EXO1 (exonuclease 1)

Gene Basic Information

Gene Basic Information

symbol
EXO1
locus group
protein-coding gene
location
1q43
gene_family
Exonucleases
alias symbol
HEX1|hExoI
alias name
rad2 nuclease family member, homol…
entrez id
9156
ensembl gene id
ENSG00000174371
ucsc gene id
uc001hzh.4
refseq accession
NM_006027
hgnc_id
HGNC:3511
approved reserved
1999-07-07

Chromosome Location

Chromosome Location

1q43

Gene Summary

Gene Summary

ChineseEnglish

This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]

OMIM entry for EXO1     Wikipedia entry for EXO1

Gene Sequence

Gene Sequence

Nucleotide sequence of EXO1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MGIQGLLQFI KEASEPIHVR KYKGQVVAVD TYCWLHKGAI
41ACAEKLAKGE PTDRYVGFCM KFVNMLLSHG IKPILVFDGC
81 TLPSKKEVE RSRRERRQAN LLKGKQLLRE GKVSEARECF
121TRSINITHAM AHKVIKAARS QGVDCLVAPY EADAQLAYLN
161K AGIVQAII TEDSDLLAFG CKKVILKMDQ FGNGLEIDQA
201RLGMCRQLGD VFTEEKFRYM CILSGCDYLS SLRGIGLAKA
241CK VLRLANN PDIVKVIKKI GHYLKMNITV PEDYINGFIR
281ANNTFLYQLV FDPIKRKLIP LNAYEDDVDP ETLSYAGQYV
321DDS IALQIA LGNKDINTFE QIDDYNPDTA MPAHSRSHSW
361DDKTCQKSAN VSSIWHRNYS PRPESGTVSD APQLKENPST
401VGVE RVIST KGLNLPRKSS IVKRPRSAEL SEDDLLSQYS
441LSFTKKTKKN SSEGNKSLSF SEVFVPDLVN GPTNKKSVST
481PPRTR NKFA TFLQRKNEES GAVVVPGTRS RFFCSSDSTD
521CVSNKVSIQP LDETAVTDKE NNLHESEYGD QEGKRLVDTD
561VARNSS DDI PNNHIPGDHI PDKATVFTDE ESYSFESSKF
601TRTISPPTLG TLRSCFSWSG GLGDFSRTPS PSPSTALQQF
641RRKSDSP TS LPENNMSDVS QLKSEESSDD ESHPLREEAC
681SSQSQESGEF SLQSSNASKL SQCSSKDSDS EESDCNIKLL
721DSQSDQTS K LRLSHFSKKD TPLRNKVPGL YKSSSADSLS
761TTKIKPLGPA RASGLSKKPA SIQKRKHHNA ENKPGLQIKL
801NELWKNFGF KKDSEKLPPC KKPLSPVRDN IQLTPEAEED
841IFNKPECGRV QRAIFQ
Structure predicted by AlphaFold DB(UniProt: Q9UQ84). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of EXO1:           Showing partial SNPs
rs9350       rs735943       rs757539       rs851778       rs851779       rs851780       rs851781       rs851782       rs851783       rs851784       rs851785       rs851786       rs851787       rs851788       rs851789       rs851791       rs851792      

Gene Expression

Gene Expression

Tissue expression of EXO1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
ACTGATAGAAGACGACAAGC
58
GAAACACTCTCGAGCTTCC
58
ACTGATAGAAGACGACAAGC
58
GAAACACTCTCGAGCTTCC
58
GAAACTTATTCCTCTGAACGC
57
GAATCATCAACATATTGCCCAG
58
TCAGCCATTCTTACTACGCT
59
ATGGTGCCAAATTAACTACCTC
59
TGAGATTACAGCTTCCTCCA
58
ATGATGGGTCCTCTATGACC
58
GTAATTAAAGCTGCCCGGTC
59
GTTAAGATAGGCCAACTGCG
59
TGAACCTACTGATAGGTATGTAGG
59
TACGAGAATAGGCTTGATCCC
59
GACTCTGATTCAGAGGTTCCT
59
TCCTAGAGGTTTGATCTTGGT
58
AGCCTATTCTCGTATTTGATGG
58
TTGGCTTGTCGTCTTTCTC
58
TGAACCTACTGATAGGTATGTAGG
59
TACGAGAATAGGCTTGATCCC
59

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
TCF3
EXO1
Repression
19698732

Gene Ontology

Subcellular localization of EXO1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for EXO1:

GO ID
Protein
Source DB
GO:0006281
E5RGY3 (UniProtKB)
IEA
GO:0035312
E5RGY3 (UniProtKB)
IEA
GO:0090305
E5RGY3 (UniProtKB)
IEA
GO:0090305
E5RGY3 (UniProtKB)
IEA
GO:0006281
H0YAZ2 (UniProtKB)
IEA
GO:0035312
H0YAZ2 (UniProtKB)
IEA
GO:0090305
H0YAZ2 (UniProtKB)
IEA
GO:0090305
H0YAZ2 (UniProtKB)
IEA
GO:0006281
Q5T397 (UniProtKB)
IEA
GO:0035312
Q5T397 (UniProtKB)
IEA
GO:0090305
Q5T397 (UniProtKB)
IEA
GO:0090305
Q5T397 (UniProtKB)
IEA
GO:0006281
Q5T398 (UniProtKB)
IEA
GO:0035312
Q5T398 (UniProtKB)
IEA
GO:0090305
Q5T398 (UniProtKB)
IEA
GO:0090305
Q5T398 (UniProtKB)
IEA
GO:0006281
Q5T399 (UniProtKB)
IEA
GO:0035312
Q5T399 (UniProtKB)
IEA
GO:0090305
Q5T399 (UniProtKB)
IEA
GO:0090305
Q5T399 (UniProtKB)
IEA
GO:0000731
Q9UQ84 (UniProtKB)
TAS
GO:0000732
Q9UQ84 (UniProtKB)
TAS
GO:0002455
Q9UQ84 (UniProtKB)
IEA
GO:0003677
Q9UQ84 (UniProtKB)
IDA
GO:0003682
Q9UQ84 (UniProtKB)
IEA
GO:0004523
Q9UQ84 (UniProtKB)
TAS
GO:0004527
Q9UQ84 (UniProtKB)
TAS
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005515
Q9UQ84 (UniProtKB)
IPI
GO:0005634
Q9UQ84 (UniProtKB)
IDA
GO:0005634
Q9UQ84 (UniProtKB)
IDA
GO:0005634
Q9UQ84 (UniProtKB)
IDA
GO:0005654
Q9UQ84 (UniProtKB)
IDA
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005654
Q9UQ84 (UniProtKB)
TAS
GO:0005737
Q9UQ84 (UniProtKB)
IDA
GO:0006260
Q9UQ84 (UniProtKB)
TAS
GO:0006260
Q9UQ84 (UniProtKB)
TAS
GO:0006281
Q9UQ84 (UniProtKB)
TAS
GO:0006298
Q9UQ84 (UniProtKB)
IMP
GO:0006298
Q9UQ84 (UniProtKB)
IDA
GO:0006298
Q9UQ84 (UniProtKB)
ISS
GO:0006298
Q9UQ84 (UniProtKB)
IPI
GO:0006298
Q9UQ84 (UniProtKB)
TAS
GO:0006310
Q9UQ84 (UniProtKB)
IGI
GO:0008409
Q9UQ84 (UniProtKB)
ISS
GO:0008409
Q9UQ84 (UniProtKB)
TAS
GO:0016446
Q9UQ84 (UniProtKB)
IEA
GO:0035312
Q9UQ84 (UniProtKB)
IDA
GO:0045145
Q9UQ84 (UniProtKB)
IDA
GO:0045190
Q9UQ84 (UniProtKB)
IEA
GO:0046872
Q9UQ84 (UniProtKB)
IEA
GO:0048256
Q9UQ84 (UniProtKB)
IDA
GO:0048256
Q9UQ84 (UniProtKB)
IDA
GO:0051321
Q9UQ84 (UniProtKB)
IEA
GO:0051908
Q9UQ84 (UniProtKB)
IDA
GO:0051908
Q9UQ84 (UniProtKB)
IDA
GO:0090502
Q9UQ84 (UniProtKB)
IEA
GO:1901796
Q9UQ84 (UniProtKB)
TAS

Related microRNA

Related microRNA

microRNAs potentially regulating EXO1:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
MINT
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Colorectal Neoplasms 0.125991584 4 0 BeFree_CTD_human_LHGDN
Menopause present (finding) 0.122367032 1 1 GAD_GWASCAT
Mammary Neoplasms 0.120271442 2 0 BeFree_CTD_human
Peripheral Neuropathy 0.12 1 0 CTD_human
Malignant neoplasm of lung 0.012378044 5 0 BeFree_GAD
Colorectal Cancer 0.005819831 5 0 BeFree_GAD
Hereditary Nonpolyposis Colorectal Neoplasms 0.00272435 1 0 LHGDN
Lung Neoplasms 0.00272435 1 0 LHGDN
Adenocarcinoma 0.002638474 2 0 BeFree_GAD
Malignant neoplasm of breast 0.002638474 1 0 BeFree_GAD

Related Publications

Related Publications

Slx4 and Fun30/SMARCAD1 coordinate S-phase checkpoint regulation and replication fork protection in response to Top1-DNA crosslinks.
Courtes M, Boissière T, Barthe A, Pasero P, Pardo B Nucleic Acids Res IF: 15.0 2026-04-13
Strand-independent degradation of uncoupled forks by EXO1 activates ATR and restrains synthesis.
Grogan EJ, Ozua OE, Kavlashvili T, Conwell SC, Dewar JM bioRxiv 2026-03-25
Genetic and Molecular Mechanisms Linking Breast Cancer to Meningioma Risk: Roles of EXO1, BRCA2, and ESR1.
Lin C, Hu J, Cai F, Chen J, Huang J, Lin Y Curr Med Chem IF: 3.2 2026-03-18
DNA repair-associated nucleases induce double-strand breaks following sequential exposure to UVA1 and UVB.
Narimichi M, Komaki Y, Suzuki T, Ibuki Y Photochem Photobiol Sci IF: 3.5 2026-04-00
Genome-wide CRISPR screens identify the EXO1-CAF-1 pathway suppressing R-loop-associated DNA damage.
Nusawardhana A, Hale A, Straka J, Nicolae CM, Moldovan GL Nucleic Acids Res IF: 15.0 2026-02-24
Molecular and functional characterization of telomeric repeat-containing RNAs in Chinese hamster ovary cells.
Domingues-Silva B, Seixas AF, Azzalin CM Nucleic Acids Res IF: 15.0 2026-07-17
DNA damage response genes in lung cancer: Diagnostic, prognostic, and therapeutic implications - A narrative review.
Durán-Toribio AK, Jiménez-Díaz IF, Caballé-Pérez E, Lucio-Lozada J, Castillo-Ruiz C, Barrios-Bernal P, Romero-Núñez E, Hernández-Pedro N, Arrieta O Crit Rev Oncol Hematol IF: 6.2 2026-08-15
CTCF primes repressive chromatin for rapid BRCA1/BARD1 recruitment to drive homologous recombination repair of DNA double-strand breaks.
Hwang SY, Choi D, Choi MJ, Jo HR, Jeong JH, Kang MA, Lee JS Nucleic Acids Res IF: 15.0 2026-07-17
Development and validation of gene expression-based signature for high-grade serous ovarian cancer.
Vaicekauskaitė I, Juodakis J, Kazlauskaitė P, Čiurlienė R, Smailytė G, Lazutka JR, Sabaliauskaitė R J Ovarian Res IF: 2.461 2026-01-27

Related Services

Related Services

Comments

Comments

Loading comments...

Log in to post comments Log In Sign Up

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2