RAD17 (RAD17 checkpoint clamp loader component)

Gene Basic Information

Gene Basic Information

symbol
RAD17
locus group
protein-coding gene
location
5q13.2
gene_family
-
alias symbol
Rad24|RAD17Sp|CCYC
alias name
None
entrez id
5884
ensembl gene id
ENSG00000152942
ucsc gene id
uc003jwo.5
refseq accession
NM_133344
hgnc_id
HGNC:9807
approved reserved
1998-07-31

Chromosome Location

Chromosome Location

5q13.2

Gene Summary

Gene Summary

ChineseEnglish

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]

OMIM entry for RAD17     Wikipedia entry for RAD17

Gene Sequence

Gene Sequence

Nucleotide sequence of RAD17:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MSKTFLRPKV SSTKVTDWVD PSFDDFLECS GVSTITATSL
41GVNNSSHRRK NGPSTLESSR FPARKRGNLS SLEQIYGLEN
81 SKEYLSENE PWVDKYKPET QHELAVHKKK IEEVETWLKA
121QVLERQPKQG GSILLITGPP GCGKTTTLKI LSKEHGIQVQ
161E WINPVLPD FQKDDFKGMF NTESSFHMFP YQSQIAVFKE
201FLLRATKYNK LQMLGDDLRT DKKIILVEDL PNQFYRDSHT
241LH EVLRKYV RIGRCPLIFI ISDSLSGDNN QRLLFPKEIQ
281EECSISNISF NPVAPTIMMK FLNRIVTIEA NKNGGKITVP
321DKT SLELLC QGCSGDIRSA INSLQFSSSK GENNLRPRKK
361GMSLKSDAVL SKSKRRKKPD RVFENQEVQA IGGKDVSLFL
401FRAL GKILY CKRASLTELD SPRLPSHLSE YERDTLLVEP
441EEVVEMSHMP GDLFNLYLHQ NYIDFFMEID DIVRASEFLS
481FADIL SGDW NTRSLLREYS TSIATRGVMH SNKARGYAHC
521QGGGSSFRPL HKPQWFLINK KYRENCLAAK ALFPDFCLPA
561LCLQTQ LLP YLALLTIPMR NQAQISFIQD IGRLPLKRHF
601GRLKMEALTD REHGMIDPDS GDEAQLNGGH SAEESLGEPT
641QATVPET WS LPLSQNSASE LPASQPQPFS AQGDMEENII
681IEDYESDGT
Structure predicted by AlphaFold DB(UniProt: O75943). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of RAD17:           Showing partial SNPs
rs2293790       rs2293790       rs3756399       rs3756399       rs3756400       rs3756400       rs3756401       rs3756401       rs3756402       rs3756402       rs4252213       rs4252213       rs4252214       rs4252214       rs4252215       rs4252215       rs4252216      

Gene Expression

Gene Expression

Tissue expression of RAD17:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
AGAAGCTAACAAGAATGGAGGA
59
ATCACCAGAACATCCCTGAC
59
CTACCTCTGACATCTCATTTCAG
58
ATTACAGTTGCAGGTCTCCT
58
GAAACTCAGCATGAACTTGC
58
TTTCCACATCCAGGAGGAC
59
GCAAATCAGAATTGCTGTCG
58
TCAACCCAGTCTGTTACCTG
59
TGAATCAGCATGAACTTGCT
58
CTTTCCACATCCAGGAGGA
58
TTAGACTCACCTCGGTTGC
59
GACATTTCTACTACCTCCTCAGG
59
TTTCACCTAGGGTAGTCCCT
59
ACCATGAATTCACTTGTTTCCC
59
TGAATCAGCATGAACTTGCTG
59
TTTCCACATCCAGGAGGAC
59
TACCTCTGACATCTCATTTCAG
57
AATTACAGTTGCAGGTCTCC
57
AAACTCAGCATGAACTTGCTG
59
TTTCCACATCCAGGAGGAC
59

Gene Ontology

Subcellular localization of RAD17 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for RAD17:

GO ID
Protein
Source DB
GO:0000077
A0A0G2JNH5 (UniProtKB)
IEA
GO:0003689
A0A0G2JNH5 (UniProtKB)
IEA
GO:0005634
A0A0G2JNH5 (UniProtKB)
IEA
GO:0006281
A0A0G2JNH5 (UniProtKB)
IEA
GO:0031389
A0A0G2JNH5 (UniProtKB)
IEA
GO:0005634
A0A0G2JP31 (UniProtKB)
IEA
GO:0006281
A0A0G2JP31 (UniProtKB)
IEA
GO:0007049
A0A0G2JP31 (UniProtKB)
IEA
GO:0000077
A0A0G2JP78 (UniProtKB)
IEA
GO:0003689
A0A0G2JP78 (UniProtKB)
IEA
GO:0005634
A0A0G2JP78 (UniProtKB)
IEA
GO:0006281
A0A0G2JP78 (UniProtKB)
IEA
GO:0031389
A0A0G2JP78 (UniProtKB)
IEA
GO:0000077
A0A0G2JPT5 (UniProtKB)
IEA
GO:0003689
A0A0G2JPT5 (UniProtKB)
IEA
GO:0005634
A0A0G2JPT5 (UniProtKB)
IEA
GO:0006281
A0A0G2JPT5 (UniProtKB)
IEA
GO:0031389
A0A0G2JPT5 (UniProtKB)
IEA
GO:0005634
D6RAW6 (UniProtKB)
IEA
GO:0006281
D6RAW6 (UniProtKB)
IEA
GO:0007049
D6RAW6 (UniProtKB)
IEA
GO:0005634
D6RHU1 (UniProtKB)
IEA
GO:0006281
D6RHU1 (UniProtKB)
IEA
GO:0007049
D6RHU1 (UniProtKB)
IEA
GO:0005634
H0Y9J8 (UniProtKB)
IEA
GO:0006281
H0Y9J8 (UniProtKB)
IEA
GO:0007049
H0Y9J8 (UniProtKB)
IEA
GO:0005634
H0Y9T7 (UniProtKB)
IEA
GO:0006281
H0Y9T7 (UniProtKB)
IEA
GO:0007049
H0Y9T7 (UniProtKB)
IEA
GO:0000076
O75943 (UniProtKB)
TAS
GO:0000077
O75943 (UniProtKB)
IMP
GO:0003689
O75943 (UniProtKB)
IEA
GO:0005515
O75943 (UniProtKB)
IPI
GO:0005515
O75943 (UniProtKB)
IPI
GO:0005515
O75943 (UniProtKB)
IPI
GO:0005515
O75943 (UniProtKB)
IPI
GO:0005515
O75943 (UniProtKB)
IPI
GO:0005515
O75943 (UniProtKB)
IPI
GO:0005515
O75943 (UniProtKB)
IPI
GO:0005515
O75943 (UniProtKB)
IPI
GO:0005524
O75943 (UniProtKB)
IEA
GO:0005634
O75943 (UniProtKB)
TAS
GO:0005654
O75943 (UniProtKB)
IDA
GO:0005654
O75943 (UniProtKB)
TAS
GO:0005654
O75943 (UniProtKB)
TAS
GO:0005654
O75943 (UniProtKB)
TAS
GO:0005654
O75943 (UniProtKB)
TAS
GO:0005654
O75943 (UniProtKB)
TAS
GO:0005654
O75943 (UniProtKB)
TAS
GO:0005654
O75943 (UniProtKB)
TAS
GO:0005654
O75943 (UniProtKB)
TAS
GO:0005654
O75943 (UniProtKB)
TAS
GO:0005654
O75943 (UniProtKB)
TAS
GO:0005654
O75943 (UniProtKB)
TAS
GO:0005654
O75943 (UniProtKB)
TAS
GO:0005730
O75943 (UniProtKB)
IDA
GO:0006260
O75943 (UniProtKB)
TAS
GO:0006260
O75943 (UniProtKB)
TAS
GO:0006260
O75943 (UniProtKB)
TAS
GO:0006281
O75943 (UniProtKB)
IEA
GO:0006974
O75943 (UniProtKB)
IMP
GO:0007093
O75943 (UniProtKB)
IMP
GO:0008156
O75943 (UniProtKB)
IMP
GO:0031389
O75943 (UniProtKB)
IEA
GO:0042325
O75943 (UniProtKB)
IMP
GO:1901796
O75943 (UniProtKB)
TAS
GO:0000781
O75943 (UniProtKB)
IDA

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Malignant neoplasm of breast 0.002909916 3 0 BeFree_GAD
Breast Carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of lung 0.000542884 2 0 BeFree
Secondary malignant neoplasm of lymph node 0.000542884 2 0 BeFree
Non-Small Cell Lung Carcinoma 0.000542884 2 0 BeFree
Lung Neoplasms 0.000271442 1 0 BeFree
Lip and Oral Cavity Carcinoma 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Squamous cell carcinoma of the head and neck 0.000271442 1 0 BeFree
Seminoma 0.000271442 1 0 BeFree

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Mechanistic diversity of clamp loading at small DNA gaps.
Zheng F, O'Donnell ME, Li H J Biol Chem 2026-08-10
High glucose promotes cisplatin chemoresistance in MDA-MB-231 breast cancer derived cells through changes in gene expression and multiple signaling pathways.
Viedma-Rodríguez AR, Martínez-Hernández MG, Flores-López LA, Velázquez-Flores MÁ, Esparza-Garrido RR, Prado-Baeza JR, Baiza-Gutman LA Biomed Rep IF: 2.5 2025-12-00
Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.
Shen John Paul, Srivas Rohith, Gross Andrew, Li Jianfeng, Jaehnig Eric J, Sun Su Ming, Bojorquez-Gomez Ana, Licon Katherine, Sivaganesh Vignesh, Xu Jia L, Klepper Kristin, Yeerna Huwate, Pekin Daniel, Qiu Chu Ping, van Attikum Haico, Sobol Robert W, Ideker Trey Oncotarget IF: 5.168 2016-08-29
Regulation of ATRIP protein abundance by RAD9 in the DNA damage repair pathway.
Peng X-J, Liu S-J, Bao C-M, Liu Y-Z, Xie H-W, Cai Y-H, Li B-M, Hang H-Y, Ding X Cell Mol Biol (Noisy-le-grand) IF: 1.5 2016-09-14
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