CAND2 (cullin associated and neddylation dissociated 2 (putative))

Gene Basic Information

Gene Basic Information

symbol:
CAND2
locus group:
protein-coding gene
location:
3p25.2
gene_family:
alias symbol:
TIP120B|KIAA0667|Tp120b
alias name:
TBP interacting protein
entrez id:
23066
ensembl gene id:
ENSG00000144712
ucsc gene id:
uc003bxk.3
refseq accession:
NM_001162499
hgnc_id:
HGNC:30689
approved reserved:
2005-05-24

Chromosome Location

Chromosome Location

3p25.2

Gene Summary

Gene Summary

CAND2（也称为NAC2或NAC2β）是NAC（Nascent polypeptide-Associated Complex）基因家族的一员，该家族在真核生物中高度保守，主要参与调控蛋白质的合成、折叠和转运过程。NAC家族成员通常由α和β亚基组成，共同形成异源二聚体，协助新生肽链从核糖体释放并防止错误折叠。CAND2作为β亚基之一，与CAND1（α亚基）结合形成功能性复合物，在细胞内广泛表达，尤其在需要高蛋白合成的组织中（如肝脏、肌肉）活性较高。其核心功能包括：协助核糖体-新生肽链复合物的稳定性、参与蛋白质质量控制、调节内质网应激反应，并在自噬过程中发挥间接作用。CAND2的突变可能导致其与α亚基结合能力下降，引发错误折叠蛋白积累，与神经退行性疾病（如阿尔茨海默病、帕金森病）和某些癌症的发生相关。过表达CAND2可能增强细胞应对蛋白质毒性应激的能力，但长期过表达可能干扰正常蛋白稳态，导致自噬通路异常；而表达降低则会使错误折叠蛋白清除效率下降，加速细胞凋亡。此外，CAND2通过影响mTOR信号通路间接调控细胞生长，其表达水平变化可能影响肿瘤发展。该基因与家族成员CAND1/NAC1具有约60%的序列相似性，家族共性包括：均含有保守的NAC结构域、依赖亚基互作发挥功能、参与翻译后调控等。研究还发现CAND2在多发性骨髓瘤中表达异常，可能成为潜在治疗靶点。

ChineseEnglish

None

OMIM entry for CAND2     Wikipedia entry for CAND2

Gene Sequence

Gene Sequence

Nucleotide sequence of CAND2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MSTAAFHISS LLEKMTSSDK DFRFMATSDL MSELQKDSIQ
41LDEDSERKVV KMLLRLLEDK NGEVQNLAVK CLGPLVVKVK
81 EYQVETIVD TLCTNMRSDK EQLRDIAGIG LKTVLSELPP
121AATGSGLATN VCRKITGQLT SAIAQQEDVA VQLEALDILS
161D MLSRLGVP LGAFHASLLH CLLPQLSSPR LAVRKRAVGA
201LGHLAAACST DLFVELADHL LDRLPGPRVP TSPTAIRTLI
241QC LGSVGRQ AGHRLGAHLD RLVPLVEDFC NLDDDELRES
281CLQAFEAFLR KCPKEMGPHV PNVTSLCLQY IKHDPNYNYD
321SDE DEEQME TEDSEFSEQE SEDEYSDDDD MSWKVRRAAA
361KCIAALISSR PDLLPDFHCT LAPVLIRRFK EREENVKADV
401FTAY IVLLR QTQPPKGWLE AMEEPTQTGS NLHMLRGQVP
441LVVKALQRQL KDRSVRARQG CFSLLTELAG VLPGSLAEHM
481PVLVS GIIF SLADRSSSST IRMDALAFLQ GLLGTEPAEA
521FHPHLPILLP PVMACVADSF YKIAAEALVV LQELVRALWP
561LHRPRM LDP EPYVGEMSAV TLARLRATDL DQEVKERAIS
601CMGHLVGHLG DRLGDDLEPT LLLLLDRLRN EITRLPAIKA
641LTLVAVS PL QLDLQPILAE ALHILASFLR KNQRALRLAT
681LAALDALAQS QGLSLPPSAV QAVLAELPAL VNESDMHVAQ
721LAVDFLAT V TQAQPASLVE VSGPVLSELL RLLRSPLLPA
761GVLAAAEGFL QALVGTRPPC VDYAKLISLL TAPVYEQAVD
801GGPGLHKQV FHSLARCVAA LSAACPQEAA STASRLVCDA
841RSPHSSTGVK VLAFLSLAEV GQVAGPGHQR ELKAVLLEAL
881GSPSEDVRAA ASYALGRVG AGSLPDFLPF LLEQIEAEPR
921RQYLLLHSLR EALGAAQPDS LKPYAEDIWA LLFQRCEGAE
961EGTRGVVAEC I GKLVLVNP SFLLPRLRKQ LAAGRPHTRS
1001TVITAVKFLI SDQPHPIDPL LKSFIGEFME SLQDPDLNVR
1041RATLAFFNSA VH NKPSLVR DLLDDILPLL YQETKIRRDL
1081IREVEMGPFK HTVDDGLDVR KAAFECMYSL LESCLGQLDI
1121CEFLNHVEDG LKD HYDIRM LTFIMVARLA TLCPAPVLQR
1161VDRLIEPLRA TCTAKVKAGS VKQEFEKQDE LKRSAMRAVA
1201ALLTIPEVGK SPIM ADFSS QIRSNPELAA LFESIQKDSA
1241SAPSTDSMEL S
结构预测来自 AlphaFold DB（UniProt: O75155），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of CAND2:           Showing partial SNPs
rs731646       rs906671       rs1079361       rs1508757       rs1876617       rs2002725       rs2004577       rs2305396       rs2305397       rs2305398       rs3105785       rs3732675       rs3732676       rs3732677       rs3732678       rs3732679       rs3732680      

Gene Expression

Gene Expression

Tissue expression of CAND2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CAAGGACTTCAGGTTCATGG
59
TTATGGCAACTCAATGGCC
59
TGTATTCACTGCTTGAGAGCT
60
TGATGAAGGTCAGCATCCG
60
CTTCATCGGAGAGTTCATGG
58
GCTGAGTTGAAGAAAGCCA
58
GAAGAGCTTCATCGCTGTG
59
CTTTGTCTCCTGGTAGAGGA
58
TGCTGACCTTCATCATGGT
59
GTTTGGTTCCTTGGCAGTG
60
AGGACTTCAGGTTCATGGC
60
CACTTTGACCACCAGAGGA
59
TGGATTCACCTTCCCACTC
59
TACTCCTTCACTTTGACCACC
60
CAAGGACTTCAGGTTCATGG
59
TTATGGCAACTCAATGGCC
59
GTATTCACTGCTTGAGAGCTG
59
TGATGAAGGTCAGCATCCG
60
CTGACCTTCATCATGGTTGC
59
GTTTGGTTCCTTGGCAGTG
60

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of CAND2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for CAND2:

GO ID
Protein
Source DB
GO:0005515
O75155 (UniProtKB)
IPI
GO:0005515
O75155 (UniProtKB)
IPI
GO:0005622
O75155 (UniProtKB)
IDA
GO:0005634
O75155 (UniProtKB)
IBA
GO:0006351
O75155 (UniProtKB)
IEA
GO:0010265
O75155 (UniProtKB)
IBA
GO:0016567
O75155 (UniProtKB)
IBA
GO:0017025
O75155 (UniProtKB)
IEA
GO:0017025
O75155 (UniProtKB)
IEA
GO:0045893
O75155 (UniProtKB)
ISS

Related microRNA

Related microRNA

microRNAs potentially regulating CAND2:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Congenital clubfoot 0.002638474 1 0 BeFree_GAD

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