A mitotic role for BRCA1/BARD1 in tumor suppression?

Cell ·第 127 卷 ·第 3 期 ·2006-12-19

Clarke Paul R, Sanderson Helen S

摘要

The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.

文献信息

期刊

Cell

期刊简称

Cell

ISSN

0092-8674

DOI

10.1016/j.cell.2006.10.020

发表日期

2006-12-19

收录日期

2006-11-03

更新日期

2016-11-24

语言

英语

国家/地区

United States

NLM ID

0413066

外部链接

PubMed 原文 DOI: 10.1016/j.cell.2006.10.020 查看期刊详情

分析服务

A mitotic role for BRCA1/BARD1 in tumor suppression?

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