RAD1P2 (RAD1 pseudogene 2)

Gene Basic Information

Gene Basic Information

symbol:
RAD1P2
locus group:
pseudogene
location:
1q23.1
gene_family:
alias symbol:
None
alias name:
None
entrez id:
100129690
ensembl gene id:
ENSG00000233473
ucsc gene id:
None
refseq accession:
NG_022741
hgnc_id:
HGNC:49480
approved reserved:
2013-12-20

Chromosome Location

Chromosome Location

1q23.1

Gene Summary

Gene Summary

RAD1P2（也称为RAD1 Paralog 2）是RAD1基因的一个假基因，属于RAD1基因家族。假基因通常是由功能基因复制而来，但由于突变积累而失去功能性表达或蛋白质产物。RAD1基因家族的主要成员包括RAD1，它在DNA损伤修复和细胞周期检查点调控中起关键作用，特别是在核苷酸切除修复（NER）和同源重组修复（HR）过程中。RAD1与HUS1和RAD9形成9-1-1复合物，该复合物在DNA损伤响应中充当滑动夹，促进修复蛋白的募集。RAD1P2作为假基因，目前尚未发现其具有功能性表达或参与DNA修复的能力，但它可能通过调控RAD1的表达或作为基因进化的遗迹而存在。由于RAD1P2是假基因，其突变通常不会对机体产生直接影响，但假基因的异常表达或调控可能干扰功能基因的表达或剪接。RAD1P2的过表达或降低表达对机体的影响尚不明确，但假基因的异常调控有时会通过竞争性结合miRNA或转录因子来影响功能基因的表达。如果RAD1P2所在的基因组区域发生结构性变异，可能影响邻近基因的功能。RAD1基因家族的共性在于它们大多参与DNA损伤修复和基因组稳定性维持，其中功能成员（如RAD1）在癌症和衰老相关疾病中具有重要作用。由于RAD1P2缺乏功能性产物，它目前未被直接关联到特定疾病，但假基因的异常调控可能与某些癌症或遗传性疾病的发展有关。

ChineseEnglish

None

OMIM entry for RAD1P2     Wikipedia entry for RAD1P2

Gene Sequence

Gene Sequence

Nucleotide sequence of RAD1P2:[NCBI]
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Gene Variants

Gene Variants

SNP variants of RAD1P2:           Showing partial SNPs

Gene Expression

Gene Expression

Tissue expression of RAD1P2:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
ATGTGTTACCAAGGTTATGGTG
59
TCACCATTCGTCTTTCTTCC
58
GATTGGATGTGACGACTGAG
59
CTGAAATAATGCTTGTCAGGAG
58
GCTCTGAAGCATTTCCCAG
59
GGAGACATGATAATCTGTAGGAC
58

Transcription Factors

Transcription Factors

      No data available

Gene Ontology

Subcellular localization of RAD1P2 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for RAD1P2:

Related microRNA

Related microRNA

microRNAs potentially regulating RAD1P2:     

Gene Interactions

Gene Interactions

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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source

Related Publications

Related Publications

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