DNA-damage control: Claspin destruction turns off the checkpoint.

Current biology : CB ·Vol. 16 ·No. 21 ·2007-01-03

Gewurz Benjamin E, Harper J Wade

Abstract

The ATR-Claspin-Chk1 pathway is critical for turning on the cellular response to DNA damage and replication stress. Five recent reports uncover new mechanisms controlling the recovery phase of the checkpoint response, and introduce crucial roles for Claspin, Rad17 phosphorylation and the ubiquitin proteasome pathway in Chk1 signaling.

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/j.cub.2006.09.046

Published

2007-01-03

Indexed

2006-11-06

Updated

2016-11-24

Language

English

Country/Region

England

NLM ID

9107782

External Links

PubMed source DOI: 10.1016/j.cub.2006.09.046 View journal details

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