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PMID: 27197191 已发表 · ppublish 英语

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

Cancer research ·第 76 卷 ·第 17 期 ·0000-00-00

Fehringer Gordon, Kraft Peter, Pharoah Paul D, Eeles Rosalind A, Chatterjee Nilanjan, Schumacher Fredrick R, Schildkraut Joellen M, Lindström Sara, Brennan Paul, Bickeböller Heike, Houlston Richard S, Landi Maria Teresa, Caporaso Neil, Risch Angela, Amin Al Olama Ali, Berndt Sonja I, Giovannucci Edward L, Grönberg Henrik, Kote-Jarai Zsofia, Ma Jing, Muir Kenneth, Stampfer Meir J, Stevens Victoria L, Wiklund Fredrik, Willett Walter C, Goode Ellen L, Permuth Jennifer B, Risch Harvey A, Reid Brett M, Bezieau Stephane, Brenner Hermann, Chan Andrew T, Chang-Claude Jenny, Hudson Thomas J, Kocarnik Jonathan K, Newcomb Polly A, Schoen Robert E, Slattery Martha L, White Emily, Adank Muriel A, Ahsan Habibul, Aittomäki Kristiina, Baglietto Laura, Blomquist Carl, Canzian Federico, Czene Kamila, Dos-Santos-Silva Isabel, Eliassen A Heather, Figueroa Jonine D, Flesch-Janys Dieter, Fletcher Olivia, Garcia-Closas Montserrat, Gaudet Mia M, Johnson Nichola, Hall Per, Hazra Aditi, Hein Rebecca, Hofman Albert, Hopper John L, Irwanto Astrid, Johansson Mattias, Kaaks Rudolf, Kibriya Muhammad G, Lichtner Peter, Liu Jianjun, Lund Eiliv, Makalic Enes, Meindl Alfons, Müller-Myhsok Bertram, Muranen Taru A, Nevanlinna Heli, Peeters Petra H, Peto Julian, Prentice Ross L, Rahman Nazneen, Sanchez Maria Jose, Schmidt Daniel F, Schmutzler Rita K, Southey Melissa C, Tamimi Rulla, Travis Ruth C, Turnbull Clare, Uitterlinden Andre G, Wang Zhaoming, Whittemore Alice S, Yang Xiaohong R, Zheng Wei, Buchanan Daniel D, Casey Graham, Conti David V, Edlund Christopher K, Gallinger Steven, Haile Robert W, Jenkins Mark, Le Marchand Loïc, Li Li, Lindor Noralene M, Schmit Stephanie L, Thibodeau Stephen N, Woods Michael O, Rafnar Thorunn, Gudmundsson Julius, Stacey Simon N, Stefansson Kari, Sulem Patrick, Chen Y Ann, Tyrer Jonathan P, Christiani David C, Wei Yongyue, Shen Hongbing, Hu Zhibin, Shu Xiao-Ou, Shiraishi Kouya, Takahashi Atsushi, Bossé Yohan, Obeidat Ma'en, Nickle David, Timens Wim, Freedman Matthew L, Li Qiyuan, Seminara Daniela, Chanock Stephen J, Gong Jian, Peters Ulrike, Gruber Stephen B, Amos Christopher I, Sellers Thomas A, Easton Douglas F, Hunter David J, Haiman Christopher A, Henderson Brian E, Hung Rayjean J, , , , ,

摘要

Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR.

文献信息
期刊
Cancer research
期刊简称
Cancer Res
发表日期
0000-00-00
收录日期
2016-09-02
更新日期
2016-12-08
语言
英语
国家/地区
United States
NLM ID
2984705R
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