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PMID: 23580138 Published · ppublish English

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

Earnshaw W C, Allshire R C, Black B E, Bloom K, Brinkley B R, Brown W, Cheeseman I M, Choo K H A, Copenhaver G P, Deluca J G, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich D W, Glover D M, Gorbsky G J, Harrison S C, Heun P, Hirota T, Jansen L E T, Karpen G, Kops G J P L, Lampson M A, Lens S M, Losada A, Luger K, Maiato H, Maddox P S, Margolis R L, Masumoto H, McAinsh A D, Mellone B G, Meraldi P, Musacchio A, Oegema K, O'Neill R J, Salmon E D, Scott K C, Straight A F, Stukenberg P T, Sullivan B A, Sullivan K F, Sunkel C E, Swedlow J R, Walczak C E, Warburton P E, Westermann S, Willard H F, Wordeman L, Yanagida M, Yen T J, Yoda K, Cleveland D W

Abstract

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

Article Info
Journal
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
Abbr.
Chromosome Res
Published
2013-10-30
Indexed
2013-04-16
Updated
2016-11-22
Language
English
Country/Region
Netherlands
NLM ID
9313452
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