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Strategy for enhanced production of A40926B0 in Nonomuraea gerenzanensis usin...

Wang(X),Zhai(H),Gu(D),Wang(Y),Gao(J),Du(L)... Synth Syst Biotechnol 2027-04-00

...CRISPR/AsCas12f1 genome editing system and applied systematic metabolic engineering to boost A40926B0 biosynthesis. Firs...

CRISPR-Cas9 mediated adiA knockout in Hafnia paralvei: Implications for agmat...

Casado(A),Wellner(SM),Quirós(A),Herrero-Fr... Food Microbiol 2027-01-00

...CRISPR-Cas9 system, marking the first successful application of this technology in the genus Hafnia. Moreover, the adiA ...

Systematic evaluation of the DNA repair machinery facilitated the development...

Chen(Q),Lyu(L),Wang(S),Zhao(ZK) Synth Syst Biotechnol 2027-03-00

...CRISPR-Cas9 system was used to introduce double-strand breaks (DSBs), HR efficiency was dramatically increased to 16%, a...

Reduced LOXL3 Expression Disrupts Microtubule Acetylation and Drives TP53-Dep...

Laurentino(TS),Soares(RDS),Lerario(AM),Cin... Cells 2026-01-23

...CRISPR-Cas9-mediated LOXL3 knockdown in two genetically distinct GBM cell lines: U87MG (wild-type TP53) and U251 (mutant...

Dual Effect of EZH2 Gene Editing with CRISPR/Cas9 in Lung Cancer.

Menezes(JM),de Mello(DC),Saito(KC),Kimura(... Biology (Basel) 2026-01-29

...CRISPR/Cas9 gene editing and PRC2 activity was inhibited with EZH2 inhibitor EPZ6438 or EED inhibitor MAK683. EZH2 gene ...

CRISPR-Cas9-mediated genome editing in fungi: applications, challenges, and f...

Boubakri(H) J Appl Microbiol 2026-03-05

...CRISPR)/CRISPR-associated protein 9 (Cas9) system has been shown to be an effective genome-editing tool in many organism...

mcr gene family evolution and structural mechanisms of colistin resistance: f...

Mehmood(MS),Marakkalage(UKRK),Arif(T),Java... Arch Microbiol 2026-02-12

...CRISPR-based gene editing. Our review concludes that combating mcr-mediated colistin resistance requires global surveill...

Alpha-1 Antitrypsin Deficiency: Current Landscape of Detection, Management, a...

Mawani(R),Pye(A),Turner(AM) Adv Ther 2026-04-00

...CRISPR-based strategies, aim to correct the protease-antiprotease imbalance and restore endogenous AAT production. The t...

Insight into modulating osteoarthritis progression: lncRNAs and TGF-β/Smad si...

Li(C),Yang(Y),Zhang(Y),Guo(P),Dong(Y),Ma(Y... Clin Exp Rheumatol 2026-01-28

...CRISPR-Cas9), and precision treatment guided by dynamic biomarkers. Although lncRNA therapy still faces challenges in te...

A CRISPR-based mitochondrial gene therapy tool derived by engineering guide R...

Wang(Y),Su(X),Chen(Y),Chen(Y),Shi(C),Liu(F... Cell Rep 2026-02-24

...CRISPR-mediated mtDNA therapy. Here, through network analysis of mitochondrion-localized long noncoding RNAs (lncRNAs) a...

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