[Mutation BRCA1 gene in 186 breast cancer patients].

To analysis the mutation of BRCA1 gene in 186 breast cancer patients.,Polymerase chain reaction-single stranded conformational polymorphism (PCR-SSCP) and sequential were used in this analysis.,13/186 of patients showed mutation which comprised 7% of the total number of patients. In 8 patients, the mutation was observed in the intron splicing region and in 5 patients, the mutation was on the exon.,Mutation analysis of BRCA1 gene is helpful in the determination of developmental potential, early diagnosis and gene therapy for breast cancer.