Home LiteratureArticle Details

PMID: 26840089 Published · ppublish English Journal Article Review

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer.

Oncotarget ·Vol. 7 ·No. 15 ·2016-04-12 ·页码 19430-44

Pandey P, Sliker B, Peters HL, Tuli A, Herskovitz J, Smits K, Purohit A, Singh RK, Dong J, Batra SK, Coulter DW, Solheim JC

Abstract

Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members' roles in cancer progression and metastasis.

Keywords

amyloid precursor protein amyloid precursor-like protein 2 cancer growth migration

MeSH 主题词

Alternative Splicing Amino Acid Sequence Amyloid beta-Protein Precursor/chemistry,genetics,metabolism Animals Cell Movement Cell Proliferation Humans Neoplasms/genetics,metabolism,pathology Nerve Tissue Proteins/chemistry,genetics,metabolism Protein Unfolding

化学物质

APLP2 protein, human Amyloid beta-Protein Precursor Nerve Tissue Proteins

作者与单位

共 12 位作者，点击展开单位 / ORCID

Pandey Poomy

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.

Sliker Bailee

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.

Peters Haley L

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. | Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Tuli Amit

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. | Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. | Wellcome Trust/DBT India Alliance Intermediate Fellow, CSIR-Institute of Microbial Technology, Chandigarh, India.

Herskovitz Jonathan

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.

Smits Kaitlin

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.

Purohit Abhilasha

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

Singh Rakesh K

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA. | Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

Dong Jixin

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. | Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

Batra Surinder K

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. | Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

Coulter Donald W

Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. | Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA.

Solheim Joyce C

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. | Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. | Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA. | Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

Article Info

Journal

Oncotarget

Abbr.

Oncotarget

ISSN

1949-2553

DOI

10.18632/oncotarget.7103

Published

2016-04-12

页码

19430-44

Language

English

Country/Region

United States

NLM ID

101532965

基金资助

DBT-Wellcome Trust India Alliance · IA/I/14/2/501543 · India

NIGMS NIH HHS · P30 GM106397 · United States

NCI NIH HHS · R03 CA169953 · United States

NCI NIH HHS · P50 CA127297 · United States

NCI NIH HHS · P30 CA036727 · United States

NIGMS NIH HHS · R01 GM109066 · United States

NCI NIH HHS · R03 CA176557 · United States

NCI NIH HHS · T32 CA009476 · United States

External Links

PubMed source DOI: 10.18632/oncotarget.7103 View journal details

Analysis Services

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer.

Contact

WeChat Official Account