The genetic susceptibility to IgA nephropathy: a novel functional candidate gene for incomplete O-glycosylation of IgA1.

Kidney international ·Vol. 71 ·No. 5 ·2007-04-12

Narita I, Kaneko Y, Kondo D, Goto S, Sakatsume M, Gejyo F

Abstract

Incompleteness of O-glycosylation in the IgA1 hinge has been implicated as a central mechanism in the development of IgA nephropathy. Although underglycosylation was reported to be an acquired abnormality, genes for enzymes of O-glycosylation, such as C1GALT1, may be responsible for susceptibility to IgA nephropathy.

Article Info

Journal

Kidney international

Abbr.

Kidney Int

ISSN

0085-2538

DOI

10.1038/sj.ki.5002139

Published

2007-04-12

Indexed

2007-02-22

Updated

2007-02-22

Language

English

Country/Region

United States

NLM ID

0323470

External Links

PubMed source DOI: 10.1038/sj.ki.5002139 View journal details

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The genetic susceptibility to IgA nephropathy: a novel functional candidate gene for incomplete O-glycosylation of IgA1.

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