About Face: Molecular Aberrations in Head and Neck Mucosal Melanomas.

Detailed molecular characterization of a large cohort of mucosal melanomas, most arising from head and neck primaries, suggests that chromosomal translocations and other complex rearrangements have prognostic importance. CDK4 amplification is a frequent event in these rare tumors, and CDK4/6 inhibition may represent a rational clinical trial strategy.See related article by Zhou et al., p. 3548.