CHST1 (carbohydrate sulfotransferase 1)

Gene Basic Information

Gene Basic Information

symbol
CHST1
locus group
protein-coding gene
location
11p11.2
gene_family
Sulfotransferases, membrane-bound
alias symbol
C6ST|KSGal6ST
alias name
Keratan sulfotransferase
entrez id
8534
ensembl gene id
ENSG00000175264
ucsc gene id
uc001mys.3
refseq accession
NM_003654
hgnc_id
HGNC:1969
approved reserved
1998-10-02

Chromosome Location

Chromosome Location

11p11.2

Gene Summary

Gene Summary

ChineseEnglish

This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]

OMIM entry for CHST1     Wikipedia entry for CHST1

Gene Sequence

Gene Sequence

Nucleotide sequence of CHST1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MQCSWKAVLL LALASIAIQY TAIRTFTAKS FHTCPGLAEA
41GLAERLCEES PTFAYNLSRK THILILATTR SGSSFVGQLF
81 NQHLDVFYL FEPLYHVQNT LIPRFTQGKS PADRRVMLGA
121SRDLLRSLYD CDLYFLENYI KPPPVNHTTD RIFRRGASRV
161L CSRPVCDP PGPADLVLEE GDCVRKCGLL NLTVAAEACR
201ERSHVAIKTV RVPEVNDLRA LVEDPRLNLK VIQLVRDPRG
241IL ASRSETF RDTYRLWRLW YGTGRKPYNL DVTQLTTVCE
281DFSNSVSTGL MRPPWLKGKY MLVRYEDLAR NPMKKTEEIY
321GFL GIPLDS HVARWIQNNT RGDPTLGKHK YGTVRNSAAT
361AEKWRFRLSY DIVAFAQNAC QQVLAQLGYK IAASEEELKN
401PSVS LVEER DFRPFS
Structure predicted by AlphaFold DB(UniProt: O43916). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of CHST1:           Showing partial SNPs
rs895729       rs895730       rs895731       rs895733       rs895734       rs1026078       rs1447570       rs1447571       rs1447572       rs1447573       rs1447574       rs1562460       rs2012019       rs2028984       rs2277272       rs3740702       rs3802762      

Gene Expression

Gene Expression

Tissue expression of CHST1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GTCCCTCTTTGACCTCACC
60
TGTACTGGATGGCAATGGAG
60
GTTGGAAGAAGACTTTCTCCC
59
TACCAAAGAGGGACTGCTC
59
GCACCACATTTACACATCCA
59
AGACAGACAGCATCACCAC
60
AATGGTCTGTGGTGATGCT
59
TCAGTCATCACTGGTCCAG
59
GAATGGTCTGTGGTGATGC
59
CAGTCATCACTGGTCCAGG
60
ACCACATTTACACATCCACAC
59
CAGACAGACAGCATCACCA
60
AGTCCCTCTTTGACCTCAC
59
TACTGGATGGCAATGGAGG
59
TTGGAAGAAGACTTTCTCCC
57
TTACCAAAGAGGGACTGCT
58
ACCACATTTACACATCCACAC
59
AGACAGACAGCATCACCAC
60
GTCCCTCTTTGACCTCACC
60
TACTGGATGGCAATGGAGG
59

Gene Ontology

Subcellular localization of CHST1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for CHST1:

GO ID
Protein
Source DB
GO:0000139
O43916 (UniProtKB)
TAS
GO:0001517
O43916 (UniProtKB)
IBA
GO:0005976
O43916 (UniProtKB)
TAS
GO:0006012
O43916 (UniProtKB)
IDA
GO:0006790
O43916 (UniProtKB)
IDA
GO:0006954
O43916 (UniProtKB)
IEA
GO:0008146
O43916 (UniProtKB)
IDA
GO:0016021
O43916 (UniProtKB)
NAS
GO:0018146
O43916 (UniProtKB)
TAS
GO:0042339
O43916 (UniProtKB)
IDA
GO:0045130
O43916 (UniProtKB)
IDA
GO:0045130
O43916 (UniProtKB)
TAS

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Osteochondrodysplasias 0.00272435 1 0 LHGDN
Psychoses, Substance-Induced 0.002367032 1 0 GAD
Marijuana Abuse 0.002367032 1 0 GAD
Cataract 0.000271442 1 0 BeFree
Bilateral cataracts (disorder) 0.000271442 1 0 BeFree

Related Publications

Related Publications

Enzymatic basis of branching and extension of O-Man glycans for keratan sulfate biosynthesis.
Itoh T, Tanaka HN, Pareek M, Nagae M, Manya H, Ido A, Mishra SK, Kizuka Y J Biol Chem 2026-02-00
An Integrative Network Analysis Framework for Identifying Altered Glycosylation Pathways Associated with Autism Spectrum Disorder.
Oommen AM, Morel M, Cunningham S, Seoighe C, Joshi L Genes (Basel) IF: 3.600 2026-04-19
Expression of sulfate pathway genes in human neurodevelopment.
Vijayakumar P, Summers KM, Dawson PA J Neurogenet IF: 1.1 None
Identification of polymorphic variants associated with erlotinib-related skin toxicity in advanced non-small cell lung cancer patients by DMET microarray analysis.
Arbitrio Mariamena, Di Martino Maria Teresa, Barbieri Vito, Agapito Giuseppe, Guzzi Pietro Hiram, Botta Cirino, Iuliano Eleonora, Scionti Francesca, Altomare Emanuela, Codispoti Stefania, Conforti Serafino, Cannataro Mario, Tassone Pierfrancesco, Tagliaferri Pierosandro Cancer Chemother Pharmacol IF: 2.5 2016-05-17
In TCR-stimulated T-cells, N-ras regulates specific genes and signal transduction pathways.
Lynch Stephen J, Zavadil Jiri, Pellicer Angel PLoS One IF: 2.6 2015-01-28
DMET™ (Drug-Metabolizing Enzymes and Transporters) microarray analysis of colorectal cancer patients with severe 5-fluorouracil-induced toxicity.
Rumiato Enrica, Boldrin Elisa, Amadori Alberto, Saggioro Daniela Cancer Chemother Pharmacol IF: 2.5 2013-09-24
Identification of mono- and disulfated N-acetyl-lactosaminyl Oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer.
Shibata Toshiaki K, Matsumura Fumiko, Wang Ping, Yu Shinyi, Chou Chi-Chi, Khoo Kay-Hooi, Kitayama Kazuko, Akama Tomoya O, Sugihara Kazuhiro, Kanayama Naohiro, Kojima-Aikawa Kyoko, Seeberger Peter H, Fukuda Minoru, Suzuki Atsushi, Aoki Daisuke, Fukuda Michiko N J Biol Chem IF: 4.1 2012-04-25
Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs.
Guo Jin P, Brummet Mary E, Myers Allen C, Na Ho Jeong, Rowland Elizabeth, Schnaar Ronald L, Zheng Tao, Zhu Zhou, Bochner Bruce S Am J Respir Cell Mol Biol IF: 5.4 2011-03-14

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