ARRDC3 (arrestin domain containing 3)

Gene Basic Information

Gene Basic Information

symbol:
ARRDC3
locus group:
protein-coding gene
location:
5q14.3
gene_family:
alias symbol:
KIAA1376|TLIMP
alias name:
alpha-arrestin 3|TBP-2-like induci…
entrez id:
57561
ensembl gene id:
ENSG00000113369
ucsc gene id:
uc003kjz.3
refseq accession:
NM_020801
hgnc_id:
HGNC:29263
approved reserved:
2004-02-11

Chromosome Location

Chromosome Location

5q14.3

Gene Summary

Gene Summary

ARRDC3（Arrestin Domain Containing 3）属于Arrestin基因家族，该家族成员主要参与细胞信号转导的调控，特别是通过介导G蛋白偶联受体（GPCR）的内化和降解来调节受体活性。ARRDC3与其他Arrestin家族成员（如β-arrestin1和β-arrestin2）类似，含有保守的Arrestin结构域，但它是非视觉Arrestin亚家族的一员，功能上更偏向于调控膜蛋白的运输和降解。ARRDC3在多种组织中表达，尤其在脂肪组织、肌肉和心脏中较为丰富。其主要功能包括参与泛素-蛋白酶体系统，通过招募E3泛素连接酶（如NEDD4）促进靶蛋白的泛素化和降解，从而调控细胞代谢、能量平衡和应激反应。ARRDC3还与肿瘤抑制相关，通过抑制致癌信号通路（如Notch和Hippo通路）来限制细胞增殖和迁移。突变或表达异常可能导致代谢紊乱（如肥胖和糖尿病）或癌症发生。例如，ARRDC3低表达与某些乳腺癌和前列腺癌的进展相关，可能因其失去对促癌蛋白的降解能力。过表达ARRDC3则可能增强对GPCR和生长因子受体的负调控，抑制细胞过度增殖，但也可能干扰正常信号传导导致代谢异常。在脂肪组织中，ARRDC3通过调节GLUT4转运影响葡萄糖摄取，其表达下降会加剧胰岛素抵抗。此外，ARRDC3与TP53等抑癌基因存在相互作用，共同维持基因组稳定性。该基因家族成员普遍具有支架蛋白特性，能整合多种信号分子，但ARRDC3独特地偏向代谢调控而非经典的GPCR脱敏作用。研究还发现，ARRDC3可通过外泌体分泌参与细胞间通讯，其表达水平变化可能影响微环境中的信号传递。

ChineseEnglish

None

OMIM entry for ARRDC3     Wikipedia entry for ARRDC3

Gene Sequence

Gene Sequence

Nucleotide sequence of ARRDC3:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MVLGKVKSLT ISFDCLNDSN VPVYSSGDTV SGRVNLEVTG
41EIRVKSLKIH ARGHAKVRWT ESRNAGSNTA YTQNYTEEVE
81 YFNHKDILI GHERDDDNSE EGFHTIHSGR HEYAFSFELP
121QTPLATSFEG RHGSVRYWVK AELHRPWLLP VKLKKEFTVF
161E HIDINTPS LLSPQAGTKE KTLCCWFCTS GPISLSAKIE
201RKGYTPGESI QIFAEIENCS SRMVVPKAAI YQTQAFYAKG
241KM KEVKQLV ANLRGESLSS GKTETWNGKL LKIPPVSPSI
281LDCSIIRVEY SLMVYVDIPG AMDLFLNLPL VIGTIPLHPF
321GSR TSSVSS QCSMNMNWLS LSLPERPEAP PSYAEVVTEE
361QRRNNLAPVS ACDDFERALQ GPLFAYIQEF RFLPPPLYSE
401IDPN PDQSA DDRPSCPSR
结构预测来自 AlphaFold DB（UniProt: Q96B67），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of ARRDC3:           Showing partial SNPs
rs1060403       rs1060613       rs2287875       rs3205096       rs7705465       rs7715402       rs11948056       rs11948075       rs35712350       rs58727127       rs62376565       rs72771512       rs73773374       rs74629591       rs75574377       rs78534333       rs111241874      

Gene Expression

Gene Expression

Tissue expression of ARRDC3:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CAACACTCCTTCATTACTGTCAC
60
ATATTGGGCCTGAGGTACAG
59
TGTAGTATAATCCGCGTGGA
58
CCATAGCTCCAGGAATATCC
57
CAACACTCCTTCATTACTGTCAC
60
ATATTGGGCCTGAGGTACAG
59
TTCAGGAAGGCATGAATATGC
59
AATGAGGTAGCGAGTGGTG
60
CAACACTCCTTCATTACTGTCAC
60
ATATTGGGCCTGAGGTACAG
59
TCTTAATTGGGCACGAAAGAG
59
GAATGAATAGTGTGGAAGCCT
58
CTCGACTGTAGTATAATCCGC
58
CTCCAGGAATATCCACATATACCA
60
TGAAAGACCTGAAGCACCA
59
ATCACAAGCACTCACTGGT
59
CACCTCTTTATTCAGAGATTGATCC
60
AGTGTTCCTTCAACGAGAGG
60
GTTGCTGGTTCTGTACCTC
58
ATCTGAATTGATTCACCTGGG
58

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of ARRDC3 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for ARRDC3:

GO ID
Protein
Source DB
GO:0001659
Q96B67 (UniProtKB)
IEA
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005515
Q96B67 (UniProtKB)
IPI
GO:0005764
Q96B67 (UniProtKB)
IEA
GO:0005768
Q96B67 (UniProtKB)
IDA
GO:0005769
Q96B67 (UniProtKB)
IEA
GO:0005886
Q96B67 (UniProtKB)
IDA
GO:0031651
Q96B67 (UniProtKB)
IEA
GO:0031699
Q96B67 (UniProtKB)
IDA
GO:0043588
Q96B67 (UniProtKB)
IEA
GO:0044252
Q96B67 (UniProtKB)
IEA
GO:0051443
Q96B67 (UniProtKB)
IPI
GO:0060613
Q96B67 (UniProtKB)
IEA
GO:0071879
Q96B67 (UniProtKB)
IEA
GO:0090327
Q96B67 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating ARRDC3:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Mammary Neoplasms 0.12 1 0 CTD_human
Malignant neoplasm of breast 0.000814326 3 3 BeFree
Breast Carcinoma 0.000814326 3 3 BeFree
Obesity 0.000271442 1 0 BeFree
Cardiomyopathy, Familial Idiopathic 0.000271442 1 0 BeFree

Related Publications

Related Publications

Targeting the ARRDC3-DRP1 Axis via hUMSC-Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury.
Ji R, Zhang Z, Liu Z, Yang K, Mao X, Chu M, Wang Y, Zhao J Adv Healthc Mater IF: 11.0 2026-04-00
Identification of specific molecular markers in severe heatstroke using transcriptomics techniques.
Duan Z, Wang M, Zhou Y, Lu J, Ma Y, Xu Y, Deng J, Liu H, Chen J Int J Legal Med IF: 2.6 2026-01-00
Lysosomal Expression Profile in Plasma Associates with Disease Severity in Parkinson's Disease.
van Wetering J, van Ingen MM, Timmermans E, In't Veld SGJG, Berendse HW, Teunissen CE, van de Berg WDJ Mov Disord IF: 7.7 2026-09-21
ARRDC3 promotes lysosome-mediated YAP degradation to inhibit enterovirus replication.
Huang X, Wang S, Huang Y, Wang Y, Zang G, Liang Y, Liu J, Han X, Liao J, Chen T, Lu N, Zhang G Virol Sin IF: 4.7 2025-08-00
Comparative Transcriptomic Analysis for Identification of Environmental-Responsive Genes in Seven Species of Threadfin Breams (Nemipterus).
Dang Z, Wu Q, Zhou Y, Wang L, Liu Y, Yang C, Liu M, Xie Q, Chen C, Ma S, Shan B Int J Mol Sci IF: 3.226 2025-07-23

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