Home LiteratureArticle Details
PMID: 20852633 Published · ppublish English

Common variants at 19p13 are associated with susceptibility to ovarian cancer.

Nature genetics ·Vol. 42 ·No. 10 ·2010-10-28

Bolton Kelly L, Tyrer Jonathan, Song Honglin, Ramus Susan J, Notaridou Maria, Jones Chris, Sher Tanya, Gentry-Maharaj Aleksandra, Wozniak Eva, Tsai Ya-Yu, Weidhaas Joanne, Paik Daniel, Van Den Berg David J, Stram Daniel O, Pearce Celeste Leigh, Wu Anna H, Brewster Wendy, Anton-Culver Hoda, Ziogas Argyrios, Narod Steven A, Levine Douglas A, Kaye Stanley B, Brown Robert, Paul Jim, Flanagan James, Sieh Weiva, McGuire Valerie, Whittemore Alice S, Campbell Ian, Gore Martin E, Lissowska Jolanta, Yang Hanna P, Medrek Krzysztof, Gronwald Jacek, Lubinski Jan, Jakubowska Anna, Le Nhu D, Cook Linda S, Kelemen Linda E, Brooks-Wilson Angela, Brook-Wilson Angela, Massuger Leon F A G, Kiemeney Lambertus A, Aben Katja K H, van Altena Anne M, Houlston Richard, Tomlinson Ian, Palmieri Rachel T, Moorman Patricia G, Schildkraut Joellen, Iversen Edwin S, Phelan Catherine, Vierkant Robert A, Cunningham Julie M, Goode Ellen L, Fridley Brooke L, Kruger-Kjaer Susan, Blaeker Jan, Hogdall Estrid, Hogdall Claus, Gross Jenny, Karlan Beth Y, Ness Roberta B, Edwards Robert P, Odunsi Kunle, Moyisch Kirsten B, Baker Julie A, Modugno Francesmary, Heikkinenen Tuomas, Butzow Ralf, Nevanlinna Heli, Leminen Arto, Bogdanova Natalia, Antonenkova Natalia, Doerk Thilo, Hillemanns Peter, Dürst Matthias, Runnebaum Ingo, Thompson Pamela J, Carney Michael E, Goodman Marc T, Lurie Galina, Wang-Gohrke Shan, Hein Rebecca, Chang-Claude Jenny, Rossing Mary Anne, Cushing-Haugen Kara L, Doherty Jennifer, Chen Chu, Rafnar Thorunn, Besenbacher Soren, Sulem Patrick, Stefansson Kari, Birrer Michael J, Terry Kathryn L, Hernandez Dena, Cramer Daniel W, Vergote Ignace, Amant Frederic, Lambrechts Diether, Despierre Evelyn, Fasching Peter A, Beckmann Matthias W, Thiel Falk C, Ekici Arif B, Chen Xiaoqing, , , , Johnatty Sharon E, Webb Penelope M, Beesley Jonathan, Chanock Stephen, Garcia-Closas Montserrat, Sellers Tom, Easton Douglas F, Berchuck Andrew, Chenevix-Trench Georgia, Pharoah Paul D P, Gayther Simon A

Abstract

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10⁻⁴ and P = 6 × 10⁻⁴, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10⁻⁹ and P = 4 × 10⁻¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.

Article Info
Journal
Nature genetics
Abbr.
Nat Genet
Published
2010-10-28
Indexed
2010-09-29
Updated
2016-12-03
Language
English
Country/Region
United States
NLM ID
9216904
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com