DRAP1 (DR1 associated protein 1)

Gene Basic Information

Gene Basic Information

symbol:
DRAP1
locus group:
protein-coding gene
location:
11q13.1
gene_family:
alias symbol:
NC2-alpha
alias name:
negative cofactor 2 alpha|DR1-asso…
entrez id:
10589
ensembl gene id:
ENSG00000175550
ucsc gene id:
uc001ogj.3
refseq accession:
NM_006442
hgnc_id:
HGNC:3019
approved reserved:
1998-09-22

Chromosome Location

Chromosome Location

11q13.1

Gene Summary

Gene Summary

DRAP1（DR1-associated protein 1）是一种重要的转录调控因子，它与DR1（下游调控元件1结合蛋白）形成异源二聚体，共同参与基因表达的负调控。DRAP1的主要功能是通过与DR1结合，抑制基础转录机制中的TATA盒结合蛋白（TBP）与DNA的结合，从而降低RNA聚合酶II介导的转录活性。这种抑制作用在细胞周期调控、细胞分化和发育过程中尤为重要。DRAP1广泛表达于多种组织中，尤其在增殖活跃的细胞中表达较高，表明它在细胞增殖和分化平衡中起关键作用。DRAP1属于DRAP/NC2基因家族，该家族成员共同特点是能够与DR1相互作用并参与转录抑制，通过调节转录起始复合物的形成来精细调控基因表达。DRAP1的突变可能导致其与DR1或TBP的结合能力改变，进而影响转录抑制功能。研究表明，DRAP1表达异常与多种疾病相关，包括癌症和发育障碍。在多种肿瘤中观察到DRAP1的过表达，这可能通过解除对增殖相关基因的转录抑制，促进肿瘤细胞不受控的生长。相反，DRAP1表达降低可能导致某些发育关键基因的异常激活，影响正常发育过程。DRAP1的表达水平变化还会影响其他转录调控因子的功能，例如它可能通过竞争性结合DR1来调节NC2复合物的活性。此外，DRAP1与组蛋白去乙酰化酶（HDACs）的相互作用表明它可能参与染色质结构的重塑。在胚胎发育中，DRAP1的时空表达模式提示它在组织特异性基因表达调控中发挥作用。DRAP1的功能研究不仅有助于理解转录调控的分子机制，也为相关疾病的治疗提供潜在靶点。

ChineseEnglish

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]

OMIM entry for DRAP1     Wikipedia entry for DRAP1

Gene Sequence

Gene Sequence

Nucleotide sequence of DRAP1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MPSKKKKYNA RFPPARIKKI MQTDEEIGKV AAAVPVIISR
41ALELFLESLL KKACQVTQSR NAKTMTTSHL KQCIELEQQF
81 DFLKDLVAS VPDMQGDGED NHMDGDKGAR RGRKPGSGGR
121KNGGMGTKSK DKKLSGTDSE QEDESEDTDT DGEEETSQPP
161P QASHPSAH FQSPPTPFLP FASTLPLPPA PPGPSAPDEE
201DEEDYDS
结构预测来自 AlphaFold DB（UniProt: Q14919），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of DRAP1:           Showing partial SNPs
rs10143       rs1055564       rs7941334       rs7947504       rs7947619       rs9326360       rs9326361       rs9666530       rs9667389       rs9795434       rs11542177       rs11546556       rs12273159       rs12284841       rs12289280       rs12576319       rs73496433      

Gene Expression

Gene Expression

Tissue expression of DRAP1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GAAGACAACCACATGGATGG
59
AGATTCATCCTCCTGCTCC
59
GAAGACAACCACATGGATGG
59
AGATTCATCCTCCTGCTCC
59
GGGTGGAAGGAGAATAACTG
58
AGGATCTTTCGGGAGAACAG
59
GAAGACAACCACATGGATGG
59
AGATTCATCCTCCTGCTCC
59
GAAGACAACCACATGGATGG
59
AGATTCATCCTCCTGCTCC
59
GAAGACAACCACATGGATGG
59
AGATTCATCCTCCTGCTCC
59
GAAGACAACCACATGGATGG
59
AGATTCATCCTCCTGCTCC
59
CTTCTTGAAGGACCTGGTG
58
GAAGGTACAGTCCATCTGC
58
ACTGTACCTTCCCAAAGGG
59
TCAGATTCATCCTCCTGCTC
59
AGACAACCACATGGATGGG
60
TCAGATTCATCCTCCTGCTC
59

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
DRAP1
TBP
Unknown
15509807

Gene Ontology

Subcellular localization of DRAP1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for DRAP1:

GO ID
Protein
Source DB
GO:0005634
C9JCC6 (UniProtKB)
IEA
GO:0046982
C9JCC6 (UniProtKB)
IEA
GO:0046982
E9PMW2 (UniProtKB)
IEA
GO:0005634
E9PNC7 (UniProtKB)
IEA
GO:0046982
E9PNC7 (UniProtKB)
IEA
GO:0005634
E9PQX9 (UniProtKB)
IEA
GO:0046982
E9PQX9 (UniProtKB)
IEA
GO:0000122
Q14919 (UniProtKB)
TAS
GO:0003677
Q14919 (UniProtKB)
IEA
GO:0003700
Q14919 (UniProtKB)
TAS
GO:0003714
Q14919 (UniProtKB)
TAS
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005515
Q14919 (UniProtKB)
IPI
GO:0005634
Q14919 (UniProtKB)
IEA
GO:0006351
Q14919 (UniProtKB)
IEA
GO:0046982
Q14919 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating DRAP1:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
melanoma 0.12 1 0 CTD_human

Related Publications

Related Publications

Evaluation of housekeeping genes for normalizing real-time quantitative PCR assays in pig skeletal muscle at multiple developmental stages.
Wang Yueying, Zhao Yuqiang, Li Ji, Liu Huijing, Ernst Catherine W, Liu Xiaoran, Liu Guorong, Xi Yu, Lei Minggang Gene IF: 2.7 2015-08-07
Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells.
Kantidakis Theodoros, White Robert J Nucleic Acids Res IF: 15.0 2010-04-02
To bleed or not to bleed. A prediction based on individual gene profiling combined with dose-volume histogram shapes in prostate cancer patients undergoing three-dimensional conformal radiation therapy.
Valdagni Riccardo, Rancati Tiziana, Ghilotti Marco, Cozzarini Cesare, Vavassori Vittorio, Fellin Gianni, Fiorino Claudio, Girelli Giuseppe, Barra Salvina, Zaffaroni Nadia, Pierotti Marco Alessandro, Gariboldi Manuela Int J Radiat Oncol Biol Phys IF: 7.4 2009-08-03
The dual control of TFIIB recruitment by NC2 is gene specific.
Masson Patrick, Leimgruber Elisa, Creton Sandrine, Collart Martine A Nucleic Acids Res IF: 15.0 2008-03-17
The initiator core promoter element antagonizes repression of TATA-directed transcription by negative cofactor NC2.
Malecová Barbora, Gross Petra, Boyer-Guittaut Michael, Yavuz Sevil, Oelgeschläger Thomas J Biol Chem IF: 4.1 2007-10-11
FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region.
Assmann Eliana M, Alborghetti Marcos R, Camargo Maria E R, Kobarg Jörg J Biol Chem IF: 4.1 2006-06-05
The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03.
Bitto Eduard, Bingman Craig A, Robinson Howard, Allard Simon T M, Wesenberg Gary E, Phillips George N Acta Crystallogr Sect F Struct Biol Cryst Commun IF: 0.000 2006-08-18
Nodal signaling in vertebrate development.
Schier Alexander F Annu Rev Cell Dev Biol IF: 12.5 2004-02-12
NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein.
Klejman Marcin P, Pereira Lloyd A, van Zeeburg Hester J T, Gilfillan Siv, Meisterernst Michael, Timmers H T Marc Mol Cell Biol IF: 2.8 2004-12-06

Related Services

Related Services

Comments

Comments

Loading comments...

Log in to post comments Log In Sign Up

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2