Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability.

Current biology : CB ·Vol. 26 ·No. 8 ·0000-00-00

Toth Attila, Jessberger Rolf

Abstract

Meiotic chromosome segregation in mouse oocytes seems to rely on highly stable cohesins and CENP-A produced in the fetus and not replenished during postnatal life. Hence, demise of these proteins may underpin declining oocyte quality in ageing mammals and thus marks a major problem of reproductive health in humans.

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/j.cub.2016.02.059

Published

0000-00-00

Indexed

2016-04-27

Updated

2016-04-27

Language

English

Country/Region

England

NLM ID

9107782

External Links

PubMed source DOI: 10.1016/j.cub.2016.02.059 View journal details

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