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Biomimetic nanosystem rewires microRNA-mediated inflammatory circuits and dis...

Gong(Y),Zhou(Z),Huang(J),Zhang(Y),Cheng(J)... Biomaterials 2027-01-00

Rheumatoid arthritis (RA) persists due to the intractable pro-inflammatory M1 macrophage phenotype, sustained by dysregu...

Babaodan ameliorates metabolic dysfunction-associated steatotic liver disease...

Qiu(S),Qiang(S),Wang(Z),Yang(L),Guo(S),Zen... J Ethnopharmacol 2027-01-10

...single-cell transcriptomics of MASLD mouse livers, untargeted serum metabolomics, targeted liver proteomics of bile acid...

Self-powered photothermal-thermoelectric bioelectronic dressings combined wit...

Yuan(X),Shi(J),Zhang(Y),Ding(M),Zhang(Y),L... Biomaterials 2027-01-00

...single-cell RNA sequencing confirm the dressing effectively eradicates Staphylococcus aureus infection, accelerates re-e...

Engineered senescence-targeting apoptotic extracellular vesicles-laden inject...

Shi(P),Yang(ZR),Wu(W),Cheng(Z),Gao(H),Chen... Biomaterials 2027-01-00

As the rapid growth of aging population, intervertebral disc degeneration (IVDD) becomes a prevalent degenerative disord...

scYeast: a biological-knowledge-guided foundation model on yeast single-cell ...

Fan(X),Liao(W),Xiao(L),Yan(X),Lu(H) Synth Syst Biotechnol 2027-02-00

...single-cell transcriptomics that effectively embeds biological priors. scYeast employs a novel asymmetric parallel archi...

Strategies and applications for alleviating carbon catabolite repression.

Lu(M),Ding(H),Zhang(H),Xu(J),Meng(R),Li(Y)... Synth Syst Biotechnol 2027-04-00

...single-cell omics, are then highlighted for revealing CCR as a dynamic and multilayered regulatory system by resolving i...

BMP-2-driven osteo-organoid formation retains key osteogenic-support features...

Zhu(F),Ji(L),Wang(J),Liu(C) Bioact Mater 2027-01-00

...Single-cell RNA sequencing further resolved mature B-cell loss and enrichment of inflammatory and mature neutrophil stat...

Regulatory roles of Smt3, an ortholog of small ubiquitin-like modifier, in fu...

Zhu(Y),Liu(X),Zhou(G),Chen(G),Liu(T),Xie(L... Food Microbiol 2027-01-00

The small ubiquitin-like modifier (SUMO) is pivotal to SUMOylation and exerts diverse roles in filamentous fungi, yet it...

Biomaterials for intervertebral disc regeneration: Niche reprogramming, preci...

Jiang(Y),Li(H),Wang(W),Guo(Q),Wang(C),Li(Y... Bioact Mater 2027-02-00

Intervertebral disc degeneration (IDD) arises from coupled redox imbalance, inflammation, cellular senescence, nutrient ...

Dual metabolic checkpoint blockade via a 3D-Printed metalloplatform remodels ...

Meng(X),Liu(Z),Hao(Y),Zhu(Y),Gu(J),Zhong(H... Bioact Mater 2027-02-00

...single-cell analysis, we identified a metabolic division of labor: cancer cells exhibit hyperactive glycolysis, while im...

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