CENPE基因详情-基因数据库-基因云馆

CENPE (centromere protein E)

symbol:: CENPE
locus group:: protein-coding gene
location:: 4q24
gene_family:: Kinesins|Protein phosphatase 1 regulatory subunits
alias symbol:: KIF10|PPP1R61
alias name:: protein phosphatase 1, regulator...
entrez id:: 1062
ensembl gene id:: ENSG00000138778
ucsc gene id:: uc003hxb.1
refseq accession:: NM_001286734
hgnc_id:: HGNC:1856
approved reserved:: 1994-07-04

4q24

CENPE（着丝粒相关蛋白E）是一种微管动力蛋白，属于驱动蛋白（kinesin）家族中的Kinesin-7亚家族。该基因编码的蛋白质在有丝分裂过程中发挥关键作用，主要定位在动粒（kinetochore）上，负责介导染色体与纺锤体微管的正确连接和染色体向赤道板的排列。CENPE具有ATP酶活性，能够沿着微管移动，帮助纠正错误的染色体-微管连接，确保染色体的正确分离。CENPE的突变或功能异常可能导致染色体错误分离，引发非整倍体（aneuploidy），这与多种癌症的发生密切相关，如结直肠癌、乳腺癌和肺癌等。此外，CENPE的突变还与某些罕见的遗传性疾病相关，如Mosaic Variegated Aneuploidy（MVA）综合征，患者表现为发育迟缓、小头畸形和癌症易感性增加。CENPE过表达可能导致细胞分裂异常，促进肿瘤细胞的增殖和侵袭性增强；而降低表达则会导致染色体分离错误，细胞周期停滞或凋亡。CENPE属于驱动蛋白家族，该家族成员通常具有保守的ATP结合和微管结合结构域，能够利用ATP水解产生的能量沿微管运输货物或调节微管动力学。Kinesin-7亚家族的成员主要参与有丝分裂和减数分裂过程中的染色体运动。CENPE的功能受到多种激酶（如Aurora B和PLK1）的调控，这些激酶通过磷酸化修饰调节其与微管和动粒的结合能力。CENPE已成为抗癌药物开发的潜在靶点，抑制其功能可干扰肿瘤细胞的有丝分裂，目前已有针对CENPE的小分子抑制剂进入临床前研究阶段。

中文English

None

OMIM数据库中对CENPE基因的介绍 Wikipedia数据库中对CENPE基因的介绍

CENPE基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MAEEGAVAVC VRVRPLNSRE ESLGETAQVY WKTDNNVIYQ
41VDGSKSFNFD RVFHGNETTK NVYEEIAAPI IDSAIQGYNG
81
TIFAYGQTA SGKTYTMMGS EDHLGVIPRA IHDIFQKIKK
121FPDREFLLRV SYMEIYNETI TDLLCGTQKM KPLIIREDVN
161R
NVYVADLT EEVVYTSEMA LKWITKGEKS RHYGETKMNQ
201RSSRSHTIFR MILESREKGE PSNCEGSVKV SHLNLVDLAG
241SE
RAAQTGA AGVRLKEGCN INRSLFILGQ VIKKLSDGQV
281GGFINYRDSK LTRILQNSLG GNAKTRIICT ITPVSFDETL
321TAL
QFASTA KYMKNTPYVN EVSTDEALLK RYRKEIMDLK
361KQLEEVSLET RAQAMEKDQL AQLLEEKDLL QKVQNEKIEN
401LTRM
LVTSS SLTLQQELKA KRKRRVTWCL GKINKMKNSN
441YADQFNIPTN ITTKTHKLSI NLLREIDESV CSESDVFSNT
481LDTLS
EIEW NPATKLLNQE NIESELNSLR ADYDNLVLDY
521EQLRTEKEEM ELKLKEKNDL DEFEALERKT KKDQEMQLIH
561EISNLK
NLV KHAEVYNQDL ENELSSKVEL LREKEDQIKK
601LQEYIDSQKL ENIKMDLSYS LESIEDPKQM KQTLFDAETV
641ALDAKRE
SA FLRSENLELK EKMKELATTY KQMENDIQLY
681QSQLEAKKKM QVDLEKELQS AFNEITKLTS LIDGKVPKDL
721LCNLELEG
K ITDLQKELNK EVEENEALRE EVILLSELKS
761LPSEVERLRK EIQDKSEELH IITSEKDKLF SEVVHKESRV
801QGLLEEIGK
 TKDDLATTQS NYKSTDQEFQ NFKTLHMDFE
841QKYKMVLEEN ERMNQEIVNL SKEAQKFDSS LGALKTELSY
881KTQELQEKTR 
EVQERLNEM EQLKEQLENR DSTLQTVERE
921KTLITEKLQQ TLEEVKTLTQ EKDDLKQLQE SLQIERDQLK
961SDIHDTVNMN I
DTQEQLRN ALESLKQHQE TINTLKSKIS
1001EEVSRNLHME ENTGETKDEF QQKMVGIDKK QDLEAKNTQT
1041LTADVKDNEI IE
QQRKIFS LIQEKNELQQ MLESVIAEKE
1081QLKTDLKENI EMTIENQEEL RLLGDELKKQ QEIVAQEKNH
1121AIKKEGELSR TCD
RLAEVE EKLKEKSQQL QEKQQQLLNV
1161QEEMSEMQKK INEIENLKNE LKNKELTLEH METERLELAQ
1201KLNENYEEVK SITK
ERKVL KELQKSFETE RDHLRGYIRE
1241IEATGLQTKE ELKIAHIHLK EHQETIDELR RSVSEKTAQI
1281INTQDLEKSH TKLQE
EIPV LHEEQELLPN VKEVSETQET
1321MNELELLTEQ STTKDSTTLA RIEMERLRLN EKFQESQEEI
1361KSLTKERDNL KTIKEA
LEV KHDQLKEHIR ETLAKIQESQ
1401SKQEQSLNMK EKDNETT

结构预测来自 AlphaFold DB（UniProt: Q02224），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

CENPE基因的碱基突变：仅显示部分snp

rs1031803 rs1031804 rs1049660 rs1381657 rs1381658 rs1967006 rs1986614 rs2045746 rs2126468 rs2126470 rs2169508 rs2243682 rs2251322 rs2251634 rs2276974 rs2276975 rs2279116

CENPE基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GGCTACAATGGTACTATATTTGCC

60

GGTATAACTCCCAAATGATCTTCTG

60

TCAACTGATGAAGCTCTCCT

58

CGTCTCTAAAGAAACCTCCTC

57

CAACTGATGAAGCTCTCCTG

58

GCGTCTCTAAAGAAACCTCC

58

GTTGCCTGAAAGAACAAGAG

57

TCCTTCTCTGAAAGATTCACTC

58

TTACTGCTCTCCAGTTTGC

58

GAGCTTCATCAGTTGATACCT

58

TGAAGAGATACTCAGAGATGGA

58

GATTCTGTGGAATTCCATTTCC

58

GCAGAAAGAACTTGAGGTGAC

60

TCCTAAAGCAACTTTGTCCTG

59

TGATAGCTAGAGACCGACAG

58

TCTCAGGCTTTCCGTAAGG

59

CAAGAAGAGATCCCAGTGCT

60

CATTGTTTCCTGAGTCTCACTG

59

AATGATAGCTAGAGACCGACAG

59

TCAGGCTTTCCGTAAGGTG

60

尚未收录相关数据

CENPE基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

CENPE基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0003777

A0A087X0P0 (UniProtKB)

IEA

GO:0005524

A0A087X0P0 (UniProtKB)

IEA

GO:0005623

A0A087X0P0 (UniProtKB)

IEA

GO:0007018

A0A087X0P0 (UniProtKB)

IEA

GO:0007080

A0A087X0P0 (UniProtKB)

IEA

GO:0008017

A0A087X0P0 (UniProtKB)

IEA

GO:0043515

A0A087X0P0 (UniProtKB)

IEA

GO:0051315

A0A087X0P0 (UniProtKB)

IEA

GO:0003777

D6RBW0 (UniProtKB)

IEA

GO:0005524

D6RBW0 (UniProtKB)

IEA

GO:0005737

D6RBW0 (UniProtKB)

IDA

GO:0007018

D6RBW0 (UniProtKB)

IEA

GO:0007080

D6RBW0 (UniProtKB)

IEA

GO:0008017

D6RBW0 (UniProtKB)

IEA

GO:0015630

D6RBW0 (UniProtKB)

IDA

GO:0043515

D6RBW0 (UniProtKB)

IEA

GO:0051315

D6RBW0 (UniProtKB)

IEA

GO:0003777

D6RHK2 (UniProtKB)

IEA

GO:0005524

D6RHK2 (UniProtKB)

IEA

GO:0005874

D6RHK2 (UniProtKB)

IEA

GO:0007018

D6RHK2 (UniProtKB)

IEA

GO:0007080

D6RHK2 (UniProtKB)

IEA

GO:0008017

D6RHK2 (UniProtKB)

IEA

GO:0043515

D6RHK2 (UniProtKB)

IEA

GO:0051315

D6RHK2 (UniProtKB)

IEA

GO:0000278

Q02224 (UniProtKB)

IMP

GO:0000775

Q02224 (UniProtKB)

IDA

GO:0000775

Q02224 (UniProtKB)

IDA

GO:0000776

Q02224 (UniProtKB)

IDA

GO:0000776

Q02224 (UniProtKB)

IDA

GO:0000779

Q02224 (UniProtKB)

IDA

GO:0003777

Q02224 (UniProtKB)

IMP

GO:0005515

Q02224 (UniProtKB)

IPI

GO:0005515

Q02224 (UniProtKB)

IPI

GO:0005515

Q02224 (UniProtKB)

IPI

GO:0005515

Q02224 (UniProtKB)

IPI

GO:0005524

Q02224 (UniProtKB)

IEA

GO:0005634

Q02224 (UniProtKB)

IMP

GO:0005694

Q02224 (UniProtKB)

IDA

GO:0005737

Q02224 (UniProtKB)

IDA

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005829

Q02224 (UniProtKB)

TAS

GO:0005871

Q02224 (UniProtKB)

IBA

GO:0005874

Q02224 (UniProtKB)

IDA

GO:0006890

Q02224 (UniProtKB)

TAS

GO:0007018

Q02224 (UniProtKB)

TAS

GO:0007059

Q02224 (UniProtKB)

IMP

GO:0007062

Q02224 (UniProtKB)

TAS

GO:0007079

Q02224 (UniProtKB)

TAS

GO:0007080

Q02224 (UniProtKB)

IMP

GO:0007275

Q02224 (UniProtKB)

IEA

GO:0008017

Q02224 (UniProtKB)

IEA

GO:0015630

Q02224 (UniProtKB)

IDA

GO:0016020

Q02224 (UniProtKB)

IDA

GO:0016887

Q02224 (UniProtKB)

IBA

GO:0019886

Q02224 (UniProtKB)

TAS

GO:0030071

Q02224 (UniProtKB)

IMP

GO:0030496

Q02224 (UniProtKB)

IDA

GO:0043515

Q02224 (UniProtKB)

IDA

GO:0045860

Q02224 (UniProtKB)

IMP

GO:0051301

Q02224 (UniProtKB)

IEA

GO:0051315

Q02224 (UniProtKB)

IMP

GO:0051382

Q02224 (UniProtKB)

NAS

GO:1990023

Q02224 (UniProtKB)

IDA

GO:0000940

Q02224 (UniProtKB)

TAS

可能调控 CENPE基因的相关microRNA：

hsa-miR-192 hsa-miR-215

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

Reactomepathway

名称
Adaptive Immune System
Cell Cycle
Cell Cycle, Mitotic
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Kinesins
M Phase
MHC class II antigen presentation
Mitotic Anaphase
Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Resolution of Sister Chromatid Cohesion
RHO GTPase Effectors
RHO GTPases Activate Formins
Separation of Sister Chromatids
Signal Transduction
Signaling by Rho GTPases

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Testicular Germ Cell Tumor	0.12	2	1	GWASCAT
MICROCEPHALY 13, PRIMARY, AUTOSOMAL RECESSIVE	0.12	1	2	UNIPROT
Seckel syndrome	0.12	0	0	ORPHANET
Malignant neoplasm of breast	0.002638474	2	0	BeFree_GAD
Testicular Neoplasms	0.002367032	1	1	GAD
Alcoholic Intoxication, Chronic	0.002367032	1	0	GAD
Central neuroblastoma	0.000542884	2	0	BeFree
Neuroblastoma	0.000542884	2	0	BeFree
Pituitary Diseases	0.000271442	1	0	BeFree
Dwarfism	0.000271442	1	0	BeFree

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Time-Dependent Anti-inflammatory and Antibacterial Dual-Functional Suture Fibers for Surgical Treatment.

Lu J, Zhong W, Ma H, Pan L, Zhou Z, Hou K, Shao G, Zhu M ACS Appl Mater Interfaces IF: 7.8 2026-04-29

The dynamics of centromere assembly and disassembly during quiescence.

Marescal O, Su KC, Moodie B, Taylor NJL, Cheeseman IM J Cell Biol IF: 6.1 2026-06-01

Assembly and phosphoregulatory mechanisms of the budding yeast outer kinetochore KMN complex.

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Haplotype-resolved centromeric chromatin organization from a complete diploid human genome.

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Disrupting Neutrophil Extracellular Traps with Targeted Cerium Oxide Nanoparticles Ameliorates Diabetic Periodontitis.

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Mitotic BLM functions are required to maintain genomic stability.

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CENPE (centromere protein E)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

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