CAND1Gene Detail-Gene Database-Genelibs

CAND1 (cullin associated and neddylation dissociated 1)

symbol:: CAND1
locus group:: protein-coding gene
location:: 12q14.3-q15
gene_family:
alias symbol:: TIP120A|DKFZp434M1414|KIAA0829|TIP120
alias name:: TBP interacting protein
entrez id:: 55832
ensembl gene id:: ENSG00000111530
ucsc gene id:: uc001stn.3
refseq accession:: NM_018448
hgnc_id:: HGNC:30688
approved reserved:: 2005-05-24

12q14.3-q15

CAND1（Cullin-associated and neddylation-dissociated 1）是一个重要的调控蛋白，属于CAND蛋白家族，主要参与泛素-蛋白酶体系统的调控。CAND1的核心功能是与Cullin-RING泛素连接酶（CRLs）复合物相互作用，通过阻止Cullin蛋白的neddylation修饰来调控CRLs的组装和活性。CRLs是细胞内最大的泛素连接酶家族，负责靶向特定底物蛋白进行泛素化标记，进而通过蛋白酶体降解这些蛋白，从而调控多种细胞过程如细胞周期、信号转导和DNA修复等。CAND1通过结合未neddylated的Cullin蛋白，阻止其与底物适配器（如F-box蛋白或SOCS-box蛋白）的结合，从而负调控CRLs的活性。这种动态平衡对维持细胞内蛋白质稳态至关重要。CAND1的突变或表达异常可能导致CRLs功能紊乱，进而影响细胞增殖、分化或凋亡。例如，CAND1功能缺失可能导致CRLs过度激活，引发某些底物蛋白的异常降解，与肿瘤发生、神经退行性疾病或免疫失调相关。研究表明，CAND1在某些癌症中表达下调，可能通过破坏CRLs的正常调控促进肿瘤发展。相反，CAND1过表达可能抑制CRLs活性，导致细胞周期调控蛋白积累，影响细胞分裂。CAND1属于CAND基因家族，该家族成员通常含有TPR（tetratricopeptide repeat）结构域，介导蛋白质相互作用，并在CRLs调控中发挥类似功能。CAND1的TPR结构域是其与Cullin蛋白结合的关键区域，突变可能破坏这种相互作用，导致CRLs调控失衡。此外，CAND1的表达受细胞状态和环境信号影响，如DNA损伤或氧化应激可调节其水平，进一步影响CRLs的活性。总之，CAND1是CRLs动态组装和功能的重要调节因子，其表达或功能异常与多种疾病相关，尤其在癌症和神经退行性疾病中具有潜在的研究价值。

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OMIM entry for CAND1 Wikipedia entry for CAND1

Nucleotide sequence of CAND1:[NCBI]

Loading Gene Browser...

Protein Sequence

1MASASYHISN LLEKMTSSDK DFRFMATNDL MTELQKDSIK
41LDDDSERKVV KMILKLLEDK NGEVQNLAVK CLGPLVSKVK
81
EYQVETIVD TLCTNMLSDK EQLRDISSIG LKTVIGELPP
121ASSGSALAAN VCKKITGRLT SAIAKQEDVS VQLEALDIMA
161D
MLSRQGGL LVNFHPSILT CLLPQLTSPR LAVRKRTIIA
201LGHLVMSCGN IVFVDLIEHL LSELSKNDSM STTRTYIQCI
241AA
ISRQAGH RIGEYLEKII PLVVKFCNVD DDELREYCIQ
281AFESFVRRCP KEVYPHVSTI INICLKYLTY DPNYNYDDED
321EDE
NAMDAD GGDDDDQGSD DEYSDDDDMS WKVRRAAAKC
361LDAVVSTRHE MLPEFYKTVS PALISRFKER EENVKADVFH
401AYLS
LLKQT RPVQSWLCDP DAMEQGETPL TMLQSQVPNI
441VKALHKQMKE KSVKTRQCCF NMLTELVNVL PGALTQHIPV
481LVPGI
IFSL NDKSSSSNLK IDALSCLYVI LCNHSPQVFH
521PHVQALVPPV VACVGDPFYK ITSEALLVTQ QLVKVIRPLD
561QPSSFD
ATP YIKDLFTCTI KRLKAADIDQ EVKERAISCM
601GQIICNLGDN LGSDLPNTLQ IFLERLKNEI TRLTTVKALT
641LIAGSPL
KI DLRPVLGEGV PILASFLRKN QRALKLGTLS
681ALDILIKNYS DSLTAAMIDA VLDELPPLIS ESDMHVSQMA
721ISFLTTLA
K VYPSSLSKIS GSILNELIGL VRSPLLQGGA
761LSAMLDFFQA LVVTGTNNLG YMDLLRMLTG PVYSQSTALT
801HKQSYYSIA
 KCVAALTRAC PKEGPAVVGQ FIQDVKNSRS
841TDSIRLLALL SLGEVGHHID LSGQLELKSV ILEAFSSPSE
881EVKSAASYAL 
GSISVGNLP EYLPFVLQEI TSQPKRQYLL
921LHSLKEIISS ASVVGLKPYV ENIWALLLKH CECAEEGTRN
961VVAECLGKLT L
IDPETLLP RLKGYLISGS SYARSSVVTA
1001VKFTISDHPQ PIDPLLKNCI GDFLKTLEDP DLNVRRVALV
1041TFNSAAHNKP SL
IRDLLDT VLPHLYNETK VRKELIREVE
1081MGPFKHTVDD GLDIRKAAFE CMYTLLDSCL DRLDIFEFLN
1121HVEDGLKDHY DIK
MLTFLM LVRLSTLCPS AVLQRLDRLV
1161EPLRATCTTK VKANSVKQEF EKQDELKRSA MRAVAALLTI
1201PEAEKSPLMS EFQS
QISSN PELAAIFESI QKDSSSTNLE
1241SMDTS

结构预测来自 AlphaFold DB（UniProt: Q86VP6），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

SNP variants of CAND1: Showing partial SNPs

rs710621 rs710622 rs710623 rs710629 rs710630 rs775306 rs775308 rs775309 rs775310 rs775311 rs775312 rs775625 rs775627 rs775628 rs775657 rs775658 rs775659

Tissue expression of CAND1: [UniProt]

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

GATATCAGGCTCATCATATGCC

59

ATCAATAGGTTGTGGATGGTC

58

CAGAAAGATTCCATCAAGTTGG

58

CTAAAGGACCAAGACATTTGAC

57

GATATGTTGAGCAGGCAAGG

59

GTCTAGGGCTGGTCAACTG

60

CTGTCAAATGTCTTGGTCCT

58

AAAGCATGTTAGTGCAGAGG

59

AAGTTGGCTATGTGACCCT

59

ACAATGTTGGGAACCTGAC

58

CAAGGACTTTAGGTTTATGGCT

59

AGCTAAATTCTGTACCTCTCCA

59

TACCCTCTGCACTAACATGC

60

CTAATGCAGAGCCACTGGA

60

GGACTTTAGTTCCTCTTGTCAG

59

TTAAGATCCAGCAATCCACC

58

TTTGGTTCCTCCAGTGGTG

60

TATGATGAGCTTTGACAAGCTG

59

TGATATCAGGCTCATCATATGC

58

TCAATAGGTTGTGGATGGTC

57

No data available

Subcellular localization of CAND1 (and its protein):

[UniProt] [GenomeNet]

plasma membrane
cytoplasm
extracellular
golgi
vesicle
cytoskeleton
endoplasmic reticulum
nucleus
endosome
lysosome
mitochondrion

Gene Ontology (GO) terms for CAND1:

GO ID

Protein

Source DB

GO:0000151

Q86VP6 (UniProtKB)

IDA

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005515

Q86VP6 (UniProtKB)

IPI

GO:0005634

Q86VP6 (UniProtKB)

IDA

GO:0005634

Q86VP6 (UniProtKB)

IDA

GO:0005634

Q86VP6 (UniProtKB)

IDA

GO:0005654

Q86VP6 (UniProtKB)

IDA

GO:0005737

Q86VP6 (UniProtKB)

IDA

GO:0005737

Q86VP6 (UniProtKB)

IDA

GO:0005794

Q86VP6 (UniProtKB)

IDA

GO:0010265

Q86VP6 (UniProtKB)

IDA

GO:0010265

Q86VP6 (UniProtKB)

IDA

GO:0016020

Q86VP6 (UniProtKB)

IDA

GO:0016567

Q86VP6 (UniProtKB)

IDA

GO:0016567

Q86VP6 (UniProtKB)

IDA

GO:0016567

Q86VP6 (UniProtKB)

IDA

GO:0017025

Q86VP6 (UniProtKB)

IEA

GO:0030154

Q86VP6 (UniProtKB)

IDA

GO:0031461

Q86VP6 (UniProtKB)

IDA

GO:0031461

Q86VP6 (UniProtKB)

IDA

GO:0031461

Q86VP6 (UniProtKB)

IDA

GO:0043086

Q86VP6 (UniProtKB)

IDA

GO:0045899

Q86VP6 (UniProtKB)

IEA

GO:0070062

Q86VP6 (UniProtKB)

IDA

GO:0070062

Q86VP6 (UniProtKB)

IDA

GO:0070062

Q86VP6 (UniProtKB)

IDA

microRNAs potentially regulating CAND1:

hsa-miR-1 hsa-let-7b hsa-let-7b* hsa-miR-16 hsa-miR-30a hsa-miR-30a* hsa-miR-30b hsa-miR-30b* hsa-miR-30c hsa-miR-30d

BioGrid

IntAct

mentha

MINT

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Interacting Gene	Interaction	Source/Score

Disease

Score

NofPmids

NofSnps

Source

Disease	Score	NofPmids	NofSnps	Source
Osteoporosis	0.002367032	1	1	GAD
Prostatic Neoplasms	0.000271442	1	0	BeFree
Malignant neoplasm of prostate	0.000271442	1	0	BeFree
Adenocarcinoma	0.000271442	1	0	BeFree
Prostate carcinoma	0.000271442	1	0	BeFree
Carcinogenesis	0.000271442	1	0	BeFree

Genome-wide association study identified genomic regions and putative candidate genes affecting different backfat layers in Landrace pigs.

Meng Z, Liu Y, Yang W, Wang J, Li PH, Huang RH, Wu WJ Animal IF: 4.1 2026-03-00

Identification of Candidate Genes Associated with Growth Traits in Procambarus clarkii Using Whole-Genome Resequencing.

Li J, Hu P, Zhang H, Luo Y, Huang X, Wang D, Li J, Wang Z, Wang Y, Liu S Int J Mol Sci IF: 3.226 2026-08-29

Proximal Proteomics Reveals Potential Regulators of Programmed Death-Ligand 1 in Human Cancer.

Shi F, Liu D, Liu Y, Li F, Zhang CZ, Li Q, Tian QH ACS Omega IF: 5.2 2026-08-25

The role of plectin as a druggable target in papillary thyroid carcinoma: therapeutic potential of troglitazone.

Lv YC, Zhou JH, Shi TF, Cui YF Front Immunol IF: 7.0 2026-00-00

CAND1 drives intestinal ischemia/reperfusion injury via SCFFBXO6-PKM2-mediated mitochondrial fission and apoptosis.

Qiang M, Zhao Y, Wang G, Chen Z, Zhang F, Wang Z, Wang G, Zhuang C, Ning S, Yao J, Tian X Free Radic Biol Med IF: 8.0 2026-10-00

Identification of CAND1 as a DNA-dependent protein kinase-regulated coactivator of androgen receptor and the ARv7 splice variant.

Hamilton RA, Paul B, Yi P, Rajapakshe K, Panigrahi AK, Grimm SL, Coarfa C, Malovannaya A, Weigel NL, Lonard DM, Foulds CE PLoS One IF: 2.6 None

CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1.

Wang K, Kenny S, Chagan Z, Li L, Das C, Liu X Structure IF: 4.6 2026-06-04

Integrated molecular mechanisms of salinity response in Apostichopus japonicus: focus on miRNA-driven core pathways and target gene regulation.

Chen J, Zhao Y, Li N, Wang H, Wu X, Wang B, Wei X, Chang Y, Tian Y Mar Biotechnol (NY) IF: 2.8 2026-08-10

Early regulatory networks driving somatic embryogenesis in Saccharum spp. L. revealed by time-resolved proteomics.

da Paschoa RP, Xavier LR, Corrêa CCG, Vieira KDS, Pacheco DDR, Gomes LDES, da Silva CEA, Alves LEO, Pinto VB, Santa-Catarina C, Silveira V J Proteomics IF: 3.1 2026-04-20

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.

Schumacher Frances-Rose, Siew Keith, Zhang Jinwei, Johnson Clare, Wood Nicola, Cleary Sarah E, Al Maskari Raya S, Ferryman James T, Hardege Iris, Yasmin, Figg Nichola L, Enchev Radoslav, Knebel Axel, O'Shaughnessy Kevin M, Kurz Thimo EMBO Mol Med IF: 7.9 2016-07-11

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CAND1 (cullin associated and neddylation dissociated 1)

Gene Basic Information

Gene Basic Information

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Chromosome Location

Gene Summary

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Gene Sequence

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Encoded Protein

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