REV1 (REV1 DNA directed polymerase)
symbol
REV1
locus group
protein-coding gene
location
2q11.2
gene_family
Polymerases, DNA-directed
alias symbol
-
alias name
None
entrez id
51455
ensembl gene id
ENSG00000135945
ucsc gene id
uc002tad.4
refseq accession
NM_016316
hgnc_id
HGNC:14060
approved reserved
2001-01-10
ChineseEnglish
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. [provided by RefSeq, Jul 2008]
Protein Sequence
1MRRGGWRKRA ENDGWETWGG YMAAKVQKLE EQFRSDAAMQ
41KDGTSSTIFS GVAIYVNGYT DPSAEELRKL MMLHGGQYHV
81
YYSRSKTTH IIATNLPNAK IKELKGEKVI RPEWIVESIK
121AGRLLSYIPY QLYTKQSSVQ KGLSFNPVCR PEDPLPGPSN
161I
AKQLNNRV NHIVKKIETE NEVKVNGMNS WNEEDENNDF
201SFVDLEQTSP GRKQNGIPHP RGSTAIFNGH TPSSNGALKT
241QD
CLVPMVN SVASRLSPAF SQEEDKAEKS STDFRDCTLQ
281QLQQSTRNTD ALRNPHRTNS FSLSPLHSNT KINGAHHSTV
321QGP
SSTKST SSVSTFSKAA PSVPSKPSDC NFISNFYSHS
361RLHHISMWKC ELTEFVNTLQ RQSNGIFPGR EKLKKMKTGR
401SALV
VTDTG DMSVLNSPRH QSCIMHVDMD CFFVSVGIRN
441RPDLKGKPVA VTSNRGTGRA PLRPGANPQL EWQYYQNKIL
481KGKAA
DIPD SSLWENPDSA QANGIDSVLS RAEIASCSYE
521ARQLGIKNGM FFGHAKQLCP NLQAVPYDFH AYKEVAQTLY
561ETLASY
THN IEAVSCDEAL VDITEILAET KLTPDEFANA
601VRMEIKDQTK CAASVGIGSN ILLARMATRK AKPDGQYHLK
641PEEVDDF
IR GQLVTNLPGV GHSMESKLAS LGIKTCGDLQ
681YMTMAKLQKE FGPKTGQMLY RFCRGLDDRP VRTEKERKSV
721SAEINYGI
R FTQPKEAEAF LLSLSEEIQR RLEATGMKGK
761RLTLKIMVRK PGAPVETAKF GGHGICDNIA RTVTLDQATD
801NAKIIGKAM
LNMFHTMKLN ISDMRGVGIH VNQLVPTNLN
841PSTCPSRPSV QSSHFPSGSY SVRDVFQVQK AKKSTEEEHK
881EVFRAAVDLE
ISSASRTCT FLPPFPAHLP TSPDTNKAES
921SGKWNGLHTP VSVQSRLNLS IEVPSPSQLD QSVLEALPPD
961LREQVEQVCA V
QQAESHGD KKKEPVNGCN TGILPQPVGT
1001VLLQIPEPQE SNSDAGINLI ALPAFSQVDP EVFAALPAEL
1041QRELKAAYDQ RQ
RQGENST HQQSASASVP KNPLLHLKAA
1081VKEKKRNKKK KTIGSPKRIQ SPLNNKLLNS PAKTLPGACG
1121SPQKLIDGFL KHE
GPPAEK PLEELSASTS GVPGLSSLQS
1161DPAGCVRPPA PNLAGAVEFN DVKTLLREWI TTISDPMEED
1201ILQVVKYCTD LIEE
KDLEK LDLVIKYMKR LMQQSVESVW
1241NMAFDFILDN VQVVLQQTYG STLKVT
Structure predicted by AlphaFold DB(UniProt: Q9UBZ9). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).
Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GGTATCTTTCCAGGAAGGGA
59
AGATACACAAATCCTGTGTCAG
58
GGGTCATACTCTGTCCGTG
60
CCCGAAATACTTCTTTGTGCT
59
AATCATGGTACGAAAGCCTG
58
TCTTCCATTGGATCTGGCA
59
GCGTATGATCAAAGACAAAGG
58
GTAAAGGATTCTTTGGCACAG
58
ACAACAGGGTAAATCACATCG
59
CTTCATTCCAACTGTTCATGC
58
ACATTGGCAAGCTACACTC
58
GTCTCTGCAAGGATTTCGG
59
AACATGAAGGACCTCCTGC
60
CACACCTGAAGTAGAAGCAG
58
ATCATGGTACGAAAGCCTG
58
TTCTTCCATTGGATCTGGC
58
TGAAACATTGGCAAGCTACAC
60
TGCAAGGATTTCGGTAATGTC
59
AACAACAGGGTAAATCACATCG
59
TTCATTCCAACTGTTCATGCC
60
Gene Ontology
Subcellular localization of REV1 (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for REV1:
GO ID
Protein
Source DB
GO:0006281
C9JPS2 (UniProtKB)
IEA
GO:0003684
H7C263 (UniProtKB)
IEA
GO:0006281
H7C263 (UniProtKB)
IEA
GO:0003684
Q9UBZ9 (UniProtKB)
IEA
GO:0005515
Q9UBZ9 (UniProtKB)
IPI
GO:0005515
Q9UBZ9 (UniProtKB)
IPI
GO:0005515
Q9UBZ9 (UniProtKB)
IPI
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0005654
Q9UBZ9 (UniProtKB)
TAS
GO:0006260
Q9UBZ9 (UniProtKB)
TAS
GO:0009411
Q9UBZ9 (UniProtKB)
IDA
GO:0017125
Q9UBZ9 (UniProtKB)
TAS
GO:0019985
Q9UBZ9 (UniProtKB)
TAS
GO:0042276
Q9UBZ9 (UniProtKB)
TAS
GO:0042276
Q9UBZ9 (UniProtKB)
TAS
GO:0042276
Q9UBZ9 (UniProtKB)
TAS
GO:0042276
Q9UBZ9 (UniProtKB)
TAS
GO:0046872
Q9UBZ9 (UniProtKB)
IEA
String
BioGrid
mentha
MINT
Loading…
| Interacting Gene | Interaction | Source/Score |
| Name |
|---|
| 3460 Fanconi anemia pathway [PATH:hsa03460] |
| Name |
|---|
| DNA Damage Bypass |
| DNA Repair |
| Termination of translesion DNA synthesis |
| Translesion synthesis by POLI |
| Translesion synthesis by POLK |
| Translesion synthesis by REV1 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| Disease | Score | NofPmids | NofSnps | Source |
| Malignant neoplasm of lung | 0.00764398 | 4 | 1 | BeFree_GAD |
| Meningioma | 0.002367032 | 1 | 0 | GAD |
| Cervical Intraepithelial Neoplasia | 0.002367032 | 1 | 0 | GAD |
| Squamous cell carcinoma | 0.002367032 | 1 | 0 | GAD |
| Meningeal Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Uterine Cervical Neoplasm | 0.002367032 | 1 | 0 | GAD |
| Chronic Lymphocytic Leukemia | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of breast | 0.002367032 | 1 | 0 | GAD |
| Brucella melitensis infection | 0.001085767 | 4 | 0 | BeFree |
| Fanconi Anemia | 0.000814326 | 3 | 0 | BeFree |
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