APC (APC regulator of WNT signaling pathway)

Gene Basic Information

Gene Basic Information

symbol
APC
locus group
protein-coding gene
location
5q22.2
gene_family
Armadillo repeat containing|Protein phosphatase 1 regulatory subunits
alias symbol
DP2|DP3|DP2.5|PPP1R46
alias name
protein phosphatase 1, regulatory …
entrez id
324
ensembl gene id
ENSG00000134982
ucsc gene id
uc003kpy.5
refseq accession
NM_000038
hgnc_id
HGNC:583
approved reserved
1986-01-01

Chromosome Location

Chromosome Location

5q22.2

Gene Summary

Gene Summary

ChineseEnglish

The APC (Adenomatous Polyposis Coli) gene encodes a large, evolutionarily conserved tumor suppressor protein that serves as a central regulator of the canonical Wnt signaling pathway, playing a pivotal role in controlling cell proliferation, differentiation, and migration. Functionally, the APC protein acts as a critical component of the destruction complex, where it binds to β-catenin to facilitate its ubiquitination and subsequent proteasomal degradation, thereby preventing the aberrant accumulation of β-catenin and the consequent overactivation of Wnt target genes that drive uncontrolled cell growth. Beyond its canonical role in Wnt signaling, APC is integral to cytoskeletal organization, interacting with microtubule-associated proteins to maintain cell polarity, ensure chromosomal stability, and regulate mitotic fidelity and cell migration. Mutations in APC are the primary driver of familial adenomatous polyposis (FAP), an autosomal dominant disorder characterized by the development of hundreds to thousands of intestinal polyps that carry a near-certain risk of progressing to colorectal cancer; furthermore, somatic APC mutations are frequently observed in sporadic colorectal carcinomas, where their loss leads to sustained Wnt pathway activation and tumorigenesis. The gene’s function is further modulated by alternative splicing variants that produce distinct isoforms with tissue-specific roles, adding layers of complexity to its regulatory network. While APC loss is predominantly associated with colorectal malignancies, its inactivation has also been implicated in other neoplasms, including medulloblastoma and thyroid cancer. Conversely, dysregulated expression of APC, whether through overexpression that disrupts normal embryonic development and tissue homeostasis or through downregulation that promotes oncogenic signaling, underscores the delicate balance required for proper cellular function and highlights APC’s broad significance in both developmental biology and cancer pathogenesis.

OMIM entry for APC     Wikipedia entry for APC

Gene Sequence

Gene Sequence

Nucleotide sequence of APC:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE
41ASNMKEVLKQ LQGSIEDEAM ASSGQIDLLE RLKELNLDSS
81 NFPGVKLRS KMSLRSYGSR EGSVSSRSGE CSPVPMGSFP
121RRGFVNGSRE STGYLEELEK ERSLLLADLD KEEKEKDWYY
161A QLQNLTKR IDSLPLTENF SLQTDMTRRQ LEYEARQIRV
201AMEEQLGTCQ DMEKRAQRRI ARIQQIEKDI LRIRQLLQSQ
241AT EAERSSQ NKHETGSHDA ERQNEGQGVG EINMATSGNG
281QGSTTRMDHE TASVLSSSST HSAPRRLTSH LGTKVEMVYS
321LLS MLGTHD KDDMSRTLLA MSSSQDSCIS MRQSGCLPLL
361IQLLHGNDKD SVLLGNSRGS KEARARASAA LHNIIHSQPD
401DKRG RREIR VLHLLEQIRA YCETCWEWQE AHEPGMDQDK
441NPMPAPVEHQ ICPAVCVLMK LSFDEEHRHA MNELGGLQAI
481AELLQ VDCE MYGLTNDHYS ITLRRYAGMA LTNLTFGDVA
521NKATLCSMKG CMRALVAQLK SESEDLQQVI ASVLRNLSWR
561ADVNSK KTL REVGSVKALM ECALEVKKES TLKSVLSALW
601NLSAHCTENK ADICAVDGAL AFLVGTLTYR SQTNTLAIIE
641SGGGILR NV SSLIATNEDH RQILRENNCL QTLLQHLKSH
681SLTIVSNACG TLWNLSARNP KDQEALWDMG AVSMLKNLIH
721SKHKMIAM G SAAALRNLMA NRPAKYKDAN IMSPGSSLPS
761LHVRKQKALE AELDAQHLSE TFDNIDNLSP KASHRSKQRH
801KQSLYGDYV FDTNRHDDNR SDNFNTGNMT VLSPYLNTTV
841LPSSSSSRGS LDSSRSEKDR SLERERGIGL GNYHPATENP
881GTSSKRGLQI STTAAQIAK VMEEVSAIHT SQEDRSSGST
921TELHCVTDER NALRRSSAAH THSNTYNFTK SENSNRTCSM
961PYAKLEYKRS S NDSLNSVS SSDGYGKRGQ MKPSIESYSE
1001DDESKFCSYG QYPADLAHKI HSANHMDDND GELDTPINYS
1041LKYSDEQLNS GR QSPSQNE RWARPKHIIE DEIKQSEQRQ
1081SRNQSTTYPV YTESTDDKHL KFQPHFGQQE CVSPYRSRGA
1121NGSETNRVGS NHG INQNVS QSLCQEDDYE DDKPTNYSER
1161YSEEEQHEEE ERPTNYSIKY NEEKRHVDQP IDYSLKYATD
1201IPSSQKQSFS FSKS SSGQS SKTEHMSSSS ENTSTPSSNA
1241KRQNQLHPSS AQSRSGQPQK AATCKVSSIN QETIQTYCVE
1281DTPICFSRCS SLSSL SSAE DEIGCNQTTQ EADSANTLQI
1321AEIKEKIGTR SAEDPVSEVP AVSQHPRTKS SRLQGSSLSS
1361ESARHKAVEF SSGAKS PSK SGAQTPKSPP EHYVQETPLM
1401FSRCTSVSSL DSFESRS
Structure predicted by AlphaFold DB(UniProt: P25054). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of APC:           Showing partial SNPs
rs1914       rs12189       rs41115       rs41116       rs42427       rs187075       rs351771       rs351772       rs369952       rs375377       rs376845       rs377860       rs380589       rs383256       rs386522       rs386830       rs390092      

Gene Expression

Gene Expression

Tissue expression of APC:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TGTACCACCCTCAGTTCTC
58
CTTCCTTCATATTAGATGCCTCAG
59
ACTCAAATCTTCGACAAGAGC
59
AGTTAAGCTCTTTAAGACGCTC
59
GAATGAACTAGGAATCAACCCT
58
TGTGCTGACAAATTCCATAAGG
59
ATTATTGAAAGTGGAGGTGGGA
60
TCTTAGGATTTGCCTGTGGT
59
TGAAGCAAGGCAAATCAGAG
59
TATTCTTCGCTGTGCTCGT
60
TGAAGCAAGGCAAATCAGAG
59
TATTCTTCGCTGTGCTCGT
60
CAATGAATGAACTAGGTAGGAAGG
59
TCTGCAATGGCCTGTAGTC
60
AAGGCAAATCAGAGTTGCG
59
TGTTCTGAGATGACCTCTGTG
60
CTATGAAAGGCTGCATGAGAG
59
AAACACTCGCAATAACCTGC
60
TGAAGCAAGGCAAATCAGAG
59
TATTCTTCGCTGTGCTCGT
60

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
APC
AKT1
Repression
15888491
APC
AMHR2
Repression
12724325
APC
BIRC5
Unknown
11751382
APC
DLG1
Unknown
21858148
APC
DNMT1
Repression
12538344
APC
F8
Unknown
12010799
APC
KLF4
Unknown
12387883
APC
MYC
Repression
16510874
APC
NOS2
Activation
11935128
APC
ODC1
Repression
12112318

Gene Ontology

Subcellular localization of APC (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for APC:

GO ID
Protein
Source DB
GO:0000281
A0A087X2F3 (UniProtKB)
IEA
GO:0005634
A0A087X2F3 (UniProtKB)
IEA
GO:0005737
A0A087X2F3 (UniProtKB)
IEA
GO:0006974
A0A087X2F3 (UniProtKB)
IEA
GO:0007026
A0A087X2F3 (UniProtKB)
IEA
GO:0007050
A0A087X2F3 (UniProtKB)
IEA
GO:0008013
A0A087X2F3 (UniProtKB)
IEA
GO:0008285
A0A087X2F3 (UniProtKB)
IEA
GO:0016477
A0A087X2F3 (UniProtKB)
IEA
GO:0030178
A0A087X2F3 (UniProtKB)
IEA
GO:0043065
A0A087X2F3 (UniProtKB)
IEA
GO:0000281
B7Z2B6 (UniProtKB)
IEA
GO:0005634
B7Z2B6 (UniProtKB)
IEA
GO:0005737
B7Z2B6 (UniProtKB)
IEA
GO:0006974
B7Z2B6 (UniProtKB)
IEA
GO:0007026
B7Z2B6 (UniProtKB)
IEA
GO:0007050
B7Z2B6 (UniProtKB)
IEA
GO:0008013
B7Z2B6 (UniProtKB)
IEA
GO:0008285
B7Z2B6 (UniProtKB)
IEA
GO:0016055
B7Z2B6 (UniProtKB)
IEA
GO:0016477
B7Z2B6 (UniProtKB)
IEA
GO:0030178
B7Z2B6 (UniProtKB)
IEA
GO:0043065
B7Z2B6 (UniProtKB)
IEA
GO:0000281
D6RFL6 (UniProtKB)
IEA
GO:0005634
D6RFL6 (UniProtKB)
IEA
GO:0005737
D6RFL6 (UniProtKB)
IEA
GO:0006974
D6RFL6 (UniProtKB)
IEA
GO:0007026
D6RFL6 (UniProtKB)
IEA
GO:0007050
D6RFL6 (UniProtKB)
IEA
GO:0008013
D6RFL6 (UniProtKB)
IEA
GO:0008285
D6RFL6 (UniProtKB)
IEA
GO:0016477
D6RFL6 (UniProtKB)
IEA
GO:0030178
D6RFL6 (UniProtKB)
IEA
GO:0043065
D6RFL6 (UniProtKB)
IEA
GO:0000281
E7EMH9 (UniProtKB)
IEA
GO:0005634
E7EMH9 (UniProtKB)
IEA
GO:0005737
E7EMH9 (UniProtKB)
IEA
GO:0006974
E7EMH9 (UniProtKB)
IEA
GO:0007026
E7EMH9 (UniProtKB)
IEA
GO:0007050
E7EMH9 (UniProtKB)
IEA
GO:0008013
E7EMH9 (UniProtKB)
IEA
GO:0008285
E7EMH9 (UniProtKB)
IEA
GO:0016477
E7EMH9 (UniProtKB)
IEA
GO:0030178
E7EMH9 (UniProtKB)
IEA
GO:0043065
E7EMH9 (UniProtKB)
IEA
GO:0000281
E9PFT7 (UniProtKB)
IEA
GO:0005634
E9PFT7 (UniProtKB)
IEA
GO:0005737
E9PFT7 (UniProtKB)
IEA
GO:0006974
E9PFT7 (UniProtKB)
IEA
GO:0007026
E9PFT7 (UniProtKB)
IEA
GO:0007050
E9PFT7 (UniProtKB)
IEA
GO:0008013
E9PFT7 (UniProtKB)
IEA
GO:0008285
E9PFT7 (UniProtKB)
IEA
GO:0016055
E9PFT7 (UniProtKB)
IEA
GO:0016477
E9PFT7 (UniProtKB)
IEA
GO:0030178
E9PFT7 (UniProtKB)
IEA
GO:0043065
E9PFT7 (UniProtKB)
IEA
GO:0000281
P25054 (UniProtKB)
IMP
GO:0000776
P25054 (UniProtKB)
IDA
GO:0001708
P25054 (UniProtKB)
IBA
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005515
P25054 (UniProtKB)
IPI
GO:0005634
P25054 (UniProtKB)
IDA
GO:0005634
P25054 (UniProtKB)
IDA
GO:0005634
P25054 (UniProtKB)
IDA
GO:0005654
P25054 (UniProtKB)
TAS
GO:0005654
P25054 (UniProtKB)
TAS
GO:0005737
P25054 (UniProtKB)
IDA
GO:0005737
P25054 (UniProtKB)
IDA
GO:0005737
P25054 (UniProtKB)
IDA
GO:0005813
P25054 (UniProtKB)
IDA
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005829
P25054 (UniProtKB)
TAS
GO:0005886
P25054 (UniProtKB)
IDA
GO:0005923
P25054 (UniProtKB)
IDA
GO:0005938
P25054 (UniProtKB)
IEA
GO:0006461
P25054 (UniProtKB)
IDA
GO:0006921
P25054 (UniProtKB)
TAS
GO:0006974
P25054 (UniProtKB)
IDA
GO:0007026
P25054 (UniProtKB)
IDA
GO:0007026
P25054 (UniProtKB)
IMP
GO:0007050
P25054 (UniProtKB)
IDA
GO:0007094
P25054 (UniProtKB)
IMP
GO:0007155
P25054 (UniProtKB)
NAS
GO:0007163
P25054 (UniProtKB)
IEA
GO:0007389
P25054 (UniProtKB)
IBA
GO:0008013
P25054 (UniProtKB)
IPI
GO:0008013
P25054 (UniProtKB)
IPI
GO:0008013
P25054 (UniProtKB)
IPI
GO:0008013
P25054 (UniProtKB)
IPI
GO:0008017
P25054 (UniProtKB)
IDA
GO:0008017
P25054 (UniProtKB)
IDA
GO:0008285
P25054 (UniProtKB)
IDA
GO:0016055
P25054 (UniProtKB)
TAS
GO:0016328
P25054 (UniProtKB)
IDA
GO:0016342
P25054 (UniProtKB)
IDA
GO:0016477
P25054 (UniProtKB)
IMP
GO:0019887
P25054 (UniProtKB)
IDA
GO:0019901
P25054 (UniProtKB)
IPI
GO:0030027
P25054 (UniProtKB)
IDA
GO:0030335
P25054 (UniProtKB)
IMP
GO:0030425
P25054 (UniProtKB)
IEA
GO:0030877
P25054 (UniProtKB)
IDA
GO:0030877
P25054 (UniProtKB)
IDA
GO:0030877
P25054 (UniProtKB)
IDA
GO:0030877
P25054 (UniProtKB)
IDA
GO:0031016
P25054 (UniProtKB)
IEA
GO:0031175
P25054 (UniProtKB)
IEA
GO:0031274
P25054 (UniProtKB)
IMP
GO:0031965
P25054 (UniProtKB)
IEA
GO:0032587
P25054 (UniProtKB)
IDA
GO:0032886
P25054 (UniProtKB)
IMP
GO:0042493
P25054 (UniProtKB)
IEA
GO:0043025
P25054 (UniProtKB)
IEA
GO:0043065
P25054 (UniProtKB)
IMP
GO:0043161
P25054 (UniProtKB)
TAS
GO:0044295
P25054 (UniProtKB)
IEA
GO:0044306
P25054 (UniProtKB)
IEA
GO:0045202
P25054 (UniProtKB)
IEA
GO:0045295
P25054 (UniProtKB)
IPI
GO:0045595
P25054 (UniProtKB)
IBA
GO:0045732
P25054 (UniProtKB)
IGI
GO:0045732
P25054 (UniProtKB)
IGI
GO:0045732
P25054 (UniProtKB)
IC
GO:0045736
P25054 (UniProtKB)
IDA
GO:0051010
P25054 (UniProtKB)
IDA
GO:0051988
P25054 (UniProtKB)
NAS
GO:0051988
P25054 (UniProtKB)
IMP
GO:0060070
P25054 (UniProtKB)
NAS
GO:0060070
P25054 (UniProtKB)
IC
GO:0070830
P25054 (UniProtKB)
NAS
GO:0070852
P25054 (UniProtKB)
IEA
GO:0090090
P25054 (UniProtKB)
IGI
GO:0090090
P25054 (UniProtKB)
IGI
GO:0097305
P25054 (UniProtKB)
IEA
GO:1904885
P25054 (UniProtKB)
TAS
GO:1904886
P25054 (UniProtKB)
TAS
GO:1990090
P25054 (UniProtKB)
IEA
GO:1990909
P25054 (UniProtKB)
NAS
GO:2000211
P25054 (UniProtKB)
IEA
GO:0045296
P25054 (UniProtKB)
IDA
GO:0005881
P25054 (UniProtKB)
IBA
GO:0005886
P25054 (UniProtKB)
IDA
GO:0005913
P25054 (UniProtKB)
IDA
GO:0000281
R4GMU6 (UniProtKB)
IEA
GO:0005634
R4GMU6 (UniProtKB)
IEA
GO:0005737
R4GMU6 (UniProtKB)
IEA
GO:0006974
R4GMU6 (UniProtKB)
IEA
GO:0007026
R4GMU6 (UniProtKB)
IEA
GO:0007050
R4GMU6 (UniProtKB)
IEA
GO:0008013
R4GMU6 (UniProtKB)
IEA
GO:0008285
R4GMU6 (UniProtKB)
IEA
GO:0016477
R4GMU6 (UniProtKB)
IEA
GO:0030178
R4GMU6 (UniProtKB)
IEA
GO:0043065
R4GMU6 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating APC:     

Gene Interactions

Gene Interactions

String
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Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Adenomatous Polyposis Coli 0.776808767 654 12 BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT
Desmoid disease, hereditary 0.361085767 4 0 BeFree_CLINVAR_CTD_human_ORPHANET
Liver carcinoma 0.328067311 21 1 BeFree_CLINVAR_CTD_human_GAD_MGD
Gardner Syndrome 0.244810009 9 10 BeFree_CLINVAR_GAD_ORPHANET
Medulloblastoma 0.24434307 18 0 BeFree_CTD_human_UNIPROT
Stomach Neoplasms 0.240814326 3 2 BeFree_CLINVAR_CTD_human
Colorectal Neoplasms 0.240791019 114 2 BeFree_CTD_human_GAD_LHGDN
Colorectal Cancer 0.24 321 5 BeFree_GAD_MGD
Colonic Neoplasms 0.231776019 46 1 BeFree_CTD_human_GAD_LHGDN_RGD
Adenoma 0.190731622 149 4 BeFree_CTD_human_GAD_LHGDN

Related Publications

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Somatic Mosaic AXIN2-associated Colonic Polyposis Predominantly Involving the Proximal Colon: A Case Report.
Murakami T, Arai M, Eguchi H, Hirasawa Y, Hata W, Otsuki Y, Yamauchi T, Kamba E, Yao T, Nagahara A DEN Open IF: 1.5 2027-04-00
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Jeong H, Yoon G, Lee DW, Yu H, Kim YB, Kim N, Choi J, Shin E, Kim YJ, Jeong HS, Kim HG, Kim D, Nah WS, Lee JY, Chung CP, Park YJ Biomaterials IF: 13.6 2027-01-00
National Trends in Emergency Department Boarding and Interfacility Transfers by Rurality.
Bermudez ES, Mullen A, Mohr NM, Jeffery M J Rural Health IF: 3.2 2026-09-00
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Zamalloa SID, Santos CCD, Santos LM, Arana-Chavez VE, Nogueira FN, Sipert CR, Caldeira CL J Appl Oral Sci IF: 3.0 2026-00-00
PD-L1+ neutrophils at the invasive margin drive contact-dependent CD8+ T cell exhaustion in hepatic alveolar echinococcosis.
Shi D, Tie C, Pang M, Xu X, Wang Z, Wang H, Fan H Front Immunol IF: 7.0 2026-00-00
Breast cancer and diabetes mellitus-related mortality among U.S. adults: a 25-year CDC WONDER analysis (1999-2023).
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Motorcycle-Related Mortality in Brazil, 2000-2023: National Trends by Region, Sex, and Age.
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