TAF3 (TATA-box binding protein associated factor 3)
- symbol:
- TAF3
- locus group:
- protein-coding gene
- location:
- 10p14
- gene_family:
- PHD finger proteins
- alias symbol:
- TAF140|TAFII140
- alias name:
- None
- entrez id:
- 83860
- ensembl gene id:
- ENSG00000165632
- ucsc gene id:
- uc010qbd.4
- refseq accession:
- NM_031923
- hgnc_id:
- HGNC:17303
- approved reserved:
- 2001-12-03
TAF3（TATA-box binding protein associated factor 3）是转录因子IID（TFIID）复合体的重要组成部分，属于TAF基因家族。TAF家族成员通常与TBP（TATA结合蛋白）结合形成TFIID复合体，共同参与RNA聚合酶II介导的基因转录起始过程。TAF3在转录调控中发挥关键作用，它通过识别组蛋白修饰标记（如H3K4me3，即组蛋白H3第4位赖氨酸的三甲基化）将TFIID招募到启动子区域，从而激活基因表达。TAF3还含有PHD锌指结构域（一种能结合组蛋白修饰的蛋白结构域），使其能够特异性识别染色质修饰信号。TAF3在胚胎发育、细胞周期调控和分化过程中起重要作用，尤其在维持胚胎干细胞多能性方面不可或缺。TAF3突变或表达异常与多种疾病相关，包括癌症（如结直肠癌和肝癌中常见TAF3扩增导致的过表达）、神经发育障碍和心血管疾病。TAF3过表达可能通过异常激活促癌基因导致肿瘤发生，而TAF3表达降低则可能影响干细胞自我更新能力，导致发育缺陷。在基因家族层面，TAF家族成员（如TAF1、TAF4等）均参与转录起始复合体的组装，但各自具有组织特异性表达模式和独特的调控功能。研究表明TAF3与p53肿瘤抑制通路存在交叉调控，其表达水平变化会影响p53靶基因的转录活性。此外，TAF3在细胞应激反应中也扮演重要角色，氧化应激条件下TAF3的表达变化可能影响细胞的生存或凋亡决定。
The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]
Gene Ontology
Subcellular localization of TAF3 (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for TAF3:
| Interacting Gene | Interaction | Source/Score |
| Name |
|---|
| 3022 Basal transcription factors [PATH:hsa03022] |
| 5168 Herpes simplex infection [PATH:hsa05168] |
| Name |
|---|
| Disease |
| Gene Expression |
| HIV Infection |
| HIV Life Cycle |
| HIV Transcription Initiation |
| Infectious disease |
| Late Phase of HIV Life Cycle |
| RNA Polymerase II HIV Promoter Escape |
| RNA Polymerase II Pre-transcription Events |
| RNA Polymerase II Promoter Escape |
| RNA Polymerase II Transcription |
| RNA Polymerase II Transcription Initiation |
| RNA Polymerase II Transcription Initiation And Promoter Clearance |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| Transcription |
| Transcription of the HIV genome |
| Disease | Score | NofPmids | NofSnps | Source |
| Brain Ischemia | 0.002367032 | 1 | 0 | GAD |
| Coronary heart disease | 0.002367032 | 1 | 0 | GAD |
| Cardiovascular Diseases | 0.002367032 | 1 | 0 | GAD |
| Cerebrovascular accident | 0.002367032 | 1 | 0 | GAD |
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