MCC (MCC regulator of WNT signaling pathway)

Gene Basic Information

Gene Basic Information

symbol
MCC
locus group
protein-coding gene
location
5q22.2
gene_family
EF-hand domain containing
alias symbol
-
alias name
None
entrez id
4163
ensembl gene id
ENSG00000171444
ucsc gene id
uc003kql.5
refseq accession
NM_001085377
hgnc_id
HGNC:6935
approved reserved
1991-08-19

Chromosome Location

Chromosome Location

5q22.2

Gene Summary

Gene Summary

ChineseEnglish

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

OMIM entry for MCC     Wikipedia entry for MCC

Gene Sequence

Gene Sequence

Nucleotide sequence of MCC:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MNSGVAMKYG NDSSAELSEL HSAALASLKG DIVELNKRLQ
41QTERERDLLE KKLAKAQCEQ SHLMREHEDV QERTTLRYEE
81 RITELHSVI AELNKKIDRL QGTTIREEDE YSELRSELSQ
121SQHEVNEDSR SMDQDQTSVS IPENQSTMVT ADMDNCSDLN
161S ELQRVLTG LENVVCGRKK SSCSLSVAEV DKHIEQLTTA
201SEHCDLAIKT VEEIEGVLGR DLYPNLAEER SRWEKELAGL
241RE ENESLTA MLCSKEEELN RTKATMNAIR EERDRLRRRV
281RELQTRLQSV QATGPSSPGR LTSTNRPINP STGELSTSSS
321SND IPIAKI AERVKLSKTR SESSSSDRPV LGSEISSIGV
361SSSVAEHLAH SLQDCSNIQE IFQTLYSHGS AISESKIREF
401EVET ERLNS RIEHLKSQND LLTITLEECK SNAERMSMLV
441GKYESNATAL RLALQYSEQC IEAYELLLAL AESEQSLILG
481QFRAA GVGS SPGDQSGDEN ITQMLKRAHD CRKTAENAAK
521ALLMKLDGSC GGAFAVAGCS VQPWESLSSN SHTSTTSSTA
561SSCDTE FTK EDEQRLKDYI QQLKNDRAAV KLTMLELESI
601HIDPLSYDVK PRGDSQRLDL ENAVLMQELM AMKEEMAELK
641AQLYLLE KE KKALELKLST REAQEQAYLV HIEHLKSEVE
681EQKEQRMRSL SSTSSGSKDK PGKECADAAS PALSLAELRT
721TCSENELA A EFTNAIRREK KLKARVQELV SALERLTKSS
761EIRHQQSAEF VNDLKRANSN LVAAYEKAKK KHQNKLKKLE
801SQMMAMVER HETQVRMLKQ RIALLEEENS RPHTNETSL
Structure predicted by AlphaFold DB(UniProt: P23508). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of MCC:           Showing partial SNPs
rs7033       rs9122       rs34654580       rs76268784       rs113000845       rs116262829       rs141047308       rs141186816       rs141284335       rs142324828       rs143302002       rs146550342       rs148332789       rs183359647       rs187614621       rs188135096       rs189537898      

Gene Expression

Gene Expression

Tissue expression of MCC:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CATTGAGCACCTGAAGTCC
59
ATCATATCACCTTGCCAGGT
59
GGCTATTAAGACAGTCGAGGA
59
TCATTCTCTTCCCTCAGCC
58
TGAGTGAGCTCCATTCAGC
60
TGGACATCCTCATGCTCTC
59
TGAGTGAGCTCCATTCAGC
60
TGGACATCCTCATGCTCTC
59
TACATCAGCAGAAATGACTTGC
59
CAACTGGTTCATGATCTCAGC
59
ATGTCAAGCTCCATTCAGC
58
CTCTCATGAGGTGGGACTG
59
CATCAGCAGGTTATGCACC
59
AGATGGAGGATCCACAGGA
59
ATCAGAACTCAGCCAGAGC
60
CTGCAGTTGTCCATGTCAG
59
ACTCTACTCACACGGATCTG
59
CTCAATCCGGCTATTCAGC
59
GGCTATTAAGACAGTCGAGGA
59
TCATTCTCTTCCCTCAGCC
59

Gene Ontology

Subcellular localization of MCC (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for MCC:

GO ID
Protein
Source DB
GO:0005654
D6REY2 (UniProtKB)
IDA
GO:0005737
D6REY2 (UniProtKB)
IDA
GO:0004872
P23508 (UniProtKB)
TAS
GO:0005515
P23508 (UniProtKB)
IPI
GO:0005515
P23508 (UniProtKB)
IPI
GO:0005515
P23508 (UniProtKB)
IPI
GO:0005515
P23508 (UniProtKB)
IPI
GO:0005515
P23508 (UniProtKB)
IPI
GO:0005515
P23508 (UniProtKB)
IPI
GO:0005515
P23508 (UniProtKB)
IPI
GO:0005515
P23508 (UniProtKB)
IPI
GO:0005515
P23508 (UniProtKB)
IPI
GO:0005515
P23508 (UniProtKB)
IPI
GO:0005515
P23508 (UniProtKB)
IPI
GO:0005515
P23508 (UniProtKB)
IPI
GO:0005634
P23508 (UniProtKB)
IDA
GO:0005634
P23508 (UniProtKB)
IDA
GO:0005634
P23508 (UniProtKB)
IDA
GO:0005654
P23508 (UniProtKB)
IDA
GO:0005737
P23508 (UniProtKB)
IDA
GO:0005737
P23508 (UniProtKB)
IDA
GO:0005737
P23508 (UniProtKB)
IDA
GO:0005737
P23508 (UniProtKB)
IDA
GO:0005886
P23508 (UniProtKB)
IDA
GO:0007165
P23508 (UniProtKB)
TAS
GO:0010633
P23508 (UniProtKB)
IMP
GO:0016055
P23508 (UniProtKB)
IEA
GO:0030027
P23508 (UniProtKB)
IEA
GO:0045184
P23508 (UniProtKB)
IDA
GO:0050680
P23508 (UniProtKB)
IDA
GO:0090090
P23508 (UniProtKB)
IDA
GO:0090090
P23508 (UniProtKB)
IMP

Related microRNA

Related microRNA

microRNAs potentially regulating MCC:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Adenomatous Polyposis Coli 0.124071628 16 2 BeFree_CTD_human
Colon Carcinoma 0.120542884 2 2 BeFree_CLINVAR
Autistic Disorder 0.12 1 0 CTD_human
Rectal Neoplasms 0.12 1 0 CTD_human
Intellectual Disability 0.12 1 0 CTD_human
Colorectal Carcinoma 0.003528744 13 1 BeFree
Colorectal Neoplasms 0.003267234 3 0 BeFree_LHGDN
Colorectal Cancer 0.002985861 11 1 BeFree
Carcinogenesis 0.002442977 9 2 BeFree
Anemia, Sickle Cell 0.002367032 1 1 GAD

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