TAF1A (TATA-box binding protein associated factor, RNA polymerase I subunit A)
- symbol:
- TAF1A
- locus group:
- protein-coding gene
- location:
- 1q41
- gene_family:
- alias symbol:
- TAFI48|SL1
- alias name:
- None
- entrez id:
- 9015
- ensembl gene id:
- ENSG00000143498
- ucsc gene id:
- uc009xdz.2
- refseq accession:
- NM_005681
- hgnc_id:
- HGNC:11532
- approved reserved:
- 1999-01-18
TAF1A（TATA-box binding protein associated factor 1A）是RNA聚合酶II转录起始复合物TFIID的一个亚基，属于TAF（TATA-box binding protein-associated factors）基因家族。TAF家族成员是转录起始复合物的核心组成部分，通过与TBP（TATA-box binding protein）结合，协助RNA聚合酶II识别启动子并启动基因转录。TAF1A在核糖体RNA（rRNA）的转录中起关键作用，特别是在RNA聚合酶I介导的rRNA合成过程中，它参与调控核糖体生物发生，影响细胞生长和增殖。TAF1A的主要作用位点是核仁（nucleolus），这是细胞核内负责rRNA合成和加工的区域。TAF1A突变可能导致其功能异常，影响rRNA的转录效率，进而干扰核糖体组装和蛋白质合成，最终导致细胞增殖受阻或凋亡。研究表明，TAF1A的异常表达与某些癌症（如肝癌、乳腺癌）的发生发展相关，其过表达可能促进肿瘤细胞增殖，而降低表达则可能抑制肿瘤生长。此外，TAF1A还参与细胞周期调控，影响G1/S期转换。TAF家族成员的共性是它们均与TBP结合形成TFIID复合物，协助转录起始，并在不同RNA聚合酶（I、II、III）的转录过程中发挥作用。TAF1A过表达可能增强rRNA合成，促进细胞增殖，但也可能导致核糖体应激（ribosome stress）和基因组不稳定性；而降低表达则可能抑制rRNA生成，减缓细胞生长，甚至引发细胞周期停滞。TAF1A的功能异常还可能影响其他依赖核糖体功能的基因表达，如参与代谢、DNA修复和信号转导的基因。
This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]
Gene Ontology
Subcellular localization of TAF1A (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for TAF1A:
| Interacting Gene | Interaction | Source/Score |
| Name |
|---|
| Epigenetic regulation of gene expression |
| Gene Expression |
| Negative epigenetic regulation of rRNA expression |
| NoRC negatively regulates rRNA expression |
| RNA Polymerase I Chain Elongation |
| RNA Polymerase I Promoter Clearance |
| RNA Polymerase I Promoter Escape |
| RNA Polymerase I Transcription |
| RNA Polymerase I Transcription Initiation |
| RNA Polymerase I Transcription Termination |
| RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| SIRT1 negatively regulates rRNA Expression |
| Transcription |
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