AIMP2（也称为JTV-1或SCYE1）是一种多功能蛋白，属于氨基酰-tRNA合成酶复合物多功能蛋白家族（ARS-interacting multifunctional protein family）。该家族成员通常参与蛋白质翻译过程，通过与氨基酰-tRNA合成酶（ARS）相互作用形成多酶复合物，确保tRNA的正确氨基酰化，从而保证蛋白质合成的准确性。AIMP2不仅参与翻译过程，还在细胞信号传导、凋亡调控和肿瘤抑制中发挥重要作用。AIMP2的主要作用位点包括细胞质和细胞核，它在细胞质中参与翻译复合物的组装，而在细胞核中则可能参与转录调控。AIMP2的突变或表达异常可能导致其功能丧失，进而影响蛋白质合成的保真性，甚至与多种疾病相关，特别是癌症。例如，AIMP2的缺失或功能异常与肺癌、乳腺癌和胶质母细胞瘤的发生发展密切相关，因为它可以抑制肿瘤细胞的增殖并促进凋亡。AIMP2过表达通常具有肿瘤抑制作用，它可以通过激活p53通路或抑制NF-κB信号通路来抑制肿瘤生长。相反，AIMP2表达降低可能导致翻译错误增加、细胞凋亡受阻，从而促进肿瘤发生。此外，AIMP2还参与炎症反应和纤维化过程，其表达异常可能与某些炎症性疾病或纤维化疾病相关。AIMP2基因家族的共性在于它们都与ARS相互作用，参与蛋白质合成的质量控制，并在多种细胞过程中发挥调控作用。总的来说，AIMP2是一个关键的调控分子，其功能异常可能对细胞稳态和疾病发展产生深远影响。

的JTV1基因位于由两个基因，HRI和PMS2侧翼染色体7p22。 JTV1和HRI稍微重叠并排列成一尾对尾的方式。 JTV1和PMS2由大约200个碱基对分离，并且被布置头 - 头。 JTV1是在相反的方向相比HRI和PMS2转录。该JTV1基因产物的功能是未知的。 [由RefSeq的，2008年7月提供]

AIMP2, also known as JTV-1 or SCYE1, is a multifunctional protein belonging to the aminoacyl-tRNA synthetase-interacting multifunctional protein (AIM) family, a group of cytosolic proteins that physically associate with aminoacyl-tRNA synthetases (ARSs) to form large multi-enzyme complexes essential for the accurate and efficient charging of tRNAs during protein synthesis. Beyond its canonical role in ensuring translational fidelity, AIMP2 functions as a critical regulator of cell survival and death, exerting potent tumor suppressive activities by modulating key signaling pathways such as the activation of p53-mediated apoptosis and the inhibition of the pro-survival NF-κB pathway. This dual functionality allows AIMP2 to act as a checkpoint in cellular homeostasis; its overexpression typically inhibits tumor cell proliferation and promotes apoptosis, whereas its downregulation or loss-of-function mutations are frequently observed in various malignancies, including lung cancer, breast cancer, and glioblastoma, where they contribute to increased translational errors, impaired apoptotic responses, and enhanced tumor progression. Furthermore, AIMP2 is implicated in broader physiological processes, including the regulation of inflammatory responses and fibrotic pathways, suggesting that its dysregulation may underlie the pathogenesis of certain inflammatory and fibrotic diseases. As a central node connecting protein synthesis quality control with cell fate determination, AIMP2 serves as a vital molecular switch whose functional integrity is crucial for maintaining cellular stability and preventing the development of diverse pathological conditions.

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