RAD51 (RAD51 recombinase)

Gene Basic Information

Gene Basic Information

symbol
RAD51
locus group
protein-coding gene
location
15q15.1
gene_family
-
alias symbol
HsRad51|HsT16930|BRCC5|FANCR
alias name
BRCA1/BRCA2-containing complex, su…
entrez id
5888
ensembl gene id
ENSG00000051180
ucsc gene id
uc001zmi.5
refseq accession
NM_002875|NM_133487
hgnc_id
HGNC:9817
approved reserved
1993-05-26

Chromosome Location

Chromosome Location

15q15.1

Gene Summary

Gene Summary

ChineseEnglish

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

OMIM entry for RAD51     Wikipedia entry for RAD51

Gene Sequence

Gene Sequence

Nucleotide sequence of RAD51:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAMQMQLEAN ADTSVEEESF GPQPISRLEQ CGINANDVKK
41LEEAGFHTVE AVAYAPKKEL INIKGISEAK ADKILAEAAK
81 LVPMGFTTA TEFHQRRSEI IQITTGSKEL DKLLQGGIET
121GSITEMFGEF RTGKTQICHT LAVTCQLPID RGGGEGKAMY
161I DTEGTFRP ERLLAVAERY GLSGSDVLDN VAYARAFNTD
201HQTQLLYQAS AMMVESRYAL LIVDSATALY RTDYSGRGEL
241SA RQMHLAR FLRMLLRLAD EFGVAVVITN QVVAQVDGAA
281MFAADPKKPI GGNIIAHAST TRLYLRKGRG ETRICKIYDS
321PCL PEAEAM FAINADGVGD AKD
Structure predicted by AlphaFold DB(UniProt: Q06609). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of RAD51:           Showing partial SNPs
rs1801320       rs1801321       rs2619679       rs2619680       rs2619681       rs3092981       rs5030789       rs5030790       rs5030791       rs7171780       rs28373018       rs28439060       rs34445444       rs34504099       rs35104813       rs35302835       rs35722406      

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GGACTACAGGTGGAATTGAG
58
CGTATGACAGATCTGGGTC
57
TACTTCAAGGTGGAATTGAGAC
58
TATGACAGATCTGGGTCTTCC
59
TTTCACGGTTAGAGCAGTG
58
ATTAGCTCCTTCTTTGGCG
58
CTACTTCAAGGTGGAATTGAGAC
59
ATGACAGATCTGGGTCTTCC
59
AAATTCTGACGGAGTCTCG
57
AGGAGAATCACTTGAACCTG
57
GAACAGACTACTCGGGTCG
60
CAGATACAATCTCATCAGCGAG
59
TACTTCAAGGTGGAATTGAGAC
58
TATGACAGATCTGGGTCTTCC
59
TTCCATACTGTGGAGGCTG
59
TCCAGTCTCAATTCCACCAG
60
CAACAACCAGATTGTATCTGAGG
60
GCTTCAGGAAGACAGGGAG
60
TTTCACGGTTAGAGCAGTG
58
ATTAGCTCCTTCTTTGGCG
58

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
BRCA2
RAD51
Unknown
12967658; 17515904; 19628690; 20729859
CREBBP
RAD51
Unknown
23285190
E2F1
RAD51
Unknown
23285190
E2F4
RAD51
Repression
20133863; 21701264
E2F4
RAD51
Unknown
17001309
EP300
RAD51
Unknown
23285190
HSF4
RAD51
Unknown
22587838
MEN1
RAD51
Unknown
23648481
RAD51
SP1
Activation
18769160
RBL2
RAD51
Repression
21701264

Gene Ontology

Subcellular localization of RAD51 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for RAD51:

GO ID
Protein
Source DB
GO:0000166
E9PI54 (UniProtKB)
IEA
GO:0003677
E9PJ30 (UniProtKB)
IEA
GO:0005524
E9PJ30 (UniProtKB)
IEA
GO:0006281
E9PJ30 (UniProtKB)
IEA
GO:0008094
E9PJ30 (UniProtKB)
IEA
GO:0003677
E9PNT5 (UniProtKB)
IEA
GO:0005524
E9PNT5 (UniProtKB)
IEA
GO:0005730
E9PNT5 (UniProtKB)
IDA
GO:0005737
E9PNT5 (UniProtKB)
IDA
GO:0006281
E9PNT5 (UniProtKB)
IEA
GO:0008094
E9PNT5 (UniProtKB)
IEA
GO:0000166
H0YD61 (UniProtKB)
IEA
GO:0000150
Q06609 (UniProtKB)
IBA
GO:0000228
Q06609 (UniProtKB)
IDA
GO:0000400
Q06609 (UniProtKB)
IBA
GO:0000722
Q06609 (UniProtKB)
ISS
GO:0000724
Q06609 (UniProtKB)
TAS
GO:0000724
Q06609 (UniProtKB)
IDA
GO:0000724
Q06609 (UniProtKB)
IMP
GO:0000724
Q06609 (UniProtKB)
IMP
GO:0000730
Q06609 (UniProtKB)
IBA
GO:0000731
Q06609 (UniProtKB)
TAS
GO:0000732
Q06609 (UniProtKB)
TAS
GO:0000784
Q06609 (UniProtKB)
IDA
GO:0000785
Q06609 (UniProtKB)
IDA
GO:0000793
Q06609 (UniProtKB)
ISS
GO:0000794
Q06609 (UniProtKB)
ISS
GO:0000794
Q06609 (UniProtKB)
IBA
GO:0000800
Q06609 (UniProtKB)
IEA
GO:0001932
Q06609 (UniProtKB)
IEA
GO:0003682
Q06609 (UniProtKB)
IEA
GO:0003690
Q06609 (UniProtKB)
IDA
GO:0003697
Q06609 (UniProtKB)
IDA
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005515
Q06609 (UniProtKB)
IPI
GO:0005524
Q06609 (UniProtKB)
IDA
GO:0005634
Q06609 (UniProtKB)
ISS
GO:0005634
Q06609 (UniProtKB)
IDA
GO:0005634
Q06609 (UniProtKB)
IDA
GO:0005634
Q06609 (UniProtKB)
IDA
GO:0005634
Q06609 (UniProtKB)
IDA
GO:0005634
Q06609 (UniProtKB)
IDA
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005654
Q06609 (UniProtKB)
TAS
GO:0005730
Q06609 (UniProtKB)
IDA
GO:0005737
Q06609 (UniProtKB)
IDA
GO:0005737
Q06609 (UniProtKB)
IDA
GO:0005737
Q06609 (UniProtKB)
IDA
GO:0005739
Q06609 (UniProtKB)
IDA
GO:0005759
Q06609 (UniProtKB)
IEA
GO:0005815
Q06609 (UniProtKB)
IEA
GO:0006268
Q06609 (UniProtKB)
IDA
GO:0006281
Q06609 (UniProtKB)
TAS
GO:0006310
Q06609 (UniProtKB)
TAS
GO:0006312
Q06609 (UniProtKB)
TAS
GO:0006974
Q06609 (UniProtKB)
IDA
GO:0006974
Q06609 (UniProtKB)
IDA
GO:0007126
Q06609 (UniProtKB)
ISS
GO:0007131
Q06609 (UniProtKB)
TAS
GO:0008022
Q06609 (UniProtKB)
IPI
GO:0009636
Q06609 (UniProtKB)
IEA
GO:0010165
Q06609 (UniProtKB)
IEA
GO:0010569
Q06609 (UniProtKB)
IDA
GO:0010833
Q06609 (UniProtKB)
ISS
GO:0016605
Q06609 (UniProtKB)
IDA
GO:0031297
Q06609 (UniProtKB)
IMP
GO:0031297
Q06609 (UniProtKB)
IDA
GO:0035861
Q06609 (UniProtKB)
IDA
GO:0042148
Q06609 (UniProtKB)
IBA
GO:0042493
Q06609 (UniProtKB)
IEA
GO:0042802
Q06609 (UniProtKB)
IPI
GO:0042802
Q06609 (UniProtKB)
IPI
GO:0042802
Q06609 (UniProtKB)
IPI
GO:0042802
Q06609 (UniProtKB)
IPI
GO:0043142
Q06609 (UniProtKB)
IDA
GO:0043142
Q06609 (UniProtKB)
IDA
GO:0048471
Q06609 (UniProtKB)
IDA
GO:0051106
Q06609 (UniProtKB)
IDA
GO:0051260
Q06609 (UniProtKB)
IPI
GO:0070182
Q06609 (UniProtKB)
IPI
GO:0070192
Q06609 (UniProtKB)
IBA
GO:0071479
Q06609 (UniProtKB)
IDA
GO:0071479
Q06609 (UniProtKB)
IDA
GO:0071480
Q06609 (UniProtKB)
IEA
GO:0072711
Q06609 (UniProtKB)
IEA
GO:0072719
Q06609 (UniProtKB)
IEA
GO:0072757
Q06609 (UniProtKB)
IDA
GO:1902521
Q06609 (UniProtKB)
IEA
GO:1990414
Q06609 (UniProtKB)
IEA
GO:1990426
Q06609 (UniProtKB)
IEA
GO:0004520
Q06609 (UniProtKB)
IBA
GO:0000166
Q9NZG9 (UniProtKB)
IEA
GO:0005730
Q9NZG9 (UniProtKB)
IDA
GO:0005737
Q9NZG9 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating RAD51:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Malignant neoplasm of breast 0.215831722 88 4 BeFree_GAD_UNIPROT
Mammary Neoplasms 0.150967744 16 0 BeFree_CTD_human_GAD_LHGDN
Head and Neck Neoplasms 0.127458414 4 0 CTD_human_GAD_LHGDN
Breast Cancer, Familial 0.122714419 10 4 BeFree_CLINVAR
IGA Glomerulonephritis 0.12 1 0 CTD_human
MIRROR MOVEMENTS 2 0.12 0 2 CLINVAR
Hereditary Breast and Ovarian Cancer Syndrome 0.12 0 0 ORPHANET
Cardiomyopathies 0.080271442 1 0 BeFree_RGD
Hypertensive disease 0.08 1 0 RGD
Liver Neoplasms, Experimental 0.08 1 0 RGD

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