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Polycomb-mediated 3D-genome organization controls replication timing.

Chetlangia(N),Thakur(BL),Redon(CE),Zinder(OJ… Sci Adv 2026-06-26

...LRWD1 localizing at these sites. ORCA interacts with the polycomb-repressive complex, stabilizes the H3K27 methyltransfe...

Germline-specific deletion of testis-highly expressed Lrwd1 reveals nonessentia…

Luo(C),Liu(D),Yu(Z),Fan(Z),Xu(H),Zhou(S),Zhu… Theriogenology 2025-07-15

...Lrwd1) in male reproduction. Here we generated germ cell-specific Lrwd1 knockout mice with Stra8-Cre (Lrwd1-sKO) using C...

Association of Circular RNAs with Sperm Fertility Potential: Implications for M…

Esmaeilzadeh(S),Ghasemian(F),Aziziyan(F),Bah… J Reprod Infertil 2025-10-00

...LRWD1-hsa-circ-0003327, circRNF17-chr13:25341410-25356082, and circBRDT-chr1:92428275-92433817, were investigated in thi...

Comprehensive Analysis Reveals Biomarkers Related to Diabetic Peripheral Neurop…

Zhu(Q),Fan(S),Mou(J),Zhao(M),Li(C),Yang(B),S… Int J Gen Med 2025-00-00

...LRWD1, showing significant causal relationships with DPN. Sensitivity analysis along with the Steiger test validated the...

The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysin…

Giri(Sumanprava),Aggarwal(Vasudha),Pontis(Ju… Elife 2016-01-27

...LRWD1), preferentially localizes to heterochromatic regions in post-replicated cells. Its role in heterochromatin organi...

Association of ORCA/LRWD1 with repressive histone methyl transferases mediates …

Giri(Sumanprava),Prasanth(Supriya G) Nucleus 2016-11-01

...LRWD1) protein is required for the initiation of DNA replication and also plays crucial roles in heterochromatin organiz...

Single-nucleotide polymorphisms in the LRWD1 gene may be a genetic risk factor …

Miyamoto(T),Koh(E),Tsujimura(A),Miyagawa(Y),… Andrologia 2015-02-21

...LRWD1, have been identified by expression microarray analysis of human testictissue. The human LRWD1 protein mediates th...

Nuclear factor-κB (NF-κB) regulates the expression of human testis-enriched Leu…

Teng(Yen-Ni),Chuang(Po-Jung),Liu(Yo-Wen) Int J Mol Sci 2015-08-31

...LRWD1. A 198 bp segment upstream of the LRWD1 transcription initiation site exhibited promoter activity. The LRWD1 core ...

Correlation between leucine rich domain and the stability of LRWD1 protein in h…

Tsai(Yung-Chieh),Teng(Yen-Ni),Hung(Jui-Hsian… Adv Med Sci 2015-08-19

...LRWD1(ΔLRR)), WD1 domain (LRWD1(ΔWD1)), WD2 domain (LRWD1(ΔWD2)), WD3 domain (LRWD1(ΔWD3)) and entire three WD domains (...

Orc2 protects ORCA from ubiquitin-mediated degradation.

Shen(Zhen),Prasanth(Supriya G) Cell Cycle 2013-02-26

...LRWD1) stabilizes the ORC on chromatin and facilitates pre-RC assembly. Further, ORCA levels are cell cycle-regulated, w...

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