MAD2L2 (mitotic arrest deficient 2 like 2)

Gene Basic Information

Gene Basic Information

symbol
MAD2L2
locus group
protein-coding gene
location
1p36.22
gene_family
Polymerases, DNA-directed
alias symbol
MAD2B|REV7|POLZ2|FANCV
alias name
mitotic arrest deficient homolog-l…
entrez id
10459
ensembl gene id
ENSG00000116670
ucsc gene id
uc001asq.5
refseq accession
NM_006341
hgnc_id
HGNC:6764
approved reserved
1999-06-22

Chromosome Location

Chromosome Location

1p36.22

Gene Summary

Gene Summary

ChineseEnglish

The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]

OMIM entry for MAD2L2     Wikipedia entry for MAD2L2

Gene Sequence

Gene Sequence

Nucleotide sequence of MAD2L2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MTTLTRQDLN FGQVVADVLC EFLEVAVHLI LYVREVYPVG
41IFQKRKKYNV PVQMSCHPEL NQYIQDTLHC VKPLLEKNDV
81 EKVVVVILD KEHRPVEKFV FEITQPPLLS ISSDSLLSHV
121EQLLRAFILK ISVCDAVLDH NPPGCTFTVL VHTREAATRN
161M EKIQVIKD FPWILADEQD VHMHDPRLIP LKTMTSDILK
201MQLYVEERAH KGS
Structure predicted by AlphaFold DB(UniProt: Q9UI95). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of MAD2L2:           Showing partial SNPs
rs752940       rs2038132       rs2143296       rs2336031       rs6657068       rs6657612       rs6658345       rs6667330       rs6679089       rs6693852       rs6694489       rs6700817       rs7527599       rs9430206       rs9430207       rs9430208       rs9430609      

Gene Expression

Gene Expression

Tissue expression of MAD2L2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TCCAGGTCATCAAGGATTTCC
60
AAATGTCCGACGTCATGGT
60
TGTCCATCAGCTCAGACTC
59
CTTCTCCATGTTGCGAGTG
59
AACGCAAGAAGTACAACGTG
60
ATATACTGATTCAGCTCCGGG
59
TCCAGGTCATCAAGGATTTCC
60
AAATGTCCGACGTCATGGT
60
CCTGGAGAAGAATGATGTGGA
59
TCAAAGACGAATTTCTCCACTG
59
CTCAACTTTGGCCAAGTGG
59
TAGAGGATGAGATGCACAGC
59
TGTCCATCAGCTCAGACTC
59
CTTCTCCATGTTGCGAGTG
59
TCCAGGTCATCAAGGATTTCC
60
AAATGTCCGACGTCATGGT
60
TCCAGGTCATCAAGGATTTCC
60
AAATGTCCGACGTCATGGT
60
TCCAGGTCATCAAGGATTTCC
60
AAATGTCCGACGTCATGGT
60

Gene Ontology

Subcellular localization of MAD2L2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MAD2L2:

GO ID
Protein
Source DB
GO:0000122
Q9UI95 (UniProtKB)
IDA
GO:0001102
Q9UI95 (UniProtKB)
IPI
GO:0001558
Q9UI95 (UniProtKB)
IGI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005515
Q9UI95 (UniProtKB)
IPI
GO:0005634
Q9UI95 (UniProtKB)
IDA
GO:0005634
Q9UI95 (UniProtKB)
IDA
GO:0005654
Q9UI95 (UniProtKB)
TAS
GO:0005654
Q9UI95 (UniProtKB)
TAS
GO:0005654
Q9UI95 (UniProtKB)
TAS
GO:0005654
Q9UI95 (UniProtKB)
TAS
GO:0005654
Q9UI95 (UniProtKB)
TAS
GO:0005654
Q9UI95 (UniProtKB)
TAS
GO:0005654
Q9UI95 (UniProtKB)
TAS
GO:0005654
Q9UI95 (UniProtKB)
TAS
GO:0005654
Q9UI95 (UniProtKB)
TAS
GO:0005737
Q9UI95 (UniProtKB)
IEA
GO:0005819
Q9UI95 (UniProtKB)
IDA
GO:0006302
Q9UI95 (UniProtKB)
IGI
GO:0006351
Q9UI95 (UniProtKB)
IEA
GO:0007015
Q9UI95 (UniProtKB)
IMP
GO:0007067
Q9UI95 (UniProtKB)
IEA
GO:0007094
Q9UI95 (UniProtKB)
TAS
GO:0008432
Q9UI95 (UniProtKB)
IDA
GO:0010719
Q9UI95 (UniProtKB)
IMP
GO:0010944
Q9UI95 (UniProtKB)
IMP
GO:0016035
Q9UI95 (UniProtKB)
IDA
GO:0033138
Q9UI95 (UniProtKB)
IDA
GO:0042177
Q9UI95 (UniProtKB)
IDA
GO:0042276
Q9UI95 (UniProtKB)
TAS
GO:0042276
Q9UI95 (UniProtKB)
TAS
GO:0042276
Q9UI95 (UniProtKB)
TAS
GO:0042772
Q9UI95 (UniProtKB)
IDA
GO:0043433
Q9UI95 (UniProtKB)
IDA
GO:0045893
Q9UI95 (UniProtKB)
IMP
GO:0051301
Q9UI95 (UniProtKB)
IEA
GO:0090090
Q9UI95 (UniProtKB)
IMP
GO:1904667
Q9UI95 (UniProtKB)
IDA
GO:2000048
Q9UI95 (UniProtKB)
IMP
GO:2000678
Q9UI95 (UniProtKB)
IMP
GO:0005680
Q9UI95 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating MAD2L2:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Renal Cell Carcinoma 0.002995792 2 0 BeFree_LHGDN
Colorectal Neoplasms 0.002995792 1 0 BeFree_LHGDN
Malignant neoplasm of breast 0.002638474 2 3 BeFree_GAD
Carcinogenesis 0.000814326 3 0 BeFree
Down Syndrome 0.000271442 1 0 BeFree
Shigella Infections 0.000271442 1 0 BeFree
Congenital chromosomal disease 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Colorectal Cancer 0.000271442 1 0 BeFree
Epithelial ovarian cancer 0.000271442 1 0 BeFree

Related Publications

Related Publications

Targeting MAD2L2-dependent translesion synthesis impairs DNA damage tolerance and enhances cellular response to cisplatin.
Ayiku PJ, Barda N, Weiss OE, Sherman C, Litvinov D, Fozailoff D, Dromi I, Turgeman G, Listovsky T Front Cell Dev Biol IF: 5.3 None
A high-risk sepsis subtype identified by regulated cell death signatures and MAD2L2 validation.
Luo L, Cao D, Liao Z, Lin C, Wang A, Zeng L, Yang J, Song W, Deng Y Front Immunol IF: 7.0 2026-00-00
Destabilization of pluripotency in the absence of Mad2l2.
Pirouz Mehdi, Rahjouei Ali, Shamsi Farnaz, Eckermann Kolja Neil, Salinas-Riester Gabriela, Pommerenke Claudia, Kessel Michael Cell Cycle IF: 3.9 2016-02-25
Association between cell cycle gene transcription and tumor size in oral squamous cell carcinoma.
Diniz Marina Gonçalves, Silva Jeane de Fatima Correia, de Souza Fabricio Tinôco Alvim, Pereira Núbia Braga, Gomes Carolina Cavaliéri, Gomez Ricardo Santiago Tumour Biol IF: 3.650 2016-04-26
Rev7/Mad2B plays a critical role in the assembly of a functional mitotic spindle.
Bhat Audesh, Wu Zhaojia, Maher Veronica M, McCormick J Justin, Xiao Wei Cell Cycle IF: 3.9 2016-09-26
Overlapping in short motif sequences for binding to human REV7 and MAD2 proteins.
Hanafusa Tomo, Habu Toshiyuki, Tomida Junya, Ohashi Eiji, Murakumo Yoshiki, Ohmori Haruo Genes Cells IF: 1.4 2015-07-02
MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection.
Boersma Vera, Moatti Nathalie, Segura-Bayona Sandra, Peuscher Marieke H, van der Torre Jaco, Wevers Brigitte A, Orthwein Alexandre, Durocher Daniel, Jacobs Jacqueline J L Nature IF: 56.1 2015-06-29
REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
Xu Guotai, Chapman J Ross, Brandsma Inger, Yuan Jingsong, Mistrik Martin, Bouwman Peter, Bartkova Jirina, Gogola Ewa, Warmerdam Daniël, Barazas Marco, Jaspers Janneke E, Watanabe Kenji, Pieterse Mark, Kersbergen Ariena, Sol Wendy, Celie Patrick H N, Schouten Philip C, van den Broek Bram, Salman Ahmed, Nieuwland Marja, de Rink Iris, de Ronde Jorma, Jalink Kees, Boulton Simon J, Chen Junjie, van Gent Dik C, Bartek Jiri, Jonkers Jos, Borst Piet, Rottenberg Sven Nature IF: 56.1 2015-06-29
A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation.
Hatano Koji, Kumar Binod, Zhang Yonggang, Coulter Jonathan B, Hedayati Mohammad, Mears Brian, Ni Xiaohua, Kudrolli Tarana A, Chowdhury Wasim H, Rodriguez Ronald, DeWeese Theodore L, Lupold Shawn E Nucleic Acids Res IF: 15.0 2015-07-21
REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ.
Tomida Junya, Takata Kei-ichi, Lange Sabine S, Schibler Andria C, Yousefzadeh Matthew J, Bhetawal Sarita, Dent Sharon Y R, Wood Richard D Nucleic Acids Res IF: 15.0 2015-05-01

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