APLP2 (amyloid beta precursor like protein 2)

Gene Basic Information

Gene Basic Information

symbol
APLP2
locus group
protein-coding gene
location
11q24.3
gene_family
-
alias symbol
APPH
alias name
None
entrez id
334
ensembl gene id
ENSG00000084234
ucsc gene id
uc010sby.3
refseq accession
NM_001642
hgnc_id
HGNC:598
approved reserved
1993-06-23

Chromosome Location

Chromosome Location

11q24.3

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

OMIM entry for APLP2     Wikipedia entry for APLP2

Gene Sequence

Gene Sequence

Nucleotide sequence of APLP2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN
41AGTGFAVAEP QIAMFCGKLN MHVNIQTGKW EPDPTGTKSC
81 FETKEEVLQ YCQEMYPELQ ITNVMEANQR VSIDNWCRRD
121KKQCKSRFVT PFKCLVGEFV SDVLLVPEKC QFFHKERMEV
161C ENHQHWHT VVKEACLTQG MTLYSYGMLL PCGVDQFHGT
201EYVCCPQTKI IGSVSKEEEE EDEEEEEEED EEEDYDVYKS
241EF PTEADLE DFTEAAVDED DEDEEEGEEV VEDRDYYYDT
281FKGDDYNEEN PTEPGSDGTM SDKEITHDVK AVCSQEAMTG
321PCR AVMPRW YFDLSKGKCV RFIYGGCGGN RNNFESEDYC
361MAVCKAMIPP TPLPTNDVDV YFETSADDNE HARFQKAKEQ
401LEIR HRNRM DRVKKEWEEA ELQAKNLPKA ERQTLIQHFQ
441AMVKALEKEA ASEKQQLVET HLARVEAMLN DRRRMALENY
481LAALQ SDPP RPHRILQALR RYVRAENKDR LHTIRHYQHV
521LAVDPEKAAQ MKSQVMTHLH VIEERRNQSL SLLYKVPYVA
561QEIQEE IDE LLQEQRADMD QFTASISETP VDVRVSSEES
601EEIPPFHPFH PFPALPENED TQPELYHPMK KGSGVGEQDG
641GLIGAEE KV INSKNKVDEN MVIDETLDVK EMIFNAERVG
681GLEEERESVG PLREDFSLSS SALIGLLVIA VAIATVIVIS
721LVMLRKRQ Y GTISHGIVEV DPMLTPEERH LNKMQNHGYE
761NPTYKYLEQM QI
Structure predicted by AlphaFold DB(UniProt: Q06481). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of APLP2:           Showing partial SNPs
rs10381       rs13207       rs13562       rs14437       rs592125       rs594451       rs603163       rs619606       rs623250       rs651935       rs672669       rs674442       rs694875       rs694876       rs747180       rs879780       rs879781      

Gene Expression

Gene Expression

Tissue expression of APLP2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TGTAAAGCGATGATTCCTCC
58
CTCATTATCATCTGCAGAGGTC
59
TACATCGAGATGTATCCAGAGC
59
AAAGCGACTCTTGCATTGC
60
GCTGCGTATTTGGATACTATCC
59
CCACTCCAGATCCAAGGTC
60
TAGTATTGACAACTGGTGCC
58
AAATTCACCCACGAGACAC
58
TGGGAACCTGATCCAACAG
59
CCTCCATCCGCTATTTGTG
58
TCAGATCTGTTGCAGTCCC
59
GGCTGCAAGAGCATTAATCTC
60
TAGTATTGACAACTGGTGCC
58
AAATTCACCCACGAGACAC
58
GTTCTTCAGTACTGTCAGGAG
58
CAATAATCTTTGTCCGCTGG
57
GATCACAAATAGCGGATGGAG
59
ATTCCCTGAGTCAGACATGC
60
AAGAGTGTTGCCAATGTATCC
59
CACCAGTTGTCAATACTAACCC
59

Gene Ontology

Subcellular localization of APLP2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for APLP2:

GO ID
Protein
Source DB
GO:0008201
E9PK76 (UniProtKB)
IEA
GO:0008201
E9PQS3 (UniProtKB)
IEA
GO:0046914
E9PQS3 (UniProtKB)
IEA
GO:0008201
E9PSC7 (UniProtKB)
IEA
GO:0002576
Q06481 (UniProtKB)
TAS
GO:0003677
Q06481 (UniProtKB)
NAS
GO:0004867
Q06481 (UniProtKB)
IEA
GO:0005515
Q06481 (UniProtKB)
IPI
GO:0005515
Q06481 (UniProtKB)
IPI
GO:0005515
Q06481 (UniProtKB)
IPI
GO:0005515
Q06481 (UniProtKB)
IPI
GO:0005515
Q06481 (UniProtKB)
IPI
GO:0005515
Q06481 (UniProtKB)
IPI
GO:0005515
Q06481 (UniProtKB)
IPI
GO:0005515
Q06481 (UniProtKB)
IPI
GO:0005634
Q06481 (UniProtKB)
IDA
GO:0005886
Q06481 (UniProtKB)
TAS
GO:0007186
Q06481 (UniProtKB)
NAS
GO:0008201
Q06481 (UniProtKB)
IEA
GO:0010951
Q06481 (UniProtKB)
IEA
GO:0016020
Q06481 (UniProtKB)
IDA
GO:0016021
Q06481 (UniProtKB)
NAS
GO:0031092
Q06481 (UniProtKB)
TAS
GO:0042802
Q06481 (UniProtKB)
IPI
GO:0046914
Q06481 (UniProtKB)
IEA
GO:0070062
Q06481 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating APLP2:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Nerve Degeneration 0.12 1 0 CTD_human
Myocardial Ischemia 0.12 1 0 CTD_human
Alzheimer's Disease 0.08272435 2 0 LHGDN_RGD
Tobacco Use Disorder 0.002367032 1 0 GAD
Neuroblastoma 0.000542884 2 0 BeFree
Pancreatic carcinoma 0.000542884 2 0 BeFree
Central neuroblastoma 0.000542884 2 0 BeFree
Malignant neoplasm of pancreas 0.000542884 2 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
Cerebral Thrombosis 0.000271442 1 0 BeFree

Related Publications

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Tu YJ, Liu YF, Zhang M, Ju XJ, Shan YJ, Ji GG, Shu JT Poult Sci IF: 4.5 2026-07-00
Trans-dimerization of Amyloid Precursor Protein Family Members Induces Pre- and Postsynaptic Differentiation through Distinct Signaling Pathways.
Rajender R, Foth N, Eggert S, Schilling S, Fäßler M, Ott C, Mühlhaus T, Sommer F, Schroda M, Maritzen T, Banicevic M, Bengelsdorff V, Kiss E, Buchholz CJ, Müller UC, Kins S J Neurosci IF: 4.3 2026-07-22
APLP2 as a molecular link between immune regulation and bone metabolism in hepatocellular carcinoma: evidence from scRNA-seq and functional validation.
Liang Z, Zheng J, Su Z, Wu B, Yang H, Bai S, Wu X, Sun C, Duan L, Chen S, Wei B, Fan X, Lin S Cancer Cell Int IF: 2.740 2026-06-14
Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis.
Kawase H, Liu S, Kurz S, Bengelsdorff V, Bonnavion R, Jin YJ, Roquid KA, Cho H, Liang G, Banićević M, Shiva N, Yunes-Leites PS, Günther S, Tombor L, Dimmeler S, Looso M, Mattonet K, Wettschureck N, Müller UC, Offermanns S Sci Adv IF: 12.5 2026-05-22
Brain delivery of a neurotrophic peptide derived from secreted amyloid precursor protein APPsα as a therapeutic strategy for Alzheimer's disease.
Rehra L, Erdinger S, Wagner L, Baltissen D, Just J, König L, Mühlberg E, Eisenzapf T, Kilian L, Banicevic M, Bengelsdorff V, Buchholz CJ, Mier W, Uhl P, Korte M, Fricker G, Müller UC J Control Release IF: 12.4 2026-01-10
APP family in inhibitory neurons controls inhibitory recruitment and short-term plasticity in the hippocampus.
Lee SH, Kang J, Zhang C, Bolshakov VY, Shen J Mol Brain IF: 3.410 2026-03-29
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