RAD1P1 (RAD1 pseudogene 1)

Gene Basic Information

Gene Basic Information

symbol:
RAD1P1
locus group:
pseudogene
location:
10q26.11
gene_family:
alias symbol:
None
alias name:
None
entrez id:
100128880
ensembl gene id:
ENSG00000234569
ucsc gene id:
None
refseq accession:
NG_022192
hgnc_id:
HGNC:49479
approved reserved:
2013-12-20

Chromosome Location

Chromosome Location

10q26.11

Gene Summary

Gene Summary

RAD1P1（RAD1 Paralog 1）属于RAD1基因家族，该家族成员主要参与DNA损伤修复和细胞周期调控。RAD1P1与RAD1基因高度同源，共享相似的蛋白结构域，如PCNA结合域和核酸酶活性域，表明其在DNA代谢中可能发挥类似功能。RAD1P1的表达产物被认为参与DNA损伤应答，特别是在核苷酸切除修复（NER）和复制应激响应中起作用。其主要作用位点可能在细胞核内，与RAD9和HUS1形成9-1-1复合物，作为检查点 clamp loader 复合物的一部分，在DNA损伤位点募集修复因子。突变可能破坏其与DNA或蛋白的相互作用，导致修复缺陷、基因组不稳定，甚至增加癌症风险。研究表明，RAD1P1表达异常与多种肿瘤相关，如乳腺癌和结直肠癌，可能通过影响DNA修复效率促进肿瘤发生。过表达可能增强基因组稳定性但可能干扰正常细胞周期，而低表达可能导致修复能力下降、突变累积。该基因家族（RAD1家族）的共性包括保守的DNA结合与修复功能，成员间常形成复合物协同工作。由于RAD1P1研究较少，部分功能仍需进一步验证，但现有证据支持其在维持基因组完整性中的潜在重要性。

ChineseEnglish

None

OMIM entry for RAD1P1     Wikipedia entry for RAD1P1

Gene Sequence

Gene Sequence

Nucleotide sequence of RAD1P1:[NCBI]
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Gene Variants

Gene Variants

SNP variants of RAD1P1:           Showing partial SNPs

Gene Expression

Gene Expression

Tissue expression of RAD1P1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CTCTACAAAGGCATTAGTCCTG
59
GAAGCCTCGGTTATCTGTC
58
AACAGATCCAAGACGAGCA
59
TTCCTAACATTGTCAAGGCTG
59
GACTTGAACTGCACTTCGG
59
CAGGAACAGCATCAAAGGG
59

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of RAD1P1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for RAD1P1:

Related microRNA

Related microRNA

microRNAs potentially regulating RAD1P1:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

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