GAL3ST4 (galactose-3-O-sulfotransferase 4)

Gene Basic Information

Gene Basic Information

symbol:
GAL3ST4
locus group:
protein-coding gene
location:
7q22.1
gene_family:
Sulfotransferases, membrane-bound
alias symbol:
FLJ12116
alias name:
None
entrez id:
79690
ensembl gene id:
ENSG00000197093
ucsc gene id:
uc003utu.4
refseq accession:
NM_024637
hgnc_id:
HGNC:24145
approved reserved:
2004-03-23

Chromosome Location

Chromosome Location

7q22.1

Gene Summary

Gene Summary

GAL3ST4（半乳糖-3-O-磺基转移酶4）属于磺基转移酶基因家族，该家族主要负责催化硫酸基团从供体分子转移到特定底物上，参与糖脂和糖蛋白的修饰。GAL3ST4主要作用于半乳糖残基的3位羟基，催化其硫酸化反应，这种修饰在细胞信号传导、细胞粘附和免疫应答中起重要作用。GAL3ST4的表达产物是一种膜结合蛋白，主要在高尔基体中发挥作用，参与糖鞘脂的生物合成。该基因的突变可能导致糖脂代谢异常，影响神经系统的发育和功能，并与某些遗传性神经退行性疾病相关。研究表明，GAL3ST4的异常表达可能与癌症进展有关，其过表达可能促进肿瘤细胞的迁移和侵袭，而表达降低则可能影响髓鞘形成，导致神经系统功能障碍。GAL3ST4属于一个较大的磺基转移酶基因家族，该家族成员均含有保守的磺基转移酶结构域，但各自具有不同的底物特异性。家族成员广泛参与多种生物过程，包括激素代谢、解毒和外源物质代谢等。GAL3ST4在多种组织中表达，但在神经系统和某些内分泌组织中表达较高，提示其可能在这些组织的特定功能中发挥重要作用。目前对GAL3ST4的研究仍在深入，其在疾病发生发展中的确切机制和潜在治疗价值有待进一步阐明。

ChineseEnglish

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq, Jul 2008]

OMIM entry for GAL3ST4     Wikipedia entry for GAL3ST4

Gene Sequence

Gene Sequence

Nucleotide sequence of GAL3ST4:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MGPLSPARTL RLWGPRSLGV ALGVFMTIGF ALQLLGGPFQ
41RRLPGLQLRQ PSAPSLRPAL PSCPPRQRLV FLKTHKSGSS
81 SVLSLLHRY GDQHGLRFAL PARYQFGYPK LFQASRVKGY
121RPQGGGTQLP FHILCHHMRF NLKEVLQVMP SDSFFFSIVR
161D PAALARSA FSYYKSTSSA FRKSPSLAAF LANPRGFYRP
201GARGDHYARN LLWFDFGLPF PPEKRAKRGN IHPPRDPNPP
241QL QVLPSGA GPRAQTLNPN ALIHPVSTVT DHRSQISSPA
281SFDLGSSSFI QWGLAWLDSV FDLVMVAEYF DESLVLLADA
321LCW GLDDVV GFMHNAQAGH KQGLSTVSNS GLTAEDRQLT
361ARARAWNNLD WALYVHFNRS LWARIEKYGQ GRLQTAVAEL
401RARR EALAK HCLVGGEASD PKYITDRRFR PFQFGSAKVL
441GYILRSGLSP QDQEECERLA TPELQYKDKL DAKQFPPTVS
481LPLKT SRPL SP
结构预测来自 AlphaFold DB（UniProt: Q96RP7），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of GAL3ST4:           Showing partial SNPs
rs3800951       rs3800952       rs3823646       rs7807641       rs13232713       rs13232718       rs13247092       rs59528184       rs74883328       rs78325297       rs78430927       rs111273114       rs112880621       rs113124394       rs113955884       rs138298556       rs138915937      

Gene Expression

Gene Expression

Tissue expression of GAL3ST4:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CAGAGGAGGTACTTCAGGTC
59
ATAGTAGGAGAAGGCAGAGC
58
CCTGAAAGAGGTACTTCAGG
57
TAGTAGGAGAAGGCAGAGC
57
CATTGGCTTTGCACTCCAG
59
GTGTCTTCAGGAACACCAG
58
CTGAAAGAGGTACTTCAGGTC
57
ATAGTAGGAGAAGGCAGAGC
58
CCAGAGGAGGTACTTCAGG
58
TAGTAGGAGAAGGCAGAGC
57
CATTGGCTTTGCACTCCAG
59
TGTCTTCAGGAACACCAGTC
59
CTGAAAGAGGTACTTCAGGTC
57
TAGTAGGAGAAGGCAGAGC
57
CAGAGGAGGTACTTCAGGT
57
TAGTAGGAGAAGGCAGAGC
57
CATTGGCTTTGCACTCCAG
59
TCTTCAGGAACACCAGTCG
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of GAL3ST4 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for GAL3ST4:

GO ID
Protein
Source DB
GO:0001733
A0A0J9YVN4 (UniProtKB)
IEA
GO:0005794
A0A0J9YVN4 (UniProtKB)
IEA
GO:0009247
A0A0J9YVN4 (UniProtKB)
IEA
GO:0016021
A0A0J9YVN4 (UniProtKB)
IEA
GO:0016021
A0A0J9YXX0 (UniProtKB)
IEA
GO:0001733
A0A0J9YYD8 (UniProtKB)
IEA
GO:0005794
A0A0J9YYD8 (UniProtKB)
IEA
GO:0009247
A0A0J9YYD8 (UniProtKB)
IEA
GO:0016021
A0A0J9YYD8 (UniProtKB)
IEA
GO:0016021
C9IZ77 (UniProtKB)
IEA
GO:0001733
Q96RP7 (UniProtKB)
IEA
GO:0006790
Q96RP7 (UniProtKB)
NAS
GO:0007267
Q96RP7 (UniProtKB)
NAS
GO:0009100
Q96RP7 (UniProtKB)
NAS
GO:0009247
Q96RP7 (UniProtKB)
IEA
GO:0009311
Q96RP7 (UniProtKB)
NAS
GO:0016020
Q96RP7 (UniProtKB)
IDA
GO:0016021
Q96RP7 (UniProtKB)
NAS
GO:0030166
Q96RP7 (UniProtKB)
NAS
GO:0032580
Q96RP7 (UniProtKB)
IEA
GO:0050656
Q96RP7 (UniProtKB)
NAS
GO:0050694
Q96RP7 (UniProtKB)
IDA
GO:0050698
Q96RP7 (UniProtKB)
NAS
GO:0070062
Q96RP7 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating GAL3ST4:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

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