PSMC3 (proteasome 26S subunit, ATPase 3)

Gene Basic Information

Gene Basic Information

symbol
PSMC3
locus group
protein-coding gene
location
11p11.2
gene_family
AAA ATPases (ATPases associated with diverse cellular activities)|Proteasome (prosome, macropain) subunits
alias symbol
TBP1|TBP-1|RPT5
alias name
Tat-binding protein-1
entrez id
5702
ensembl gene id
ENSG00000165916
ucsc gene id
uc001nfh.2
refseq accession
NM_002804
hgnc_id
HGNC:9549
approved reserved
1995-12-06

Chromosome Location

Chromosome Location

11p11.2

Gene Summary

Gene Summary

ChineseEnglish

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

OMIM entry for PSMC3     Wikipedia entry for PSMC3

Gene Sequence

Gene Sequence

Nucleotide sequence of PSMC3:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MNLLPNIESP VTRQEKMATV WDEAEQDGIG EEVLKMSTEE
41IIQRTRLLDS EIKIMKSEVL RVTHELQAMK DKIKENSEKI
81 KVNKTLPYL VSNVIELLDV DPNDQEEDGA NIDLDSQRKG
121KCAVIKTSTR QTYFLPVIGL VDAEKLKPGD LVGVNKDSYL
161I LETLPTEY DSRVKAMEVD ERPTEQYSDI GGLDKQIQEL
201VEAIVLPMNH KEKFENLGIQ PPKGVLMYGP PGTGKTLLAR
241AC AAQTKAT FLKLAGPQLV QMFIGDGAKL VRDAFALAKE
281KAPSIIFIDE LDAIGTKRFD SEKAGDREVQ RTMLELLNQL
321DGF QPNTQV KVIAATNRVD ILDPALLRSG RLDRKIEFPM
361PNEEARARIM QIHSRKMNVS PDVNYEELAR CTDDFNGAQC
401KAVC VEAGM IALRRGATEL THEDYMEGIL EVQAKKKANL
441QYYA
Structure predicted by AlphaFold DB(UniProt: P17980). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of PSMC3:           Showing partial SNPs
rs2242511       rs2293579       rs2293580       rs3781624       rs3781625       rs3781626       rs3781627       rs3781628       rs3781629       rs3837376       rs4752833       rs4753000       rs7101772       rs7105005       rs7105122       rs7106027       rs7120244      

Gene Expression

Gene Expression

Tissue expression of PSMC3:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GAGGTGCTCAAGATGTCCA
59
CTTCACTCTTCATGATCTTGATCTC
60
TGCCAATATTGACCTGGAC
58
TCTTTGTTCACACCCTGTC
58
CCGAGCAAGATGGAATTGG
59
TGATCTCACTGTCCAGCAG
59
GAGGGAAGGAGCAAGATGG
60
CTTGATCTCACTGTCCAGCA
60
GGGTCAAGATGGAATTGGG
58
CTTGATCTCACTGTCCAGC
58
CGAGCAAGATGGAATTGGG
59
CTCTTCATGATCTTGATCTCACTG
59
CAATATTGACCTGGACTCCCA
60
ACAGGAAGGAAGTACGTCTG
59
GATAGAGTTCCCGATGCCC
60
TAGTTCACGTCAGGACTGAC
59
CGAGCAAGATGGAATTGGG
59
CTCTTCATGATCTTGATCTCACTG
59
GTGAGATCAAGCTCCTGGA
59
TTTGATCACAGCACACTTGC
60

Gene Ontology

Subcellular localization of PSMC3 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for PSMC3:

GO ID
Protein
Source DB
GO:0005524
E9PKD5 (UniProtKB)
IEA
GO:0005524
E9PM69 (UniProtKB)
IEA
GO:0005737
E9PM69 (UniProtKB)
IEA
GO:0016787
E9PM69 (UniProtKB)
IEA
GO:0030163
E9PM69 (UniProtKB)
IEA
GO:0005524
E9PMD8 (UniProtKB)
IEA
GO:0005524
E9PN50 (UniProtKB)
IEA
GO:0000165
P17980 (UniProtKB)
TAS
GO:0000209
P17980 (UniProtKB)
TAS
GO:0000502
P17980 (UniProtKB)
IDA
GO:0000932
P17980 (UniProtKB)
ISS
GO:0001824
P17980 (UniProtKB)
IEA
GO:0002223
P17980 (UniProtKB)
TAS
GO:0002479
P17980 (UniProtKB)
TAS
GO:0003713
P17980 (UniProtKB)
TAS
GO:0003714
P17980 (UniProtKB)
TAS
GO:0005515
P17980 (UniProtKB)
IPI
GO:0005515
P17980 (UniProtKB)
IPI
GO:0005515
P17980 (UniProtKB)
IPI
GO:0005515
P17980 (UniProtKB)
IPI
GO:0005515
P17980 (UniProtKB)
IPI
GO:0005515
P17980 (UniProtKB)
IPI
GO:0005515
P17980 (UniProtKB)
IPI
GO:0005524
P17980 (UniProtKB)
IEA
GO:0005634
P17980 (UniProtKB)
IDA
GO:0005654
P17980 (UniProtKB)
TAS
GO:0005654
P17980 (UniProtKB)
TAS
GO:0005654
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0005829
P17980 (UniProtKB)
TAS
GO:0006521
P17980 (UniProtKB)
TAS
GO:0008540
P17980 (UniProtKB)
IBA
GO:0016020
P17980 (UniProtKB)
IDA
GO:0016032
P17980 (UniProtKB)
IEA
GO:0016887
P17980 (UniProtKB)
ISS
GO:0017025
P17980 (UniProtKB)
IBA
GO:0022624
P17980 (UniProtKB)
ISS
GO:0030433
P17980 (UniProtKB)
IBA
GO:0031145
P17980 (UniProtKB)
TAS
GO:0031145
P17980 (UniProtKB)
TAS
GO:0031595
P17980 (UniProtKB)
IBA
GO:0031597
P17980 (UniProtKB)
IBA
GO:0033209
P17980 (UniProtKB)
TAS
GO:0036402
P17980 (UniProtKB)
IBA
GO:0038061
P17980 (UniProtKB)
TAS
GO:0038095
P17980 (UniProtKB)
TAS
GO:0043161
P17980 (UniProtKB)
TAS
GO:0043161
P17980 (UniProtKB)
TAS
GO:0043161
P17980 (UniProtKB)
TAS
GO:0043488
P17980 (UniProtKB)
TAS
GO:0045899
P17980 (UniProtKB)
IBA
GO:0050852
P17980 (UniProtKB)
TAS
GO:0051436
P17980 (UniProtKB)
TAS
GO:0051437
P17980 (UniProtKB)
TAS
GO:0060071
P17980 (UniProtKB)
TAS
GO:0090090
P17980 (UniProtKB)
TAS
GO:0090263
P17980 (UniProtKB)
TAS
GO:1901800
P17980 (UniProtKB)
IEA
GO:1903507
P17980 (UniProtKB)
IEA
GO:0005524
R4GNH3 (UniProtKB)
IEA
GO:0005737
R4GNH3 (UniProtKB)
IEA
GO:0016787
R4GNH3 (UniProtKB)
IEA
GO:0030163
R4GNH3 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating PSMC3:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
HIV Infections 0.120271442 2 0 BeFree_CTD_human
Breast Carcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree

Related Publications

Related Publications

Convergent mitochondrial impairment and apoptosis driven by simultaneous down-regulation of multiple genes at 11p11.2 in Alzheimer's disease.
Yu J, Xu M, Wu XR, Kang WB, Zou WY, Liu Q, Zhang DF, Yao YG Mol Psychiatry IF: 10.4 2026-05-28
Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's disease.
Bledsoe X, Wang TC, Wu Y, Archer D, Chen HH, Naj AC, Bush WS, Hohman TJ, Dumitrescu L, Below JE, Gamazon ER Alzheimers Dement IF: 12.8 2026-02-00
Integrated phenotypic and proteomic screening identifies top-tier Alzheimer's disease therapeutic targets.
Cary GA, Li Q, Wiley JC, Paisie CA, Du Y, Zoeller EL, Duong D, Fu H, Seyfried NT, Levey AI, Betarbet R, Carter GW bioRxiv 2025-10-16
Identification of PANoptosis-related genes as biomarkers in ischemic stroke.
Jiang A, Zhang H, Jia X, Zhao H, Zhao H, Lu Z Front Neurol IF: 3.3 2025-00-00
Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's Disease.
Bledsoe X, Wang TC, Wu Y, Archer D, Chen HH, Naj A, Bush WS, Hohman TJ, Dumitrescu L, Below JE, Gamazon ER medRxiv 2025-09-19
Complex Genetics and Regulatory Drivers of Hypermobile Ehlers-Danlos Syndrome: Insights from Genome-Wide Association Study Meta-analysis.
Petrucci-Nelson T, Guilhaumou S, Berrandou TE, Gensemer C, Georges A, Huff M, Fustier MA, Esmael A, Henry J, Jaye O, Phookan R, Dooley S, Byerly K, Loizzi B, Fenner R, Mach E, Weintraub A, Daylor V, Weninger J, Koren N, Bistran E, Griggs C, Griggs M, Severance S, Byrd R, Patel S, Kautz SA, Maitland A, Bouatia-Naji N, Norris RA medRxiv 2025-09-21
The impact of PANoptosis-related genes on immune profiles and subtype classification in ischemic stroke.
Cai X, Ren Y, Wu H, Tan Y, Zhou L, Wang Y, Yang Q, Wang J, Tang H, Wen J, Zhao Y, Wang L, Xu X, Huang J, Yang Q Sci Rep IF: 4.9 2025-10-24
Screening of cellular proteins that interact with the classical swine fever virus non-structural protein 5A by yeast two-hybrid analysis.
Zhang Chengcheng, He Lei, Kang Kai, Chen Heng, Xu Lei, Zhang Yanming J Biosci IF: 1.7 2014-09-29
Intergenic region between TATA-box binding protein and proteasome subunit C3 genes of Medaka function as the bidirectional promoter in vitro and in vivo.
Fujimori Kazuhiro E, Hazama Kumiko, Kawasaki Takashi, Deguchi Tomonori, Yuba Syunsuke Gene IF: 2.7 2013-01-15

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