Outcome of Surgical Intervention in Giant Neurofibromas in Two Sisters with Neurofibromatosis Type 1: A Case Series and Literature Review.

Neurofibromatosis type I (NF1) is an autosomal dominant disorder involving the skin and nervous system. We present the surgical resection experience of two siblings with neurofibromatosis type I (NF1) and giant neurofibromas. The sisters had multiple skin discolorations and swollen areas that gradually increased in size with age. The gradually growing tumors have an impact on their lives and their quality of life. In one case, staged resection was performed following preoperative arterial embolization of the tumor. Through surgery, a tumor weighing 16 kg was removed from one sister and another weighing 11 kg from the other sister. Following surgery, both sisters demonstrated significant improvement in appearance and resumed normal daily activities. Regular follow-up visits were scheduled to monitor for recurrence or new growth.