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Activated protein C generation is greatly decreased in plasma from newborns com…

Chan(AK),Patel(S),Male(C),Berry(LR),Mitchell… Thromb Haemost 2004-02-00

...APC-PC inhibitor (APC-PCI) or APC-alpha1 antitrypsin (APC-alpha1 AT) by ELISAs. Since heparin converts free APC to APC-P...

Different phenotypic consequences of simultaneous versus stepwise Apc loss.

Fischer(JM),Miller(AJ),Shibata(D),Liskay(RM) Oncogene 2012-04-19

...Apc(Min) or Apc(1638N). Transformation efficiency following stepwise Apc loss (Apc(Min/CKO) or Apc(1638N/CKO)) was incre...

Activated Protein C (APC) and 3K3A-APC-Induced Regression of Choroidal Neovascu…

Livnat(T),Weinberger(Y),Fernández(JA),Bashir… Biomolecules 2021-00-26

...APC and 3K3A-APC treatment. Reduction in VEGF was sustained 14 days post a single APC injection. As 3K3A-APC retained AP...

Laboratory diagnosis of APC-resistance: a critical evaluation of the test and t…

de Ronde(H),Bertina(RM) Thromb Haemost 1994-12-00

...APC), and is a simple and reliable method to detect a reduced sensitivity to the anticoagulant action of APC (APC-resist...

Immunopurification of adenomatous polyposis coli (APC) proteins.

Elliott(KL),Catimel(B),Church(NL),Coates(JL)… BMC Res Notes 2013-10-25

...APC both in solution and in fixed cells. Full-length APC(1-2843) and cancer-associated, truncated APC proteins, APC(1-16...

Complete deletion of Apc results in severe polyposis in mice.

Cheung(AF),Carter(AM),Kostova(KK),Woodruff(J… Oncogene 2010-03-25

...APC protein. Biochemical and molecular studies have revealed localization of APC/Apc to different sub-cellular compartme...

Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice.

Sohn(KJ),Choi(M),Song(J),Chan(S),Medline(A),… Carcinogenesis 2003-02-00

...Apc and p53 mutations in Apc+/-Msh2-/- mice. Somatic Apc mutations (5/sample) were observed in the non-neoplastic intest...

Progressive changes in adherens junction structure during intestinal adenoma fo…

Carothers(AM),Melstrom(KA),Mueller(JD),Weyan… J Biol Chem 2001-10-19

...Apc allele (Apc(Min/-)). Previously, we found that histologically normal enterocytes bearing a truncated Apc protein (Ap...

In vivo and in vitro complexes of activated protein C with two inhibitors in ba…

España(F),Gruber(A),Heeb(MJ),Hanson(SR),Hark… Blood 1991-04-15

...APC-alpha 1AT complex were found in the baboon plasma. At the lower APC dose, APC-PCI and APC-alpha 1AT complex levels w...

Screening for APC mutations based on detection of truncated APC proteins.

Tominaga(O),Nita(ME),Nagawa(H),Muto(T) Dig Dis Sci 1998-02-00

...APC mutation is time-consuming and costly due to the large size of the APC gene. As the majority of APC mutations result...

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