Mismatch DNA-specific enzymatic cleavage employed in a new method for the electrochemical detection of genetic mutations.

Chemical communications (Cambridge, England) ·No. 28 ·2009-09-18

Won Byoung Yeon, Shin Sung Chul, Chung Won-young, Shin Sujeong, Cho Dae-Yeon, Park Hyun Gyu

Abstract

Utilizing enzymatic mismatched DNA-specific cleavage and electrocatalytic signaling, a new electrochemical method for the detection of DNA mutations was developed and successfully applied to detect various mutations in the BRCA1 gene.

Article Info

Journal

Chemical communications (Cambridge, England)

Abbr.

Chem Commun (Camb)

ISSN

1359-7345

DOI

10.1039/b907268c

Published

2009-09-18

Indexed

2009-07-08

Updated

2009-07-08

Language

English

Country/Region

England

NLM ID

9610838

External Links

PubMed source DOI: 10.1039/b907268c View journal details

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Mismatch DNA-specific enzymatic cleavage employed in a new method for the electrochemical detection of genetic mutations.

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