BRCA1 (BRCA1 DNA repair associated)

基因基本信息

基因基本信息

symbol:
BRCA1
locus group:
protein-coding gene
location:
17q21.31
gene_family:
Ring finger proteins|Protein phosphatase 1 regulatory subunits
alias symbol:
RNF53|BRCC1|PPP1R53|FANCS
alias name:
BRCA1/BRCA2-containing complex, ...
entrez id:
672
ensembl gene id:
ENSG00000012048
ucsc gene id:
uc002ict.4
refseq accession:
NM_007294
hgnc_id:
HGNC:1100
approved reserved:
1991-02-20

基因染色体位置

基因染色体位置

17q21.31

基因简述

基因简述

BRCA1（乳腺癌1号基因，Breast Cancer 1）是一种重要的抑癌基因，属于BRCA基因家族，该家族还包括BRCA2。BRCA家族基因的共同特点是参与DNA损伤修复和维持基因组稳定性，尤其在双链DNA断裂的同源重组修复（HR）中起核心作用。BRCA1编码的蛋白质是一种多功能核蛋白，具有多个功能域，包括RING结构域（负责泛素化修饰）和BRCT结构域（参与蛋白质相互作用）。其主要生物学功能包括：1）DNA损伤修复，通过与RAD51等修复蛋白结合促进同源重组修复；2）细胞周期调控，在G2/M检查点发挥作用；3）转录调控，影响多种基因表达；4）染色质重塑。BRCA1主要作用位点是细胞核，尤其在DNA损伤位点聚集形成修复焦点。突变（如致病性截短突变）会导致蛋白质功能丧失，显著增加乳腺癌、卵巢癌、前列腺癌和胰腺癌等风险，这种癌症易感性被称为遗传性乳腺癌-卵巢癌综合征（HBOC）。BRCA1突变还可能导致对PARP抑制剂敏感，这是基于"合成致死"原理的靶向治疗策略。过表达BRCA1可能增强基因组稳定性但可能干扰正常细胞周期，而表达降低则会导致DNA修复缺陷、基因组不稳定性增加和肿瘤发生风险升高。BRCA1与多个信号通路相互作用，包括p53、ATM/ATR和Fanconi贫血通路，其功能异常会影响这些通路的活动。在临床应用中，BRCA1突变检测已成为遗传性癌症风险评估的重要指标，并指导预防性措施和治疗选择。需要注意的是，不同种群中BRCA1突变谱存在差异，某些突变（如Ashkenazi犹太人中的185delAG和5382insC）具有族群特异性高频特征。

中文English

无

OMIM数据库中对BRCA1基因的介绍     Wikipedia数据库中对BRCA1基因的介绍

基因序列

基因序列

BRCA1基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MDLSALRVEE VQNVINAMQK ILECPICLEL IKEPVSTKCD
41HIFCKFCMLK LLNQKKGPSQ CPLCKNDITK RSLQESTRFS
81 QLVEELLKI ICAFQLDTGL EYANSYNFAK KENNSPEHLK
121DEVSIIQSMG YRNRAKRLLQ SEPENPSLQE TSLSVQLSNL
161G TVRTLRTK QRIQPQKTSV YIELGSDSSE DTVNKATYCS
201VGDQELLQIT PQGTRDEISL DSAKKAACEF SETDVTNTEH
241HQ PSNNDLN TTEKRAAERH PEKYQGSSVS NLHVEPCGTN
281THASSLQHEN SSLLLTKDRM NVEKAEFCNK SKQPGLARSQ
321HNR WAGSKE TCNDRRTPST EKKVDLNADP LCERKEWNKQ
361KLPCSENPRD TEDVPWITLN SSIQKVNEWF SRSDELLGSD
401DSHD GESES NAKVADVLDV LNEVDEYSGS SEKIDLLASD
441PHEALICKSE RVHSKSVESN IEDKIFGKTY RKKASLPNLS
481HVTEN LIIG AFVTEPQIIQ ERPLTNKLKR KRRPTSGLHP
521EDFIKKADLA VQKTPEMINQ GTNQTEQNGQ VMNITNSGHE
561NKTKGD SIQ NEKNPNPIES LEKESAFKTK AEPISSSISN
601MELELNIHNS KAPKKNRLRR KSSTRHIHAL ELVVSRNLSP
641PNCTELQ ID SCSSSEEIKK KKYNQMPVRH SRNLQLMEGK
681EPATGAKKSN KPNEQTSKRH DSDTFPELKL TNAPGSFTKC
721SNTSELKE F VNPSLPREEK EEKLETVKVS NNAEDPKDLM
761LSGERVLQTE RSVESSSISL VPGTDYGTQE SISLLEVSTL
801GKAKTEPNK CVSQCAAFEN PKGLIHGCSK DNRNDTEGFK
841YPLGHEVNHS RETSIEMEES ELDAQYLQNT FKVSKRQSFA
881PFSNPGNAEE ECATFSAHS GSLKKQSPKV TFECEQKEEN
921QGKNESNIKP VQTVNITAGF PVVGQKDKPV DNAKCSIKGG
961SRFCLSSQFR G NETGLITP NKHGLLQNPY RIPPLFPIKS
1001FVKTKCKKNL LEENFEEHSM SPEREMGNEN IPSTVSTISR
1041NNIRENVFKE AS SSNINEV GSSTNEVGSS INEIGSSDEN
1081IQAELGRNRG PKLNAMLRLG VLQPEVYKQS LPGSNCKHPE
1121IKKQEYEEVV QTV NTDFSP YLISDNLEQP MGSSHASQVC
1161SETPDDLLDD GEIKEDTSFA ENDIKESSAV FSKSVQKGEL
1201SRSPSPFTHT HLAQ GYRRG AKKLESSEEN LSSEDEELPC
1241FQHLLFGKVN NIPSQSTRHS TVATECLSKN TEENLLSLKN
1281SLNDCSNQVI LAKAS QEHH LSEETKCSAS LFSSQCSELE
1321DLTANTNTQD PFLIGSSKQM RHQSESQGVG LSDKELVSDD
1361EERGTGLEEN NQEEQS MDS NLGEAASGCE SETSVSEDCS
1401GLSSQSDILT TQQRDTMQHN LIKLQQEMAE LEAVLEQHGS
1441QPSNSYPSII SDSSALE DL RNPEQSTSEK AVLTSQKSSE
1481YPISQNPEGL SADKFEVSAD SSTSKNKEPG VERSSPSKCP
1521SLDDRWYMHS CSGSLQNR N YPSQEELIKV VDVEEQQLEE
1561SGPHDLTETS YLPRQDLEGT PYLESGISLF SDDPESDPSE
1601DRAPESARVG NIPSSTSAL KVPQLKVAES AQSPAAAHTT
1641DTAGYNAMEE SVSREKPELT ASTERVNKRM SMVVSGLTPE
1681EFMLVYKFAR KHHITLTNLI TEETTHVVM KTDAEFVCER
1721TLKYFLGIAG GKWVVSYFWV TQSIKERKML NEHDFEVRGD
1761VVNGRNHQGP KRARESQDRK I FRGLEICC YGPFTNMPTD
1801QLEWMVQLCG ASVVKELSSF TLGTGVHPIV VVQPDAWTED
1841NGFHAIGQMC EAPVVTREWV LD SVALYQC QELDTYLIPQ
1881IPHSHY
结构预测来自 AlphaFold DB（UniProt: P38398），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

BRCA1基因的碱基突变：           仅显示部分snp
rs12516       rs16940       rs16941       rs16942       rs799902       rs799903       rs799905       rs799906       rs799907       rs799908       rs799909       rs799912       rs799913       rs799914       rs799916       rs799917       rs799918      

基因表达

基因表达

BRCA1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TTTGGAGTATGCAAACAGCT
58
TTCTGTAGCCCATACTTTGGA
58
AGGAGAATCGCTAGAACCC
58
TTCTGTTCCAATGAACAGCC
58
GCTATTTCTGGGTGACCCA
59
TGACCACATCTCCTCTGAC
58
GAGCCTACAAGAAAGTACGAG
58
TGTTTGCATACTCCAAACCT
57
ATGGCTTCCATGCAATTGG
59
TGGTAGAGTGCTACACTGTC
58
TTAACCACTCAGCAGAGGG
59
TAACACAGCTTCTAGTTCAGC
58
GGTAGATCTGAATGCTGATCC
58
TGGCAGTTTCTGCTTATTCC
58
TAGTTCCATACTAGCAGAGGG
58
ACACAGCTTCTAGTTCAGC
57
TTTGGAGTATGCAAACAGCT
58
TTCTGTAGCCCATACTTTGG
57
TGTAGTTCCATACTAGCAGAGG
58
ACAGCTTCTAGTTCAGCCA
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
AHR
BRCA1
Unknown
18259752
ARNT
BRCA1
Unknown
16567799
BRCA1
AREG
Repression
20103632
BRCA1
ASPM
Activation
16123590
BRCA1
ATM
Activation
22832221
BRCA1
BACH1
Unknown
14576433
BRCA1
BRCA2
Unknown
11405179
BRCA1
CASR
Unknown
21296416
BRCA1
CCNB1
Unknown
12647291
BRCA1
CCND1
Unknown
12032322

基因本体信息

BRCA1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

BRCA1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003677
A0A0A0MSN1 (UniProtKB)
IEA
GO:0004842
A0A0A0MSN1 (UniProtKB)
IEA
GO:0005634
A0A0A0MSN1 (UniProtKB)
IEA
GO:0006281
A0A0A0MSN1 (UniProtKB)
IEA
GO:0008270
A0A0A0MSN1 (UniProtKB)
IEA
GO:0016567
A0A0A0MSN1 (UniProtKB)
IEA
GO:0003677
A0A0U1RRA9 (UniProtKB)
IEA
GO:0004842
A0A0U1RRA9 (UniProtKB)
IEA
GO:0005634
A0A0U1RRA9 (UniProtKB)
IEA
GO:0006281
A0A0U1RRA9 (UniProtKB)
IEA
GO:0008270
A0A0U1RRA9 (UniProtKB)
IEA
GO:0016567
A0A0U1RRA9 (UniProtKB)
IEA
GO:0003677
B7ZA85 (UniProtKB)
IEA
GO:0004842
B7ZA85 (UniProtKB)
IEA
GO:0005634
B7ZA85 (UniProtKB)
IEA
GO:0006281
B7ZA85 (UniProtKB)
IEA
GO:0008270
B7ZA85 (UniProtKB)
IEA
GO:0016567
B7ZA85 (UniProtKB)
IEA
GO:0003677
C6YB45 (UniProtKB)
IEA
GO:0004842
C6YB45 (UniProtKB)
IEA
GO:0005634
C6YB45 (UniProtKB)
IEA
GO:0006281
C6YB45 (UniProtKB)
IEA
GO:0008270
C6YB45 (UniProtKB)
IEA
GO:0016021
C6YB45 (UniProtKB)
IEA
GO:0016567
C6YB45 (UniProtKB)
IEA
GO:0003677
C9IZW4 (UniProtKB)
IEA
GO:0004842
C9IZW4 (UniProtKB)
IEA
GO:0005634
C9IZW4 (UniProtKB)
IEA
GO:0006281
C9IZW4 (UniProtKB)
IEA
GO:0008270
C9IZW4 (UniProtKB)
IEA
GO:0016567
C9IZW4 (UniProtKB)
IEA
GO:0003677
E7ENB7 (UniProtKB)
IEA
GO:0004842
E7ENB7 (UniProtKB)
IEA
GO:0005634
E7ENB7 (UniProtKB)
IEA
GO:0006281
E7ENB7 (UniProtKB)
IEA
GO:0008270
E7ENB7 (UniProtKB)
IEA
GO:0016567
E7ENB7 (UniProtKB)
IEA
GO:0003677
E7EQW4 (UniProtKB)
IEA
GO:0004842
E7EQW4 (UniProtKB)
IEA
GO:0005634
E7EQW4 (UniProtKB)
IEA
GO:0006281
E7EQW4 (UniProtKB)
IEA
GO:0008270
E7EQW4 (UniProtKB)
IEA
GO:0016567
E7EQW4 (UniProtKB)
IEA
GO:0003677
E7EUM2 (UniProtKB)
IEA
GO:0004842
E7EUM2 (UniProtKB)
IEA
GO:0005634
E7EUM2 (UniProtKB)
IEA
GO:0006281
E7EUM2 (UniProtKB)
IEA
GO:0008270
E7EUM2 (UniProtKB)
IEA
GO:0016567
E7EUM2 (UniProtKB)
IEA
GO:0003677
E7EWN5 (UniProtKB)
IEA
GO:0004842
E7EWN5 (UniProtKB)
IEA
GO:0005634
E7EWN5 (UniProtKB)
IEA
GO:0006281
E7EWN5 (UniProtKB)
IEA
GO:0008270
E7EWN5 (UniProtKB)
IEA
GO:0016567
E7EWN5 (UniProtKB)
IEA
GO:0003677
E9PC22 (UniProtKB)
IEA
GO:0004842
E9PC22 (UniProtKB)
IEA
GO:0005634
E9PC22 (UniProtKB)
IEA
GO:0006281
E9PC22 (UniProtKB)
IEA
GO:0008270
E9PC22 (UniProtKB)
IEA
GO:0016567
E9PC22 (UniProtKB)
IEA
GO:0003677
E9PH68 (UniProtKB)
IEA
GO:0004842
E9PH68 (UniProtKB)
IEA
GO:0005634
E9PH68 (UniProtKB)
IEA
GO:0006281
E9PH68 (UniProtKB)
IEA
GO:0008270
E9PH68 (UniProtKB)
IEA
GO:0016567
E9PH68 (UniProtKB)
IEA
GO:0003677
H0Y850 (UniProtKB)
IEA
GO:0004842
H0Y850 (UniProtKB)
IEA
GO:0005634
H0Y850 (UniProtKB)
IEA
GO:0006281
H0Y850 (UniProtKB)
IEA
GO:0008270
H0Y850 (UniProtKB)
IEA
GO:0016567
H0Y850 (UniProtKB)
IEA
GO:0003677
H0Y881 (UniProtKB)
IEA
GO:0004842
H0Y881 (UniProtKB)
IEA
GO:0005634
H0Y881 (UniProtKB)
IEA
GO:0006281
H0Y881 (UniProtKB)
IEA
GO:0008270
H0Y881 (UniProtKB)
IEA
GO:0016567
H0Y881 (UniProtKB)
IEA
GO:0003677
H0Y8B8 (UniProtKB)
IEA
GO:0004842
H0Y8B8 (UniProtKB)
IEA
GO:0005634
H0Y8B8 (UniProtKB)
IEA
GO:0006281
H0Y8B8 (UniProtKB)
IEA
GO:0008270
H0Y8B8 (UniProtKB)
IEA
GO:0016567
H0Y8B8 (UniProtKB)
IEA
GO:0003677
H0Y8D8 (UniProtKB)
IEA
GO:0004842
H0Y8D8 (UniProtKB)
IEA
GO:0005634
H0Y8D8 (UniProtKB)
IEA
GO:0006281
H0Y8D8 (UniProtKB)
IEA
GO:0008270
H0Y8D8 (UniProtKB)
IEA
GO:0016567
H0Y8D8 (UniProtKB)
IEA
GO:0003677
K7EJW3 (UniProtKB)
IEA
GO:0004842
K7EJW3 (UniProtKB)
IEA
GO:0005634
K7EJW3 (UniProtKB)
IEA
GO:0006281
K7EJW3 (UniProtKB)
IEA
GO:0008270
K7EJW3 (UniProtKB)
IEA
GO:0016567
K7EJW3 (UniProtKB)
IEA
GO:0003677
K7EPC7 (UniProtKB)
IEA
GO:0004842
K7EPC7 (UniProtKB)
IEA
GO:0005634
K7EPC7 (UniProtKB)
IEA
GO:0006281
K7EPC7 (UniProtKB)
IEA
GO:0008270
K7EPC7 (UniProtKB)
IEA
GO:0016567
K7EPC7 (UniProtKB)
IEA
GO:0000151
P38398 (UniProtKB)
NAS
GO:0000724
P38398 (UniProtKB)
IDA
GO:0000729
P38398 (UniProtKB)
TAS
GO:0000731
P38398 (UniProtKB)
TAS
GO:0000732
P38398 (UniProtKB)
TAS
GO:0000794
P38398 (UniProtKB)
IEA
GO:0003677
P38398 (UniProtKB)
TAS
GO:0003682
P38398 (UniProtKB)
IEA
GO:0003684
P38398 (UniProtKB)
IEA
GO:0003713
P38398 (UniProtKB)
NAS
GO:0003723
P38398 (UniProtKB)
IDA
GO:0004842
P38398 (UniProtKB)
IDA
GO:0004842
P38398 (UniProtKB)
IDA
GO:0004842
P38398 (UniProtKB)
IDA
GO:0004842
P38398 (UniProtKB)
IDA
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005515
P38398 (UniProtKB)
IPI
GO:0005634
P38398 (UniProtKB)
IDA
GO:0005634
P38398 (UniProtKB)
IDA
GO:0005634
P38398 (UniProtKB)
IDA
GO:0005634
P38398 (UniProtKB)
IDA
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005654
P38398 (UniProtKB)
TAS
GO:0005694
P38398 (UniProtKB)
ISS
GO:0005737
P38398 (UniProtKB)
IDA
GO:0005759
P38398 (UniProtKB)
IEA
GO:0005886
P38398 (UniProtKB)
IDA
GO:0006260
P38398 (UniProtKB)
TAS
GO:0006260
P38398 (UniProtKB)
TAS
GO:0006301
P38398 (UniProtKB)
IDA
GO:0006302
P38398 (UniProtKB)
IMP
GO:0006302
P38398 (UniProtKB)
IMP
GO:0006302
P38398 (UniProtKB)
IMP
GO:0006302
P38398 (UniProtKB)
IDA
GO:0006303
P38398 (UniProtKB)
TAS
GO:0006349
P38398 (UniProtKB)
IEA
GO:0006351
P38398 (UniProtKB)
IEA
GO:0006357
P38398 (UniProtKB)
TAS
GO:0006359
P38398 (UniProtKB)
TAS
GO:0006633
P38398 (UniProtKB)
IEA
GO:0006915
P38398 (UniProtKB)
TAS
GO:0006974
P38398 (UniProtKB)
TAS
GO:0006978
P38398 (UniProtKB)
TAS
GO:0007059
P38398 (UniProtKB)
IMP
GO:0007098
P38398 (UniProtKB)
IEA
GO:0007420
P38398 (UniProtKB)
IEA
GO:0007584
P38398 (UniProtKB)
IEA
GO:0008270
P38398 (UniProtKB)
IEA
GO:0008274
P38398 (UniProtKB)
NAS
GO:0008630
P38398 (UniProtKB)
IDA
GO:0009048
P38398 (UniProtKB)
IBA
GO:0010212
P38398 (UniProtKB)
IMP
GO:0010212
P38398 (UniProtKB)
IMP
GO:0010212
P38398 (UniProtKB)
IMP
GO:0010575
P38398 (UniProtKB)
IMP
GO:0010628
P38398 (UniProtKB)
IMP
GO:0015631
P38398 (UniProtKB)
NAS
GO:0016567
P38398 (UniProtKB)
IDA
GO:0016874
P38398 (UniProtKB)
IEA
GO:0016925
P38398 (UniProtKB)
TAS
GO:0019899
P38398 (UniProtKB)
IPI
GO:0030521
P38398 (UniProtKB)
NAS
GO:0030529
P38398 (UniProtKB)
IDA
GO:0031052
P38398 (UniProtKB)
IEA
GO:0031398
P38398 (UniProtKB)
IDA
GO:0031436
P38398 (UniProtKB)
IDA
GO:0031436
P38398 (UniProtKB)
IDA
GO:0031436
P38398 (UniProtKB)
IDA
GO:0031436
P38398 (UniProtKB)
IDA
GO:0031572
P38398 (UniProtKB)
IMP
GO:0031572
P38398 (UniProtKB)
IMP
GO:0031572
P38398 (UniProtKB)
IMP
GO:0031625
P38398 (UniProtKB)
IPI
GO:0032355
P38398 (UniProtKB)
IEA
GO:0033147
P38398 (UniProtKB)
IMP
GO:0033160
P38398 (UniProtKB)
IEA
GO:0035066
P38398 (UniProtKB)
IDA
GO:0035067
P38398 (UniProtKB)
IBA
GO:0042127
P38398 (UniProtKB)
TAS
GO:0042981
P38398 (UniProtKB)
TAS
GO:0043009
P38398 (UniProtKB)
IBA
GO:0043234
P38398 (UniProtKB)
IDA
GO:0043627
P38398 (UniProtKB)
IDA
GO:0044030
P38398 (UniProtKB)
IEA
GO:0044212
P38398 (UniProtKB)
IDA
GO:0045717
P38398 (UniProtKB)
IMP
GO:0045739
P38398 (UniProtKB)
IMP
GO:0045739
P38398 (UniProtKB)
IMP
GO:0045739
P38398 (UniProtKB)
IMP
GO:0045766
P38398 (UniProtKB)
IMP
GO:0045892
P38398 (UniProtKB)
IDA
GO:0045893
P38398 (UniProtKB)
TAS
GO:0045893
P38398 (UniProtKB)
NAS
GO:0045893
P38398 (UniProtKB)
IDA
GO:0045944
P38398 (UniProtKB)
IDA
GO:0045944
P38398 (UniProtKB)
IMP
GO:0046600
P38398 (UniProtKB)
NAS
GO:0050681
P38398 (UniProtKB)
NAS
GO:0051571
P38398 (UniProtKB)
IDA
GO:0051572
P38398 (UniProtKB)
IEA
GO:0051573
P38398 (UniProtKB)
IDA
GO:0051574
P38398 (UniProtKB)
IEA
GO:0051865
P38398 (UniProtKB)
IDA
GO:0051865
P38398 (UniProtKB)
IDA
GO:0070512
P38398 (UniProtKB)
IDA
GO:0070531
P38398 (UniProtKB)
IDA
GO:0070531
P38398 (UniProtKB)
IDA
GO:0070531
P38398 (UniProtKB)
IDA
GO:0070531
P38398 (UniProtKB)
IDA
GO:0070531
P38398 (UniProtKB)
IDA
GO:0071158
P38398 (UniProtKB)
IDA
GO:0071356
P38398 (UniProtKB)
IMP
GO:0071681
P38398 (UniProtKB)
IDA
GO:0085020
P38398 (UniProtKB)
IDA
GO:0085020
P38398 (UniProtKB)
IDA
GO:1901796
P38398 (UniProtKB)
TAS
GO:1902042
P38398 (UniProtKB)
IMP
GO:2000378
P38398 (UniProtKB)
IMP
GO:2000617
P38398 (UniProtKB)
IDA
GO:2000620
P38398 (UniProtKB)
IDA
GO:0003677
Q3B891 (UniProtKB)
IEA
GO:0004842
Q3B891 (UniProtKB)
IEA
GO:0005634
Q3B891 (UniProtKB)
IEA
GO:0006281
Q3B891 (UniProtKB)
IEA
GO:0008270
Q3B891 (UniProtKB)
IEA
GO:0016567
Q3B891 (UniProtKB)
IEA
GO:0003677
Q5YLB2 (UniProtKB)
IEA
GO:0004842
Q5YLB2 (UniProtKB)
IEA
GO:0005694
Q5YLB2 (UniProtKB)
IEA
GO:0006281
Q5YLB2 (UniProtKB)
IEA
GO:0006310
Q5YLB2 (UniProtKB)
IEA
GO:0007049
Q5YLB2 (UniProtKB)
IEA
GO:0008270
Q5YLB2 (UniProtKB)
IEA
GO:0016874
Q5YLB2 (UniProtKB)
IEA
GO:0031436
Q5YLB2 (UniProtKB)
IEA
GO:0051865
Q5YLB2 (UniProtKB)
IEA
GO:0085020
Q5YLB2 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 BRCA1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
MINT
Reactome
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Hereditary Breast and Ovarian Cancer Syndrome 0.419988654 221 113 BeFree_CLINVAR_CTD_human_ORPHANET
Malignant neoplasm of breast 0.36 2339 76 BeFree_GAD_MGD_UNIPROT
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 0.36 1 973 CLINVAR_CTD_human_UNIPROT
Mammary Neoplasms 0.32641656 391 0 BeFree_CTD_human_GAD_LHGDN
ovarian neoplasm 0.301443908 213 1 BeFree_CTD_human_GAD_LHGDN
Malignant neoplasm of ovary 0.28 1463 23 BeFree_GAD_UNIPROT
Animal Mammary Neoplasms 0.2 79 0 CTD_human_GAD
Mammary Neoplasms, Experimental 0.2 1 0 CTD_human_RGD
Breast Cancer, Familial 0.195656337 270 704 BeFree_CLINVAR_GAD
Prostatic Neoplasms 0.144989972 16 0 BeFree_CTD_human_GAD_LHGDN

基因相关文献

基因相关文献

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells.
Datta A, Jackson J, Morozov YI, Qiu J, Vindigni A, Greenberg RA bioRxiv 2026-03-22
Re-evaluating hereditary breast and ovarian cancer risk: clinical impact of updated multigene panel sequencing and genetic counseling.
Gislinge JIP, Byrjalsen A, Naver KV, Clausen HV, Ravn P, Petersen KR, Wadt KAW Fam Cancer IF: 2.1 2026-03-27
Endogenous and environmental factors that induce DNA replication defects and genomic instability in ER-negative heterozygous BRCA1 cells.
Deshpande M, Paniza T, Brown R, Heslin K, Patel N, Madireddy A, Rosenwaks Z, Gerhardt J Sci Rep IF: 4.9 2026-03-27
Gene Expression Profiles Associated with Molecular Subtypes and Pathological Response to Neoadjuvant Treatment in Surgical Breast Cancer.
Baulies S, Molina-Vila MA, Tresserra F, Rodríguez I, Hurni Y, Giménez-Capitán A, Cabrera S, Fábregas R Int J Mol Sci IF: 3.226 2026-03-11
ESCO2 Interacts with TRF1/2 and Facilitates Telomere Maintenance.
Guo J, Ji J, Liu J, Tang M Int J Mol Sci IF: 3.226 2026-03-13
STK11 and DNA Repair Gene Mutations Define Hereditary Subset of Middle Eastern Papillary Thyroid Cancer.
Bu R, Haqawi W, Razzaq EAA, Azam S, Iqbal K, Qadri Z, Parvathareddy SK, Alrasheed M, Alobaisi K, Al-Dayel F, Siraj AK, Al-Kuraya KS Int J Mol Sci IF: 3.226 2026-03-14
MicroRNA Mimics Based on the miR-15/107 Consensus Sequence Sensitise NSCLC Cells to Targeted Therapy.
Carpenter C, Simmons N, Davis WJH, Thompson M, Zandwijk NV, Drummond CJ, Reid G Int J Mol Sci IF: 3.226 2026-03-16
Assessment of Homologous Recombination System Gene Expression in Chemologically Induced Carcinogenesis In Vivo Models.
Tsyganov MM, Bulatova DZ, Fedorenko AA, Loos DM, Nikiforov PE, Tsydenova IA, Bayanbayeva AA, Sharipkhanova Z, Timoshenko SS, Ibragimova MK Curr Issues Mol Biol IF: 4.1 2026-03-04

基因相关服务

基因相关服务

基因相关评论

基因相关评论

评论加载中...

登录后即可发表评论 登录 注册

联系地址

山东省济南市章丘区文博路2号

齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号

大学科技园北区F座4单元2楼

电话： 0531-88819269

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。


商务邮箱

E-mail: product@genelibs.com

版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备20007159号-2