NF1 inactivation in adult acute myelogenous leukemia

·Released Dec. 2, 2010 ·Updated May 2, 2014

187

Samples

187

Assays

Array Platforms

Description

Purpose: This study was conducted to identify novel genes with importance to the biology of adult acute myelogenous leukemia (AML). Conclusions: NF1 null states are present in 7/95=7% of adult AML and delineate a disease subset that could be preferentially targeted by Ras or mTOR-directed therapeutics. Experimental design: We analyzed DNA from highly purified AML blasts and paired buccal cells from 95 patients for recurrent genomic microdeletions using ultra-high density Affymetrix SNP 6.0 array-based genomic profiling. 006, 096 and 136 normal Samples have been excluded from study.

Array Platforms

A-AFFY-142

Affymetrix GeneChip Genome-Wide Human SNP 6.0 [GenomeWideSNP_6]（187 items）

Sample Attributes

disease state

normal, tumor

Organism

Homo sapiens

Experiment Info

Accession

E-GEOD-21107

GEO ID

GSE21107

Type

genotyping by array, comparative genomic hybridization by array

Organism

Homo sapiens

Released

Dec. 2, 2010

Updated

May 2, 2014

Submitter

Yang Liu、 Anjali Purkayastha、 Moshe Talpaz、 Lisa Kujawski、 Sami N Malek、 Paula Bockenstedt、 Yin Wang、 Judith Karp、 Harry Erba、 Sami N Malek、 Sajid Shakhan、 Peter Ouillette、 Amanda Dressel、 Yan Liu、 Whitney Wright、 Brian Parkin、 Ammar Al-Zoubi、 Diane Roulston、 Cheng Li、 Kerby Shedden

External Links

ArrayExpress source NCBI GEO：GSE21107

Analysis Services

NF1 inactivation in adult acute myelogenous leukemia

Contact

WeChat Official Account