Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment.

Cancer cell ·Vol. 1 ·No. 5 ·2002-06-00 ·页码 408-10

McLaughlin ME, Jacks T

Abstract

Deletion of both copies of the Nf1 gene in Schwann cells combined with Nf1 heterozygosity in the tumor environment promotes neurofibroma formation in mice.

MeSH 主题词

Animals Cell Transformation, Neoplastic Gene Deletion Genes, Neurofibromatosis 1/physiology Humans Loss of Heterozygosity Mice Mice, Transgenic Neurofibroma/genetics Schwann Cells/metabolism

作者与单位

共 2 位作者，点击展开单位 / ORCID

McLaughlin Margaret E

Howard Hughes Medical Institute, Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA.

Jacks Tyler

Article Info

Journal

Cancer cell

Abbr.

Cancer Cell

ISSN

1535-6108

DOI

10.1016/s1535-6108(02)00078-8

Published

2002-06-00

页码

408-10

Language

English

Country/Region

United States

NLM ID

101130617

External Links

PubMed source DOI: 10.1016/s1535-6108(02)00078-8 View journal details

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Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment.

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