From arrest to escape: HIV-1 Vpr cuts a deal.

Cell host & microbe ·Vol. 15 ·No. 2 ·2014-10-08

Cohen Eric A

Abstract

HIV Vpr induces a cell-cycle arrest at the G2-to-M transition through a poorly understood mechanism. In a recent issue of Cell, Laguette et al. (2014) demonstrate that untimely activation of the structure-specific endonuclease regulator SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.

Article Info

Journal

Cell host & microbe

Abbr.

Cell Host Microbe

ISSN

1931-3128

Published

2014-10-08

Indexed

2014-02-17

Updated

2016-11-22

Language

English

Country/Region

United States

NLM ID

101302316

External Links

PubMed source View journal details

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From arrest to escape: HIV-1 Vpr cuts a deal.

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