PSMC2 (proteasome 26S subunit, ATPase 2)

Gene Basic Information

Gene Basic Information

symbol
PSMC2
locus group
protein-coding gene
location
7q22.1
gene_family
AAA ATPases (ATPases associated with diverse cellular activities)|Proteasome (prosome, macropain) subunits
alias symbol
MSS1|S7|Nbla10058|RPT1
alias name
proteasome 26S subunit, ATPase, 2|…
entrez id
5701
ensembl gene id
ENSG00000161057
ucsc gene id
uc003vbs.4
refseq accession
NM_002803
hgnc_id
HGNC:9548
approved reserved
1995-12-22

Chromosome Location

Chromosome Location

7q22.1

Gene Summary

Gene Summary

ChineseEnglish

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]

OMIM entry for PSMC2     Wikipedia entry for PSMC2

Gene Sequence

Gene Sequence

Nucleotide sequence of PSMC2:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST
41YSRQIKQVED DIQQLLKKIN ELTGIKESDT GLAPPALWDL
81 AADKQTLQS EQPLQVARCT KIINADSEDP KYIINVKQFA
121KFVVDLSDQV APTDIEEGMR VGVDRNKYQI HIPLPPKIDP
161T VTMMQVEE KPDVTYSDVG GCKEQIEKLR EVVETPLLHP
201ERFVNLGIEP PKGVLLFGPP GTGKTLCARA VANRTDACFI
241RV IGSELVQ KYVGEGARMV RELFEMARTK KACLIFFDEI
281DAIGGARFDD GAGGDNEVQR TMLELINQLD GFDPRGNIKV
321LMA TNRPDT LDPALMRPGR LDRKIEFSLP DLEGRTHIFK
361IHARSMSVER DIRFELLARL CPNSTGAEIR SVCTEAGMFA
401IRAR RKIAT EKDFLEAVNK VIKSYAKFSA TPRYMTYN
Structure predicted by AlphaFold DB(UniProt: P35998). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of PSMC2:           Showing partial SNPs
rs2074624       rs10235693       rs11984360       rs12705116       rs62482404       rs71110831       rs71572233       rs74403626       rs75224659       rs79259510       rs111433407       rs111941091       rs111952306       rs112262537       rs112337325       rs112417673       rs113984977      

Gene Expression

Gene Expression

Tissue expression of PSMC2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GCTCACTGGTATTAAAGAATCTGAC
60
TCTGGAGTGTCTGCTTATCTG
59
GAGCTCACTGGTATTAAAGAATCTG
60
GGAGTGTCTGCTTATCTGCA
60
GCTCACTGGTATTAAAGAATCTGAC
60
TGGAGTGTCTGCTTATCTGC
60

Gene Ontology

Subcellular localization of PSMC2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PSMC2:

GO ID
Protein
Source DB
GO:0000165
P35998 (UniProtKB)
TAS
GO:0000209
P35998 (UniProtKB)
TAS
GO:0000502
P35998 (UniProtKB)
IDA
GO:0000502
P35998 (UniProtKB)
IDA
GO:0000932
P35998 (UniProtKB)
ISS
GO:0001649
P35998 (UniProtKB)
IDA
GO:0002223
P35998 (UniProtKB)
TAS
GO:0002479
P35998 (UniProtKB)
TAS
GO:0005515
P35998 (UniProtKB)
IPI
GO:0005515
P35998 (UniProtKB)
IPI
GO:0005515
P35998 (UniProtKB)
IPI
GO:0005515
P35998 (UniProtKB)
IPI
GO:0005515
P35998 (UniProtKB)
IPI
GO:0005515
P35998 (UniProtKB)
IPI
GO:0005515
P35998 (UniProtKB)
IPI
GO:0005515
P35998 (UniProtKB)
IPI
GO:0005515
P35998 (UniProtKB)
IPI
GO:0005515
P35998 (UniProtKB)
IPI
GO:0005515
P35998 (UniProtKB)
IPI
GO:0005515
P35998 (UniProtKB)
IPI
GO:0005524
P35998 (UniProtKB)
IEA
GO:0005634
P35998 (UniProtKB)
IDA
GO:0005654
P35998 (UniProtKB)
TAS
GO:0005654
P35998 (UniProtKB)
TAS
GO:0005654
P35998 (UniProtKB)
TAS
GO:0005737
P35998 (UniProtKB)
IDA
GO:0005737
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0005829
P35998 (UniProtKB)
TAS
GO:0006511
P35998 (UniProtKB)
IDA
GO:0006521
P35998 (UniProtKB)
TAS
GO:0008540
P35998 (UniProtKB)
IBA
GO:0016020
P35998 (UniProtKB)
IDA
GO:0016020
P35998 (UniProtKB)
IDA
GO:0016032
P35998 (UniProtKB)
IEA
GO:0016887
P35998 (UniProtKB)
IDA
GO:0017025
P35998 (UniProtKB)
IBA
GO:0022624
P35998 (UniProtKB)
ISS
GO:0030433
P35998 (UniProtKB)
IBA
GO:0031145
P35998 (UniProtKB)
TAS
GO:0031145
P35998 (UniProtKB)
TAS
GO:0031595
P35998 (UniProtKB)
IBA
GO:0031597
P35998 (UniProtKB)
IBA
GO:0033209
P35998 (UniProtKB)
TAS
GO:0036402
P35998 (UniProtKB)
IBA
GO:0038061
P35998 (UniProtKB)
TAS
GO:0038095
P35998 (UniProtKB)
TAS
GO:0043161
P35998 (UniProtKB)
TAS
GO:0043161
P35998 (UniProtKB)
TAS
GO:0043161
P35998 (UniProtKB)
TAS
GO:0043231
P35998 (UniProtKB)
IDA
GO:0043488
P35998 (UniProtKB)
TAS
GO:0045899
P35998 (UniProtKB)
IBA
GO:0050852
P35998 (UniProtKB)
TAS
GO:0051436
P35998 (UniProtKB)
TAS
GO:0051437
P35998 (UniProtKB)
TAS
GO:0060071
P35998 (UniProtKB)
TAS
GO:0090090
P35998 (UniProtKB)
TAS
GO:0090263
P35998 (UniProtKB)
TAS
GO:1901800
P35998 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating PSMC2:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Alveolar Soft Part Sarcoma 0.000271442 1 0 BeFree

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