewed p.E166 0.592 66 0% 62 22.6% 0 - - - - NULL H2AFV 94239 genome.wustl.edu 37 7 44875212 44875212 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_012412.4 -1 reviewed p.R81C 1.000 164 0% 210 25.2% 180 39.4% benign(0.26) deleterious(0) deleterious(0.472) HMMSmart_SM00414,HMMPfam_Histone,superfamily_Histone-fold CLIP2 7461 genome.wustl.edu 37 7 73803434 73803434 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000493166 +1 known p.R105H 0.006 26 0% 26 30.8% 6 0% - - - NULL STEAP4 79689 genome.wustl.edu 37 7 87912125 87912125 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_024636.2 -1 validated p.R272Q 0.999 172 0.6% 246 26.4% 1 0% benign(0.009) tolerated(0.15) neutral(0.241) HMMPfam_Ferric_reduct SMURF1 57154 genome.wustl.edu 37 7 98633233 98633233 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020429.1 -1 reviewed p.A665V 1.000 128 0.8% 101 19.8% 8 37.5% benign(0.036) tolerated(0.89) neutral(0.002) HMMPfam_HECT,HMMSmart_SM00119,superfamily_Hect E3 ligase catalytic domain MUC17 140453 genome.wustl.edu 37 7 100684272 100684272 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001040105.1 +1 provisional p.S3192N 0.000 410 0% 486 23.3% 0 - probably_damaging(0.99) - - NULL ORAI2 80228 genome.wustl.edu 37 7 102087259 102087259 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001126340.1 +1 validated p.P175 0.001 110 0% 94 28.7% 24 8.3% - - - HMMPfam_DUF1650 ATXN7L1 222255 genome.wustl.edu 37 7 105283308 105283308 + Missense_Mutation SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020725.1 -1 validated p.N280S 1.000 859 0% 882 24.4% 2 0% benign(0) tolerated(0.38) neutral(0.018) HMMPfam_SCA7 OPN1SW 611 genome.wustl.edu 37 7 128414669 128414669 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001708.2 -1 reviewed p.T190 0.905 153 0% 283 24.4% 0 - - - - HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like KCNH2 3757 genome.wustl.edu 37 7 150642533 150642533 + Nonsense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000238.2 -1 reviewed p.R1134* 0.996 15 0% 33 33.3% 0 - - - - NULL LOXL2 4017 genome.wustl.edu 37 8 23190949 23190949 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002318.2 -1 reviewed p.G311R 0.056 67 0% 34 11.8% 13 0% benign(0.016) tolerated(0.44) neutral(0.013) superfamily_Srcr_receptor ENTPD4 9583 genome.wustl.edu 37 8 23290619 23290619 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004901.3 -1 validated p.G557 1.000 59 0% 51 17.6% 25 40% - - - NULL PNMA2 10687 genome.wustl.edu 37 8 26365469 26365469 + Missense_Mutation SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_007257.5 -1 validated p.Y268C 0.923 138 0% 133 15.8% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Retrotrans_gag ESCO2 157570 genome.wustl.edu 37 8 27645471 27645471 + Silent SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001017420.2 +1 reviewed p.N361 0.001 215 0% 467 25.3% 1 0% - - - NULL WWP1 11059 genome.wustl.edu 37 8 87450848 87450848 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_007013.3 +1 validated p.R595H 1.000 346 0% 522 25.3% 14 28.5% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00119,superfamily_Hect E3 ligase catalytic domain FER1L6 654463 genome.wustl.edu 37 8 125072870 125072870 + Nonsense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001039112.2 +1 validated p.G1023* 0.996 336 0% 309 23.6% 0 - - - - superfamily_C2 domain (Calcium/lipid-binding domain CaLB) ZFAT 57623 genome.wustl.edu 37 8 135621016 135621016 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020863.3 -1 reviewed p.Y247 0.325 222 0% 266 23.7% 1 0% - - - NULL EIF2C2 27161 genome.wustl.edu 37 8 141559336 141559336 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000220592 -1 known p.P489S 1.000 84 0% 81 24.7% 3 33.3% benign(0.276) deleterious(0) deleterious(0.474) NULL PLEC 5339 genome.wustl.edu 37 8 144995412 144995412 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_201380.2 -1 reviewed p.H2996 0.862 145 0% 150 23.3% 41 19.5% - - - HMMSmart_SM00250,superfamily_Plakin repeat GPAA1 8733 genome.wustl.edu 37 8 145139491 145139491 + Missense_Mutation SNP A A T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003801.3 +1 reviewed p.Y330F 0.998 103 0% 91 14.3% 114 31.5% benign(0.002) tolerated(0.7) neutral(0.002) HMMPfam_Gaa1 FREM1 158326 genome.wustl.edu 37 9 14746950 14746950 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_144966.5 -1 reviewed p.A2037T 0.003 181 0% 170 25.3% 4 0% benign(0.001) tolerated(0.33) neutral(0.024) NULL TEK 7010 genome.wustl.edu 37 9 27197529 27197529 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000459.3 +1 reviewed p.R614Q 0.997 129 2.3% 151 22.5% 4 0% probably_damaging(0.956) tolerated(0.32) neutral(0.424) HMMPfam_fn3,HMMSmart_FN3,superfamily_FN_III-like DAPK1 1612 genome.wustl.edu 37 9 90321196 90321196 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004938.2 +1 reviewed p.Q1070 1.000 66 0% 49 28.6% 33 33.3% - - - NULL PHF2 5253 genome.wustl.edu 37 9 96436132 96436132 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005392.3 +1 reviewed p.D872N 1.000 57 0% 40 30% 22 18.1% probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL GRIN3A 116443 genome.wustl.edu 37 9 104499576 104499576 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_133445.2 -1 reviewed p.P229L 1.000 90 0% 76 17.1% 0 - possibly_damaging(0.777) tolerated(0.07) deleterious(0.609) superfamily_SSF53822 PTPN3 5774 genome.wustl.edu 37 9 112166751 112166751 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002829.3 -1 reviewed p.G644R 1.000 192 0% 159 28.9% 7 28.5% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_SSF52799 SVEP1 79987 genome.wustl.edu 37 9 113198775 113198775 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_153366.3 -1 validated p.A1550V 1.000 208 0% 175 24.6% 1 0% probably_damaging(0.991) tolerated(0.33) neutral(0.468) HMMPfam_Pentaxin,HMMSmart_SM00159,superfamily_Concanavalin A-like lectins/glucanases RC3H2 54542 genome.wustl.edu 37 9 125643050 125643051 + Frame_Shift_Del DEL AG AG - novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 AG AG Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001100588.1 -1 validated p.S261fs 0.998:1.000 - - - - - - - - - NULL PPP2R4 5524 genome.wustl.edu 37 9 131885349 131885349 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_178001.1 +1 reviewed p.G50R 1.000 52 0% 81 21% 38 34.2% probably_damaging(0.994) deleterious(0) deleterious(0.897) HMMPfam_PTPA RAPGEF1 2889 genome.wustl.edu 37 9 134497216 134497216 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000414781 -1 known p.A4T 0.155 84 0% 58 20.7% 8 0% - - - NULL NOTCH1 4851 genome.wustl.edu 37 9 139417612 139417612 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_017617.3 -1 reviewed p.C144 1.000 38 0% 23 34.8% 6 0% - - - HMMPfam_EGF,HMMSmart_EGF,superfamily_SSF57196 ZMYND11 10771 genome.wustl.edu 37 10 293392 293392 + Nonsense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_006624.4 +1 reviewed p.E365* 1.000 235 0% 375 26.7% 13 0% - - - NULL SPAG6 9576 genome.wustl.edu 37 10 22680763 22680763 + Missense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_012443.2 +1 reviewed p.A371S 1.000 257 0% 282 25.2% 0 - benign(0.082) tolerated(0.14) neutral(0.256) superfamily_ARM repeat LYZL2 119180 genome.wustl.edu 37 10 30915087 30915087 + Nonsense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_183058.2 -1 validated p.W128* 0.947 259 0% 235 24.3% 0 - - - - HMMPfam_Lys,HMMSmart_LYZ1,superfamily_SSF53955 RBP3 5949 genome.wustl.edu 37 10 48390525 48390525 + Missense_Mutation SNP T T G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002900.2 -1 reviewed p.Q118P 0.905 100 0% 66 31.8% 0 - possibly_damaging(0.846) deleterious(0) deleterious(0.770) HMMSmart_SM00245,superfamily_ClpP/crotonase C10orf71 118461 genome.wustl.edu 37 10 50532748 50532748 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001135196.1 +1 validated p.P720S 0.455 109 0% 109 23.9% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL TFAM 7019 genome.wustl.edu 37 10 60145389 60145389 + Nonsense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003201.1 +1 provisional p.R28* 0.023 98 0% 68 20.6% 16 6.2% - - - NULL TET1 80312 genome.wustl.edu 37 10 70332938 70332938 + Missense_Mutation SNP G G C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_030625.2 +1 validated p.K281N 0.978 83 0% 129 17.1% 0 - probably_damaging(0.996) deleterious(0) deleterious(0.906) NULL COL13A1 1305 genome.wustl.edu 37 10 71681683 71681683 + Missense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001130103.1 +1 reviewed p.G368W 1.000 134 0% 131 21.4% 4 0% probably_damaging(1) - - HMMPfam_Collagen MAT1A 4143 genome.wustl.edu 37 10 82039972 82039972 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000429.2 -1 reviewed p.R169H 1.000 92 0% 66 36.4% 0 - benign(0.303) deleterious(0.03) neutral(0.459) HMMPfam_S-AdoMet_synt_M,superfamily_S-AdoMet_synt PTEN 5728 genome.wustl.edu 37 10 89692802 89692802 + Missense_Mutation SNP C C G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000371953 +1 known p.P96A 1.000 453 0% 564 24.3% 12 8.3% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMSmart_SM00404,superfamily_(Phosphotyrosine protein) phosphatases II ENTPD7 57089 genome.wustl.edu 37 10 101458581 101458581 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020354.3 +1 validated p.R434H 0.797 84 0% 91 35.2% 5 60% benign(0.002) tolerated(0.16) neutral(0.059) HMMPfam_GDA1_CD39 PCGF6 84108 genome.wustl.edu 37 10 105110561 105110563 + In_Frame_Del DEL TCT TCT - novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 TCT TCT Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001011663.1 -1 reviewed p.E89in_frame_del 0.999:0.986:0.508 - - - - - - - - - NULL GSTO1 9446 genome.wustl.edu 37 10 106025846 106025846 + Missense_Mutation SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004832.1 +1 reviewed p.L157P 0.997 654 0% 734 23.8% 68 29.4% benign(0.348) deleterious(0.01) deleterious(0.516) HMMPfam_GST_C,superfamily_GST_C_like MUC2 4583 genome.wustl.edu 37 11 1086086 1086086 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002457.2 +1 reviewed p.V976M 0.000 30 0% 35 34.3% 2 100% possibly_damaging(0.948) - - HMMPfam_VWD,HMMSmart_SM00216 DNHD1 144132 genome.wustl.edu 37 11 6593003 6593003 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_144666.2 +1 provisional p.P4683 0.008 94 0% 68 29.4% 1 0% - - - HMMPfam_Dynein_heavy SWAP70 23075 genome.wustl.edu 37 11 9771475 9771476 + Frame_Shift_Del DEL AG AG - novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 AG AG Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_015055.2 +1 validated p.K576fs 0.738:0.782 - - - - - - - - - NULL USP47 55031 genome.wustl.edu 37 11 11974391 11974391 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_017944.3 +1 validated p.S1161 1.000 366 0% 418 24.2% 27 33.3% - - - NULL COPB1 1315 genome.wustl.edu 37 11 14512125 14512125 + Missense_Mutation SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001144061.1 -1 reviewed p.I198V 0.999 277 0% 376 25.8% 33 39.3% benign(0.002) tolerated(0.53) neutral(0.007) HMMPfam_Adaptin_N,superfamily_ARM-type_fold PHF21A 51317 genome.wustl.edu 37 11 45967528 45967528 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001101802.1 -1 validated p.L438 1.000 358 0% 439 24.8% 3 0% - - - NULL OR5M11 219487 genome.wustl.edu 37 11 56310547 56310547 + Missense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001005245.1 -1 provisional p.L63I 1.000 233 0% 301 22.6% 0 - probably_damaging(0.995) deleterious(0.04) deleterious(0.806) HMMPfam_7tm_1,superfamily_SSF81321 OR5AK3P 81228 genome.wustl.edu 37 11 56738782 56738782 + Silent SNP A A T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000326876 +1 known p.T86 0.000 126 0% 180 27.8% 0 - - - - HMMPfam_7tm_1,superfamily_SSF81321 CTNND1 1500 genome.wustl.edu 37 11 57577603 57577603 + Nonsense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001085458.1 +1 validated p.R820* 1.000 153 0% 192 25.5% 25 4% - - - HMMSmart_SM00185,superfamily_ARM repeat PRPF19 27339 genome.wustl.edu 37 11 60668143 60668143 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014502.4 -1 validated p.V247I 0.984 329 0% 307 21.8% 103 39.8% benign(0.002) tolerated(0.25) neutral(0.037) HMMSmart_WD40,superfamily_WD40_like,HMMPfam_WD40 TRPT1 83707 genome.wustl.edu 37 11 63993014 63993014 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001033678.3 -1 validated p.A38 1.000 77 0% 42 28.6% 29 44.8% - - - HMMPfam_PTS_2-RNA CABP4 57010 genome.wustl.edu 37 11 67225137 67225137 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_145200.3 +1 reviewed p.R212H 0.931 161 0% 155 24.5% 4 50% probably_damaging(0.995) deleterious(0) deleterious(0.902) HMMSmart_SM00054,HMMPfam_efhand,superfamily_EF-hand DHCR7 1717 genome.wustl.edu 37 11 71146862 71146862 + Silent SNP G G A rs145901607 by1000genomes TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001360.2 -1 reviewed p.P329 0.031 18 0% 12 41.7% 26 38.4% unknown(0) - - HMMPfam_ERG4_ERG24 PDE2A 5138 genome.wustl.edu 37 11 72307680 72307680 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002599.3 -1 validated p.P149L 1.000 85 0% 94 25.5% 1 0% unknown(0) - - NULL STARD10 10809 genome.wustl.edu 37 11 72470295 72470295 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_006645.2 -1 validated p.D113 0.994 173 0% 188 24.5% 197 44.6% - - - HMMPfam_START,HMMSmart_START,superfamily_SSF55961 XRRA1 143570 genome.wustl.edu 37 11 74574105 74574105 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000431210 -1 known p.R28Q 0.000 78 0% 112 26.8% 0 - - - - NULL C11orf30 56946 genome.wustl.edu 37 11 76253301 76253301 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020193.3 +1 validated p.R867W 1.000 296 0% 305 26.6% 4 25% probably_damaging(1) deleterious(0) deleterious(0.945) NULL C11orf73 51501 genome.wustl.edu 37 11 86055742 86055742 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_016401.3 +1 validated p.P173L 1.000 279 0% 312 52.6% 61 65.5% probably_damaging(0.962) deleterious(0) deleterious(0.850) HMMPfam_DUF775 ME3 10873 genome.wustl.edu 37 11 86157394 86157394 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001014811.1 -1 reviewed p.R506W 1.000 83 0% 87 29.9% 19 26.3% possibly_damaging(0.792) tolerated(0.09) deleterious(0.593) HMMPfam_Malic_M,superfamily_NAD(P)-bd ME3 10873 genome.wustl.edu 37 11 86198431 86198431 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001014811.1 -1 reviewed p.G253R 1.000 260 0% 169 24.9% 13 23% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_malic,superfamily_SSF53223 MRE11A 4361 genome.wustl.edu 37 11 94189501 94189501 + Missense_Mutation SNP G G A rs186333183 by1000genomes TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005591.3 -1 reviewed p.R502C 0.995 559 0% 625 26.7% 3 33.3% benign(0.011) deleterious(0.03) neutral(0.365) NULL C11orf70 85016 genome.wustl.edu 37 11 101929675 101929675 + Missense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_032930.1 +1 predicted p.W48L 1.000 95 0% 128 22.7% 11 0% probably_damaging(1) deleterious(0) deleterious(0.945) NULL MMP20 9313 genome.wustl.edu 37 11 102479681 102479681 + Silent SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004771.3 -1 reviewed p.I266 1.000 306 0% 367 21% 0 - - - - "HMMPfam_Peptidase_M10,HMMSmart_SM00235,superfamily_Metalloproteases (""zincins"") catalytic domain" RAB39A 54734 genome.wustl.edu 37 11 107832867 107832867 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_017516.1 +1 provisional p.E141 0.997 160 0% 231 27.7% 0 - - - - HMMSmart_SM00176,HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases GRIK4 2900 genome.wustl.edu 37 11 120745948 120745948 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014619.2 +1 reviewed p.R387Q 1.000 156 0% 191 22% 0 - benign(0.009) tolerated(0.64) neutral(0.004) superfamily_SSF53822 SORL1 6653 genome.wustl.edu 37 11 121474944 121474944 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003105.4 +1 reviewed p.C1521Y 1.000 156 0% 103 22.3% 6 33.3% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Ldl_recept_a,HMMSmart_SM00192,superfamily_LDL receptor-like module UBASH3B 84959 genome.wustl.edu 37 11 122650260 122650260 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_032873.4 +1 validated p.R153H 1.000 148 0.7% 129 27.1% 3 0% benign(0.047) tolerated(0.21) neutral(0.047) NULL MSANTD2 79684 genome.wustl.edu 37 11 124637722 124637722 + Nonsense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_024631.2 -1 validated p.R292* 1.000 168 0% 180 27.8% 5 20% - - - NULL DCP1B 196513 genome.wustl.edu 37 12 2062350 2062350 + Missense_Mutation SNP C C G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_152640.3 -1 validated p.Q252H 0.000 83 2.4% 74 24.3% 7 42.8% benign(0) tolerated(0.61) neutral(0.004) NULL TEAD4 7004 genome.wustl.edu 37 12 3120173 3120173 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003213.2 +1 reviewed p.R77Q 1.000 60 0% 56 30.4% 2 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_TEA,HMMSmart_TEA,PatternScan_TEA_1 CHD4 1108 genome.wustl.edu 37 12 6710104 6710104 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001273.2 -1 reviewed p.R305 0.952 411 0% 360 25% 17 11.7% - - - NULL PTMS 5763 genome.wustl.edu 37 12 6878779 6878781 + In_Frame_Del DEL AGA AGA - novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 AGA AGA Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002824.4 +1 validated p.K21in_frame_del 1.000:1.000:1.000 - - - - - - - - - HMMPfam_Prothymosin C3AR1 719 genome.wustl.edu 37 12 8212518 8212518 + Nonsense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004054.2 -1 validated p.W88* 1.000 213 0% 235 23% 8 0% - - - HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like ENSG00000246407 0 genome.wustl.edu 37 12 8384806 8384806 + RNA SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000499592 -1 known NULL 0.000 20 0% 46 28.3% 0 - - - - - ETV6 2120 genome.wustl.edu 37 12 11992105 11992105 + Missense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001987.4 +1 reviewed p.D65E 1.000 118 0% 138 38.4% 4 25% probably_damaging(1) deleterious(0.04) deleterious(0.849) HMMPfam_SAM_PNT,HMMSmart_SM00251,superfamily_SAM/Pointed domain C12orf36 283422 genome.wustl.edu 37 12 13526205 13526205 + Missense_Mutation SNP T T G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_182558.1 -1 provisional p.K117T 0.000 418 0% 498 25.5% 0 - unknown(0) - - NULL PPFIBP1 8496 genome.wustl.edu 37 12 27832470 27832470 + Missense_Mutation SNP C C G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003622.2 +1 reviewed p.S555C 0.921 129 0% 103 27.2% 4 25% possibly_damaging(0.474) deleterious(0.03) deleterious(0.521) NULL CAPRIN2 65981 genome.wustl.edu 37 12 30906403 30906403 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001002259.1 -1 validated p.R99W 0.993 298 0% 348 26.4% 2 50% probably_damaging(0.994) deleterious(0.01) deleterious(0.858) NULL MLL2 8085 genome.wustl.edu 37 12 49433506 49433506 + Splice_Site SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003482.3 -1 validated e31+1 1.000 81 0% 71 32.4% 0 - - - - - MLL2 8085 genome.wustl.edu 37 12 49433845 49433845 + Missense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003482.3 -1 validated p.P2570T 1.000 149 0% 165 25.5% 1 100% unknown(0) - - NULL PRPF40B 25766 genome.wustl.edu 37 12 50031273 50031273 + Missense_Mutation SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000395012 +1 known p.M1T 0.445 114 0% 86 22.1% 13 30.7% - - - NULL NCKAP5L 57701 genome.wustl.edu 37 12 50187645 50187645 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001037806.3 -1 validated p.R1044W 0.998 51 0% 42 19% 11 27.2% probably_damaging(1) tolerated(0.06) deleterious(0.823) NULL ACVR1B 91 genome.wustl.edu 37 12 52377938 52377938 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004302.3 +1 reviewed p.V323M 0.979 177 0% 197 26.4% 10 0% possibly_damaging(0.799) deleterious(0.04) deleterious(0.650) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase ACVR1B 91 genome.wustl.edu 37 12 52387827 52387827 + Missense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004302.3 +1 reviewed p.R484L 1.000 95 0% 84 31% 15 20% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase PHC1P1 653441 genome.wustl.edu 37 12 55806811 55806811 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000326184 -1 known p.A570 0.885 85 0% 55 18.2% 0 - - - - NULL METTL21B 25895 genome.wustl.edu 37 12 58174313 58174314 + Frame_Shift_Ins INS - - AGAGC novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_015433.2 +1 validated p.F191fs 0.102:0.220 - - - - - - - - - HMMPfam_Methyltransf_16,superfamily_S-adenosyl-L-methionine-dependent methyltransferases LRIG3 121227 genome.wustl.edu 37 12 59272737 59272737 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_153377.3 -1 provisional p.R651H 1.000 158 0% 111 28.8% 9 22.2% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_I-set,superfamily_Immunoglobulin USP15 9958 genome.wustl.edu 37 12 62777895 62777895 + Nonsense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_006313.1 +1 provisional p.R400* 0.988 493 0% 580 22.8% 2 0% - - - HMMPfam_UCH,superfamily_SSF54001 KITLG 4254 genome.wustl.edu 37 12 88910138 88910138 + Missense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000899.3 -1 reviewed p.V165F 0.285 162 0% 161 23.6% 1 0% benign(0.002) deleterious(0.01) neutral(0.406) HMMPfam_SCF,superfamily_4-helical cytokines NR2C1 7181 genome.wustl.edu 37 12 95452262 95452262 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003297.2 -1 reviewed p.R123H 1.000 201 0% 264 28.4% 3 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_zf-C4,HMMSmart_SM00399,PatternScan_NUCLEAR_REC_DBD_1,superfamily_Glucocorticoid receptor-like (DNA-binding domain) TCP11L2 255394 genome.wustl.edu 37 12 106708135 106708135 + Splice_Site SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_152772.1 +1 provisional e2-1 1.000 178 0% 199 24.1% 0 - - - - - ALKBH2 121642 genome.wustl.edu 37 12 109527846 109527846 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001001655.2 -1 validated p.T149 0.345 150 0% 157 17.8% 28 32.1% - - - NULL ALKBH2 121642 genome.wustl.edu 37 12 109527868 109527868 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001001655.2 -1 validated p.R142Q 1.000 169 0% 153 33.3% 26 34.6% probably_damaging(1) deleterious(0.02) deleterious(0.883) NULL CCDC64 92558 genome.wustl.edu 37 12 120510399 120510399 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_207311.2 +1 validated p.V392I 1.000 50 0% 33 30.3% 3 33.3% possibly_damaging(0.767) tolerated(0.34) neutral(0.307) NULL TMEM132D 121256 genome.wustl.edu 37 12 129569187 129569187 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_133448.2 -1 validated p.V502M 0.020 231 0% 213 20.7% 0 - benign(0.212) tolerated(0.23) neutral(0.062) NULL FREM2 341640 genome.wustl.edu 37 13 39263687 39263687 + Nonsense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_207361.4 +1 reviewed p.R736* 1.000 96 0% 95 25.3% 0 - - - - NULL STK24 8428 genome.wustl.edu 37 13 99127107 99127107 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003576.3 -1 validated p.E201K 1.000 150 0% 131 25.2% 47 42.5% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase RNASE12 493901 genome.wustl.edu 37 14 21058856 21058856 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001024822.2 -1 validated p.L9 0.723 318 0% 366 22.4% 0 - - - - NULL SPTB 6710 genome.wustl.edu 37 14 65235770 65235770 + Missense_Mutation SNP A A C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001024858.2 -1 reviewed p.W2002G 0.043 223 0% 181 24.9% 0 - possibly_damaging(0.618) tolerated(0.06) deleterious(0.537) HMMPfam_Spectrin,HMMSmart_SPEC,superfamily_Spectrin RAB15 376267 genome.wustl.edu 37 14 65418360 65418361 + Frame_Shift_Del DEL TC TC - novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 TC TC Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_198686.2 -1 validated p.R69fs 0.956:1.000 - - - - - - - - - HMMSmart_RAB,HMMPfam_Ras,superfamily_SSF52540 GPHN 10243 genome.wustl.edu 37 14 67390936 67390936 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020806.4 +1 reviewed p.A252V 1.000 391 0% 362 24.3% 9 11.1% possibly_damaging(0.915) deleterious(0) deleterious(0.811) NULL ZFP36L1 677 genome.wustl.edu 37 14 69257025 69257025 + Frame_Shift_Del DEL G G - novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004926.2 -1 reviewed p.S81fs 0.537 - - - - - - - - - HMMPfam_Tis11B_N YLPM1 56252 genome.wustl.edu 37 14 75248810 75248810 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_019589.2 +1 validated p.P688 0.714 374 0.3% 342 24.6% 5 0% - - - NULL PTPN21 11099 genome.wustl.edu 37 14 88945968 88945968 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_007039.3 -1 reviewed p.V603M 1.000 16 0% 13 38.5% 1 0% probably_damaging(1) tolerated(0.09) deleterious(0.796) NULL MOAP1 64112 genome.wustl.edu 37 14 93650536 93650536 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_022151.4 -1 reviewed p.R18W 0.220 129 0.8% 128 20.3% 15 46.6% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL FAM181A 90050 genome.wustl.edu 37 14 94394613 94394613 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_138344.3 +1 predicted p.S56 0.001 75 0% 53 24.5% 5 40% - - - NULL WDR20 91833 genome.wustl.edu 37 14 102676134 102676134 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_181291.1 +1 reviewed p.E543K 1.000 151 0% 233 21% 8 37.5% probably_damaging(1) tolerated(0.1) deleterious(0.786) superfamily_WD40_like IGHM 3507 genome.wustl.edu 37 14 106320535 106320535 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000390558 -1 known p.P421L 0.978 125 0% 105 23.8% 2671 0% - - - HMMPfam_C1-set,superfamily_Immunoglobulin MKRN3 7681 genome.wustl.edu 37 15 23812358 23812358 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005664.3 +1 reviewed p.R477W 0.118 268 0% 317 20.2% 0 - probably_damaging(0.986) deleterious(0.02) deleterious(0.818) NULL ZNF770 54989 genome.wustl.edu 37 15 35274406 35274406 + Missense_Mutation SNP A A C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014106.2 -1 validated p.F410L 0.661 119 0% 133 30.1% 4 75% benign(0.01) tolerated(0.27) neutral(0.034) NULL ZNF770 54989 genome.wustl.edu 37 15 35275296 35275296 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014106.2 -1 validated p.V114I 0.942 184 0% 162 25.9% 1 100% possibly_damaging(0.906) tolerated(0.54) neutral(0.367) NULL EHD4 30844 genome.wustl.edu 37 15 42193279 42193279 + Missense_Mutation SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_139265.3 -1 validated p.M397T 1.000 144 0% 154 26.6% 31 25.8% possibly_damaging(0.794) deleterious(0) deleterious(0.742) NULL CAPN3 825 genome.wustl.edu 37 15 42693961 42693961 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000070.2 +1 reviewed p.R493W 1.000 95 0% 92 23.9% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Calpain_III,HMMSmart_SM00720,superfamily_Calpain large subunit middle domain (domain III) PPIP5K1 9677 genome.wustl.edu 37 15 43826979 43826979 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001130858.1 -1 validated p.A1399T 0.982 138 0% 118 23.7% 9 22.2% benign(0.012) deleterious(0.01) neutral(0.406) NULL DMXL2 23312 genome.wustl.edu 37 15 51763591 51763591 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_015263.3 -1 validated p.P2406 0.991 307 0% 284 27.1% 2 0% - - - superfamily_WD40 repeat-like GCOM1 145781 genome.wustl.edu 37 15 57976677 57976677 + Missense_Mutation SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001018100.2 +1 reviewed p.M461T 0.000 166 0% 169 22.5% 5 0% benign(0) tolerated(0.83) neutral(0.001) NULL MAP2K1 5604 genome.wustl.edu 37 15 66781572 66781572 + Missense_Mutation SNP G G C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002755.3 +1 reviewed p.S327T 1.000 195 0% 284 23.2% 26 30.7% benign(0.001) tolerated(0.2) neutral(0.049) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase MPI 4351 genome.wustl.edu 37 15 75185047 75185047 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002435.1 +1 reviewed p.D131N 1.000 97 0% 109 23.9% 41 29.2% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_PMI_typeI,superfamily_RmlC-like cupins,PatternScan_PMI_I_1 C15orf26 161502 genome.wustl.edu 37 15 81436089 81436089 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_173528.2 +1 predicted p.S188 0.959 231 0% 223 21.5% 7 0% - - - NULL TMC3 342125 genome.wustl.edu 37 15 81625552 81625552 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001080532.1 -1 provisional p.S837 0.388 176 0% 224 29.5% 1 0% - - - NULL ACAN 176 genome.wustl.edu 37 15 89391215 89391215 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_013227.3 +1 reviewed p.V560M 0.147 119 0% 133 26.3% 0 - unknown(0) tolerated(0.18) - HMMPfam_Xlink,HMMSmart_SM00445,superfamily_C-type lectin-like CCDC154 645811 genome.wustl.edu 37 16 1488623 1488623 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001143980.1 -1 provisional p.A341V 0.385 48 0% 49 26.5% 1 0% probably_damaging(0.996) tolerated(0.94) neutral(0.462) NULL MAPK8IP3 23162 genome.wustl.edu 37 16 1779192 1779192 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_015133.3 +1 reviewed p.H165Y 1.000 169 0% 195 19.5% 3 33.3% possibly_damaging(0.947) deleterious(0) deleterious(0.835) HMMPfam_Jnk-SapK_ap_N E4F1 1877 genome.wustl.edu 37 16 2283030 2283030 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004424.3 +1 reviewed p.A301V 0.003 65 0% 47 25.5% 17 35.2% benign(0) tolerated(0.53) neutral(0.007) NULL SEC14L5 9717 genome.wustl.edu 37 16 5046404 5046404 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014692.1 +1 validated p.M241I 1.000 48 0% 39 43.6% 0 - benign(0) tolerated(0.18) neutral(0.056) HMMPfam_CRAL_TRIO_N,superfamily_Sec14p_like_N DNAH3 55567 genome.wustl.edu 37 16 20974932 20974932 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_017539.1 -1 provisional p.R3425H 1.000 172 0% 182 23.6% 2 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Dynein_heavy EEF2K 29904 genome.wustl.edu 37 16 22260105 22260105 + Missense_Mutation SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_013302.3 +1 reviewed p.D126G 0.907 132 0% 153 31.4% 7 57.1% benign(0.052) tolerated(0.28) neutral(0.035) HMMPfam_Alpha_kinase,HMMSmart_Alpha_kinase,superfamily_Kinase_like FHOD1 29109 genome.wustl.edu 37 16 67270542 67270542 + Missense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_013241.2 -1 reviewed p.G413C 0.000 86 0% 97 20.6% 6 0% benign(0.187) deleterious(0.01) neutral(0.423) NULL DDX19A 55308 genome.wustl.edu 37 16 70404241 70404241 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_018332.3 +1 provisional p.R379Q 1.000 423 0% 555 21.1% 27 22.2% probably_damaging(0.955) deleterious(0) deleterious(0.843) HMMPfam_Helicase_C,HMMSmart_SM00490,superfamily_P-loop containing nucleoside triphosphate hydrolases HYDIN 54768 genome.wustl.edu 37 16 71025285 71025285 + Missense_Mutation SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_032821.2 -1 validated p.D1267G 0.030 339 0% 404 16.8% 1 0% benign(0.022) tolerated(0.16) neutral(0.060) NULL DHX38 9785 genome.wustl.edu 37 16 72133143 72133143 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014003.3 +1 reviewed p.T308 0.149 117 0% 166 29.5% 11 45.4% - - - NULL ZFHX3 463 genome.wustl.edu 37 16 72831719 72831720 + Frame_Shift_Ins INS - - G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_006885.3 -1 reviewed p.Q1621fs 1.000:1.000 - - - - - - - - - HMMSmart_SM00451 CHST5 23563 genome.wustl.edu 37 16 75563169 75563169 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_024533.3 -1 validated p.A372T 0.959 15 0% 22 36.4% 2 0% benign(0) tolerated(0.57) neutral(0.006) HMMPfam_Sulfotransfer_1,superfamily_P-loop containing nucleoside triphosphate hydrolases EIF4A1 1973 genome.wustl.edu 37 17 7476181 7476181 + Nonsense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001416.2 +1 validated p.R8* 1.000 144 0.7% 171 24% 186 19.8% - - - NULL SOX15 6665 genome.wustl.edu 37 17 7492706 7492706 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_006942.1 -1 reviewed p.P97S 1.000 65 0% 31 19.4% 2 0% probably_damaging(0.996) deleterious(0) deleterious(0.906) HMMPfam_HMG_box,HMMSmart_HMG,superfamily_HMG-box CHD3 1107 genome.wustl.edu 37 17 7806722 7806722 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001005271.2 +1 reviewed p.R1269W 1.000 78 0% 80 21.2% 15 20% probably_damaging(1) - - superfamily_P-loop containing nucleoside triphosphate hydrolases USP43 124739 genome.wustl.edu 37 17 9590172 9590172 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_153210.3 +1 validated p.Q433 0.997 175 0% 130 23.8% 2 50% - - - HMMPfam_UCH,superfamily_SSF54001 ZNF287 57336 genome.wustl.edu 37 17 16456451 16456451 + Silent SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020653.2 -1 validated p.L335 1.000 125 0% 185 21.6% 0 - - - - NULL PRPSAP2 5636 genome.wustl.edu 37 17 18832162 18832162 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002767.2 +1 reviewed p.A281 0.839 285 0% 300 24% 53 35.8% - - - HMMPfam_Pribosyltran,superfamily_SSF53271 LGALS9 3965 genome.wustl.edu 37 17 25969343 25969343 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_009587.2 +1 reviewed p.G138D 0.474 391 0% 294 27.2% 66 1.5% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Gal-bind_lectin,HMMSmart_SM00276,superfamily_Concanavalin A-like lectins/glucanases TMEM98 26022 genome.wustl.edu 37 17 31266554 31266554 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001033504.1 +1 validated p.R158Q 1.000 271 0% 294 28.9% 76 7.8% probably_damaging(0.993) deleterious(0) deleterious(0.895) NULL GPR179 440435 genome.wustl.edu 37 17 36482864 36482864 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001004334.2 -1 validated p.Q2196 0.934 224 0% 182 25.8% 0 - - - - NULL CWC25 54883 genome.wustl.edu 37 17 36971274 36971274 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_017748.3 -1 provisional p.R90C 0.994 135 0% 118 29.7% 5 20% probably_damaging(1) deleterious(0) deleterious(0.945) NULL TOP2A 7153 genome.wustl.edu 37 17 38556273 38556273 + Missense_Mutation SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001067.2 -1 reviewed p.L1016S 0.978 175 0% 189 22.8% 7 57.1% benign(0.004) tolerated(0.47) neutral(0.011) HMMPfam_DNA_topoisoIV,HMMSmart_SM00434,superfamily_Type II DNA topoisomerase KRT24 192666 genome.wustl.edu 37 17 38855720 38855720 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_019016.2 -1 reviewed p.R446H 1.000 304 0.7% 243 21.8% 0 - probably_damaging(1) deleterious(0.02) deleterious(0.883) HMMPfam_Filament,PatternScan_IF HDAC5 10014 genome.wustl.edu 37 17 42157798 42157798 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001015053.1 -1 reviewed p.I933 0.994 64 0% 45 26.7% 45 24.4% - - - HMMPfam_Hist_deacetyl,superfamily_Arginase/deacetylase GRN 2896 genome.wustl.edu 37 17 42429885 42429885 + Missense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002087.2 +1 reviewed p.N530K 0.535 76 0% 92 16.3% 940 29.5% possibly_damaging(0.916) tolerated(0.48) neutral(0.378) HMMSmart_SM00277,superfamily_Granulin repeat DBF4B 80174 genome.wustl.edu 37 17 42818794 42818794 + Silent SNP G G C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_145663.1 +1 validated p.T268 0.000 220 0% 270 23.3% 3 0% - - - NULL ACBD4 79777 genome.wustl.edu 37 17 43213875 43213875 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001135704.1 +1 reviewed p.R33C 1.000 62 0% 32 43.8% 11 36.3% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_ACBP,superfamily_ACBP SNF8 11267 genome.wustl.edu 37 17 47009026 47009026 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_007241.2 -1 provisional p.T206 0.019 236 0.4% 234 25.6% 110 3.6% - - - "HMMPfam_EAP30,superfamily_""Winged helix"" DNA-binding domain" MRC2 9902 genome.wustl.edu 37 17 60755963 60755963 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_006039.3 +1 validated p.Y717 0.379 32 0% 32 28.1% 6 0% - - - HMMPfam_Lectin_C,HMMSmart_SM00034,superfamily_C-type lectin-like SCN4A 6329 genome.wustl.edu 37 17 62049141 62049141 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000334.4 -1 reviewed p.D184 0.062 81 0% 79 24.1% 0 - - - - HMMPfam_Ion_trans,superfamily_Voltage-gated potassium channels GALK1 2584 genome.wustl.edu 37 17 73758963 73758963 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000154.1 -1 reviewed p.S205 0.996 53 0% 28 35.7% 27 14.8% - - - superfamily_Ribosomal_S5_D2-typ_fold RNF213 57674 genome.wustl.edu 37 17 78343365 78343365 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000508628 +1 known p.V4073 0.007 131 0% 107 26.2% 7 42.8% - - - NULL HGS 9146 genome.wustl.edu 37 17 79663956 79663956 + Missense_Mutation SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004712.3 +1 provisional p.M604V 0.999 15 0.000 8 0.500 58 24.1% benign(0.012) tolerated(0.06) neutral(0.323) NULL TBCD 6904 genome.wustl.edu 37 17 80881552 80881552 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005993.4 +1 reviewed p.A735T 0.842 117 0% 111 27.9% 39 30.7% possibly_damaging(0.765) tolerated(0.55) neutral(0.291) superfamily_ARM repeat ZFP161 7541 genome.wustl.edu 37 18 5291608 5291608 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001143823.1 -1 validated p.A200V 1.000 145 0% 117 27.4% 9 11.1% possibly_damaging(0.799) deleterious(0) deleterious(0.746) NULL MC5R 4161 genome.wustl.edu 37 18 13826462 13826462 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005913.1 +1 provisional p.S233N 1.000 248 0% 235 28.9% 0 - benign(0) tolerated(0.6) neutral(0.004) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like ASXL3 80816 genome.wustl.edu 37 18 31314300 31314300 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_030632.1 +1 provisional p.R335W 1.000 210 0.5% 246 26% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL RTTN 25914 genome.wustl.edu 37 18 67806869 67806869 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_173630.3 -1 validated p.S918 0.560 133 0% 153 19.6% 1 100% - - - NULL NETO1 81832 genome.wustl.edu 37 18 70417389 70417389 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_138966.2 -1 reviewed p.S483 0.003 493 0.4% 583 23.7% 0 - - - - NULL NFATC1 4772 genome.wustl.edu 37 18 77227530 77227530 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_172387.1 +1 reviewed p.N667 0.999 128 0.8% 136 20.6% 4 0% - - - HMMPfam_TIG,HMMSmart_SM00429,superfamily_E set domains KLF16 83855 genome.wustl.edu 37 19 1863074 1863074 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_031918.3 -1 validated p.S141 0.896 34 0% 37 40.5% 13 15.3% - - - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 DOT1L 84444 genome.wustl.edu 37 19 2226432 2226432 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_032482.2 +1 validated p.D1304 0.000 13 0.000 7 0.571 10 20% - - - NULL CREB3L3 84699 genome.wustl.edu 37 19 4159700 4159700 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_032607.1 +1 provisional p.P166L 0.000 80 1.3% 77 36.4% 0 - benign(0) tolerated(0.6) neutral(0.004) NULL GTF2F1 2962 genome.wustl.edu 37 19 6381791 6381793 + In_Frame_Del DEL CTT CTT - novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 CTT CTT Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002096.2 -1 validated p.K251in_frame_del 1.000:1.000:1.000 - - - - - - - - - HMMPfam_TFIIF_alpha,superfamily_Rap30/74 interaction domains FBN3 84467 genome.wustl.edu 37 19 8203436 8203436 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_032447.3 -1 reviewed p.G293D 1.000 23 0% 19 36.8% 0 - possibly_damaging(0.891) deleterious(0.01) deleterious(0.756) superfamily_TB module/8-cys domain HNRNPM 4670 genome.wustl.edu 37 19 8551128 8551128 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005968.3 +1 validated p.R606C 1.000 44 0% 33 18.2% 169 33.7% possibly_damaging(0.946) deleterious(0) deleterious(0.835) NULL ADAMTS10 81794 genome.wustl.edu 37 19 8662205 8662205 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000393912 -1 known p.C23 1.000 180 0% 226 26.5% 1 0% - - - NULL DOCK6 57572 genome.wustl.edu 37 19 11347142 11347142 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_020812.2 -1 validated p.R758W 1.000 60 0% 52 25% 5 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL ZNF439 90594 genome.wustl.edu 37 19 11979067 11979067 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_152262.2 +1 provisional p.G395S 0.000 163 0% 215 27% 5 40% benign(0) tolerated(1) - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 MAN2B1 4125 genome.wustl.edu 37 19 12760770 12760770 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000528.3 -1 reviewed p.R742C 0.000 377 0.5% 339 25.1% 117 18.8% possibly_damaging(0.836) deleterious(0.02) deleterious(0.703) superfamily_Gal_mut_like,HMMPfam_Glyco_hydro_38C TNPO2 30000 genome.wustl.edu 37 19 12812635 12812635 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001136196.1 -1 validated p.N814 0.651 90 0% 68 14.7% 28 39.2% - - - superfamily_ARM repeat RFX1 5989 genome.wustl.edu 37 19 14074059 14074059 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002918.4 -1 validated p.R867C 1.000 61 0% 60 20% 36 30.5% probably_damaging(1) deleterious(0.04) deleterious(0.849) NULL CYP4F11 57834 genome.wustl.edu 37 19 16034637 16034637 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001128932.1 -1 reviewed p.V301 0.943 202 0% 162 17.9% 4 0% - - - HMMPfam_p450,superfamily_Cytochrome P450 CPAMD8 27151 genome.wustl.edu 37 19 17081720 17081720 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_015692.2 -1 validated p.P779S 0.028 20 0% 25 20% 5 20% benign(0) tolerated(0.41) neutral(0.015) NULL NR2F6 2063 genome.wustl.edu 37 19 17351567 17351567 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005234.3 -1 validated p.R96C 1.000 165 0% 146 26% 57 29.8% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_zf-C4,HMMSmart_SM00399,superfamily_Glucocorticoid receptor-like (DNA-binding domain) RAB3A 5864 genome.wustl.edu 37 19 18313485 18313485 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002866.4 -1 validated p.M22I 1.000 184 0.5% 175 22.3% 6 66.6% benign(0.13) deleterious(0.03) neutral(0.376) superfamily_P-loop containing nucleoside triphosphate hydrolases CEP89 84902 genome.wustl.edu 37 19 33406281 33406281 + Silent SNP T T A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_032816.3 -1 validated p.A509 0.000 323 0% 359 24.8% 6 16.6% - - - NULL FCGBP 8857 genome.wustl.edu 37 19 40383910 40383910 + Missense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003890.2 -1 validated p.R3234S 0.020 255 0% 161 7.5% 42 0% unknown(0) tolerated(0.57) - NULL IRF2BP1 26145 genome.wustl.edu 37 19 46388270 46388270 + Nonsense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_015649.1 -1 provisional p.R255* 0.988 35 0% 16 31.2% 40 40% - - - NULL HIF3A 64344 genome.wustl.edu 37 19 46807261 46807261 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_152795.2 +1 reviewed p.R45C 1.000 12 0% 10 60% 1 0% probably_damaging(0.973) tolerated(0.05) deleterious(0.760) HMMSmart_SM00353,superfamily_HLH helix-loop-helix DNA-binding domain CRX 1406 genome.wustl.edu 37 19 48342686 48342686 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_000554.4 +1 reviewed p.A121V 0.470 33 0% 31 16.1% 0 - benign(0.075) deleterious(0.02) neutral(0.388) NULL PRMT1 3276 genome.wustl.edu 37 19 50189971 50189971 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001536.3 +1 validated p.N340 0.764 24 0% 38 21.1% 397 40% - - - superfamily_S-adenosyl-L-methionine-dependent methyltransferases LENG8 114823 genome.wustl.edu 37 19 54963296 54963296 + Missense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_052925.2 +1 validated p.G22V 0.996 113 0% 108 29.6% 12 33.3% probably_damaging(1) deleterious(0) deleterious(0.945) NULL ZNF586 54807 genome.wustl.edu 37 19 58290292 58290292 + Silent SNP A A C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_017652.2 +1 validated p.R113 0.018 183 0% 233 21.5% 5 20% - - - superfamily_SSF57667 FASTKD5 60493 genome.wustl.edu 37 20 3128122 3128122 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_021826.4 -1 validated p.R532H 0.990 81 1.2% 58 22.4% 18 27.7% probably_damaging(0.955) tolerated(0.09) deleterious(0.695) HMMPfam_FAST_2 PLCB1 23236 genome.wustl.edu 37 20 8770858 8770858 + Missense_Mutation SNP G G C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_015192.2 +1 reviewed p.V1125L 0.060 177 0% 287 27.2% 6 0% benign(0.001) tolerated(0.18) neutral(0.056) HMMPfam_PLC-beta_C CBFA2T2 9139 genome.wustl.edu 37 20 32210951 32210951 + Missense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005093.3 +1 reviewed p.L190M 1.000 65 0% 59 22% 2 50% benign(0.052) deleterious(0.03) neutral(0.367) HMMPfam_TAFH,HMMSmart_SM00549 E2F1 1869 genome.wustl.edu 37 20 32267636 32267636 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005225.2 -1 reviewed p.R166H 1.000 203 0% 165 21.2% 7 42.8% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_E2F_TDP,superfamily_SSF46785 CDH4 1002 genome.wustl.edu 37 20 60509156 60509156 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001794.2 +1 reviewed p.H808Y 0.988 15 0.000 8 0.625 0 - possibly_damaging(0.617) tolerated(0.12) deleterious(0.475) HMMPfam_Cadherin_C SLCO4A1 28231 genome.wustl.edu 37 20 61290061 61290061 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_016354.3 +1 validated p.A277T 1.000 56 0% 40 35% 2 50% possibly_damaging(0.716) deleterious(0) deleterious(0.704) HMMPfam_OATP,superfamily_MFS general substrate transporter SLC17A9 63910 genome.wustl.edu 37 20 61596999 61596999 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_022082.3 +1 validated p.C328Y 1.000 123 0% 84 19% 2 0% benign(0.347) tolerated(0.06) neutral(0.432) HMMPfam_MFS_1,superfamily_MFS general substrate transporter KCNQ2 3785 genome.wustl.edu 37 20 62103608 62103608 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_172107.2 -1 reviewed p.R70H 1.000 13 0.000 8 0.625 0 - probably_damaging(0.994) deleterious(0) deleterious(0.897) NULL DGCR2 9993 genome.wustl.edu 37 22 19052396 19052396 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005137.2 -1 reviewed p.Q171 1.000 79 0% 57 19.3% 32 25% - - - HMMSmart_CLECT,superfamily_C-type_lectin_fold MYO18B 84700 genome.wustl.edu 37 22 26166060 26166060 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000418374 +1 known p.R12H 0.000 431 0% 580 21% 0 - - - - NULL ZNRF3 84133 genome.wustl.edu 37 22 29445671 29445671 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_032173.2 +1 validated p.P401L 0.121 22 0% 26 26.9% 0 - possibly_damaging(0.889) tolerated(0.1) deleterious(0.636) NULL PES1 23481 genome.wustl.edu 37 22 30976111 30976111 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014303.2 -1 reviewed p.Y366 0.010 176 0% 201 20.9% 82 29.2% - - - HMMPfam_BRCT,HMMSmart_SM00292,superfamily_BRCT domain MCM5 4174 genome.wustl.edu 37 22 35815947 35815947 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_006739.3 +1 reviewed p.G592R 1.000 32 0% 24 16.7% 55 38.1% possibly_damaging(0.877) tolerated(0.53) neutral(0.349) HMMPfam_MCM,HMMSmart_SM00350,superfamily_P-loop containing nucleoside triphosphate hydrolases TRIOBP 11078 genome.wustl.edu 37 22 38120883 38120883 + Nonsense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001039141.2 +1 reviewed p.R774* 0.016 660 0% 814 27.9% 1 0% - - - NULL CSNK1E 1454 genome.wustl.edu 37 22 38696782 38696784 + In_Frame_Del DEL TTG TTG - novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 TTG TTG Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001894.4 -1 reviewed p.N170in_frame_del 1.000:1.000:1.000 - - - - - - - - - HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase SREBF2 6721 genome.wustl.edu 37 22 42289229 42289229 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004599.2 +1 reviewed p.R773W 1.000 125 0% 101 20.8% 30 33.3% probably_damaging(0.997) deleterious(0.03) deleterious(0.831) NULL TCF20 6942 genome.wustl.edu 37 22 42564666 42564666 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005650.1 -1 reviewed p.R1959Q 1.000 116 0.9% 111 19.8% 8 25% benign(0.018) deleterious(0) neutral(0.445) NULL PLXNB2 23654 genome.wustl.edu 37 22 50714390 50714390 + Silent SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_012401.2 -1 validated p.A1780 0.114 105 0% 143 27.3% 504 40.6% - - - superfamily_Rho_GAP,HMMPfam_Plexin_cytopl GTPBP6 8225 genome.wustl.edu 37 X 221828 221828 + Silent SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000400701 -1 known p.R259C 0.948 412 0% 361 23.8% 60 25% - - - NULL VCX3B 425054 genome.wustl.edu 37 X 8434008 8434008 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001001888.2 +1 reviewed p.E109K 0.001 449 0% 422 15.6% 0 - unknown(0) tolerated(0.83) - NULL SMS 6611 genome.wustl.edu 37 X 22010810 22010810 + Silent SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_004595.2 +1 reviewed p.C347 1.000 572 0% 599 22.9% 80 0% - - - HMMPfam_Spermine_synth,superfamily_S-adenosyl-L-methionine-dependent methyltransferases LOC389842 389842 genome.wustl.edu 37 X 25664287 25664287 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 XM_372200.7 -1 model p.A53V 1.000 87 0% 83 18.1% 0 - - - - HMMPfam_Ran_BP1,HMMSmart_SM00160,superfamily_PH domain-like LOC389842 389842 genome.wustl.edu 37 X 25664376 25664376 + Silent SNP A A G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 XM_372200.7 -1 model p.H23 1.000 99 0% 139 12.9% 0 - - - - superfamily_PH domain-like BRWD3 254065 genome.wustl.edu 37 X 79960225 79960225 + Missense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_153252.4 -1 reviewed p.L891F 0.917 673 0% 850 23.2% 0 - benign(0.08) tolerated(0.07) neutral(0.325) NULL NRK 203447 genome.wustl.edu 37 X 105150501 105150501 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_198465.2 +1 validated p.R314W 0.304 312 0% 365 23% 0 - benign(0) deleterious(0) neutral(0.445) HMMSmart_SM00219,superfamily_Protein kinase-like (PK-like) MIR1911 100302222 genome.wustl.edu 37 X 113997777 113997777 + RNA SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 ENST00000410783 +1 known NULL 0.999 211 0% 154 20.8% 0 - - - - - ODZ1 10178 genome.wustl.edu 37 X 124029866 124029866 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_014253.3 -1 reviewed p.D148N 1.000 385 0.3% 428 24.3% 0 - probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_Ten_N XPNPEP2 7512 genome.wustl.edu 37 X 128888464 128888464 + Missense_Mutation SNP C C T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_003399.5 +1 reviewed p.A375V 0.997 153 0% 151 24.5% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Peptidase_M24,superfamily_Peptidase_M24_cat_core SOX3 6658 genome.wustl.edu 37 X 139586802 139586802 + Missense_Mutation SNP G G T novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_005634.2 -1 reviewed p.P142T 1.000 54 0% 37 24.3% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_HMG_box,HMMSmart_HMG,superfamily_HMG-box SLITRK4 139065 genome.wustl.edu 37 X 142716505 142716505 + Missense_Mutation SNP C C A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_173078.3 -1 reviewed p.R807M 1.000 347 0% 409 24.2% 0 - possibly_damaging(0.865) deleterious(0.03) deleterious(0.700) NULL TREX2 11219 genome.wustl.edu 37 X 152710736 152710736 + Silent SNP T T C novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_080701.3 -1 reviewed p.L51 0.000 64 0% 73 17.8% 0 - - - - HMMSmart_EXOIII,superfamily_RNaseH_fold,HMMPfam_Exonuc_X-T FLNA 2316 genome.wustl.edu 37 X 153582585 153582585 + Missense_Mutation SNP G G A novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_001110556.1 -1 reviewed p.R1831W 1.000 62 0% 48 29.2% 159 0% probably_damaging(0.987) deleterious(0) deleterious(0.881) HMMSmart_SM00557,superfamily_E set domains,HMMPfam_Filamin IL9R 3581 genome.wustl.edu 37 X 155239484 155239484 + Missense_Mutation SNP T T G novel TCGA-BS-A0UA-01A-11D-A122-09 TCGA-BS-A0UA-10A-01D-A122-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 6c1aa708-0552-4485-b859-4ade5f5a8431 d62bfc2a-9986-483c-8743-1fc609df0687 NM_002186.2 +1 reviewed p.W326G 0.505 32 0% 31 35.5% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL