LRWD1 (leucine rich repeats and WD repeat domain containing 1)
- symbol:
- LRWD1
- locus group:
- protein-coding gene
- location:
- 7q22.1
- gene_family:
- WD repeat domain containing
- alias symbol:
- DKFZp434K1815|ORCA|CENP-33
- alias name:
- origin recognition complex associa…
- entrez id:
- 222229
- ensembl gene id:
- ENSG00000161036
- ucsc gene id:
- uc003uzn.4
- refseq accession:
- NM_152892
- hgnc_id:
- HGNC:21769
- approved reserved:
- 2007-10-17
LRWD1（Leucine-rich repeats and WD repeat domain containing 1）是一个编码含有亮氨酸重复序列和WD重复结构域的蛋白质的基因。它在细胞周期调控和表观遗传学中发挥重要作用，特别是在异染色质的形成和维持中。LRWD1通过与ORC（起源识别复合物）相互作用，参与DNA复制起始点的识别和染色质结构的稳定。LRWD1的主要作用位点是细胞核，它在异染色质区域富集，帮助维持染色质的紧密结构和基因沉默。突变或功能缺失的LRWD1可能导致DNA复制异常、染色质结构紊乱，进而影响细胞周期进程和基因组稳定性。研究表明，LRWD1的异常表达可能与某些癌症的发生发展相关，如肝癌和结直肠癌，其表达水平的变化可能影响肿瘤细胞的增殖和侵袭能力。LRWD1属于WD重复蛋白家族，这一家族的成员通常含有WD40重复结构域，介导蛋白质-蛋白质相互作用，参与多种细胞过程，如信号转导、细胞周期调控和转录调控。家族成员的共性是通过WD40结构域形成β-螺旋结构，作为分子支架或平台与其他蛋白结合。LRWD1的过表达可能导致异染色质过度形成，影响基因的正常表达，而降低表达则可能破坏染色质稳定性，增加基因组不稳定性。此外，LRWD1的表达变化可能影响ORC的功能，进而干扰DNA复制和细胞周期进程。
None
Gene Ontology
Subcellular localization of LRWD1 (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for LRWD1:
| Interacting Gene | Interaction | Source/Score |
| Disease | Score | NofPmids | NofSnps | Source |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
