CENPA (centromere protein A)

Gene Basic Information

Gene Basic Information

symbol:
CENPA
locus group:
protein-coding gene
location:
2p23.3
gene_family:
alias symbol:
CENP-A|CenH3
alias name:
centromere-specific histone|histon…
entrez id:
1058
ensembl gene id:
ENSG00000115163
ucsc gene id:
uc002rhr.4
refseq accession:
NM_001809
hgnc_id:
HGNC:1851
approved reserved:
1988-05-31

Chromosome Location

Chromosome Location

2p23.3

Gene Summary

Gene Summary

CENPA（着丝粒蛋白A）是一种组蛋白H3变体，主要位于染色体的着丝粒区域，负责调控染色体的正确分离和细胞有丝分裂的稳定性。CENPA是着丝粒特异性核小体的核心组成部分，能够招募其他着丝粒相关蛋白（如CENP-C、CENP-N等）形成功能性着丝粒，确保纺锤体微管正确附着，从而在细胞分裂时精确分配染色体。CENPA的突变可能导致着丝粒功能异常，引发染色体不稳定性、非整倍体或微核形成，与多种癌症（如乳腺癌、结直肠癌）及发育障碍相关。CENPA过表达可能增加染色体错误分离的风险，促进肿瘤发生；而表达降低则可能导致着丝粒组装缺陷，引发细胞周期停滞或凋亡。CENPA属于CENP（着丝粒蛋白）家族，该家族成员（如CENPB、CENPC等）共同参与着丝粒结构与功能的维持，确保有丝分裂和减数分裂的正常进行。CENP家族蛋白通常含有保守的DNA结合或蛋白质互作域，能够特异性识别着丝粒区域并形成多蛋白复合物。CENPA的表达受细胞周期严格调控，在G1期开始积累，S期达到高峰，其异常表达可能影响其他细胞周期相关基因（如CDK1、Cyclin B）的功能。研究CENPA有助于理解染色体稳定性机制及开发针对癌症的靶向治疗策略。

ChineseEnglish

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

OMIM entry for CENPA     Wikipedia entry for CENPA

Gene Sequence

Gene Sequence

Nucleotide sequence of CENPA:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MGPRRRSRKP EAPRRRSPSP TPTPGPSRRG PSLGASSHQH
41SRRRQGWLKE IRKLQKSTHL LIRKLPFSRL AREICVKFTR
81 GVDFNWQAQ ALLALQEAAE AFLVHLFEDA YLLTLHAGRV
121TLFPKDVQLA RRIRGLEEGL G
结构预测来自 AlphaFold DB（UniProt: P49450），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of CENPA:           Showing partial SNPs
rs1007357       rs1975213       rs2117274       rs2164043       rs2196151       rs2217742       rs2289017       rs2289018       rs3806517       rs3806518       rs3901169       rs4665347       rs6710941       rs6716283       rs9807998       rs10167038       rs10184206      

Gene Expression

Gene Expression

Tissue expression of CENPA:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CTGTCTCTGAACAGCTGGA
59
TAGAGACAGGGTCCGAGAG
60
AGGTTGGCTAAAGGAGATCC
59
GAAATGCTTCTGCTGCCAG
60
CTAAAGGAGATCCGAAAGCT
57
ATATTTCTCTTGCCAGGCG
58
ATAAGGAAGCTGCCCTTCAG
59
TTCTGCTGCCTCTTGTAGG
59
AGGTTGGCTAAAGGAGATCC
59
GAAATGCTTCTGCTGCCAG
60
ACTCCTTCACAGGCAAGAG
59
TTCTGCTGCCTCTTGTAGG
59
CTAAAGGAGATCCGAAAGCT
57
ATATTTCTCTTGCCAGGCG
58
TAAGGAAGCTGCCCTTCAG
59
TTCTGCTGCCTCTTGTAGG
59
AGGAGATCCGAAAGCTTCAG
60
CACATATTTCTCTTGCCAGGC
60
TCACAGGCAAGAGAAATATGTG
59
TTCTGCTGCCTCTTGTAGG
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of CENPA (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for CENPA:

GO ID
Protein
Source DB
GO:0000786
F8WD88 (UniProtKB)
IEA
GO:0003677
F8WD88 (UniProtKB)
IEA
GO:0005634
F8WD88 (UniProtKB)
IEA
GO:0046982
F8WD88 (UniProtKB)
IEA
GO:0000132
P49450 (UniProtKB)
IMP
GO:0000775
P49450 (UniProtKB)
IDA
GO:0000778
P49450 (UniProtKB)
IDA
GO:0000780
P49450 (UniProtKB)
IDA
GO:0000786
P49450 (UniProtKB)
IEA
GO:0000939
P49450 (UniProtKB)
IEA
GO:0003677
P49450 (UniProtKB)
IEA
GO:0003682
P49450 (UniProtKB)
TAS
GO:0005515
P49450 (UniProtKB)
IPI
GO:0005515
P49450 (UniProtKB)
IPI
GO:0005515
P49450 (UniProtKB)
IPI
GO:0005515
P49450 (UniProtKB)
IPI
GO:0005515
P49450 (UniProtKB)
IPI
GO:0005515
P49450 (UniProtKB)
IPI
GO:0005515
P49450 (UniProtKB)
IPI
GO:0005515
P49450 (UniProtKB)
IPI
GO:0005515
P49450 (UniProtKB)
IPI
GO:0005515
P49450 (UniProtKB)
IPI
GO:0005634
P49450 (UniProtKB)
IDA
GO:0005634
P49450 (UniProtKB)
IDA
GO:0005654
P49450 (UniProtKB)
TAS
GO:0005654
P49450 (UniProtKB)
TAS
GO:0005654
P49450 (UniProtKB)
TAS
GO:0005829
P49450 (UniProtKB)
TAS
GO:0005829
P49450 (UniProtKB)
TAS
GO:0005829
P49450 (UniProtKB)
TAS
GO:0005829
P49450 (UniProtKB)
TAS
GO:0005829
P49450 (UniProtKB)
TAS
GO:0005829
P49450 (UniProtKB)
TAS
GO:0005829
P49450 (UniProtKB)
TAS
GO:0005829
P49450 (UniProtKB)
TAS
GO:0005829
P49450 (UniProtKB)
TAS
GO:0005829
P49450 (UniProtKB)
TAS
GO:0007062
P49450 (UniProtKB)
TAS
GO:0016032
P49450 (UniProtKB)
IEA
GO:0034080
P49450 (UniProtKB)
TAS
GO:0046982
P49450 (UniProtKB)
IEA
GO:0051382
P49450 (UniProtKB)
IDA
GO:0071459
P49450 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating CENPA:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
IGA Glomerulonephritis 0.12 1 0 CTD_human
Colorectal Neoplasms 0.00272435 1 0 LHGDN
Systemic Scleroderma 0.001085767 4 0 BeFree
Adenocarcinoma of lung (disorder) 0.000814326 3 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Scleroderma 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Colorectal Cancer 0.000542884 2 0 BeFree
Liver carcinoma 0.000542884 2 0 BeFree
Colorectal Carcinoma 0.000542884 2 0 BeFree

Related Publications

Related Publications

CENPA Promotes Endometrial Cancer Progression by Stabilizing YY1 and Enhancing Glycolytic Metabolism.
Wang L, Wu H, Tang X, Zheng X, Zhou L, Lu M Front Biosci (Landmark Ed) IF: 4.1 2026-03-18
EBNA1BP2 (EBP2) promotes the progression of hepatocellular carcinoma through upregulating the expression of MCM8 and HMGB1.
Ma E, Xing H, Sun C, Zhang Q, Shen C, Zhan Y, Li J, Li L, Xue H, Li R, Teng F, Tao Y Cell Death Dis IF: 12.2 2026-04-04
Development of a G2/M checkpoint subtype classifier for guiding precision therapy in liver hepatocellular carcinoma patients.
Zhou Q, Zhang G, Wang X, Du Z, Peng H, Zhang Y, Cao P Cancer Cell Int IF: 2.740 2026-03-13
Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans.
Hollis JA, Stonick JA, Topalidou I, Young JM, Moens CB, Lehrbach NJ, Campbell MG, Malik HS bioRxiv 2026-04-20
HIV-1 Vpr induces an NFAT-controlled transcriptional program in primary CD4+ T cells.
Leyens J, Vanegas-Torres CA, Darius A, Seizer R, Maurer B, Sauter D, Lotke R, Schindler M mBio IF: 5.1 2026-03-11
Dysregulation of microRNAs and Centromere Protein Genes in Prostate Cancer and Metastatic Progression.
Somuncu MN, Karalezli İ, Göger YE, Zamani AG, Yıldırım MS, Deveci A, Avunduk MC, Karalezli G Urol Res Pract 2026-04-02

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