SLX4 gains weight with SUMO in genome maintenance.

Molecular & cellular oncology ·Vol. 3 ·No. 2 ·2016-06-16

Guervilly Jean-Hugues, Gaillard Pierre-Henri L

Abstract

Replication stress has emerged as a key driver of oncogenesis but also represents an Achilles' heel of cancer cells. Newly reported SUMO binding and SUMO ligase functions of the DNA repair protein SLX4 that influence the outcome of replication stress open new avenues for investigating the roles played by SLX4 in tumorigenesis.

Keywords

BTB domain Chromosome stability DNA damage response E3 SUMO ligase Fanconi anemia SLX4 SUMO SUMO Interaction Motifs XPF-ERCC1 oncogenesis replication stress signal transduction structure-specific endonuclease tumor suppressor

Article Info

Journal

Molecular & cellular oncology

Abbr.

Mol Cell Oncol

ISSN

2372-3556

Published

2016-06-16

Indexed

2016-06-16

Updated

2016-06-18

Language

English

Country/Region

United States

NLM ID

101642411

External Links

PubMed source

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SLX4 gains weight with SUMO in genome maintenance.

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