CREG1 (cellular repressor of E1A stimulated genes 1)
- symbol:
- CREG1
- locus group:
- protein-coding gene
- location:
- 1q24.2
- gene_family:
- alias symbol:
- None
- alias name:
- None
- entrez id:
- 8804
- ensembl gene id:
- ENSG00000143162
- ucsc gene id:
- uc001gel.4
- refseq accession:
- NM_003851
- hgnc_id:
- HGNC:2351
- approved reserved:
- 1999-06-24
CREG1（细胞再生基因1）是一种在细胞增殖、分化和组织稳态中发挥重要作用的基因，其编码的蛋白质属于CREG家族。CREG1蛋白是一种分泌型糖蛋白，广泛表达于多种组织中，尤其在心脏、骨骼肌和胎盘等器官中表达较高。它的主要生物学功能包括抑制细胞过度增殖、促进细胞分化以及参与组织修复和再生过程。CREG1通过调节细胞周期相关蛋白（如p21和cyclin D1）的表达来影响细胞周期进程，从而维持组织的稳态。此外，CREG1还能通过抑制MAPK和PI3K/AKT信号通路来调控细胞的生长和存活。CREG1的突变可能导致其功能丧失或异常，进而引发细胞增殖失控，与某些肿瘤（如肝癌和乳腺癌）的发生发展相关。研究表明，CREG1的表达水平降低可能与肿瘤的恶性程度增加和预后不良有关。相反，CREG1的过表达可以抑制肿瘤细胞的生长并诱导其分化，显示出潜在的抑癌作用。CREG1还参与心血管系统的保护，其表达水平的变化可能与心肌肥厚和心力衰竭等心血管疾病的发生有关。CREG1属于CREG基因家族，该家族成员在结构上具有相似性，均含有保守的功能域，并在细胞增殖、分化和组织修复中发挥重要作用。CREG家族基因的共同特点是能够通过调控细胞周期和信号通路来维持组织的稳态，并在多种生理和病理过程中扮演关键角色。CREG1的表达水平受多种因素调控，包括转录因子、表观遗传修饰和微环境信号等。进一步研究CREG1的功能和调控机制，可能为开发针对肿瘤和心血管疾病的新型治疗策略提供重要线索。
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]
Gene Ontology
Subcellular localization of CREG1 (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for CREG1:
| Interacting Gene | Interaction | Source/Score |
| Disease | Score | NofPmids | NofSnps | Source |
| Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Osteoporosis | 0.002367032 | 1 | 0 | GAD |
| Hypertensive disease | 0.002367032 | 1 | 0 | GAD |
| Ankylosing spondylitis | 0.000542884 | 2 | 0 | BeFree |
| Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
| Myocardial Infarction | 0.000271442 | 1 | 0 | BeFree |
| Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Coronary Artery Disease | 0.000271442 | 1 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
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