CENPC (centromere protein C)

Gene Basic Information

Gene Basic Information

symbol:
CENPC
locus group:
protein-coding gene
location:
4q13.2
gene_family:
alias symbol:
CENP-C|hcp-4|MIF2
alias name:
None
entrez id:
1060
ensembl gene id:
ENSG00000145241
ucsc gene id:
None
refseq accession:
NM_001362481
hgnc_id:
HGNC:1854
approved reserved:
1998-01-16

Chromosome Location

Chromosome Location

4q13.2

Gene Summary

Gene Summary

CENPC（着丝粒蛋白C）是一种重要的着丝粒相关蛋白，主要参与染色体的正确分离和有丝分裂的调控。它属于着丝粒蛋白家族（CENP家族），该家族成员共同特点是定位在着丝粒区域，参与形成动粒结构并确保染色体在细胞分裂时正确分配到子细胞中。CENPC是动粒的核心组成部分，直接与DNA结合并招募其他动粒蛋白如CENPA和CENPN，形成功能性动粒复合体。CENPC的生物学功能主要体现在维持染色体稳定性上，它通过与微管结合确保纺锤体正确附着，防止染色体错误分离导致的非整倍体现象。突变或表达异常会对CENPC功能产生严重影响，如错义突变可能导致其无法正常结合DNA或与其他动粒蛋白相互作用，造成染色体分离错误，这与多种癌症的发生密切相关，特别是那些表现出染色体不稳定的肿瘤类型。CENPC表达水平变化也会显著影响细胞功能，过表达可能导致动粒结构异常和染色体错误分离，而表达降低则会引起动粒组装缺陷、纺锤体检查点失效，最终导致非整倍体细胞产生。CENPC还与某些遗传性疾病相关，如着丝粒异常导致的发育障碍。CENP家族成员通常具有保守的蛋白结构域，能特异性识别着丝粒区域并形成多蛋白复合体，共同维持基因组稳定性。研究还发现CENPC与其他细胞周期调控蛋白如CDK1存在功能关联，其表达受细胞周期严格调控。

ChineseEnglish

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]

OMIM entry for CENPC     Wikipedia entry for CENPC

Gene Sequence

Gene Sequence

Nucleotide sequence of CENPC:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAASGLDHLK NGYRRRFCRP SRARDINTEQ GQNVLEILQD
41CFEEKSLAND FSTNSTKSVP NSTRKIKDTC IQSPSKECQK
81 SHPKSVPVS SKKKEASLQF VVEPSEATNR SVQAHEVHQK
121ILATDVSSKN TPDSKKISSR NINDHHSEAD EEFYLSVGSP
161S VLLDAKTS VSQNVIPSSA QKRETYTFEN SVNMLPSSTE
201VSVKTKKRLN FDDKVMLKKI EIDNKVSDEE DKTSEGQERK
241PS GSSQNRI RDSEYEIQRQ AKKSFSTLFL ETVKRKSESS
281PIVRHAATAP PHSCPPDDTK LIEDEFIIDE SDQSFASRSW
321ITI PRKAGS LKQRTISPAE STALLQGRKS REKHHNILPK
361TLANDKHSHK PHPVETSQPS DKTVLDTSYA LIGETVNNYR
401STKY EMYSK NAEKPSRSKR TIKQKQRRKF MAKPAEEQLD
441VGQSKDENIH TSHITQDEFQ RNSDRNMEEH EEMGNDCVSK
481KQMPP VGSK KSSTRKDKEE SKKKRFSSES KNKLVPEEVT
521STVTKSRRIS RRPSDWWVVK SEESPVYSNS SVRNELPMHH
561NSSRKS TKK TNQSSKNIRK KTIPLKRQKT ATKGNQRVQK
601FLNAEGSGGI VGHDEISRCS LSEPLESDEA DLAKKKNLDC
641SRSTRSS KN EDNIMTAQNV PLKPQTSGYT CNIPTESNLD
681SGEHKTSVLE ESGPSRLNNN YLMSGKNDVD DEEVHGSSDD
721SKQSKVIP K NRIHHKLVLP SNTPNVRRTK RTRLKPLEYW
761RGERIDYQGR PSGGFVISGV LSPDTISSKR KAKENIGKVN
801KKSNKKRIC LDNDERKTNL MVNLGIPLGD PLQPTRVKDP
841ETREIILMDL VRPQDTYQFF VKHGELKVYK TLDTPFFSTG
881KLILGPQEEK GKQHVGQDI LVFYVNFGDL LCTLHETPYI
921LSTGDSFYVP SGNYYNIKNL RNEESVLLFT QIKR
结构预测来自 AlphaFold DB（UniProt: Q03188），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of CENPC:           Showing partial SNPs
rs11250       rs168538       rs173317       rs184804       rs187149       rs189579       rs190255       rs191650       rs355460       rs355461       rs355462       rs355463       rs355464       rs355465       rs355466       rs355467       rs355468      

Gene Expression

Gene Expression

Tissue expression of CENPC:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
AGAGGAAAGTGGACCTTCC
59
CCATGAACTTCCTCATCATCC
59
AGTGACTTCAACTGTCACG
58
CTATAAACAGGACTCTCCTCTG
57
GTGACTTCAACTGTCACGA
58
CTATAAACAGGACTCTCCTCTG
57
GTGACTTCAACTGTCACGA
58
CTATAAACAGGACTCTCCTCTG
57
TAGAGGAAAGTGGACCTTCC
58
CATGAACTTCCTCATCATCCAC
59
ACACGTTTGAAACCTTTGGA
59
CACTAATCACGAATCCTCCTG
58
AAGTGACTTCAACTGTCACG
59
TTCAGGCAACTCTCCTCTG
59
GAACAGCTTGATGTGGGAC
59
TTTCTTGCTTCCCACAGGT
60
TAGAGGAAAGTGGACCTTCC
59
CATGAACTTCCTCATCATCCAC
59
GTCCGGTCTGGATCATCTC
59
TTGCTCTGTGTTAATGTCACG
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of CENPC (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for CENPC:

GO ID
Protein
Source DB
GO:0000776
H0Y8J2 (UniProtKB)
IEA
GO:0019237
H0Y8J2 (UniProtKB)
IEA
GO:0051382
H0Y8J2 (UniProtKB)
IEA
GO:0000776
H0Y9W1 (UniProtKB)
IEA
GO:0019237
H0Y9W1 (UniProtKB)
IEA
GO:0051382
H0Y9W1 (UniProtKB)
IEA
GO:0000278
Q03188 (UniProtKB)
IMP
GO:0000776
Q03188 (UniProtKB)
IDA
GO:0000777
Q03188 (UniProtKB)
IEA
GO:0000780
Q03188 (UniProtKB)
IDA
GO:0003677
Q03188 (UniProtKB)
TAS
GO:0005634
Q03188 (UniProtKB)
IDA
GO:0005654
Q03188 (UniProtKB)
TAS
GO:0005654
Q03188 (UniProtKB)
TAS
GO:0005654
Q03188 (UniProtKB)
TAS
GO:0005654
Q03188 (UniProtKB)
TAS
GO:0005721
Q03188 (UniProtKB)
IDA
GO:0005737
Q03188 (UniProtKB)
IDA
GO:0005829
Q03188 (UniProtKB)
TAS
GO:0005829
Q03188 (UniProtKB)
TAS
GO:0005829
Q03188 (UniProtKB)
TAS
GO:0005829
Q03188 (UniProtKB)
TAS
GO:0005829
Q03188 (UniProtKB)
TAS
GO:0005829
Q03188 (UniProtKB)
TAS
GO:0005829
Q03188 (UniProtKB)
TAS
GO:0005829
Q03188 (UniProtKB)
TAS
GO:0005829
Q03188 (UniProtKB)
TAS
GO:0005829
Q03188 (UniProtKB)
TAS
GO:0007059
Q03188 (UniProtKB)
IMP
GO:0007062
Q03188 (UniProtKB)
TAS
GO:0007067
Q03188 (UniProtKB)
IEA
GO:0019237
Q03188 (UniProtKB)
IEA
GO:0034080
Q03188 (UniProtKB)
TAS
GO:0051301
Q03188 (UniProtKB)
IEA
GO:0051382
Q03188 (UniProtKB)
IMP

Related microRNA

Related microRNA

microRNAs potentially regulating CENPC:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Bipolar Disorder 0.002367032 1 0 GAD
Parkinson Disease 0.002367032 1 7 GAD
Atypical Lipoma 0.000271442 1 0 BeFree
Systemic Scleroderma 0.000271442 1 0 BeFree
Leishmaniasis, Visceral 0.000271442 1 0 BeFree
Lymphoma 0.000271442 1 0 BeFree

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